Stomach biopsy tissue cell sampling device

Abstract

The utility model provides a stomach biopsy tissue cell sampling device which comprises a brush head tube, the front end of the brush head tube is fixedly connected with a brush head, the brush head is of an expanded structure, the outer diameter of the brush head is larger than the diameter of the brush head tube, and the brush head is formed by winding fibers; the brush head pipe is sleeved with the sleeve, and the brush head is exposed out of the end of the sleeve. By adopting the expanded brush head structure wound by the fibers, the contact area between the fibers and the stomach tissue can be increased, the success rate of stomach biopsy tissue sampling is improved, and the end of the expanded brush head is smooth, so that the gastric mucosa is not easy to damage. The radioactive brush head arranged behind the expanded brush head is limited by the expanded brush head, so that the stomach tissue cannot be damaged, but the radioactive brush head can be used as a supplementary means for stomach biopsy tissue sampling, and the success rate of biopsy tissue printed sheet specimen sampling is further improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, and in particular to a gastric biopsy tissue cell sampling device. Background Art

[0002] By using the device of the utility model to collect gastric cells, and through Feulgen staining, Papanicolaou staining or histopathological analysis, big data diagnosis of gastric tumor cytology can be carried out, realizing the clinical application of early screening and early treatment of gastric cancer, that is, abnormal cell conditions can be found through cell image diagnosis. In the prior art, the brush head of the gastroscope brush for collecting gastric cells often adopts a radial brush head structure, which cannot meet the problem of brushing gastric tissue cells, especially exfoliated cells; at the same time, the contact area between the end of the slender brush hair and the stomach is limited, and the brush head end is sharp, which is easy to damage the gastric mucosa. For multi-cell mass tissues, there are few exfoliated cells, resulting in poor sampling effect; the brush tube is made of soft material, and it is not easy to brush cells at a fixed position. Chinese patent document CN115633996A discloses a disposable cell brush, which includes a brush head assembly, an outer tube, a catheter and a heat shrinkable tube; after the cable in the brush head assembly passes through the outer tube, it is connected to the catheter; the outer tube is connected to the heat shrinkable tube in a through manner; the double-finger fixed handle is fixed to the heat shrinkable tube, and the catheter is movably arranged through the middle of the double-finger fixed handle; the thumb handle is fixed to the catheter; the outer end of the thumb handle is movably abutted against the double-finger fixed handle. This patent only considers the flexible operation of the cell brush for biopsy sampling, but does not consider the problem that the brush head end of the sampling brush is sharp, easy to damage the gastric mucosa, and the sampling effect is poor. Content of the Utility Model

[0003] The main purpose of the utility model is to provide a gastric biopsy tissue cell sampling device, so as to solve the problems that clamping tissue cells is easy to cause damage, the brush head end of the gastroscope brush is sharp, and the contact area between the brush head and the stomach is limited, improve the success rate of gastric biopsy cell sampling, and reduce the damage of the brush head to the gastric tissue.

[0004] To solve the above technical problems, the technical solution adopted by the utility model is: a gastric biopsy tissue cell sampling device, which includes a brush head tube, a brush head is fixedly connected to the front end of the brush head tube, the brush head is an enlarged structure, the outer diameter of the brush head is larger than the diameter of the brush head tube, and the brush head is made of fiber winding;

[0005] The brush head tube is sleeved in the sleeve tube, and the brush head exposes outside the end of the sleeve tube.

[0006] In a preferred solution, one end of the sleeve tube is fixedly connected to the outer sliding sleeve, an inner sliding rod that axially slides relative to the inner part is arranged in the outer sliding sleeve, the inner sliding rod is connected to the brush head tube, and the inner sliding rod and the outer sliding sleeve form an operating handle.

[0007] In a preferred solution, a pull ring is arranged at the end of the inner sliding rod for a finger to pass through the pull ring;

[0008] The outer wall of the outer sliding sleeve is provided with an annular groove, and the double fingers are located in the annular groove for fixing the outer sliding sleeve.

[0009] In a preferred embodiment, the brush head includes an enlarged brush head, and the enlarged brush head includes a spherical shape, an oval shape, an annular shape or a gourd shape.

[0010] In a preferred embodiment, a melting layer is provided between the brush head tube and the enlarged brush head, and the melting layer is used for fixedly connecting the brush head and the brush head tube.

[0011] In a preferred embodiment, the enlarged brush head is fixedly connected to the connecting head, and the connecting head is threadedly connected to the brush head tube by a thread.

[0012] In a preferred embodiment, a radiation brush head is provided on the outer wall of the brush head tube after the enlarged brush head.

[0013] In a preferred embodiment, the outer diameter of the enlarged brush head is 1.8 - 2.2 mm; the brush head tube is made of rigid plastic.

[0014] In a preferred embodiment, the lengths of the enlarged brush head and the radiation brush head are 13 - 17 mm.

[0015] In a preferred embodiment, the enlarged brush head is formed by needling and winding fibers with a fineness less than 0.44 dtex into an enlarged structure with grooves;

[0016] The fiber material is one or a combination of animal hair, plant fiber or polyester, polyamide, polyacrylonitrile, polypropylene, polytetrafluoroethylene.

[0017] The utility model provides a gastric biopsy tissue cell sampling device. By adopting the enlarged brush head structure wound with fibers, the contact area between the fibers and the gastric tissue can be increased, the success rate of gastric biopsy tissue sampling can be improved, and the end of the enlarged brush head is smooth and not easy to damage the gastric mucosa. The radiation brush head arranged after the enlarged brush head, due to being limited by the enlarged brush head, cannot damage the gastric tissue, but can be used as a supplementary means for gastric biopsy tissue sampling to further improve the success rate of sampling for biopsy tissue imprint specimens. This device does not sample by clamping tissue cells, but uses a brush to brush the gastric tissue cells, especially exfoliated cells, which can avoid damage to the gastric mucosa and bleeding during sampling. The harm caused by its sampling is much smaller than that caused by traditional gastroscope clamping, and even can achieve almost non-invasive. This device not only has small sampling harm and a brush head with a smooth design at the end, which can meet the cell quantity requirements for exfoliated cell sampling, but also meets the clinical requirements for cell sampling, specimen preparation and slide reading. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] The following further describes the utility model in conjunction with the drawings and embodiments:

[0019] Figure 1This is the overall structure diagram of the present utility model;

[0020] Figure 2 This is the schematic diagram of the brush head tube and the brush head of the present utility model;

[0021] Figure 3 This is the structural diagram of the brush head tube and the brush head of the present utility model;

[0022] Figure 4 This is the schematic diagram of the connection structure between the brush head tube and the brush head of the present utility model;

[0023] Figure 5 This is the schematic diagram of another preferred connection structure between the brush head tube and the brush head in the present utility model;

[0024] Figure 6 This is the schematic diagram of the gourd-shaped brush head in the embodiment of the present utility model;

[0025] Figure 7 This is the imprinting diagram for cell Feulgen and Papanicolaou staining in Example 2 of the present utility model;

[0026] In the figure: brush head tube 1; brush head 2; enlarged brush head 21; radial brush head 22; melting layer 23; connecting head 24; operating handle 3; inner sliding rod 31; outer sliding sleeve 32; sleeve 4. Detailed implementation manners

[0027] Example 1:

[0028] As Figures 1 - 6 In, a gastric biopsy tissue cell sampling device includes a brush head tube 1, the front end of the brush head tube 1 is fixedly connected with a brush head 2, the brush head 2 is of an enlarged structure, the outer diameter of the brush head 2 is larger than the diameter of the brush head tube 1, and the material of the brush head 2 is composed of fiber winding; preferably, the material of the brush head 2 is a disordered winding structure of fibers formed by needle punching. The brush head tube 1 is sleeved inside the sleeve 4, and the brush head 2 is exposed outside the end of the sleeve 4. The front end of the brush head 2 is an enlarged brush head, and the end is smooth and round, which is not easy to damage the gastric mucosa, ensuring the sampling success rate, avoiding damage to the gastric mucosa during the sampling process, and having no discomfort.

[0029] The preferred scheme is as Figure 1 In, one end of the sleeve 4 is fixedly connected with the outer sliding sleeve 32, the inner sliding rod 31 that axially slides relatively is arranged inside the outer sliding sleeve 32, the inner sliding rod 31 is connected with the brush head tube 1, and the inner sliding rod 31 and the outer sliding sleeve 32 form the operating handle 3. The preferred scheme is as Figure 1In it, a pull ring is provided at the end of the inner sliding rod 31 for a finger to pass through the pull ring; an annular groove is provided on the outer wall of the outer sliding sleeve 32, and the two fingers are located in the annular groove for fixing the outer sliding sleeve 32. With this structure, the entire operating handle 3 can be fixed with the thumb, index finger and middle finger, and the sampling of gastric biopsy tissue imprint specimens can be completed through the opening and closing movement between the thumb and the index finger and middle finger.

[0030] The preferred solution is as Figure 3 , 6 In it, the brush head 2 includes an enlarged brush head 21, and the enlarged brush head 21 includes a spherical shape, an oval shape, an annular shape or a gourd shape. The gourd-shaped enlarged brush head 21 is as shown in Figure 6 shown in. Compared with the spherical shape, using the oval shape and the gourd shape can further increase the contact area between the enlarged brush head 21 and the gastric mucosa. Using the annular enlarged brush head 21 can further increase the circumscribed circle diameter of the enlarged brush head 21 and improve the success rate of sampling gastric biopsy tissue imprint specimens.

[0031] The preferred solution is as Figure 4 In it, a melting layer 23 is provided between the brush head tube 1 and the enlarged brush head 21, and the melting layer 23 is used to fixedly connect the brush head 2 and the brush head tube 1. Preferably, the brush head tube 1 is made of hard plastic, such as PVC. The formation of the melting layer 23 is to heat the end of the brush head tube 1 to the molten state, penetrate it into the groove inside the enlarged brush head 21, press the side of the enlarged brush head 21, and embed the fibers of the enlarged brush head 21 into the melting layer 23 at the end of the brush head tube 1, so that the enlarged brush head 21 and the brush head tube 1 are fixedly connected as a whole. With this structure, the enlarged brush head 21 can be fixed at the front end of the brush head 2 through the melting layer 23 to prevent the enlarged brush head 21 from falling off.

[0032] A further preferred solution is as Figure 5 In it, the enlarged brush head 21 is fixedly connected to the connecting head 24. The connecting head 24 is made of hard plastic or metal material, or a combination of hard plastic and metal material. The connecting head 24 is threadedly connected to the brush head tube 1 through a thread. Specifically, the enlarged brush head 21 is melt-connected to the hard plastic, and the hard plastic is fixedly connected to the metal rod. An external thread is provided at the other end of the metal rod, and an internal thread is provided at the end of the brush head tube 1. The metal rod is threadedly connected to the brush head tube 1. With this structure, when multiple samplings are required, the brush head tube 1 can be taken out, the enlarged brush head 21 can be taken off and put into the eluent for elution, and then a new enlarged brush head 21 can be installed and sent to another place for sampling to reduce the burden on the patient.

[0033] The preferred solution is as Figures 3 - 6In it, a radiation brush head 22 is provided on the outer wall of the brush head tube 1 behind the enlarged brush head 21. The radiation brush head 22 means that the bristles are distributed radially on the outer wall of the brush head tube 1. Since it is necessary to keep the bristles perpendicular to the wall of the brush head tube 1, the bristles need to have sufficient hardness. And by placing the radiation brush head 22 behind the enlarged brush head 21, the end of the radiation brush head 22 is limited by the enlarged brush head 21 and will not damage the gastric mucosa.

[0034] In a preferred solution, the outer diameter of the enlarged brush head 21 is 1.8 - 2.2 mm; preferably, the outer diameter of the enlarged brush head 21 is 2 mm.

[0035] In a preferred solution, the lengths of the enlarged brush head 21 and the radiation brush head 22 are 13 - 17 mm. Preferably, it is 15 mm.

[0036] In a preferred solution, the enlarged brush head 21 is formed by needling and winding fibers with a fineness less than 1 dtex into an enlarged structure with grooves, preferably fibers with a fineness less than 0.44 dtex; with this structure, the enlarged brush head 21 is relatively soft and can avoid damaging the gastric mucosa.

[0037] The fiber material is one or a combination of animal hair, plant fiber, or polyester, polyamide, polyacrylonitrile, polypropylene, polytetrafluoroethylene. Preferably, it is polyester material.

[0038] Example 2:

[0039] Further described in combination with Example 1, as Figure 7 shown, when using the device of the present utility model to take biopsy tissue imprint specimens, the standard sampling consumables for gastroscope biopsy imprints can meet the requirements for gastric cytological diagnosis. The staining methods for gastroscope biopsy imprint cells, such as Papanicolaou and Feulgen, can both be used for gastric cytological diagnosis; the number of gastric biopsy cell imprints is between 1024 and 10104, which can meet the requirements for cytological diagnosis; for gastroscope biopsy cell imprint specimens from different parts, such as cases of the stomach, intestine, esophagus, etc., the same specimen preparation method can be used. Realizing non-invasive cytological detection and exploring the innovation and development of new cell brushes is conducive to the large-scale promotion of the clinical application of non-invasive early screening of gastroscopes.

[0040] The above embodiments are only the preferred technical solutions of the present utility model and should not be regarded as limitations on the present utility model. The protection scope of the present utility model should be the technical solutions recorded in the claims, including the equivalent replacement solutions of the technical features in the technical solutions recorded in the claims. That is, the equivalent replacement improvements within this scope are also within the protection scope of the present utility model.

Claims

1. A gastric biopsy tissue cell sampling device, characterized in that: It includes a brush head tube (1), and a brush head (2) is fixedly connected to the front end of the brush head tube (1). The brush head (2) is of an enlarged structure, and the outer diameter of the brush head (2) is larger than the diameter of the brush head tube (1). The brush head (2) is made of fiber winding; the brush head tube (1) is sleeved in a sleeve tube (4), and the brush head (2) protrudes outside the end of the sleeve tube (4).

2. The gastric biopsy tissue cell sampling device according to claim 1, characterized in that: One end of the sleeve tube (4) is fixedly connected to an outer sliding sleeve (32). An inner sliding rod (31) that axially slides relative to the inner part is arranged in the outer sliding sleeve (32). The inner sliding rod (31) is connected to the brush head tube (1), and the inner sliding rod (31) and the outer sliding sleeve (32) form an operation handle (3).

3. The gastric biopsy tissue cell sampling device according to claim 2, characterized in that: A pull ring is arranged at the end of the inner sliding rod (31) for a finger to pass through the pull ring. An annular groove is arranged on the outer wall of the outer sliding sleeve (32), and two fingers are located in the annular groove to fix the outer sliding sleeve (32).

4. The gastric biopsy tissue cell sampling device according to any one of claims 1 to 3, characterized in that: The brush head (2) includes an enlarged brush head (21), and the enlarged brush head (21) includes a spherical shape, an oval shape, an annular shape or a gourd shape.

5. The gastric biopsy tissue cell sampling device according to claim 4, wherein: A melting layer (23) is arranged between the brush head tube (1) and the enlarged brush head (21), and the melting layer (23) is used to fixedly connect the brush head (2) and the brush head tube (1).

6. The gastric biopsy tissue cell sampling device according to claim 4, characterized in that: The enlarged brush head (21) is fixedly connected to a connecting head (24), and the connecting head (24) is threadedly connected to the brush head tube (1) through a thread.

7. The gastric biopsy tissue cell sampling device according to claim 4, characterized in that: A radiation brush head (22) is arranged on the outer wall of the brush head tube (1) after the enlarged brush head (21).

8. The gastric biopsy tissue cell sampling device according to any one of claims 5 to 7, characterized in that: The outer diameter of the enlarged brush head (21) is 1.8 - 2.2 mm; the brush head tube (1) is made of hard plastic.

9. The gastric biopsy tissue cell sampling device according to claim 7, wherein: The lengths of the enlarged brush head (21) and the radiation brush head (22) are 13 - 17 mm.

10. The gastric biopsy tissue cell sampling device according to claim 7, wherein: The enlarged brush head (21) is formed by needling and winding fibers with a fineness less than 0.44 dtex into an enlarged structure with grooves. The fiber material is one of animal hair, plant fiber, polyester, polyamide, polyacrylonitrile, polypropylene, and polytetrafluoroethylene.

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