Blood coagulation state monitoring and regulating device of blood purification system

Abstract

The utility model discloses a blood clotting state monitoring and regulating device of a blood purification system, and relates to the technical field of blood purification, a first blood clotting monitoring system comprises a first metal electrode and a first impedance analyzer, a second blood clotting monitoring system comprises a second metal electrode and a second impedance analyzer, one end of the first metal electrode is inserted into an arterial kettle, and the other end of the first metal electrode is inserted into a second impedance analyzer; the other end of the first metal electrode is connected with the first impedance analyzer, one end of the second metal electrode is inserted into the vein pot, the other end of the second metal electrode is connected with the second impedance analyzer, the anticoagulant injection pump is connected with the artery pot, and the control system is respectively connected with the first impedance analyzer, the second impedance analyzer and the anticoagulant injection pump. The metal electrode is in direct contact with blood to achieve real-time continuous monitoring of blood impedance, the artery pot and the vein pot are respectively connected with a blood coagulation monitoring system to monitor the blood coagulation state, timeliness and accuracy of blood coagulation state monitoring are improved, and the control system controls the anticoagulant injection pump according to the blood impedance and can regulate and control the blood coagulation state in time.

Description

Technical Field

[0001] This application relates to the technical field of blood purification, and particularly to a device for monitoring and regulating the coagulation state of a blood purification system. Background Art

[0002] Hemodialysis is a common method in the field of blood purification for the treatment of end-stage renal disease (ESRD). By purifying blood through extracorporeal circulation, it can remove waste substances in the patient's body, including small molecules such as urea, creatinine, uric acid, and medium and large molecules such as β2-microglobulin and excess fluid. During hemodialysis treatment, the activation of platelets, white blood cells, and the coagulation cascade can lead to coagulation. The consequences of coagulation during hemodialysis are very serious. When coagulation occurs on the surface of the dialysis membrane, it will reduce the effective surface area of the dialysis membrane and affect the effect of dialysis treatment. At the same time, the blood clots generated by coagulation may also block the blood from flowing back into the patient's body from the dialysis circuit, resulting in serious blood loss, which may pose a threat to the patient's life safety. Therefore, monitoring the patient's blood during dialysis to evaluate its potential coagulation risk and timely regulating the coagulation state are crucial for dialysis safety.

[0003] Currently, one method is to determine whether coagulation occurs in the venous chamber by identifying the state of the blood image in the venous chamber. However, the venous chamber is usually at the rear end of the blood purification pipeline. If the blood clots generated by coagulation are very obvious at this time, it is too late to inject anticoagulants, and dialysis treatment may need to be terminated immediately, which will affect the dialysis effect and may cause discomfort to the patient. Another method is to set up a separate observation area in the hemoperfusion cartridge and monitor the blood flow state in this observation area to identify whether coagulation occurs. However, this method has special requirements for the type of hemoperfusion cartridge, and its universality is poor. Moreover, this method still judges the coagulation state by externally monitoring the blood images in the hemoperfusion cartridge at different times, which is greatly affected by environmental light and the transparency of the hemoperfusion cartridge housing, easily affects the monitoring results, and causes large errors. In summary, the current detection of the coagulation state during hemodialysis mainly has the following problems: it is impossible to continuously, real-time, and timely monitor the coagulation state of the patient's blood to timely regulate the coagulation state; it is easily affected by the surrounding environment and testing methods, resulting in inaccurate monitoring of the coagulation situation of the patient during dialysis.

[0004] Therefore, how to achieve real-time detection of the coagulation state, improve the timeliness and accuracy of coagulation state monitoring, and how to timely regulate the coagulation state are problems that need to be solved by those skilled in the art. Utility Model Content

[0005] The object of the present application is to provide a coagulation state monitoring and regulation device for a blood purification system, which is used to solve the problems that during the current hemodialysis process, the coagulation state of the blood of dialysis patients cannot be continuously, real-time and timely monitored, and timely regulated; and it also solves the problem that it is vulnerable to the influence of the surrounding environment and testing means, resulting in inaccurate monitoring of the coagulation situation of patients during dialysis.

[0006] To solve the above technical problems, the present application provides a coagulation state monitoring and regulation device for a blood purification system. The blood purification system includes a blood pump, an arterial chamber, a hemodialysis device and a venous chamber connected in sequence through a blood purification circuit. The coagulation state monitoring and regulation device includes a first coagulation monitoring system, a second coagulation monitoring system, an anticoagulant injection pump and a control system;

[0007] The first coagulation monitoring system includes a first metal electrode and a first impedance analyzer. The second coagulation monitoring system includes a second metal electrode and a second impedance analyzer. One end of the first metal electrode is inserted into the arterial chamber, and the other end of the first metal electrode is connected to the first impedance analyzer. One end of the second metal electrode is inserted into the venous chamber, and the other end of the second metal electrode is connected to the second impedance analyzer. The first metal electrode and the second metal electrode are used to detect the blood impedance in real time. The anticoagulant injection pump is connected to the arterial chamber, and the control system is respectively connected to the first impedance analyzer, the second impedance analyzer and the anticoagulant injection pump.

[0008] Optionally, it further includes a first protective tube and a second protective tube. The first end of the first protective tube is connected to one end of the arterial chamber, and the first end of the second protective tube is connected to one end of the venous chamber. The first end of the first metal electrode is inserted into the first protective tube and extends into the arterial chamber, and the second end of the first metal electrode extends outside the first protective tube and is connected to the first impedance analyzer. The first end of the second metal electrode is inserted into the second protective tube and extends into the venous chamber, and the second end of the second metal electrode extends outside the second protective tube and is connected to the second impedance analyzer.

[0009] Optionally, a first connector is connected to the second ends of both the first protective tube and the second protective tube, and a second connector is connected to the signal lines of the first impedance analyzer and the second impedance analyzer. External threads are provided on the outside of the first connector, and internal threads are provided inside the second connector. The first metal electrode and the second metal electrode are respectively connected to the second connector to conduct the metal electrode and the signal line. The first connector and the second connector are connected by matching the external threads and the internal threads to make the blood purification system in a closed state.

[0010] Optionally, at least three inlets are provided at one end of the arterial pot. The first inlet among the three inlets is connected to the first end of the first protection tube. The second inlet among the three inlets is connected to the blood purification circuit. The third inlet among the three inlets is connected to the anticoagulant pipeline, and the anticoagulant pipeline is further connected to the anticoagulant injection pump.

[0011] Optionally, an alarm device is further included, and the alarm device is connected to the control system.

[0012] Optionally, both the first impedance analyzer and the second impedance analyzer include a display screen, and the display screen is used to display the blood impedance.

[0013] Optionally, the hemodialysis device includes a hemoperfusion cartridge and / or a hemodialyzer, and the blood purification circuit is a polyvinyl chloride tube or a silicone tube.

[0014] Optionally, the alarm device includes a warning light and / or a buzzer.

[0015] Optionally, both the arterial pot and the venous pot are connected with side branch pipes, and the side branch pipes are connected to a dialysis machine as channels for blood pressure monitoring.

[0016] A device for monitoring and regulating the coagulation state of a blood purification system provided by the present application. The blood purification system includes a blood pump, an arterial pot, a hemodialysis device, and a venous pot connected in sequence through a blood purification circuit. The device for monitoring and regulating the coagulation state includes a first coagulation monitoring system, a second coagulation monitoring system, an anticoagulant injection pump, and a control system. The first coagulation monitoring system includes a first metal electrode and a first impedance analyzer. The second coagulation monitoring system includes a second metal electrode and a second impedance analyzer. One end of the first metal electrode is inserted into the arterial pot, and the other end of the first metal electrode is connected to the first impedance analyzer. One end of the second metal electrode is inserted into the venous pot, and the other end of the second metal electrode is connected to the second impedance analyzer. The first metal electrode and the second metal electrode are used to detect the blood impedance in real time. The anticoagulant injection pump is connected to the arterial pot, and the control system is respectively connected to the first impedance analyzer, the second impedance analyzer, and the anticoagulant injection pump. The metal electrode is directly in contact with the blood to realize real-time continuous monitoring of the blood impedance. A coagulation monitoring system is connected to each of the arterial pot and the venous pot to monitor the coagulation state, which can improve the timeliness and accuracy of coagulation state monitoring. The control system can control the anticoagulant injection pump according to the blood impedance at the arterial pot and / or the venous pot, and can timely regulate the coagulation state. Judging whether there is a coagulation phenomenon through the blood impedance is more accurate than judging the coagulation state through the image of the blood or optical features such as infrared images, and is not easily affected by external factors such as ambient light. Description of the Drawings

[0017] To more clearly illustrate the embodiments of the present application, the accompanying drawings required for the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, without creative efforts, other accompanying drawings can be obtained based on these drawings.

[0018] Figure 1 Structural diagram of a coagulation state monitoring and regulation device for a blood purification system provided by an embodiment of the present application;

[0019] Figure 2 Structural diagram of an arterial chamber and a first coagulation monitoring system provided by an embodiment of the present application;

[0020] Figure 3 Structural diagram of a venous chamber and a second coagulation monitoring system provided by an embodiment of the present application;

[0021] Figure 4 Structural diagram of a first metal electrode and an impedance analyzer provided by an embodiment of the present application;

[0022] Figure 5 Structural diagram of a second metal electrode and an impedance analyzer provided by an embodiment of the present application;

[0023] The reference numerals are as follows: 1 - blood pump, 2 - arterial chamber, 3 - hemodialysis device, 4 - venous chamber, 5 - first coagulation monitoring system, 6 - second coagulation monitoring system, 7 - anticoagulant injection pump, 8 - control system, 9 - alarm device, 10 - first connector, 11 - second connector, 12 - blood purification circuit, 13 - anticoagulant pipeline, 14 - side branch pipe, 201 - first inlet, 202 - second inlet, 203 - third inlet, 204 - first outlet, 401 - fourth inlet, 402 - fifth inlet, 403 - sixth inlet, 404 - second outlet, 501 - first metal electrode, 502 - first impedance analyzer, 503 - first protective tube, 601 - second metal electrode, 602 - second impedance analyzer, 603 - second protective tube. Detailed implementation manners

[0024] The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only some embodiments of the present application, rather than all embodiments. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative efforts belong to the protection scope of the present application.

[0025] The core of this application is to provide a coagulation state monitoring and regulation device for a blood purification system, which is used to realize real-time detection of the coagulation state, improve the timeliness and accuracy of coagulation state monitoring, and timely regulate the coagulation state.

[0026] In order to enable those skilled in the art to better understand the solution of this application, the following further detailed description of this application will be given in conjunction with the accompanying drawings and specific embodiments.

[0027] Figure 1 The following is a structural diagram of a coagulation state monitoring and regulation device for a blood purification system provided by an embodiment of this application. As Figure 1 shown, the blood purification system includes a blood pump 1, an arterial chamber 2, a hemodialysis device 3, and a venous chamber 4 that are sequentially connected through a blood purification circuit 12. The coagulation state monitoring and regulation device includes a first coagulation monitoring system 5, a second coagulation monitoring system 6, an anticoagulant injection pump 7, and a control system 8. The first coagulation monitoring system 5 includes a first metal electrode 501 and a first impedance analyzer 502. The second coagulation monitoring system 6 includes a second metal electrode 601 and a second impedance analyzer 602. One end of the first metal electrode 501 is inserted into the arterial chamber 2, and the other end of the first metal electrode 501 is connected to the first impedance analyzer 502. One end of the second metal electrode 601 is inserted into the venous chamber 4, and the other end of the second metal electrode 601 is connected to the second impedance analyzer 602. The first metal electrode 501 and the second metal electrode 601 are used to detect the blood impedance in real time. The anticoagulant injection pump 7 is connected to the arterial chamber 2, and the control system 8 is respectively connected to the first impedance analyzer 502, the second impedance analyzer 602, and the anticoagulant injection pump 7.

[0028] The blood purification circuit 12 includes an arterial blood circuit and a venous blood circuit. The blood purification circuit can be made of polyvinyl chloride (PVC) tubing, silicone tubing, etc., and can withstand high pressures without rupturing. Puncture needles are respectively connected to both ends of the blood purification circuit 12. That is, puncture needles are respectively connected to the front ends of the arterial blood circuit and the venous blood circuit, and the puncture needles are respectively inserted into the artery and vein of the patient to perform blood purification treatment. The embodiment of the present application does not specifically limit the hemodialysis device 3, which may include a hemoperfusion cartridge and / or a hemodialyzer. The hemodialysis device 3 can be made of different types of hollow fiber membrane materials and is used to dialyze, filter, and remove toxins and excess fluid in the patient's blood. A first coagulation monitoring system 5 and a second coagulation monitoring system 6 are respectively connected to the arterial chamber 2 and the venous chamber 4. This coagulation monitoring system can continuously monitor the impedance value of the blood flowing through here, and the coagulation status of the blood can be judged by the change of the impedance value at the arterial chamber 2 or the venous chamber 4. An anticoagulant injection pump 7 is provided at the arterial chamber 2 to adjust the dosage of the anticoagulant to prevent coagulation, and the anticoagulant injection pump 7 is provided at the arterial chamber 2 to control the coagulation state of the entire blood circuit. In addition, both the first impedance analyzer 502 and the second impedance analyzer 602 include a display screen, and the display screen is set to display the value of the blood impedance, which is convenient for the staff to view the blood impedance at the arterial chamber 2 and the venous chamber 4.

[0029] A first coagulation monitoring system 5 and a second coagulation monitoring system 6 are respectively connected to the arterial chamber 2 and the venous chamber 4 for accurately and continuously monitoring the coagulation state of the blood in the circuit in real time. This monitoring system can continuously record the magnitude of the blood impedance when the blood passes through the arterial chamber 2 and the venous chamber 4, and realize real-time dynamic monitoring of whether the blood coagulates during the dialysis treatment, so as to take corresponding measures in time. Among them, the first metal electrode 501 and the second metal electrode 601 are in direct contact with the blood to respectively detect the magnitude of the blood impedance in the arterial chamber 2 and the venous chamber 4, and transmit the signals to the first impedance analyzer 502 and the second impedance analyzer 602 for data processing respectively. The control system 8 makes a judgment according to the values of the first impedance analyzer 502 and / or the second impedance analyzer 602, and then issues an instruction to the anticoagulant injection pump 7 to realize the automatic control of anticoagulation treatment during dialysis, prevent the further development of coagulation, and can avoid the problems of untimely use of anticoagulant or inaccurate dosage of anticoagulant caused by human factors, ensuring the safe progress of the dialysis process.

[0030] The embodiment of the present application does not specifically limit the materials of the first metal electrode 501 and the second metal electrode 601. Inert metals such as gold or silver can reduce the risks brought by the direct contact between the metal electrode and the blood.

[0031] In addition, an alarm device 9 is further included, and the alarm device 9 is connected to the control system 8. The embodiment of the present application does not specifically limit the alarm device 9. The alarm device 9 may include a warning light and / or a buzzer. When the blood impedance exceeds the threshold, the control system 8 will send an instruction to the warning light and / or the buzzer to give an alarm prompt to prevent medical accidents.

[0032] A coagulation state monitoring and regulating device for a blood purification system provided by an embodiment of the present application. The blood purification system includes a blood pump 1, an arterial chamber 2, a hemodialysis device 3, and a venous chamber 4 connected in sequence through a blood purification circuit 12. The coagulation state monitoring and regulating device includes a first coagulation monitoring system 5, a second coagulation monitoring system 6, an anticoagulant injection pump 7, and a control system 8. The first coagulation monitoring system 5 includes a first metal electrode 501 and a first impedance analyzer 502. The second coagulation monitoring system 6 includes a second metal electrode 601 and a second impedance analyzer 602. One end of the first metal electrode 501 is inserted into the arterial chamber 2, and the other end of the first metal electrode 501 is connected to the first impedance analyzer 502. One end of the second metal electrode 601 is inserted into the venous chamber 4, and the other end of the second metal electrode 601 is connected to the second impedance analyzer 602. The first metal electrode 501 and the second metal electrode 601 are used to detect the blood impedance in real time. The anticoagulant injection pump 7 is connected to the arterial chamber 2. The control system 8 is respectively connected to the first impedance analyzer 502, the second impedance analyzer 602, and the anticoagulant injection pump 7. The metal electrode is in direct contact with the blood to realize real-time continuous monitoring of the blood impedance. A coagulation monitoring system is connected at each of the arterial chamber 2 and the venous chamber 4 to monitor the coagulation state, which can improve the timeliness and accuracy of coagulation state monitoring. The control system 8 can control the anticoagulant injection pump 7 according to the blood impedance at the arterial chamber 2 and / or the venous chamber 4, and can timely regulate the coagulation state. Judging whether there is a coagulation phenomenon through the blood impedance is more accurate than judging the coagulation state through the image of the blood or optical characteristics such as infrared images and is not easily affected by external factors such as ambient light.

[0033] Figure 2 It is a structural diagram of an arterial chamber and a first coagulation monitoring system provided by an embodiment of the present application. Figure 3 It is a structural diagram of a venous chamber and a second coagulation monitoring system provided by an embodiment of the present application, as Figure 2 and Figure 3As shown, it further includes a first protective tube 503 and a second protective tube 603. The first end of the first protective tube 503 is connected to one end of the arterial pot 2, and the first end of the second protective tube 603 is connected to one end of the venous pot 4. The first end of the first metal electrode 501 is inserted into the first protective tube 503 and extends into the arterial pot 2, and the second end of the first metal electrode 501 extends outside the first protective tube 503 and is connected to the first impedance analyzer 502. The first end of the second metal electrode 601 is inserted into the second protective tube 603 and extends into the venous pot 4, and the second end of the second metal electrode 601 extends outside the second protective tube 603 and is connected to the second impedance analyzer 602.

[0034] The first end of the first protective tube 503 can be integrally connected to one end of the arterial pot 2. Similarly, the first end of the second protective tube 603 can be integrally connected to one end of the venous pot 4. By providing the first protective tube 503 and the second protective tube 603, the first metal electrode 501 and the second metal electrode 601 can be effectively prevented from being exposed to the external environment.

[0035] This embodiment of the present application does not specifically limit how the second ends of the first metal electrode 501 and the second metal electrode 601 are respectively connected to the first impedance analyzer 502 and the second impedance analyzer 602. Specifically, Figure 4 is a structural diagram of the first metal electrode and the impedance analyzer provided by this embodiment of the present application, Figure 5 is a structural diagram of the second metal electrode and the impedance analyzer provided by this embodiment of the present application, Figure 4 in which the metal electrode and the impedance analyzer are in an unconnected state, Figure 5 in which the metal electrode and the impedance analyzer are in a connected state, as Figure 4 and Figure 5 shown, the second ends of both the first protective tube 503 and the second protective tube 603 are connected with a first joint 10, the signal lines of the first impedance analyzer 502 and the second impedance analyzer 602 are both connected with a second joint 11. The outside of the first joint 10 is provided with an external thread, and the inside of the second joint 11 is provided with an internal thread. The metal electrode (the first metal electrode 501 and the second metal electrode 601) is connected to the second joint 11 to conduct the metal electrode and the signal line. The first joint 10 and the second joint 11 are connected by matching the external thread and the internal thread, so that the entire blood purification system presents a closed state, reducing the risk of blood contamination. Among them, the second joint 11 is connected to the impedance analyzer through a signal line to realize real-time recording of the impedance value of the blood in the loop. The impedance analyzer transmits the monitored blood information to the control system 8, and the control system 8 judges the coagulation state of the blood.

[0036] Based on the above embodiments, as Figure 2As shown in the figure, at least three inlets are provided at one end of the arterial pot 2 of the embodiment of the present application. The first inlet 201 among the three inlets is connected to the first end of the first protection tube 503. The second inlet 202 among the three inlets is connected to the blood purification circuit 12. The third inlet 203 among the three inlets is connected to the anticoagulant pipeline 13. The anticoagulant pipeline 13 is also connected to the anticoagulant injection pump 7. Specifically, the first inlet 201 is adhesively connected to the first end of the first protection tube 503, the second inlet 202 is adhesively connected to the blood purification circuit 12, and the third inlet 203 is adhesively connected to the anticoagulant pipeline 13. The other end of the arterial pot 2 is provided with a first outlet 204, and the first outlet 204 is adhesively connected to the blood purification circuit 12.

[0037] Based on the above embodiment, as Figure 3 shown in the figure, at least two inlets are provided at one end of the venous pot 4 of the embodiment of the present application. The fourth inlet 401 among the two inlets is connected to the first end of the second protection tube 603. The fifth inlet 402 among the two inlets is connected to the blood purification circuit 12. A third inlet, that is, the sixth inlet 403, can also be provided. The sixth inlet 403 is connected to the side branch pipe 14. The side branch pipe 14 is used to connect to the dialysis machine to provide a channel for monitoring the venous blood pressure. The other end of the venous pot 4 is provided with a second outlet 404, and the second outlet 404 is connected to the blood purification circuit 12. In addition, a side branch pipe 14 can also be connected to the arterial pot 2 to provide a channel for monitoring the arterial blood pressure.

[0038] For easy understanding, the corresponding method of the blood coagulation state monitoring and control device is introduced below.

[0039] When blood coagulates, the plasma gradually changes from a conductive liquid form to an insulating solid gel form. The impedance change between whole blood and blood clots is significant. By analyzing the change in the impedance value of the blood, it is determined whether coagulation occurs. The first blood coagulation monitoring system 5 and the second blood coagulation monitoring system 6 are respectively connected to the arterial pot 2 and the venous pot 4 to accurately monitor the blood coagulation state in the loop in real time. This monitoring system can continuously record the magnitude of the blood impedance when blood passes through the arterial pot 2 and the venous pot 4, and realize real-time dynamic monitoring of whether blood coagulates during the dialysis treatment process, so as to take corresponding measures in time.

[0040] The first metal electrode 501 and the second metal electrode 601 are in direct contact with the blood to detect the blood impedance in the arterial chamber 2 and the venous chamber 4 respectively, and transmit the signals to the first impedance analyzer 502 and the second impedance analyzer 602 for data processing. The control system 8 consists of a micro control system and a signal processing circuit, and is connected to the first impedance analyzer 502 and the second impedance analyzer 602 respectively, and can determine the current blood coagulation state in the loop according to the data fed back by the first impedance analyzer 502 and the second impedance analyzer 602; at the same time, the control system 8 is also connected to the anticoagulant injection pump 7, and can adjust the working state of the anticoagulant injection pump 7 in the blood loop according to the data fed back by the first impedance analyzer 502 and the second impedance analyzer 602; in addition, the control system 8 is also connected to the alarm device 9, if after injecting anticoagulant through the anticoagulant injection pump 7, the blood is still in a high coagulation risk or coagulation state, the control system 8 will give an instruction to the alarm system to trigger an alarm to remind the medical staff to take measures in time.

[0041] For easy understanding, an example is given below. When the first coagulation monitoring system 5 and / or the second coagulation monitoring system 6 detects that the increase in blood impedance exceeds 20% of the normal value, the control system 8 obtains this information and gives an instruction to the anticoagulant injection pump 7 to automatically inject a certain amount of anticoagulant (such as heparin or citric acid, etc.). Then the first coagulation monitoring system 5 and the second coagulation monitoring system 6 will detect the blood impedance value after the injection of the anticoagulant. If the patient's coagulation condition is not relieved after multiple injections of the anticoagulant, the alarm device 9 will be triggered to remind the medical staff to take measures in time. Regarding how much dose of anticoagulant to be injected by the anticoagulant injection pump 7, a preset table including the corresponding relationship between the blood impedance value and the anticoagulant injection dose can be preset, and the anticoagulant injection dose can be determined according to this preset table.

[0042] The above are the specific implementation steps of the present application. Through this method, it is possible to realize real-time monitoring of the blood coagulation condition of patients during dialysis, timely detect and handle the blood coagulation situation during dialysis, realize automatic anticoagulation, avoid the problem of inaccurate adjustment caused by human factors, and ensure the safe progress of the dialysis process.

[0043] Based on this, the coagulation state monitoring and regulation device of a blood purification system provided by the present application has the following advantages:

[0044] 1. Real-time monitoring: The coagulation monitoring system of the present application is based on metal electrodes, and the metal electrodes are directly in contact with the blood to monitor the blood coagulation state of patients during dialysis. The detection accuracy is high, the test data is more intuitive, and continuous real-time monitoring of the blood coagulation state during dialysis can be realized, timely detect the blood coagulation situation during dialysis, so as to take measures in time to avoid affecting the dialysis effect due to coagulation or threatening the life safety of patients.

[0045] 2. Precise Monitoring: In this application, the change in blood impedance is measured by directly contacting the electrodes with the blood to determine whether blood coagulation occurs. This method is more precise than judging the coagulation state through blood images or optical features such as infrared images and is less affected by external factors such as ambient light. At the same time, in this application, a coagulation monitoring system is connected to each of the arterial chamber and the venous chamber to monitor the coagulation state of the patient. It can analyze the blood impedance values at the arterial chamber and / or the venous chamber to achieve in-depth analysis of the blood coagulation state. Compared with only connecting the coagulation monitoring system at the arterial chamber or the venous chamber, it can accurately judge the coagulation state of the blood in the circuit and timely adjust the coagulation state of the patient, that is, this setting can achieve timely and precise monitoring of the patient's coagulation state.

[0046] 3. Automatic Adjustment: The control system in the blood circuit of this application can judge the current coagulation state of the blood in the circuit based on the information transmitted by the coagulation monitoring system and control the anticoagulant injection pump in the blood circuit to achieve automatic injection of the anticoagulant injection pump, solve the coagulation problem, reduce the workload of medical staff, and also avoid judgment errors and inaccurate adjustments caused by human factors.

[0047] 4. High Safety: Through the coordinated work of the coagulation monitoring system, the anticoagulant injection pump, the control system and the alarm device in this application, the coagulation state of the patient's blood in the circuit can be monitored in real time, and the working state of the anticoagulant injection pump can be selectively adjusted or the medical staff can be notified by alarm according to the monitoring results, thus improving the safety of dialysis and reducing the risk caused by coagulation.

[0048] The above has introduced in detail a device for monitoring and regulating the coagulation state of a blood purification system provided by this application. The various embodiments in the specification are described in a progressive manner. Each embodiment focuses on the differences from other embodiments. The same or similar parts among the various embodiments can be referred to each other. It should be noted that for those of ordinary skill in the art in this technical field, without departing from the principle of this application, several improvements and modifications can be made to this application, and these improvements and modifications also fall within the protection scope of the claims of this application.

[0049] It should also be noted that in this specification, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or device comprising the said element.

Claims

1. A coagulation state monitoring and regulating device for a blood purification system, the blood purification system comprising a blood pump (1), an arterial chamber (2), a hemodialysis device (3) and a venous chamber (4) connected in sequence through a blood purification circuit (12), characterized in that, It includes a first blood coagulation monitoring system (5), a second blood coagulation monitoring system (6), an anticoagulant injection pump (7), and a control system (8); The first blood coagulation monitoring system (5) includes a first metal electrode (501) and a first impedance analyzer (502). The second blood coagulation monitoring system (6) includes a second metal electrode (601) and a second impedance analyzer (602). One end of the first metal electrode (501) is inserted into the arterial pot (2), and the other end of the first metal electrode (501) is connected to the first impedance analyzer (502). One end of the second metal electrode (601) is inserted into the venous pot (4), and the other end of the second metal electrode (601) is connected to the second impedance analyzer (602). The first metal electrode (501) and the second metal electrode (601) are used to detect the blood impedance in real time. The anticoagulant injection pump (7) is connected to the arterial pot (2), and the control system (8) is respectively connected to the first impedance analyzer (502), the second impedance analyzer (602), and the anticoagulant injection pump (7).

2. The coagulation state monitoring and regulation device according to claim 1, characterized in that, It further includes a first protection tube (503) and a second protection tube (603). The first end of the first protection tube (503) is connected to one end of the arterial pot (2), and the first end of the second protection tube (603) is connected to one end of the venous pot (4). The first end of the first metal electrode (501) is inserted into the first protection tube (503) and extends into the arterial pot (2), and the second end of the first metal electrode (501) extends outside the first protection tube (503) and is connected to the first impedance analyzer (502). The first end of the second metal electrode (601) is inserted into the second protection tube (603) and extends into the venous pot (4), and the second end of the second metal electrode (601) extends outside the second protection tube (603) and is connected to the second impedance analyzer (602).

3. The coagulation state monitoring and regulation device according to claim 2, wherein The second ends of the first protection tube (503) and the second protection tube (603) are both connected with a first connector (10). The signal lines of the first impedance analyzer (502) and the second impedance analyzer (602) are both connected with a second connector (11). The outside of the first connector (10) is provided with an external thread, and the inside of the second connector (11) is provided with an internal thread. The first metal electrode (501) and the second metal electrode (601) are respectively connected to the second connector (11) to make the metal electrodes conduct with the signal lines. The first connector (10) and the second connector (11) are connected by the cooperation of the external thread and the internal thread to make the blood purification system in a closed state.

4. The coagulation state monitoring and regulation device according to claim 3, characterized in that, At least three inlets are provided at one end of the arterial pot (2). The first inlet (201) among the three inlets is connected to the first end of the first protection tube (503). The second inlet (202) among the three inlets is connected to the blood purification circuit (12). The third inlet (203) among the three inlets is connected to the anticoagulant pipeline (13), and the anticoagulant injection pump (7) is also connected to the anticoagulant pipeline (13).

5. The coagulation state monitoring and regulation device according to any one of claims 1 to 4, characterized in that An alarm device (9) is further included, and the alarm device (9) is connected to the control system (8).

6. The coagulation state monitoring and regulation device according to claim 5, wherein Both the first impedance analyzer (502) and the second impedance analyzer (602) include a display screen, and the display screen is used to display the blood impedance.

7. The coagulation state monitoring and regulation device according to claim 1, wherein The hemodialysis device (3) includes a hemoperfusion cartridge and / or a hemodialyzer, and the blood purification circuit (12) is a polyvinyl chloride tube or a silica gel tube.

8. The coagulation state monitoring and regulation device according to claim 5, characterized in that, The alarm device (9) includes a warning light and / or a buzzer.

9. The coagulation state monitoring and regulation device according to claim 1, wherein Side branches (14) are connected to both the arterial pot (2) and the venous pot (4), and the side branches (14) are connected to a dialysis machine as a channel for blood pressure monitoring.

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