Kit for constructing humanized flora mouse model

Abstract

The utility model relates to the technical field of a kit for a humanized flora mouse model, and discloses a kit for constructing a humanized flora mouse model, which comprises an outer shell, a drug delivery device is arranged in the outer shell, a butt joint sealing device is arranged on the surface of the drug delivery device, and the butt joint sealing device is connected with the drug delivery device. The medicine feeding device comprises a medicine box, a feeding hopper part, a feeding hole, a material guide table, an inner box part, a magnetic suction plate, a separation insertion plate and a sealing gasket; and the medicine box is fixedly connected to the top end of the interior of the outer shell. According to the kit for constructing the humanized flora mouse model, the drug feeding device is arranged, drugs can be added through the feeding hopper part during drug feeding and then poured into the drug box through the feeding hole, the device can be provided with an automatic drug feeding system, drugs can be fed through drinking water or feed, it is ensured that a mouse receives the accurate dosage, and the comparison group is arranged, so that the accuracy of drug feeding is improved. Whether the use function of the drug delivery system is feasible or not can be compared, and the use effect is good.

Description

Technical Field

[0001] The utility model relates to the technical field of kits for humanized flora mouse models, and specifically relates to a kit for constructing a humanized flora mouse model. Background Technique

[0002] Tumor treatment methods mainly include surgery, chemotherapy, radiotherapy, targeted therapy, etc. The initial clinical treatment effects of many tumors are good, but as the drug treatment time prolongs, tumors often develop drug resistance and are prone to recurrence, posing a severe challenge to clinical treatment.

[0003] The prior art discloses a kit with the publication number: CN115316343A, which includes a broad-spectrum antibiotic composition, human intestinal flora, dietary fiber pectin, and a gavage device. Using this kit, a humanized flora mouse model can be constructed, and on this basis, a tumor model can be constructed for immune checkpoint inhibitor screening or evaluation.

[0004] The above-mentioned kit for constructing a humanized flora mouse model uses high-throughput sequencing methods to sequence the intestinal flora of mice and perform bioinformatics analysis, detect the fecal flora structure and diversity, evaluate the transplantation efficiency, and obtain a humanized flora mouse model. However, the kit does not have an automatic drug delivery system and cannot administer drugs through drinking water or feed to ensure that mice receive precise doses. Moreover, no control group is set up, so it is impossible to compare whether the use function of the drug delivery system is feasible, and the effect during use is not good, and improvements need to be made in this regard. Content of the Utility Model

[0005] The purpose of the utility model is to provide a kit for constructing a humanized flora mouse model to solve the problems raised in the above background technique.

[0006] To achieve the above purpose, the utility model provides the following technical solution: A kit for constructing a humanized flora mouse model, including an outer housing, an internal drug delivery device is arranged inside the outer housing, and a docking and sealing device is arranged on the surface of the drug delivery device.

[0007] The drug delivery device includes a medicine box, a feeding hopper part, a feeding hole, a material guiding table, an inner box part, a magnetic attraction plate, a partition inserting plate, and a sealing gasket. The medicine box is fixedly connected to the inner top end of the outer housing, the feeding hopper part is fixedly connected to the top of the medicine box, the feeding hole is opened at the inner bottom end of the feeding hopper part, the material guiding table is fixedly connected to the side of the medicine box, the inner box part is fixedly connected to the inner wall of the outer housing, and the magnetic attraction plate is fixedly connected to both sides of the inner wall of the inner box part.

[0008] Preferably, the docking and sealing device includes a connecting cylinder, a magnetic sheet, a sealing plate, a sealing cushion block and a magnet semi-circular plug-in. The connecting cylinder is fixedly connected to the top of the inner box member. The sealing plate is fixedly connected to the top of the magnet semi-circular plug-in. The sealing cushion block is fixedly connected to the bottom of the sealing plate.

[0009] Preferably, a semi-circular docking groove is formed inside the connecting cylinder, and the magnetic sheet is fixedly connected inside the connecting cylinder.

[0010] Preferably, the sealing gasket is fixedly connected to the left side of the surface of the partition insertion plate, and the sealing gasket is slidably connected to the left side inside the inner box member.

[0011] Preferably, the sealing gasket is fixedly connected to the left side of the surface of the partition insertion plate, and the sealing gasket is slidably connected to the left side inside the inner box member.

[0012] Preferably, support feet are fixedly connected to the four corners of the surface of the outer housing. The support feet can carry the device and increase the stability of the device.

[0013] Preferably, the magnet semi-circular plug-in is inserted into the inside of the connecting cylinder. The magnet semi-circular plug-in is magnetically connected to the magnetic sheet. After the magnet semi-circular plug-in fits with the magnetic sheet, it can be magnetically adsorbed and connected. The magnet semi-circular plug-in continuously slides downward inside the connecting cylinder until the bottom of the sealing plate contacts the top of the inner box member, and it can be magnetically installed.

[0014] Compared with the prior art, the beneficial effects of the present utility model are as follows:

[0015] 1. For the kit for constructing a humanized flora mouse model, by providing a drug delivery device, during drug intake, it can be added through the feeding hopper member and then poured into the medicine box through the feeding hole. Moreover, the device can be provided with an automatic drug delivery system, which can deliver drugs through drinking water or feed to ensure that the mice receive accurate doses. And a control group is set up to compare whether the use function of the drug delivery system is feasible, and the effect during use is good.

[0016] 2. For the kit for constructing a humanized flora mouse model, by providing a docking and sealing device, the sealing cushion block is inserted into the front end position of the partition insertion plate inside the inner box member. After installation, aseptic treatment is carried out, which is convenient for providing a sterile environment. And it is separated by the partition insertion plate, and the two control groups are separated by only one board, which is convenient for comparison and judgment. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 is the overall three-dimensional top view structural schematic diagram of the present utility model;

[0018] Figure 2 is for the present utility model Figure 1 the enlarged structural schematic diagram at A in;

[0019] Figure 3 For the present utility model Figure 1 Schematic enlarged view of the structure at position B in the present utility model;

[0020] Figure 4 Schematic overall three - dimensional bottom - up view of the structure of the present utility model;

[0021] Figure 5 For the present utility model Figure 4 Schematic enlarged view of the structure at position C in the present utility model.

[0022] In the figure: 1. Outer shell; 2. Drug delivery device; 201. Medicine box; 202. Feeding hopper part; 203. Feeding hole; 204. Material guiding table; 205. Inner box part; 206. Magnetic attraction plate; 207. Partition inserting plate; 208. Sealing gasket; 3. Docking sealing device; 301. Connecting cylinder; 302. Magnetic attraction piece; 303. Sealing plate; 304. Sealing cushion block; 305. Magnet semi - circular plug - in. Specific implementation manners

[0023] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.

[0024] Please refer to Figures 1-5 , the present utility model provides the following technical solutions:

[0025] A kit for constructing a humanized flora mouse model, comprising an outer shell 1, a drug delivery device 2 is arranged inside the outer shell 1, a docking sealing device 3 is arranged on the surface of the drug delivery device 2, and support feet are fixedly connected to the four corners of the surface of the outer shell 1. The support feet can carry the device and increase the stability of the device.

[0026] The drug delivery device 2 includes a medicine box 201, a feeding hopper part 202, a feeding hole 203, a material guiding table 204, an inner box part 205, a magnetic attraction plate 206, a partition inserting plate 207 and a gasket 208. The medicine box 201 is fixedly connected to the inner top end of the outer housing 1. The feeding hopper part 202 is fixedly connected to the top of the medicine box 201. The feeding hole 203 is opened at the inner bottom end of the feeding hopper part 202. The material guiding table 204 is fixedly connected to the side of the medicine box 201. The inner box part 205 is fixedly connected to the inner wall of the outer housing 1. The magnetic attraction plates 206 are fixedly connected to both sides of the inner wall of the inner box part 205. A semi-circular docking groove is opened inside the connecting cylinder 301. The magnetic attraction piece 302 is fixedly connected to the inside of the connecting cylinder 301. The gasket 208 is fixedly connected to the left side of the surface of the partition inserting plate 207. The gasket 208 is slidably connected to the left side inside the inner box part 205.

[0027] The docking and sealing device 3 includes a connecting cylinder 301, a magnetic attraction piece 302, a sealing plate 303, a sealing cushion block 304 and a magnet semi-circular plug-in 305. The connecting cylinder 301 is fixedly connected to the top of the inner box part 205. The sealing plate 303 is fixedly connected to the top of the magnet semi-circular plug-in 305. The sealing cushion block 304 is fixedly connected to the bottom of the sealing plate 303. The magnet semi-circular plug-in 305 is inserted into the inside of the connecting cylinder 301. The magnet semi-circular plug-in 305 is magnetically attracted and connected to the magnetic attraction piece 302. After the magnet semi-circular plug-in 305 fits with the magnetic attraction piece 302, it can be magnetically adsorbed and connected. The magnet semi-circular plug-in 305 continuously slides downward inside the connecting cylinder 301 until the bottom of the sealing plate 303 contacts the top of the inner box part 205, and it can be magnetically installed. A semi-circular docking groove is opened inside the connecting cylinder 301. The magnetic attraction piece 302 is fixedly connected to the inside of the connecting cylinder 301.

[0028] In use, mice can be separately placed into the medicine box 201, and the partition insert plate 207 can be inserted into the interior of the medicine box 201. When inserting, the side of the partition insert plate 207 is attached to the side of the magnetic attraction plate 206, and the left sealing gasket 208 will be attached to the left side inside the medicine box 201, and it can be properly placed. When placing the mice, the same number of mice are placed at the front and rear ends of the partition insert plate 207 respectively. There is a medicine supplement device on one side, and on the other side, it is set as a sterile culture chamber by means of the docking sealing device 3. And an automatic culture medium replacement and flora growth monitoring system is equipped in the space on the back of the partition insert plate 207, which can monitor the flora growth state in real time. When feeding medicine, it can be added through the feeding hopper part 202, then poured into the medicine box 201 through the feeding hole 203, and then it can enter the interior of the medicine box 201 along the material guiding groove inside the material guiding table 204 and be located at the rear end of the partition insert plate 207, so that the device can be provided with an automatic drug delivery system, which can deliver drugs through drinking water or feed to ensure that the mice receive accurate doses. And a control group is set up to compare whether the use function of the drug delivery system is feasible, and the effect during use is good. And a sealing plate 303 can be inserted on the front of the medicine box 201. When installing, the magnet semi-circular plug 305 at the bottom of the sealing plate 303 is aligned with the connecting cylinder 301 and inserted. The magnet semi-circular plug 305 is inserted into the interior of the connecting cylinder 301 and fits together with the magnetic attraction piece 302. After the magnet semi-circular plug 305 fits with the magnetic attraction piece 302, it can be magnetically adsorbed and connected. The magnet semi-circular plug 305 continuously slides downward inside the connecting cylinder 301 until the bottom of the sealing plate 303 contacts the top of the inner box part 205 for sealing. And the sealing cushion block 304 is inserted into the front end position of the partition insert plate 207 inside the inner box part 205. After installation, it is sterilized to facilitate providing a sterile environment, and it is separated by the partition insert plate 207. The two comparative examples are separated by only one plate, which is convenient for comparative judgment.

[0029] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to the embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A kit for constructing a humanized microbiota mouse model, comprising an outer shell (1), characterized in that: Inside the outer casing (1), a drug delivery device (2) is provided, and a docking and sealing device (3) is provided on the surface of the drug delivery device (2); The drug delivery device (2) includes a medicine box (201), a feed hopper part (202), a feed hole (203), a material guiding table (204), an inner box part (205), a magnetic attraction plate (206), a partition inserting plate (207), and a sealing gasket (208). The medicine box (201) is fixedly connected to the inner top end of the outer casing (1). The feed hopper part (202) is fixedly connected to the top of the medicine box (201). The feed hole (203) is opened at the inner bottom end of the feed hopper part (202). The material guiding table (204) is fixedly connected to the side of the medicine box (201). The inner box part (205) is fixedly connected to the inner wall of the outer casing (1). The magnetic attraction plates (206) are fixedly connected to both sides of the inner wall of the inner box part (205).

2. The kit for constructing a humanized microbiota mouse model according to claim 1, characterized in that: The docking and sealing device (3) includes a connecting cylinder (301), a magnetic attraction piece (302), a sealing plate (303), a sealing cushion block (304), and a magnet semi-circular plug-in piece (305). The connecting cylinder (301) is fixedly connected to the top of the inner box part (205). The sealing plate (303) is fixedly connected to the top of the magnet semi-circular plug-in piece (305). The sealing cushion block (304) is fixedly connected to the bottom of the sealing plate (303).

3. The kit for constructing a humanized flora mouse model according to claim 2, characterized in that: A semi-circular docking groove is opened inside the connecting cylinder (301), and the magnetic attraction piece (302) is fixedly connected to the inside of the connecting cylinder (301).

4. A kit for constructing a humanized flora mouse model according to claim 1, characterized in that: The sealing gasket (208) is fixedly connected to the left side of the surface of the partition inserting plate (207), and the sealing gasket (208) is slidably connected to the left side inside the inner box part (205).

5. The kit for constructing a humanized flora mouse model according to claim 1, characterized in that: The sealing gasket (208) is fixedly connected to the left side of the surface of the partition inserting plate (207), and the sealing gasket (208) is slidably connected to the left side inside the inner box part (205).

6. A kit for constructing a humanized microbiota mouse model according to claim 1, characterized in that: Support feet are fixedly connected to the four corners of the surface of the outer casing (1).

7. A kit for constructing a humanized flora mouse model according to claim 2, characterized in that: The magnet semi-circular plug-in piece (305) is inserted into the inside of the connecting cylinder (301), and the magnet semi-circular plug-in piece (305) is magnetically connected to the magnetic attraction piece (302).

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