Hollow fiber column cleaning device

Abstract

The utility model discloses a hollow fiber column cleaning device which comprises a fiber column, a first liquid storage bag used for storing water for injection and a second liquid storage bag used for storing sodium hydroxide, and a liquid inlet of the first liquid storage bag is connected with an external water source through a first liquid inlet pipe. A liquid outlet of the first liquid storage bag and a liquid outlet of the second liquid storage bag are respectively connected with a liquid inlet of the fiber column through a second liquid inlet pipe, the second liquid inlet pipe is provided with a peristaltic pump, and a liquid outlet of the fiber column is connected with a floor drain through a liquid discharge pipe. An external water source continuously provides injection water for the first liquid storage bag, the peristaltic pump firstly conveys the injection water in the first liquid storage bag to the fiber column for flushing, cleaning water is directly discharged through the floor drain, then the peristaltic pump conveys sodium hydroxide in the second liquid storage bag to the fiber column for cleaning, and repeated manual injection water filling is not needed.

Description

Technical Field

[0001] The utility model relates to the technical field of fiber column cleaning, in particular to a hollow fiber column cleaning device. Background Technique

[0002] With the rise of gene therapy and nucleic acid vaccines / drugs, the demand for GMP-grade plasmids has increased significantly. At present, most of the hollow fiber columns are used in the tangential flow filtration process of plasmid purification. The cleaning of the hollow fiber column mainly achieves the cleaning purpose through alkali washing + washing with injection water. The current pre-use cleaning step of the hollow fiber column is to circulate and clean with 0.5M NaOH solution for at least 30 minutes first, and then wash with injection water until the pH of the cleaning water at the permeate end is neutral. The post-use cleaning step of the hollow fiber column is to wash with injection water first, then circulate and clean with 0.5M NaOH for at least 30 minutes, and finally rinse with injection water. The injection water / alkali flushing volume is not less than 20L / m2, and the cleaning flow rate is the same as the flow rate at 3000S-1 of the hollow fiber membrane column.

[0003] In the prior art, it is necessary to first add the cleaning agent made of injection water and NaOH solution to a stainless steel bucket, and during the cleaning process, the cleaning agent needs to be continuously added to the hollow fiber column by manual operation until the cleaning is completed. A large amount of waste liquid generated during cleaning needs to be first collected in an external waste liquid bucket, and then the waste liquid in the waste liquid bucket is discharged to the floor drain by manual transfer and dumping, which is inconvenient to operate and has low efficiency. Content of the Utility Model

[0004] In view of the technical problem of low efficiency caused by manual cleaning of the fiber column, the utility model provides a hollow fiber column cleaning device, which first transports the injection water in the first liquid storage bag to the fiber column for flushing through a peristaltic pump, and then transports the sodium hydroxide in the second liquid storage bag to the fiber column for cleaning, without repeated manual filling. The waste liquid after cleaning is directly discharged through the floor drain.

[0005] The technical solution adopted by the utility model is as follows: A hollow fiber column cleaning device includes a fiber column, a first liquid storage bag for storing injection water, and a second liquid storage bag for storing sodium hydroxide. The liquid inlet of the first liquid storage bag is connected to an external water source through a first liquid inlet pipe. The liquid outlets of the first liquid storage bag and the second liquid storage bag are respectively connected to the liquid inlet of the fiber column through a second liquid inlet pipe. A peristaltic pump is provided on the second liquid inlet pipe. The liquid outlet of the fiber column is connected to the floor drain through a drain pipe.

[0006] Optionally, the drain pipe is communicated with a return pipe, and the return pipe is connected to the liquid inlet of the second liquid storage bag.

[0007] Optionally, the liquid inlet of the fiber column is located at the bottom of the fiber column, and the liquid outlet of the fiber column is located at the top of the fiber column.

[0008] Optionally, one end of the drain pipe communicates with the liquid outlet of the fiber column, the other end of the drain pipe communicates with the floor drain, and the two ends of the drain pipe are communicated with the return pipe through a three-way pipe.

[0009] Optionally, the liquid outlet of the fiber column includes a first liquid outlet and a second liquid outlet. The first liquid outlet is connected to the drain pipe, the second liquid outlet is connected to a return pipe, and the return pipe is connected to the liquid inlet of the second liquid storage bag.

[0010] Optionally, a first valve is provided on the drain pipe, a second valve is provided on the return pipe, and the first valve and the second valve are not opened simultaneously.

[0011] Optionally, a solenoid valve is provided at one end of the first liquid inlet pipe close to the external water source.

[0012] Optionally, a liquid level sensor is provided on the first liquid storage bag.

[0013] The beneficial effects of the present utility model are as follows: The external water source continuously provides injection water to the first liquid storage bag. The peristaltic pump first transports the injection water in the first liquid storage bag to the fiber column for flushing, and the cleaning water is directly discharged through the floor drain. Then the peristaltic pump transports the sodium hydroxide in the second liquid storage bag to the fiber column for cleaning. There is no need to repeatedly add injection water manually. It is convenient and fast to switch the injection water cleaning agent and the NaOH cleaning agent through the peristaltic pump, and there is no need to manually connect and drain the cleaning waste, which ensures the cleaning effect of the hollow fiber column and greatly improves the cleaning efficiency at the same time. Description of the Drawings

[0014] Figure 1 It is a schematic structural diagram of the hollow fiber column cleaning device proposed in Embodiment 1 of the present utility model;

[0015] Figure 2 It is a schematic structural diagram of the hollow fiber column cleaning device proposed in Embodiment 2 of the present utility model.

[0016] The marks in each drawing are: 1, fiber column; 2, first liquid storage bag; 3, second liquid storage bag; 4, first liquid inlet pipe; 5, external water source; 6, second liquid inlet pipe; 7, peristaltic pump; 8, drain pipe; 9, floor drain; 10, return pipe; 11, three-way pipe; 12, first valve; 13, second valve; 14, solenoid valve. Detailed Embodiments

[0017] The present application will be further described in detail below with reference to the accompanying drawings and embodiments. It can be understood that the specific embodiments described herein are only used to explain the relevant utility model, rather than limiting the utility model. In addition, it should be noted that for the sake of description, only the parts related to the utility model are shown in the drawings. Multiple technical solutions in the same embodiment, as well as multiple technical solutions in different embodiments, can be combined to form new technical solutions without contradiction or conflict, all within the scope of protection required by the present utility model.

[0018] Embodiment 1

[0019] As Figure 1 shown, this embodiment discloses a hollow fiber column cleaning device, which includes a fiber column 1, a first liquid storage bag 2 for storing injection water, and a second liquid storage bag 3 for storing sodium hydroxide. The liquid inlet of the first liquid storage bag 2 is connected to an external water source 5 through a first liquid inlet pipe 4. The liquid outlets of the first liquid storage bag 2 and the second liquid storage bag 3 are respectively connected to the liquid inlet of the fiber column 1 through a second liquid inlet pipe 6. A peristaltic pump 7 is provided on the second liquid inlet pipe 6. The liquid outlet of the fiber column 1 is connected to a floor drain 9 through a drain pipe 8. The external water source 5 continuously supplies water to the first liquid storage bag 2. The peristaltic pump 7 first transports the injection water in the first liquid storage bag 2 to the fiber column 1 for flushing, and the cleaning water is directly discharged through the floor drain 9. Then the peristaltic pump 7 transports the sodium hydroxide in the second liquid storage bag 3 to the fiber column 1 for cleaning. There is no need to repeatedly add injection water manually. The injection water cleaning agent and the NaOH cleaning agent can be switched conveniently and quickly through the peristaltic pump 7, and there is no need to manually connect and drain the cleaning waste, which ensures the cleaning effect of the hollow fiber column 1 and greatly improves the cleaning efficiency at the same time.

[0020] In this embodiment, a return pipe 10 is connected to the drain pipe 8, and the return pipe 10 is connected to the liquid inlet of the second liquid storage bag 3. The sodium hydroxide cleaning solution can flow into the floor drain 9 through the drain pipe 8, or return to the second liquid storage bag 3 through the return pipe 10, increasing the utilization rate of sodium hydroxide.

[0021] In this embodiment, the liquid inlet of the fiber column 1 is located at the bottom of the fiber column 1, and the liquid outlet of the fiber column 1 is located at the top of the fiber column 1. The injection water and the sodium hydroxide cleaning solution are respectively flushed upward from the bottom of the fiber column 1, making the cleaning of the fiber column 1 more thorough.

[0022] In this embodiment, one end of the drain pipe 8 is communicated with the liquid outlet of the fiber column 1, the other end of the drain pipe 8 is communicated with the floor drain 9, and the two ends of the drain pipe 8 are communicated with the return pipe 10 through a tee pipe 11. A first valve 12 is provided on the drain pipe 8, and a second valve 13 is provided on the return pipe 10. The first valve 12 and the second valve 13 are not opened simultaneously. After flushing with injection water or sodium hydroxide, the second valve 13 is closed and the first valve 12 is opened to allow the injection water and sodium hydroxide to flow back to the floor drain 9. When sodium hydroxide needs to be recycled, the second valve 13 is opened and the first valve 12 is closed.

[0023] In this embodiment, a solenoid valve 14 is provided at one end of the first liquid inlet pipe 4 close to the external water source 5. The solenoid valve 14 and the peristaltic pump 7 are respectively connected to the controller for convenient remote operation. The solenoid valve 14 can be a pneumatic ball valve.

[0024] In this embodiment, a liquid level sensor is provided on the first liquid storage bag 2. The liquid level sensor is connected to the controller. When the injection water in the first liquid storage bag 2 is lower than a certain position, the liquid level sensor sends a signal to the controller, and the controller controls the pneumatic ball valve to open, and the external water source 5 supplies water to the first liquid storage bag 2.

[0025] Embodiment 2

[0026] As Figure 2 shown, compared with Embodiment 1, the liquid outlet of the fiber column 1 in this embodiment includes a first liquid outlet and a second liquid outlet. The first liquid outlet is connected to the drain pipe 8, and the second liquid outlet is connected to the return pipe 10. The return pipe 10 is connected to the liquid inlet of the second liquid storage bag 3.

[0027] The above are only the preferred embodiments of the present invention, and thus do not limit the patent protection scope of the present invention. Any equivalent structural transformation made by using the content of the specification and drawings of the present invention, directly or indirectly applied to other related technical fields, shall be equally included in the protection scope of the present invention.

Claims

1. A hollow fiber column cleaning device, characterized in that: It comprises a first liquid storage bag for storing water for injection and a second liquid storage bag for storing sodium hydroxide, wherein the liquid inlet of the first liquid storage bag is connected to an external water source via a first liquid inlet pipe, the liquid outlet of the first liquid storage bag and the liquid outlet of the second liquid storage bag are respectively connected to the liquid inlet of the fiber column via a second liquid inlet pipe, the second liquid inlet pipe is provided with a peristaltic pump, and the liquid outlet of the fiber column is connected to a floor drain via a drain pipe.

2. The hollow fiber column cleaning device according to claim 1, characterized in that: The liquid discharge pipe is connected to a reflux pipe, and the reflux pipe is connected to the liquid inlet of the second liquid storage bag.

3. The hollow fiber column cleaning device according to claim 1, characterized in that: The liquid inlet of the fiber column is located at the bottom of the fiber column, and the liquid outlet of the fiber column is located at the top of the fiber column.

4. The hollow fiber column cleaning device according to claim 2, characterized in that: One end of the drainage pipe is connected to the liquid outlet of the fiber column, the other end of the drainage pipe is connected to the floor drain, and the two ends of the drainage pipe are connected to the return pipe through a three-way pipe.

5. The hollow fiber column cleaning device according to claim 1, characterized in that: The liquid outlet of the fiber column includes a first liquid outlet and a second liquid outlet, the first liquid outlet is connected to the liquid discharge pipe, the second liquid outlet is connected to a reflux pipe, and the reflux pipe is connected to the liquid inlet of the second liquid storage bag.

6. The hollow fiber column cleaning device according to claim 4 or 5, characterized in that: The discharge pipe is provided with a first valve, and the reflux pipe is provided with a second valve, and the first valve and the second valve are not opened at the same time.

7. The hollow fiber column cleaning device according to claim 1, characterized in that: An electromagnetic valve is provided at one end of the first liquid inlet pipe close to the external water source.

8. The hollow fiber column cleaning device according to claim 1, characterized in that: The first liquid storage bag is provided with a liquid level sensor.

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