S-shaped multi-effect distilled water machine
The S-type multiple-effect distillation water machine addresses inefficiencies in impurity and gas removal by implementing individual discharge points in each tower, resulting in high-quality injection water with reduced bacterial endotoxin and gas content.
Patent Information
- Application Number
- CN202421675858.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-07-15
- Publication Date
- 2025-07-15
- Estimated Expiration
- 2034-07-15
AI Technical Summary
The unreasonable discharge of concentrated water in existing multi-effect distillation water machines leads to an increase in impurity concentration, affecting the quality of water for injection, and the emission capacity of non-condensable gas is insufficient, making it difficult to meet the requirements of high-quality water quality.
A separate discharge port is set up at the bottom of each distillation tower for concentrated water discharge, and a non-condensing gas discharge port is set up at the top of the shell of the distillation tower, and independent discharge is combined with a throttle valve to optimize the emission of concentrated water and non-condensing gas.
Effectively reduce the endotoxin concentration and non-coagulable gas content in the injection water, reaching extremely high water quality standards, the endotoxin content is reduced to ≤0.0125EU/cm, and the non-coagulable gas content is reduced to 1.6%, which complies with the GMP specification.
Smart Images
Figure CN223102778U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of distilled water machines, in particular to an S-type multi-effect distilled water machine. Background Art
[0002] The preparation of medicines cannot be separated from water. Water for injection is a very important process water for the production of medicines. It is a key factor in ensuring the quality of medicines in the production of injections, freeze-dried powder injections, eye drops, etc. my country's Pharmacopoeia stipulates that "water for injection should be obtained by distillation". Distillation is the most effective method to remove bacterial endotoxins, and it has a good effect on removing non-volatile organic and inorganic substances in raw water, including suspended matter, colloids, bacteria, viruses, heat sources and other impurities. Therefore, distillation is widely used in countries around the world to produce water for injection.
[0003] The multi-effect water distiller is a key equipment in pharmaceutical production. Its main function is to continuously and stably distill and "purify" raw water into "water for injection" that meets the requirements of the pharmacopoeia.
[0004] The most commonly used equipment for distillation method - multi-effect water distiller, uses purified water as raw water and boiler steam as heating source. It adopts advanced shell and tube falling film multi-effect evaporation principle and is an ideal equipment for pharmaceutical factories to produce water for injection.
[0005] The existing multi-effect distilled water machine has the following problems:
[0006] 1. Unreasonable discharge of concentrated water:
[0007] The concentrated water containing endotoxin after centrifugal separation in each distillation tower is automatically discharged from the previous tower to the next tower, and finally all the concentrated water is collected and discharged from the last tower. As the number of distillation towers increases, as the concentrated water is continuously collected at the bottom of each tower, the impurity concentration becomes higher and higher, and the endotoxin concentration also becomes higher and higher, which is bound to affect the centrifugal separation efficiency of each next tower and gradually decrease, resulting in a decrease in the quality of water for injection in each next tower;
[0008] 2. Insufficient discharge capacity of non-condensable gases:
[0009] The national GMP standard requires that the content of non-condensable gases dissolved in water for injection must be less than 3.5% by volume. Injections are medicines that directly enter the human blood circulation system to take effect. The product quality, especially the content of non-condensable gases, is very important. The existing technology has only one discharge point on the condenser shell side for the discharge of non-condensable gases dissolved in water for injection. The test result is about 3.0%, which is difficult to reduce further and cannot meet the requirements of high-quality water quality. Utility Model Content
[0010] The utility model aims to solve the problems existing in the prior art and proposes an S-type multi-effect distilled water machine.
[0011] To achieve the above object, the utility model adopts the following technical solutions:
[0012] An S-type multi-effect distiller, comprising:
[0013] A number of distillation towers, the distillation towers are vertical tube falling film evaporation structures, composed of an upper evaporator and a lower separator, wherein, the number of the distillation towers includes a primary distillation tower and a plurality of secondary distillation towers;
[0014] A condenser, an input end of the condenser is connected with a water pump, the water pump is used for inputting raw water into the condenser, an output end thereof is communicated with a preheater through a pipeline, and the preheater is communicated with a top of the primary distillation tower through a pipeline;
[0015] Above one side of the primary distillation tower is communicated with a steam inlet pipe, the steam entering through the steam inlet pipe is heated in a shell side of an upper part of the first-stage distillation tower, and performs heat exchange with the preheated raw water, the generated condensed water is discharged through a steam trap arranged at a bottom side of the primary evaporator, after the pure steam generated by evaporation of the raw water removes liquid droplets through a separator, it sequentially enters an evaporator in a plurality of secondary distillation towers through a steam outlet and a pipeline, and the unevaporated raw water sequentially enters an evaporator in a plurality of secondary distillation towers through a bottom outlet of the primary distillation tower, and exchanges heat with the steam, an output end of the separator is provided with a concentrated water discharge port for discharging liquid droplets separated by the separator.
[0016] Preferably, it further includes a concentrated water discharge pipe, a plurality of the concentrated water discharge ports are all communicated with the concentrated water discharge pipe through pipelines, and a throttle valve is arranged on the pipeline.
[0017] Preferably, the condenser includes an inner channel and an outer channel, heat exchange is performed between the inner channel and the outer channel, the water pump is communicated with the inner channel of the condenser through a pipeline, an output end of an evaporator of the last-stage secondary distillation tower and a steam outlet at a separator are communicated with the outer channel of the condenser through a pipeline.
[0018] Preferably, non-condensable gas discharge ports are arranged on tops of one sides of a plurality of the secondary distillation towers and on the outer channel of the condenser, and a plurality of non-condensable gas discharge ports are all communicated with a non-condensable gas discharge pipe through pipelines, and a throttle valve is arranged on the pipeline.
[0019] Preferably, a sewage discharge port is arranged at a bottom of the last-stage secondary distillation tower.
[0020] Preferably, a distilled water discharge pipeline is communicated with the outer channel of the condenser, and the distilled water discharge pipeline has two output ends, and first valves are arranged on both output ends, and a distilled water sampling port is arranged through a second valve at an input end position of the discharge pipeline.
[0021] Compared with the prior art, the beneficial effects of the present utility model are as follows:
[0022] 1. In the present utility model, separate discharge ports are provided at the bottom of each distillation column for separate discharge, instead of aggregating and discharging at the last column. As the concentrated water in each distillation column is continuously removed, the endotoxin concentration in the product injection water becomes lower and lower. The centrifugal separation efficiency of the next column becomes stronger in turn. As a result, the bacterial endotoxin content of the product injection water finally aggregated into the condenser is extremely low, thus obtaining injection water with extremely high quality.
[0023] 2. For the non-condensable gas dissolved in water in the present utility model, due to the relatively small gas density, the aggregated gas will flow upward and stagnate at the highest point of the shell side of the distillation column. Therefore, non-condensable gas discharge ports are set at the top of the shell side of each distillation column, and the non-condensable gas is most easily discharged. Through the separately provided non-condensable gas discharge ports, separate discharge is carried out through independent throttle valves, ensuring a low content of non-condensable gas in the injection water. BRIEF DESCRIPTION OF THE DRAWINGS
[0024] Figure 1 It is a schematic diagram of the overall composition of an S-type multi-effect distilled water machine proposed by the present utility model;
[0025] Figure 2 It is a schematic diagram of the distillation column of an S-type multi-effect distilled water machine proposed by the present utility model.
[0026] In the figure: 1. Primary distillation column; 2. Secondary distillation column; 3. Condenser; 4. Water pump; 5. Preheater; 6. Steam inlet pipe; 7. Steam trap; 8. Separator; 9. Evaporator; 10. Steam outlet; 11. Concentrated water discharge port; 12. Concentrated water discharge pipe; 13. Throttle valve; 14. Non-condensable gas discharge port; 15. Non-condensable gas discharge pipe; 16. Distilled water discharge pipeline; 17. Distilled water sampling port; 18. Lower housing; 19. Spiral separator; 20. Collector; 21. Collection hole; 22. Cavity. DETAILED DESCRIPTION OF THE EMBODIMENTS
[0027] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all of the embodiments.
[0028] Referring to Figure 1 and Figure 2 , an S-type multi-effect distilled water machine includes:
[0029] A number of distillation columns, the distillation columns being of a vertical tube falling film evaporation structure, composed of an upper evaporator 9 and a lower separator 8, wherein, a number of the distillation columns include a primary distillation column 1 and a plurality of secondary distillation columns 2;
[0030] A condenser 3, the input end of the condenser 3 is connected with a water pump 4, the water pump 4 is used for inputting raw water into the condenser 3, and its output end is communicated with a preheater 5 through a pipeline, and the preheater 5 is communicated with the top of the primary distillation column 1 through a pipeline;
[0031] Above one side of the primary distillation column 1 is communicated with a steam inlet pipe 6, the steam entering through the steam inlet pipe 6 is heated in the upper shell side of the first-stage distillation column 1 and exchanges heat with the preheated raw water, that is, the upper evaporator 9 in the distillation column includes a shell and vertically arranged pipes inside the shell, the steam enters the shell, and the raw water enters the pipes from the top of the distillation column. After heat exchange, it enters the separator 8. In the primary distillation column 1, the condensed water generated by the directly input steam is discharged through a steam trap 7 (separating liquid and steam) provided at one side of the bottom of the primary evaporator 9 (i.e., one side of the shell). After the pure steam generated by the evaporation of the raw water removes droplets through the separator 8, it enters the evaporators 9 in a plurality of secondary distillation columns 2 in sequence through a steam outlet 10 and a pipeline. The unevaporated raw water passes through the bottom outlet of the primary distillation column 1 and enters the evaporators 9 in a plurality of secondary distillation columns 2 in sequence (a pipeline is connected from this outlet to the top of another distillation column so that the raw water enters the vertical pipes in the evaporator 9) and exchanges heat with the steam. The output end of the separator 8 is provided with a concentrated water discharge port 11 for discharging the droplets separated by the separator 8;
[0032] Among them, as Figure 2As shown in the figure, the separator 8 includes a lower housing 18 installed in communication with the bottom of the evaporator 9, a spiral separator 19 disposed inside the lower housing 18, and a collector 20 installed on the inner wall of the lower housing 18 and forming a cavity 22 with the inner wall of the lower housing 18. The collector 20 is located outside the spiral separator 19. A collection hole 21 is provided on the inner wall of the collector 20. The steam outlet 10 is opened above the outside of the lower housing 18. The concentrated water discharge port 11 is arranged below the outside of the lower housing 18 and communicates with the cavity 22. The secondary pure steam generated by the evaporation of the distillation column (i.e., generated by the heat exchange of the raw water) and the water vapor mixture of the unevaporated raw water enter the lower part of the distillation column through the diversion of the separator inner tank. Under the action of gravity, the unevaporated liquid water flows into the bottom of the separator and is discharged, and enters the next distillation column for continuous evaporation. The secondary pure steam rises into the spiral plate of the spiral separator 198. There are four groups of spiral plates, which are wound around the outside of the separator inner tank. The secondary pure steam entraining water vapor droplets is forced to rotate under the action of the spiral plate. The tangential velocity of the generated air flow can reach 30 m / s. The generated high-speed centrifugal force throws the mist droplets entrained in the pure steam onto the wall of the collector 20. Finally, it is introduced into the collector 20 through the upper collection port on the wall of the collector 20. The liquid droplets, which contain impurities such as bacterial endotoxins, are removed, and finally discharged through the concentrated water discharge port 11. The clean pure steam after gas-liquid separation enters the shell side of the next-effect distillation column through the steam outlet 10 as heating steam, and at the same time condenses into distilled water (injection water) itself. By adopting the above design, the spiral centrifugal separation continuously discharges the condensed water, effectively reducing the bacterial endotoxin and non-condensable gas content of the injection water by 10 to 100 orders of magnitude, thereby obtaining injection water with extremely high quality.
[0033] In this device, separate discharge ports are provided at the bottom position of each distillation column for separate discharge, instead of being aggregated to the last column for discharge. As the concentrated water of each distillation column is continuously removed later, the endotoxin concentration in the product injection water becomes lower and lower. The centrifugal separation efficiency of the next column becomes stronger and stronger in turn. As a result, the bacterial endotoxin content of the product injection water finally aggregated to the condenser 3 is extremely low, rather than being aggregated to the last column for discharge as in the prior art. As a result, the bacterial endotoxin content of the product injection water finally aggregated to the condenser 3 is extremely low. The bacterial endotoxin can be reduced from ≤0.25 EU / cm required by the pharmacopoeia to the order of ≤0.0125 EU / cm, thereby obtaining injection water with extremely high quality.
[0034] In this embodiment, it further includes a concentrated water discharge pipe 12. A plurality of the concentrated water discharge ports 11 are all communicated with the concentrated water discharge pipe 12 through pipelines, and a throttle valve 13 is provided on this pipeline. The concentrated water of the first-stage distillation column 1 is discharged through the concentrated water discharge port 11, and the throttle valve 13 controls the discharge amount and then enters the concentrated water discharge pipe 12.
[0035] In this embodiment, the condenser 3 includes an inner channel and an outer channel sleeved outside the inner channel. Heat exchange occurs between the inner channel and the outer channel. The water pump 4 is connected to the inner channel of the condenser 3 through a pipeline. The output end of the evaporator 9 of the last-stage secondary distillation column 2 and the steam outlet 10 at the separator 8 are connected to the outer channel of the condenser 3 through a pipeline. When the two steam flows enter the outer channel, the water pump 4 conveys raw water simultaneously. On the one hand, the steam can be condensed to obtain distilled water, and on the other hand, it can be preheated to improve the thermal energy utilization rate and save energy consumption.
[0036] In this embodiment, non-condensable gas discharge ports 14 are provided at the top of one side of multiple secondary distillation columns 2 and on the outer channel of the condenser 3. A number of non-condensable gas discharge ports 14 are all connected to a non-condensable gas discharge pipe 15 through pipelines, and a throttle valve 13 is provided on this pipeline. For the non-condensable gas dissolved in water, due to the relatively small gas density, the aggregated gas will flow upward and stagnate at the highest point of the shell side of the distillation column. Therefore, by setting non-condensable gas discharge ports at the top position of the shell side of each distillation column, the non-condensable gas is most easily discharged. Through the separately provided non-condensable gas discharge ports and independent throttle valves 13 for separate discharge, the low content of non-condensable gas in the injection water is ensured. By controlling the opening degree of the throttle valve 13, it can be ensured that only non-condensable gas is discharged without pure steam escaping. The non-condensable gas discharge result of the multi-effect distilled water machine improved in this embodiment is about 1.6% in volume content, far lower than the volume content requirement of the GMP specification that the content of non-condensable gas dissolved in the injection water must be < 3.5%, meeting the high-quality water requirement.
[0037] In this embodiment, a sewage discharge port is provided at the bottom of the last-stage secondary distillation column 2.
[0038] In this embodiment, a distilled water discharge pipeline 16 is connected to the outer channel of the condenser 3. The distilled water discharge pipeline 16 has two output ends, and first valves are provided on both output ends. A distilled water sampling port 17 is provided through a second valve at the input end position of the discharge pipeline. The distilled water is discharged through the distilled water discharge pipeline 16, and the distilled water can be detected through the distilled water sampling port 17. Qualified and unqualified distilled water are discharged through the two output ends respectively.
[0039] The above is only the preferred specific implementation manner of the present utility model, but the protection scope of the present utility model is not limited thereto. Any person skilled in the art within the technical scope disclosed by the present utility model, according to the technical solution of the present utility model and its inventive concept, makes equivalent replacements or changes, and all should be covered within the protection scope of the present utility model.
Claims
1. An S-type multi-effect distiller, characterized in that: Including: A number of distillation columns, the distillation columns being of a vertical tube falling film evaporation structure, consisting of an upper evaporator and a lower separator. Among them, the number of distillation columns includes a primary distillation column and multiple secondary distillation columns; A condenser, the input end of the condenser is connected with a water pump, the water pump is used to input raw water into the condenser, and its output end is communicated with a preheater through a pipeline, and the preheater is communicated with the top of the primary distillation column through a pipeline; Above one side of the primary distillation column is communicated with a steam inlet pipe, the steam entering through the steam inlet pipe is heated in the upper shell side of the first-stage distillation column, exchanges heat with the preheated raw water, and the generated condensed water is discharged through a steam trap arranged at one side of the bottom of the primary evaporator. After the pure steam generated by the evaporation of the raw water removes droplets through the separator, it enters the evaporators in multiple secondary distillation columns in sequence through the steam outlet and the pipeline. The unevaporated raw water enters the evaporators in multiple secondary distillation columns in sequence through the bottom outlet of the primary distillation column and exchanges heat with the steam. The output end of the separator is provided with a concentrated water discharge port for discharging the droplets separated by the separator.
2. The S-type multi-effect distilled water machine according to claim 1, wherein: It further includes a concentrated water discharge pipe, and a number of the concentrated water discharge ports are all communicated with the concentrated water discharge pipe through pipelines, and a throttle valve is arranged on this pipeline.
3. The S-type multi-effect distiller according to claim 1, characterized in that: The condenser includes an inner channel and an outer channel, and heat exchange is carried out between the inner channel and the outer channel. The water pump is communicated with the inner channel of the condenser through a pipeline, and the output end of the evaporator and the steam outlet at the separator of the last-stage secondary distillation column are communicated with the outer channel of the condenser through pipelines.
4. The S-type multi-effect distiller according to claim 2, wherein: On the top of one side of multiple secondary distillation columns and on the outer channel of the condenser are all provided with non-condensable gas discharge ports, and a number of non-condensable gas discharge ports are all communicated with a non-condensable gas discharge pipe through pipelines, and a throttle valve is arranged on this pipeline.
5. The S-type multi-effect distiller according to claim 3, characterized in that: At the bottom of the last-stage secondary distillation column is provided with a sewage discharge port.
6. The S-type multi-effect distilled water machine according to claim 4, characterized in that: The outer channel of the condenser is communicated with a distilled water discharge pipeline, and the distilled water discharge pipeline has two output ends, and first valves are arranged on both output ends. At the input end position of the discharge pipeline, a distilled water sampling port is arranged through a second valve.