Adjustable solid-phase extraction device

Abstract

The utility model discloses an adjustable solid-phase extraction device, which relates to the technical field of solid-phase extraction and comprises a gasket structure formed by at least one gasket, the gasket is annular, the inner wall of the gasket protrudes inwards along the radial direction to form a mounting edge, and the gasket is arranged at an extraction column hole or a receiving tube hole; the gaskets are coaxially matched and sleeved in sequence from outside to inside, and are erected on the adjacent limiting edges on the outer sides of the gaskets in sequence; the extraction column or the receiving tube is inserted and fixed in the gasket on the innermost side in a matched manner and is limited and mounted on the extraction column frame or the receiving tube frame through the gasket structure. According to the utility model, on the premise that the whole extraction column frame is not replaced, the gaskets in the gasket structure are adjusted to adapt to the installation of extraction columns and receiving tubes with different sizes and specifications, so that the solid-phase extraction operation is simplified, and the efficiency is improved; the mounting heights of the receiving pipe frame and the receiving bin are adjustable, so that the bottom end of the extraction column can be kept to extend into the corresponding receiving pipe in the solid-phase extraction process, and the potential safety hazard caused by splashing of the extraction liquid is eliminated.

Description

Technical Field

[0001] The utility model relates to the technical field of solid-phase extraction, and particularly relates to a device for installing an extraction column, a receiving tube and collecting waste liquid in solid-phase extraction. Background Art

[0002] Solid-phase extraction is a sample pretreatment technology, which combines a liquid-solid extraction column and liquid chromatography technology, and is mainly used for the separation, purification and concentration of samples. Compared with the traditional liquid-liquid extraction method, solid-phase extraction can improve the recovery rate of analytes, more effectively separate analytes from interfering components, reduce the sample pretreatment process, and is simple, time-saving and labor-saving. Solid-phase extraction is widely used in the fields of medicine, food, environment, commodity inspection, chemical engineering, etc.

[0003] In the prior art, the holes provided on the extraction column rack in the solid-phase extraction device for installing the extraction column have the same size, that is, only extraction columns of the same specification can be used. For extraction columns of different specifications, the extraction column rack needs to be replaced as a whole accordingly, which is extremely inconvenient to use. At the same time, due to the different lengths of the extraction columns used for extraction, the distances between each extraction column and the receiving tube are also different. When the distance between the extraction column and the receiving tube is large, there is also a risk of splashing of the extraction liquid. In addition, the solid-phase extraction operation includes activation, sample loading, rinsing and elution, etc. Waste liquid will be generated during the processes of activation, sample loading and rinsing, and it is necessary to replace and elute the receiving bin for collecting waste liquid in time, which not only affects the experimental efficiency, but also has a risk of causing pollution. Summary of the Utility Model

[0004] The utility model precisely aims to avoid the deficiencies existing in the above-mentioned prior art, and provides an adjustable solid-phase extraction device.

[0005] The utility model adopts the following technical solutions to solve the technical problems: An adjustable solid-phase extraction device includes a base, a vertical plate, an extraction column rack, a receiving tube rack and a receiving bin. The vertical plate is installed on the base, and the extraction column rack, the receiving tube rack and the receiving bin are installed on the vertical plate from top to bottom. Corresponding extraction column holes and receiving tube holes are respectively provided on the extraction column rack and the receiving tube rack, and a washer structure is also included;

[0006] The washer structure includes at least one washer. The washer is annular, and its inner wall protrudes inward radially to form a limiting edge, which is arranged at the extraction column hole or the receiving tube hole; when the number of washers is greater than one, the washers are coaxially sleeved and matched with each other from outside to inside in sequence, and are sequentially erected on the limiting edge adjacent to their own outside; the extraction column or the receiving tube is inserted and fixed into the innermost washer, and is installed on the extraction column rack or the receiving tube rack through the limitation of the washer structure.

[0007] Furthermore, a linear mechanism is also included;

[0008] A linear mechanism serving as a vertical adjustment structure is further provided between the extraction column frame, the receiving pipe frame, and the receiving bin and the vertical plate;

[0009] The fixed end of the vertical adjustment structure is installed and connected to the vertical plate, the extraction column frame, the receiving pipe frame, and the receiving bin are respectively installed and connected to three output ends of the linear mechanism, and the linear mechanism provides degrees of freedom for the extraction column frame, the receiving pipe frame, and the receiving bin to move vertically upward or downward.

[0010] Further, linear mechanisms serving as transverse adjustment structures are respectively provided between the receiving pipe frame, the receiving bin and the vertical adjustment structure; the fixed ends of a pair of the transverse adjustment structures are respectively installed and connected to a pair of output ends of the vertical adjustment structure, and the output ends of the pair of the transverse adjustment structures are respectively installed and connected to the receiving pipe frame and the receiving bin, providing degrees of freedom for the receiving pipe frame and the receiving bin to move horizontally forward or backward.

[0011] Further, the vertical adjustment structure and the transverse adjustment structure are respectively any one of a slide rail-slider structure or a guide rod-slider structure.

[0012] Further, the slide rail-slider structure includes a slide rail and a slider; the slider is slidably installed on the slide rail, forming a sliding pair with the slide rail along the slide rail;

[0013] The slide rail serves as the fixed end of the vertical adjustment structure or the transverse adjustment structure and is installed and connected to the vertical plate or the output end of the vertical adjustment structure; the slider serves as the output end of the vertical adjustment structure or the transverse adjustment structure and is installed and connected to the fixed end of the transverse adjustment structure or the receiving pipe frame and the receiving bin.

[0014] Further, the slide rail-slider structure includes a pair of parallel slide rails and a pair of sliders slidably installed on the pair of slide rails.

[0015] Further, the guide rod-slider structure includes a support plate, a guide rod, and a guide rod slider; both ends of the guide rod are fixedly installed on the support plate, the guide rod slider is slidably sleeved on the guide rod, one side of which is attached to the support plate, and forms a sliding pair with the guide rod under the rotational limiting action of the support plate along the guide rod;

[0016] The support plate serves as the fixed end of the vertical adjustment structure or the transverse adjustment structure and is installed and connected to the vertical plate or the output end of the vertical adjustment structure; the guide rod slider serves as the output end of the vertical adjustment structure or the transverse adjustment structure and is installed and connected to the fixed end of the transverse adjustment structure or the receiving pipe frame and the receiving bin.

[0017] Further, a drain port is provided at the bottom of the receiving bin, and a drain valve is connected to the drain port.

[0018] Further, a partition plate is provided in the middle of the receiving bin, dividing the receiving bin into a receiving pool and a waste liquid pool;

[0019] Further, the vertical plates and the linear mechanism are symmetrically arranged in pairs.

[0020] The utility model provides an adjustable solid phase extraction device, which has the following beneficial effects:

[0021] 1. Without the need to replace the entire extraction column rack, the utility model can adjust the gasket in the gasket structure to adapt to the installation of extraction columns and receiving tubes of different sizes and specifications, which is conducive to simplifying the solid phase extraction operation and improving the efficiency.

[0022] 2. The installation heights of the receiving tube rack and the receiving bin of the utility model are adjustable. During the solid phase extraction process, the installation heights of the receiving tube rack and the receiving bin can be adjusted to keep the bottom end of the extraction column extending into the corresponding receiving tube, eliminating potential safety hazards caused by splashing of extraction liquid.

[0023] 3. The utility model adopts an open solid phase extraction structure. During the solid phase extraction process, the extraction column and the receiving tube can be replaced separately according to the flow rate of the extraction column, making it more flexible to use.

[0024] 4. The utility model can move the waste liquid pool backward to the lower part of the extraction column rack, directly perform activation, sample loading, and elution on the solid phase extraction device, collect the generated waste liquid into the waste liquid pool and discharge it through the drain port. When eluting, the receiving pool can be moved forward to the lower part of the extraction column rack, eliminating the need to pour waste liquid and disassemble and assemble the receiving pool, making it more convenient to use. BRIEF DESCRIPTION OF THE DRAWINGS

[0025] Figure 1 is a schematic structural diagram of the utility model;

[0026] Figure 2 is a schematic structural diagram of the gasket structure of the utility model.

[0027] In the figure:

[0028] 1. Base; 2. Vertical plate; 3. Extraction column rack, 31. Extraction column hole; 4. Receiving tube rack, 41. Receiving tube hole; 5. Receiving bin, 51. Drain valve, 52. Partition plate, 53. Receiving pool, 54. Waste liquid pool; 6. Gasket structure, 61. Gasket, 62. Limit edge; 7. Linear mechanism, 71. Slide rail slider structure, 711. Slide rail, 712. Slider, 72. Guide rod slider structure, 721. Support plate, 722. Guide rod, 723. Guide rod slider. Detailed implementation mode

[0029] To make the objectives, technical solutions and advantages of the embodiments of the present utility model clearer, the technical solutions in the embodiments of the present utility model will be clearly and completely described below in conjunction with the embodiments of the present utility model. Obviously, the described embodiments are part of the embodiments of the present utility model, rather than all of them. All other embodiments obtained by those of ordinary skill in the art based on the embodiments of the present utility model without creative efforts belong to the scope of protection of the present utility model.

[0030] An adjustable solid-phase extraction device, as Figures 1 to 2 shown, its structural relationship is: including a base 1, a vertical plate 2, an extraction column rack 3, a receiving tube rack 4 and a receiving bin 5. The vertical plate 2 is installed on the base 1, and the extraction column rack 3, the receiving tube rack 4 and the receiving bin 5 are installed on the vertical plate 2 from top to bottom. Corresponding extraction column holes 31 and receiving tube holes 41 are respectively provided on the extraction column rack 3 and the receiving tube rack 4. It also includes a washer structure 6;

[0031] The washer structure 6 includes at least one washer 61. The washer 61 is annular, and its inner wall protrudes radially inwards to form a limiting edge 62, which is arranged at the extraction column hole 31 or the receiving tube hole 41; when the number of washers 61 is greater than one, the washers 61 are coaxially sleeved with each other from outside to inside in sequence, and are sequentially erected on the limiting edge 62 adjacent to its outside; the extraction column or the receiving tube is inserted and fixed into the innermost washer 61, and is installed on the extraction column rack 3 or the receiving tube rack 4 through the limit of the washer structure 6.

[0032] Preferably, it further includes a linear mechanism 7;

[0033] A linear mechanism 7 as a vertical adjustment structure is further provided between the extraction column rack 3, the receiving tube rack 4 and the receiving bin 5 and the vertical plate 2;

[0034] The fixed end of the vertical adjustment structure is installed and connected to the vertical plate 2. The extraction column rack 3, the receiving tube rack 4 and the receiving bin 5 are respectively installed and connected to the three output ends of the linear mechanism 7. The linear mechanism 7 provides the freedom of rising or falling along the vertical direction to the extraction column rack 3, the receiving tube rack 4 and the receiving bin 5.

[0035] The rising and falling movements of the extraction column rack 3 and the receiving tube rack 4 are used to adapt to solid-phase extraction columns and receiving tubes of different lengths, so that during the solid-phase extraction process, the lower end of the solid-phase extraction column extends into the mouth of the receiving tube; the rising and falling movements of the receiving bin 5 are used to adapt to receiving tubes of different lengths and the adjustment of the height of the receiving tube rack 4 to ensure that the receiving bin 5 can support the receiving tube at the lower end position of the receiving tube;

[0036] In actual setting, in order to keep the extraction column rack 3, the receiving tube rack 4 and the receiving bin 5 in appropriate positions, the linear mechanism 7 should have a locking function, or a corresponding locking structure can be configured;

[0037] On the extraction column rack 3, extraction column holes 31 with a diameter of 20 mm can preferably be arranged in an array, and on the receiving tube rack 4, receiving tube holes 41 with a diameter of 24 mm can preferably be arranged in an array; at this time, the extraction column holes 31 can preferably be equipped with a washer structure 6 provided with two washers 61, the inner diameters of the two washers 61 are preferably 10 mm and 5 mm respectively, and the receiving tube holes 41 can preferably be equipped with a washer structure 6 provided with three washers 61, the inner diameters of the three washers 61 are preferably 17.5 mm, 15 mm and 13 mm respectively.

[0038] Preferably, linear mechanisms 7 serving as lateral adjustment structures are respectively provided between the receiving tube rack 4 and the receiving bin 5 and the vertical adjustment structure; the fixed ends of a pair of lateral adjustment structures are respectively installed and connected to a pair of output ends of the vertical adjustment structure, and the output ends of a pair of lateral adjustment structures are respectively installed and connected to the receiving tube rack 4 and the receiving bin 5, providing degrees of freedom for the receiving tube rack 4 and the receiving bin 5 to move forward or backward in the horizontal direction.

[0039] The forward and backward movement of the receiving bin 5 is used to adjust the relative positions of the receiving pool 53 and the waste liquid pool 54 and the extraction column rack 3. During activation, sample loading and elution, the waste liquid pool 53 should be located below the extraction column rack 3 to collect waste liquid in the waste liquid pool 53; during elution, the receiving pool 54 should be located below the extraction column rack 3 to support the receiving tube.

[0040] Preferably, the vertical adjustment structure and the lateral adjustment structure are respectively any one of a slide rail-slider structure 71 or a guide rod-slider structure 72.

[0041] Preferably, the slide rail-slider structure 71 includes a slide rail 711 and a slider 712; the slider 712 is slidably and fittingly installed on the slide rail 711, forming a sliding pair with the slide rail 711 along the slide rail 711;

[0042] The slide rail 711 serves as the fixed end of the vertical adjustment structure or the lateral adjustment structure, and is installed and connected to the vertical plate 2 or the output end of the vertical adjustment structure; the slider 712 serves as the output end of the vertical adjustment structure or the lateral adjustment structure, and is installed and connected to the fixed end of the lateral adjustment structure or the receiving tube rack 4 and the receiving bin 5.

[0043] Preferably, the slide rail-slider structure 71 includes a pair of parallel slide rails 711 and a pair of sliders 712 slidably and fittingly installed on the pair of slide rails 711.

[0044] Preferably, the guide rod slider structure 72 includes a support plate 721, a guide rod 722, and a guide rod slider 723. The two ends of the guide rod 722 are respectively fixedly installed on the support plate 721. The guide rod slider 723 is slidably sleeved on the guide rod 722, and one side of it is attached to the support plate 721. Under the rotational limiting effect of the support plate 721, a sliding pair along the guide rod 722 is formed between the guide rod slider 723 and the guide rod 722.

[0045] The support plate 721 serves as the fixed end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the vertical plate 2 or the output end of the vertical adjustment structure. The guide rod slider 723 serves as the output end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the fixed end of the horizontal adjustment structure or the receiving pipe rack 4 and the receiving bin 5.

[0046] Preferably, a drain port is opened at the bottom of the receiving bin 5, and a drain valve 51 is connected and provided at the drain port.

[0047] Preferably, a partition 52 is provided in the middle of the receiving bin 5, dividing the receiving bin 5 into a receiving pool 53 and a waste liquid pool 54.

[0048] Preferably, the vertical plate 2 and the linear mechanism 7 are symmetrically arranged in pairs to improve the structural symmetry of the solid phase extraction device, enhance the overall stability of the solid phase extraction device, improve the smoothness of the ascending and descending movements of the extraction column rack 3, the receiving pipe rack 4, and the receiving bin 5, and improve the smoothness of the forward or backward movement of the receiving pipe rack 4 and the receiving bin 5. At the same time, it is beneficial to extend the service life of the solid phase extraction device.

[0049] When performing solid phase extraction using the above solid phase extraction device, during the processes of activation, sample loading, and elution, the receiving bin 5 should be moved backward by utilizing the linear degree of freedom provided by the linear mechanism 7, so that the waste liquid pool 53 is located below the extraction column rack 3 to collect the waste liquid generated during activation, sample loading, and elution. The waste liquid in the waste liquid pool 53 can be discharged through the drain port when the drain valve 51 is opened.

[0050] Before elution, a suitable washer structure 6 should be selected according to the dimensions and specifications of the extraction column and the receiving pipe to stably limit the extraction column and the receiving pipe in the extraction column hole 31 and the receiving pipe hole 41 respectively. In addition, the heights of the extraction column rack 3, the receiving pipe rack 4, and the receiving bin 5 should be adjusted according to the lengths (i.e., heights) of the extraction column and the receiving pipe respectively, so that the lower end of the extraction column extends into the receiving pipe mouth, and the receiving bin 5 supports the extraction column at the bottom end of the extraction column.

[0051] It should be noted that in this text, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device comprising a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device. Without further limitation, an element defined by the statement "comprising an..." does not exclude the presence of additional identical elements in the process, method, article or device comprising the said element.

[0052] The above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, those of ordinary skill in the art should understand that: they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements on some of the technical features; and these modifications or replacements do not make the essence of the corresponding technical solutions deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. An adjustable solid-phase extraction device, comprising a base (1), a vertical plate (2), an extraction column rack (3), a receiving tube rack (4) and a receiving bin (5). The vertical plate (2) is installed on the base (1), and the extraction column rack (3), the receiving tube rack (4) and the receiving bin (5) are installed on the vertical plate (2) from top to bottom. Corresponding extraction column holes (31) and receiving tube holes (41) are respectively formed in the extraction column rack (3) and the receiving tube rack (4). It is characterized in that: It further includes a washer structure (6); The washer structure (6) includes at least one washer (61). The washer (61) is annular, and its inner wall protrudes inwards radially to form a limiting edge (62), which is arranged at the extraction column hole (31) or the receiving pipe hole (41). When the number of the washers (61) is greater than one, the washers (61) are coaxially and cooperatively sleeved in sequence from outside to inside, and are successively mounted on the limiting edge (62) adjacent to its outside. The extraction column or the receiving pipe is fixedly inserted and fitted into the innermost washer (61), and is limited and installed on the extraction column rack (3) or the receiving pipe rack (4) through the washer structure (6).

2. The adjustable solid-phase extraction device according to claim 1, wherein: It further includes a linear mechanism (7); A linear mechanism (7) serving as a vertical adjustment structure is further provided between the extraction column rack (3), the receiving pipe rack (4) and the receiving bin (5) and the vertical plate (2); The fixed end of the vertical adjustment structure is installed and connected to the vertical plate (2), and the extraction column rack (3), the receiving pipe rack (4) and the receiving bin (5) are respectively installed and connected to three output ends of the linear mechanism (7). The linear mechanism (7) provides degrees of freedom for the extraction column rack (3), the receiving pipe rack (4) and the receiving bin (5) to move up or down vertically.

3. The adjustable solid-phase extraction device according to claim 2, wherein: A linear mechanism (7) serving as a horizontal adjustment structure is further provided between the receiving pipe rack (4) and the receiving bin (5) and the vertical adjustment structure respectively; the fixed ends of a pair of the horizontal adjustment structures are respectively installed and connected to a pair of output ends of the vertical adjustment structure, and the output ends of the pair of the horizontal adjustment structures are respectively installed and connected to the receiving pipe rack (4) and the receiving bin (5), providing degrees of freedom for the receiving pipe rack (4) and the receiving bin (5) to move forward or backward horizontally.

4. The adjustable solid-phase extraction device according to claim 3, wherein: The vertical adjustment structure and the horizontal adjustment structure are respectively any one of a slide rail-slider structure (71) or a guide rod-slider structure (72).

5. The adjustable solid-phase extraction device according to claim 4, wherein: The slide rail-slider structure (71) includes a slide rail (711) and a slider (712); the slider (712) is slidably and cooperatively installed on the slide rail (711), and forms a sliding pair with the slide rail (711) along the slide rail (711). The slide rail (711) serves as the fixed end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the vertical plate (2) or the output end of the vertical adjustment structure; the slider (712) serves as the output end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the fixed end of the horizontal adjustment structure or the receiving pipe rack (4) and the receiving bin (5).

6. The adjustable solid-phase extraction device according to claim 5, wherein: The slide rail-slider structure (71) includes a pair of the slide rails (711) arranged in parallel and a pair of the sliders (712) slidably and cooperatively installed on the pair of the slide rails (711).

7. An adjustable solid-phase extraction device according to claim 4, characterized in that: The guide rod slider structure (72) includes a support plate (721), a guide rod (722), and a guide rod slider (723); both ends of the guide rod (722) are fixedly installed on the support plate (721), the guide rod slider (723) is slidably sleeved on the guide rod (722), one side of which is arranged in contact with the support plate (721), and a sliding pair along the guide rod (722) is formed between the guide rod slider (723) and the guide rod (722) under the rotational limiting action of the support plate (721). The support plate (721) serves as the fixed end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the vertical plate (2) or the output end of the vertical adjustment structure; the guide rod slider (723) serves as the output end of the vertical adjustment structure or the horizontal adjustment structure, and is installed and connected to the fixed end of the horizontal adjustment structure or the receiving pipe rack (4) and the receiving bin (5).

8. An adjustable solid-phase extraction device according to claim 1, characterized in that: A drain port is provided at the bottom of the receiving bin (5), and a drain valve (51) is connected and provided at the drain port.

9. The adjustable solid phase extraction device according to claim 1, characterized in that: A partition plate (52) is provided in the middle of the receiving bin (5), which divides the receiving bin (5) into a receiving pool (53) and a waste liquid pool (54).

10. An adjustable solid-phase extraction device according to any one of claims 2-7, characterized in that: The vertical plate (2) and the linear mechanism (7) are arranged symmetrically in pairs.

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