Exosome preservation device

Abstract

The utility model relates to the technical field of exosome preservation, and discloses an exosome preservation device which comprises a placement box, one side of the placement box is rotationally connected with a door plate, the middle of the door plate is fixedly connected with a transparent panel, the interior of the placement box is connected with a storage box in a sliding mode, the two sides of the storage box are fixedly connected with connecting plates, and the connecting plates are connected with the door plate in a sliding mode. A second handle is fixedly connected to the side, away from the connecting plate, of the storage box, a fixing plate and a second sleeve shell are fixedly connected to the middle of the storage box, a first spring is fixedly connected to the middle of the fixing plate, a clamping plate is fixedly connected to the end, away from the fixing plate, of the first spring, and a buffer cotton plate is slidably connected to the middle of the storage box. According to the test tube storage device, under the mutual cooperation of the buffer cotton plate, the first sleeve shell, the second spring, the connecting column, the second limiting plate, the third spring and other structures, the stored test tubes can be buffered in the transportation process, and then the test tubes can be prevented from inclining or being damaged.

Description

Technical Field

[0001] The utility model relates to the technical field of exosome preservation, in particular to an exosome preservation device. Background Art

[0002] Exosomes are a type of small membrane vesicles containing complex RNA and proteins, usually with a diameter between 30 - 150 nanometers. However, modern scientific research more specifically refers to them as discoid vesicles with a diameter between 40 - 100 nanometers. The secretion of exosomes exists in various cells, and these cells can secrete exosomes whether in a normal state or a pathological state. The main source of exosomes is lysosomes within cells, which form multivesicular bodies through microvesicle invagination. Subsequently, the outer membrane of these multivesicular bodies fuses with the cell membrane, and then the exosomes are released into the extracellular matrix. Through this process, exosomes play a key role in physiological functions such as intercellular communication, material transport, and regulation of immune responses, and also provide new perspectives and methods for the diagnosis and treatment of diseases.

[0003] In the prior art, when placing the preservation test tube of exosomes, there are usually problems of ineffective clamping and buffering. In this case, the preservation test tube is prone to vibration or impact during storage and transportation, which can lead to the movement, tilt, or damage of the test tube. This instability not only increases the risk of test tube breakage but also affects the integrity and reliability of exosome samples. Summary of the Utility Model

[0004] To make up for the above deficiencies, the utility model provides an exosome preservation device, aiming to improve the problem that in the prior art, when placing the preservation test tube, it cannot be effectively clamped and buffered, resulting in the movement, tilt, or damage of the test tube.

[0005] To achieve the above purpose, the utility model adopts the following technical scheme:

[0006] An exosome preservation device includes a placement box, one side of the placement box is rotatably connected with a door panel, a transparent panel is fixedly connected to the middle of the door panel, a storage box is slidably connected inside the placement box, connecting plates are fixedly connected to both sides of the storage box, a handle two is fixedly connected to the side of the storage box far from the connecting plate, a fixing plate and a sleeve two are fixedly connected to the middle of the storage box, a spring one is fixedly connected to the middle of the fixing plate, a clamping plate is fixedly connected to the end of the spring one far from the fixing plate, a buffer cotton plate is slidably connected to the middle of the storage box, a sleeve one is fixedly connected to the bottom of the buffer cotton plate, a limiting plate one is slidably connected to the middle of the sleeve one, a spring two is fixedly connected to the top of the limiting plate one, a connecting column is fixedly connected to the bottom of the limiting plate one, and a buffer component is provided at the bottom of the connecting column for buffering the preservation test tube;

[0007] As a further description of the above technical solution:

[0008] The buffer assembly includes a second limiting plate, the second limiting plate is fixedly connected to the bottom of the connecting column, the second limiting plate is slidably connected to the inside of the second housing, and a third spring is fixedly connected to the bottom of the second limiting plate;

[0009] As a further description of the above technical solution:

[0010] One side of the placement box is fixedly connected with a second filter plate, a support plate is fixedly connected to the inside of the placement box, a plurality of first fans are fixedly connected to the middle of the support plate, a semiconductor refrigeration sheet is fixedly connected to the top of the placement box, and a heat dissipation assembly is arranged on the top of the semiconductor refrigeration sheet for dissipating heat from the semiconductor refrigeration sheet;

[0011] As a further description of the above technical solution:

[0012] The heat dissipation assembly includes heat dissipation fins, the heat dissipation fins are fixedly connected to the top of the semiconductor refrigeration sheet, a fixing frame is fixedly connected to the top of the placement box, and a plurality of second fans are fixedly connected to the middle of the fixing frame;

[0013] As a further description of the above technical solution:

[0014] A rubber pad is fixedly connected to the bottom of the second housing;

[0015] As a further description of the above technical solution:

[0016] One end of the third spring away from the second limiting plate is fixedly connected to the inside of the second housing;

[0017] As a further description of the above technical solution:

[0018] Placement boxes and first filter plates are fixedly connected to both sides of the placement box;

[0019] As a further description of the above technical solution:

[0020] A plurality of support columns are fixedly connected to the bottom of the placement box, and a first handle is fixedly connected to the top of the placement box.

[0021] The utility model has the following beneficial effects:

[0022] 1. In the present utility model, the buffer cotton board squeezes the first housing and the second spring. When the second spring is squeezed, it drives the first limiting plate to move upward. When the first limiting plate moves upward, it drives the connecting column to move simultaneously. After the connecting column moves to a certain position, it squeezes the second limiting plate. When the second limiting plate is squeezed, it squeezes the third spring. Thus, under the action of the third spring and the second spring, the test tube can be buffered during transportation, thereby preventing the test tube from tilting or being damaged. At the same time, under the action of the clamping plate and the first spring, the test tube can be clamped and fixed, preventing the test tube from moving or shifting during transportation.

[0023] 2. In the present utility model, the first fan and the thermoelectric cooler work. When the thermoelectric cooler works, it refrigerates. When the first fan works, it pumps the cold air produced by the thermoelectric cooler and blows it into the interior of the placement box, thus facilitating the cooling and keeping the interior of the placement box at a stable low temperature all the time, thereby reducing the labor intensity of the staff and improving the overall adaptability of the device. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] Figure 1 is a three-dimensional schematic diagram of an exosome preservation device proposed by the present utility model;

[0025] Figure 2 is a structural schematic diagram of a support column of an exosome preservation device proposed by the present utility model;

[0026] Figure 3 is a structural schematic diagram of a clamping plate of an exosome preservation device proposed by the present utility model;

[0027] Figure 4 is a structural schematic diagram of a second filter plate of an exosome preservation device proposed by the present utility model;

[0028] Figure 5 is a structural schematic diagram of a heat dissipation fin of an exosome preservation device proposed by the present utility model;

[0029] Figure 6 is a structural schematic diagram of a third spring of an exosome preservation device proposed by the present utility model.

[0030] LEGEND DESCRIPTION:

[0031] 1. Placement box; 2. Placement box; 3. First filter plate; 4. Support column; 5. Door panel; 6. Transparent panel; 7. First handle; 8. Storage box; 9. Connection plate; 10. Second handle; 11. Fixed plate; 12. Clamping plate; 13. First spring; 14. Buffer cotton board; 15. First housing; 16. Second housing; 17. Second filter plate; 18. Support plate; 19. First fan; 20. Fixed frame; 21. Second fan; 22. Semiconductor refrigeration sheet; 23. Heat dissipation fins; 24. First limit plate; 25. Second spring; 26. Connection column; 27. Second limit plate; 28. Third spring; 29. Rubber pad. Detailed implementation manner

[0032] Next, the technical solutions in the embodiments of the present invention will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only a part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.

[0033] Refer to Figure 1 and Figure 2 As shown in the figure, an embodiment provided by the present invention is: An exosome preservation device includes a placement box 1. One side of the placement box 1 is rotatably connected with a door panel 5. The middle of the door panel 5 is fixedly connected with a transparent panel 6. The transparent panel 6 can facilitate the staff to observe the preservation test tubes inside the placement box 1. The inside of the placement box 1 is slidably connected with a storage box 8. The door panel 5 can facilitate the blocking of the storage box 8, thereby preventing the storage box 8 from sliding out of the inside of the placement box 1 during transportation. The storage box 8 can facilitate the placement and storage of the exosome preservation test tubes. Both sides of the storage box 8 are fixedly connected with connection plates 9. The connection plates 9 can facilitate the support and limit of the storage box 8, thereby preventing the storage box 8 from shifting during movement. The side of the storage box 8 away from the connection plate 9 is fixedly connected with a second handle 10. The second handle 10 can facilitate the staff to drive the storage box 8 to move.

[0034] Refer to Figure 2 、 Figure 3 and Figure 6, a fixing plate 11 and a second sleeve 16 are fixedly connected to the middle of the storage box 8. A first spring 13 is fixedly connected to the middle of the fixing plate 11. The fixing plate 11 can conveniently support the first spring 13. One end of the first spring 13 away from the fixing plate 11 is fixedly connected to a clamping plate 12. The first spring 13 can conveniently push the clamping plate 12 to one side. There are multiple clamping plates 12, and the multiple clamping plates 12 can conveniently clamp and fix the storage test tubes for you, so as to prevent deviation during transportation. A buffer cotton board 14 is slidably connected to the middle of the storage box 8. The buffer cotton board 14 can conveniently buffer the stored reagent, thereby preventing the storage test tubes from breaking. A first sleeve 15 is fixedly connected to the bottom of the buffer cotton board 14. A first limiting plate 24 is slidably connected to the middle of the first sleeve 15. A second spring 25 is fixedly connected to the top of the first limiting plate 24. When the first limiting plate 24 moves, it will squeeze the second spring 25. A connecting column 26 is fixedly connected to the bottom of the first limiting plate 24. When the first limiting plate 24 moves, it will drive the connecting column 26 to move simultaneously. A buffer assembly is provided at the bottom of the connecting column 26, and the buffer assembly is used to buffer the storage test tubes.

[0035] Refer to Figure 6 , the buffer assembly includes a second limiting plate 27. The second limiting plate 27 is fixedly connected to the bottom of the connecting column 26. When the connecting column 26 moves, it will drive the second limiting plate 27 to move simultaneously. The second limiting plate 27 is slidably connected inside the second sleeve 16. A third spring 28 is fixedly connected to the bottom of the second limiting plate 27. When the second limiting plate 27 moves, it will squeeze the third spring 28. Thus, under the action of the third spring 28 and the second spring 25, the storage test tubes can be buffered during transportation, and further the test tubes can be prevented from tilting or being damaged.

[0036] Refer to Figure 4 and Figure 5 , a second filter plate 17 is fixedly connected to one side of the placement box 1. The second filter plate 17 can conveniently filter the dust in the air, thereby preventing the dust in the air from affecting the exosomes. A support plate 18 is fixedly connected to the inside of the placement box 1. A plurality of first fans 19 are fixedly connected to the middle of the support plate 18. The support plate 18 can conveniently support and fix the plurality of first fans 19, so that the plurality of first fans 19 can work better. A semiconductor refrigeration sheet 22 is fixedly connected to the top of the placement box 1. When the semiconductor refrigeration sheet 22 works, it will refrigerate. When the first fans 19 work, they will pump the cold air produced by the semiconductor refrigeration sheet 22 and blow it into the inside of the placement box 1, so as to conveniently cool down, keep the inside of the placement box 1 at a stable temperature all the time, thereby reducing the labor intensity of the staff and improving the overall adaptability of the device.

[0037] Refer to Figure 5, a heat dissipation component is provided at the top of the semiconductor refrigeration chip 22. The heat dissipation component is used to dissipate heat from the semiconductor refrigeration chip 22. The heat dissipation component includes heat dissipation fins 23. The heat dissipation fins 23 are fixedly connected to the top of the semiconductor refrigeration chip 22. The heat dissipation fins 23 can facilitate heat dissipation from the other side of the semiconductor refrigeration chip 22, so that the semiconductor refrigeration chip 22 can perform better refrigeration work. A fixing frame 20 is fixedly connected to the top of the placement box 1. A plurality of second fans 21 are fixedly connected to the middle of the fixing frame 20. The fixing frame 20 can facilitate the support and fixation of the second fans 21. When the second fans 21 are working, they will blow the surfaces of the plurality of heat dissipation fins 23, thereby accelerating the heat dissipation effect of the semiconductor refrigeration chip 22.

[0038] Refer to Figure 1 and Figure 6 , a rubber pad 29 is fixedly connected to the bottom of the second housing 16. One end of the third spring 28 away from the second limiting plate 27 is fixedly connected inside the second housing 16. Placement boxes 2 and first filter plates 3 are fixedly connected to both sides of the placement box 1. The placement boxes 2 can facilitate the placement of tools and other items needed by the staff. A plurality of support columns 4 are fixedly connected to the bottom of the placement box 1. The plurality of support columns 4 can facilitate more stable support and fixation of the placement box 1. A first handle 7 is fixedly connected to the top of the placement box 1. The first handle 7 can facilitate the staff to pull the placement box 1 to move, and thus can facilitate the staff to carry the placement box 1.

[0039] Working principle: When it is necessary to buffer or clamp and fix the preservation test tube, the buffer cotton board 14 will move downward. When the buffer cotton board 14 moves downward, it will squeeze the first housing 15 and the second spring 25. When the second spring 25 is squeezed, it will drive the first limiting plate 24 to move upward. When the first limiting plate 24 moves upward, it will drive the connecting column 26 to move simultaneously. After the connecting column 26 moves to a certain position, it will squeeze the second limiting plate 27. When the second limiting plate 27 is squeezed, it will squeeze the third spring 28. Thus, under the action of the third spring 28 and the second spring 25, the preservation test tube can be buffered during transportation. At the same time, under the action of the clamping plate 12 and the first spring 13, the test tube can be clamped and fixed.

[0040] When the inside of the placement box 1 is refrigerated so that the preservation test tube is at a low temperature, the semiconductor refrigeration chip 22 will perform refrigeration work when it is working. At the same time, the first fan 19 will work. When the first fan 19 is working, it will pump the cold air produced by the semiconductor refrigeration chip 22 and blow it into the placement box 1, thereby facilitating the cooling and keeping the temperature inside the placement box 1 stable all the time.

[0041] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions recorded in the foregoing embodiments or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included within the protection scope of the present invention.

Claims

1. An exosome preservation device, comprising a placement box (1), characterized in that: One side of the placement box (1) is rotatably connected with a door panel (5). A transparent panel (6) is fixedly connected to the middle of the door panel (5). A storage box (8) is slidably connected to the inside of the placement box (1). Connecting plates (9) are fixedly connected to both sides of the storage box (8). A second handle (10) is fixedly connected to one side of the storage box (8) away from the connecting plates (9). A fixing plate (11) and a second sleeve (16) are fixedly connected to the middle of the storage box (8). A first spring (13) is fixedly connected to the middle of the fixing plate (11). One end of the first spring (13) away from the fixing plate (11) is fixedly connected to a clamping plate (12). A buffer cotton board (14) is slidably connected to the middle of the storage box (8). A first sleeve (15) is fixedly connected to the bottom of the buffer cotton board (14). A first limiting plate (24) is slidably connected to the middle of the first sleeve (15). A second spring (25) is fixedly connected to the top of the first limiting plate (24). A connecting column (26) is fixedly connected to the bottom of the first limiting plate (24). A buffer assembly is arranged at the bottom of the connecting column (26), and the buffer assembly is used for buffering the stored test tubes.

2. The exosome preservation device according to claim 1, wherein: The buffer assembly includes a second limiting plate (27). The second limiting plate (27) is fixedly connected to the bottom of the connecting column (26). The second limiting plate (27) is slidably connected to the inside of the second sleeve (16). A third spring (28) is fixedly connected to the bottom of the second limiting plate (27).

3. The exosome preservation device according to claim 1, characterized in that: A second filter plate (17) is fixedly connected to one side of the placement box (1). A support plate (18) is fixedly connected to the inside of the placement box (1). A plurality of first fans (19) are fixedly connected to the middle of the support plate (18). A semiconductor refrigeration sheet (22) is fixedly connected to the top of the placement box (1). A heat dissipation assembly is arranged at the top of the semiconductor refrigeration sheet (22), and the heat dissipation assembly is used for dissipating heat from the semiconductor refrigeration sheet (22).

4. The exosome preservation device according to claim 3, wherein: The heat dissipation assembly includes heat dissipation fins (23). The heat dissipation fins (23) are fixedly connected to the top of the semiconductor refrigeration sheet (22). A fixing frame (20) is fixedly connected to the top of the placement box (1). A plurality of second fans (21) are fixedly connected to the middle of the fixing frame (20).

5. The exosome preservation device according to claim 1, wherein: A rubber pad (29) is fixedly connected to the bottom of the second sleeve (16).

6. The exosome preservation device according to claim 2, wherein: One end of the third spring (28) away from the second limiting plate (27) is fixedly connected to the inside of the second sleeve (16).

7. The exosome preservation device according to claim 1, characterized in that: Placement boxes (2) and first filter plates (3) are fixedly connected to both sides of the placement box (1).

8. The exosome preservation device according to claim 1, wherein: A plurality of support columns (4) are fixedly connected to the bottom of the placement box (1). A first handle (7) is fixedly connected to the top of the placement box (1).

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