Sample dryer
By introducing vibration and circulation stirring mechanisms into the sample dryer, the penetration and rotary flow of liquid carbon dioxide are used to solve the problems of long drying time and structural damage, and rapid and efficient sample drying is achieved, reducing costs.
Patent Information
- Application Number
- CN202421877989.X
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-08-05
- Publication Date
- 2025-07-25
- Estimated Expiration
- 2034-08-05
AI Technical Summary
When handling biological tissue and cell samples, existing desiccants have problems with excessive drying time. Multiple replacements lead to inefficient experiments, and traditional methods may lead to deformation and damage of sample structure.
A sample dryer is adopted, including a vibration mechanism and a circulation stirring mechanism. The micro electromagnetic vibrator is used to drive the vibration of the heat insulation plate. The liquid carbon dioxide in the organic reagent container is uniformly penetrated into the sample. Combined with the liquid tube design of the circulation stirring mechanism, the rotating flow and uniform stirring of liquid carbon dioxide are realized, and the ethanol is replaced quickly, and the drying time is reduced.
Through the uniform penetration and rotary flow of liquid carbon dioxide, the drying time is significantly shortened, the sample drying efficiency is improved, the consumption of liquid carbon dioxide is reduced, the cost is reduced, and the sample structure integrity is maintained.
Smart Images
Figure CN223153923U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of sample drying, in particular to a sample dryer. Background Art
[0002] A transmission electron microscope is a high-resolution microscope used to observe and analyze the microstructure of materials. When observing a sample, it is necessary to remove the moisture in the sample. During the operation of the transmission electron microscope, if the sample contains moisture, the moisture will rapidly evaporate in a vacuum environment, and the generated gas may interfere with the electron beam, damage the vacuum, and affect the normal operation of the instrument and the imaging quality. At the same time, a dry sample has better physical and chemical stability and can maintain the relative stability of its structure and properties under long-term irradiation of the electron beam, so as to obtain reliable observation results.
[0003] Among the existing dryers, the critical point dryer can well maintain the fine structure and morphology of samples such as biological tissues and cells. It avoids the structural deformation and damage caused by surface tension due to traditional drying methods, enabling the sample to present a more real microstructure when observed under an electron microscope.
[0004] However, in order to avoid crystallization problems during subsequent work due to more moisture inside the sample, which may cause damage to the internal structure of the sample, and to ensure that the moisture and ethanol in the sample are removed completely, multiple replacements are required, resulting in a relatively long overall drying time and affecting the experimental efficiency.
[0005] Therefore, the utility model provides a sample dryer to solve the above problems. Summary of the Utility Model
[0006] Aiming at the deficiencies of the prior art, the utility model provides a sample dryer to solve the above problems.
[0007] To achieve the above purposes, the utility model is realized through the following technical solutions: A sample dryer includes a dryer, a waste liquid storage tank is arranged on the dryer, a pressure regulating valve and a heat exchanger are arranged inside the dryer, and further includes a vibration mechanism and a circulating stirring mechanism. The vibration mechanism is arranged inside the dryer, and the circulating stirring mechanism is arranged outside the vibration mechanism.
[0008] Preferably, the vibration mechanism includes a sample chamber, and a plurality of notches are arranged at the bottom end of the sample chamber.
[0009] Preferably, an organic reagent container is arranged inside the sample chamber, a plurality of micro holes are arranged on the outer side of the organic reagent container, a heat insulation plate is arranged at the bottom end of the organic reagent container, and a plurality of springs are arranged on the lower side of the heat insulation plate.
[0010] Preferably, a micro electromagnetic vibrator is provided at the bottom end of the heat insulation plate, a fixed circular plate is provided at the bottom end of the spring, several fixed cylinders are provided at the bottom end of the fixed circular plate, the fixed cylinders are fitted into the notches at the bottom end of the sample chamber, a pick-up and placement fixing block is provided outside the organic reagent container, holes are provided on the pick-up and placement fixing block, a sample cage is provided inside the organic reagent container, a sample port and a second notch are provided on the sample cage, and a sample cover is threadedly connected to the sample chamber.
[0011] Preferably, the circulating stirring mechanism includes a second liquid pipe and a fifth liquid pipe. The second liquid pipe is connected to the side wall of the sample chamber at an angle of 30 degrees, and the fifth liquid pipe is connected to the bottom end of the sample chamber at an angle of 30 degrees. A micro pump is provided outside the fifth liquid pipe.
[0012] Preferably, the circulating stirring mechanism further includes a first liquid pipe. One end of the first liquid pipe is connected to a liquid storage tank outside the dryer, a first electric three-way valve is connected to the end of the first liquid pipe close to the sample chamber, the middle part of the circulating stirring mechanism is connected to the second liquid pipe, and the end of the first electric three-way valve away from the first liquid pipe is connected to a third liquid pipe.
[0013] Preferably, the end of the third liquid pipe away from the first electric three-way valve is connected to a second electric three-way valve, and the end of the second electric three-way valve away from the third liquid pipe is connected to a fourth liquid pipe.
[0014] Advantageous Effects
[0015] The utility model provides a sample dryer. Compared with the prior art, the following advantageous effects are achieved:
[0016] (1) In a sample dryer, through the micro electromagnetic vibrator, the heat insulation plate vibrates, and the vibration of the heat insulation plate drives the organic reagent container to vibrate. Through the vibration of the liquid inside the organic reagent container, the liquid carbon dioxide uniformly penetrates the sample. At the same time, by using the vibration of the liquid, damage to the sample structure caused by local stress concentration is prevented. By utilizing the physical effects of diffusion and penetration of the liquid, the liquid carbon dioxide is gradually replaced by ethanol, thereby achieving sufficient infiltration of the sample, improving the replacement efficiency, and reducing the drying time.
[0017] (2) In a sample dryer, by utilizing the angles set by the second liquid pipe and the fifth liquid pipe, the liquid carbon dioxide rotates and flows towards the outside. When the liquid carbon dioxide inside the sample chamber reaches a certain height, the liquid inside the sample chamber rotates and flows, thereby achieving the effect of uniform stirring, improving the efficiency. In combination with the micro pump, second electric three-way valve, third liquid pipe, first electric three-way valve, and second liquid pipe provided in the circulating stirring mechanism, the liquid circulates, reducing the consumption of liquid carbon dioxide, improving the utilization rate of liquid carbon dioxide, and reducing the cost. Description of the Drawings
[0018] Figure 1 is the overall external structure diagram of the present utility model;
[0019] Figure 2 is the side view of the internal structure of the present utility model;
[0020] Figure 3 is the structure diagram of the sample chamber of the present utility model;
[0021] Figure 4 is the top view of the structure of the sample chamber of the present utility model;
[0022] Figure 5 is the side view of the partial structure of the vibration mechanism of the present utility model;
[0023] Figure 6 is the structure diagram of the sample cage of the present utility model;
[0024] Figure 7 is the side view of the structure of the vibration mechanism of the present utility model;
[0025] Figure 8 is the side view of the internal structure of the sample chamber of the present utility model.
[0026] In the figure, 1 is a dryer; 2 is a waste liquid storage tank;
[0027] Vibration mechanism: 31 is a sample chamber; 32 is a fixed cylinder; 33 is a fixed circular plate; 34 is a spring; 35 is a micro electromagnetic vibrator; 36 is an organic reagent container; 37 is a micro hole; 38 is a pick-and-place fixing block; 39 is a sample cover; 391 is a sample cage; 392 is a heat insulation plate;
[0028] Circulation stirring mechanism: 41 is a first liquid pipe; 42 is a first electric three-way valve; 43 is a second liquid pipe; 44 is a third liquid pipe; 45 is a second electric three-way valve; 46 is a micro pump; 47 is a fourth liquid pipe; 48 is a fifth liquid pipe. Detailed implementation manners
[0029] Next, the technical solutions in the embodiments of the present utility model will be clearly and completely described in conjunction with the accompanying drawings in the embodiments of the present utility model. Obviously, the described embodiments are only a part of the embodiments of the present utility model, rather than all the embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present utility model.
[0030] Embodiment 1:
[0031] Please refer to Figure 1-8, A sample dryer, comprising a dryer 1, on which a waste liquid storage tank 2 is provided. Inside the dryer 1, a pressure regulating valve and a heat exchanger are provided. It also includes a vibration mechanism and a circulating stirring mechanism. The vibration mechanism is arranged inside the dryer 1, and the circulating stirring mechanism is arranged outside the vibration mechanism.
[0032] The vibration mechanism includes a sample chamber 31, and a number of notches are provided at the bottom end of the sample chamber 31.
[0033] Inside the sample chamber 31, an organic reagent container 36 is provided. A number of micro-holes 37 are provided on the outside of the organic reagent container 36. An insulating plate 392 is provided at the bottom end of the organic reagent container 36, and a number of springs 34 are provided on the lower side of the insulating plate 392.
[0034] At the bottom end of the insulating plate 392, a micro electromagnetic vibrator 35 is provided. At the bottom end of the spring 34, a fixed circular plate 33 is provided. A number of fixed cylinders 32 are provided at the bottom end of the fixed circular plate 33, and the fixed cylinders 32 are fitted with the notches at the bottom end of the sample chamber 31. On the outside of the organic reagent container 36, a pick-and-place fixing block 38 is provided, and a hole is provided on the pick-and-place fixing block 38. Inside the organic reagent container 36, a sample cage 391 is provided. A sample port and a second notch are provided on the sample cage 391. A sample cover 39 is threadedly connected to the sample chamber 31.
[0035] Working process: Place the sample into the sample port of the sample cage 391. Use auxiliary tools to place the sample cage 391 into the organic reagent container 36 through the second notch of the sample cage 391. Use auxiliary tools to place the organic reagent container 36 into the sample chamber 31 through the pick-and-place fixing block 38 to avoid sample contamination. Fit the fixed cylinders 32 with the notches of the sample chamber 31 to avoid the displacement of the sample chamber 31. Ethanol is provided inside the organic reagent container 36. By using the good water solubility of ethanol, the water in the sample is gradually replaced, creating conditions for the subsequent replacement of ethanol with carbon dioxide, so that the sample is avoided from being damaged by surface tension during drying, and the original structure and form of the sample are maintained to the greatest extent. Threadedly connect the sample cover 39 to the sample chamber 31 to seal the inside of the sample chamber 31.
[0036] When the ethanol fills the pores of the sample, then introduce liquid carbon dioxide. The liquid carbon dioxide gradually flows into the inside of the organic reagent container 36 from the micro-holes 37, avoiding large liquid impact force and damaging the sample. By starting the micro electromagnetic vibrator 35, the insulating plate 392 vibrates. The vibration of the insulating plate 392 drives the organic reagent container 36 to vibrate. Through the vibration of the liquid inside the organic reagent container 36, the liquid carbon dioxide uniformly penetrates the sample. At the same time, it prevents damage to the sample structure caused by local stress concentration, improves work efficiency, and then uses the physical effects of liquid diffusion and penetration to gradually replace the liquid carbon dioxide with ethanol, thereby realizing the full infiltration of the sample, improving the replacement efficiency, and reducing the experimental time.
[0037] The principle of the critical point dryer is based on the special physical properties of substances at the critical point. Ethanol replaced by liquid carbon dioxide is used to displace the moisture in the sample, and then the physical properties of carbon dioxide are utilized to achieve the drying effect.
[0038] Example Two:
[0039] Please refer to Figure 1-8 , in this example, based on Example One, a technical solution for a sample dryer is provided: The circulating stirring mechanism includes a second liquid pipe 43 and a fifth liquid pipe 48. The second liquid pipe 43 is connected to the side wall of the sample chamber 31 at an inclination of 30 degrees, and the fifth liquid pipe 48 is connected to the bottom end of the sample chamber 31 at an inclination of 30 degrees. A micro pump 46 is arranged outside the fifth liquid pipe 48.
[0040] The circulating stirring mechanism further includes a first liquid pipe 41. One end of the first liquid pipe 41 is connected to a liquid storage tank outside the dryer 1, and one end of the first liquid pipe 41 close to the sample chamber 31 is connected to a first electric three-way valve 42. The middle of the circulating stirring mechanism is connected to the second liquid pipe 43, and the end of the first electric three-way valve 42 away from the first liquid pipe 41 is connected to a third liquid pipe 44.
[0041] The end of the third liquid pipe 44 away from the first electric three-way valve 42 is connected to a second electric three-way valve 45, and the end of the second electric three-way valve 45 away from the third liquid pipe 44 is connected to a fourth liquid pipe 47.
[0042] Working process: Liquid carbon dioxide is introduced through the first liquid pipe 41. The liquid carbon dioxide flows into the sample chamber 31 through the first electric three-way valve 42 and the second liquid pipe 43. By utilizing the angles set by the second liquid pipe 43 and the fifth liquid pipe 48 and their mutual cooperation, the liquid carbon dioxide moves in a direction biased towards the outside. When the liquid carbon dioxide in the sample chamber 31 reaches a certain height, the liquid in the sample chamber 31 rotates and flows, thus achieving the effect of uniform stirring, enabling the liquid carbon dioxide to uniformly and quickly penetrate into the sample, displace the ethanol in the sample, and thereby shorten the time required for the displacement process. By opening the valve of the second electric three-way valve 45, the liquid carbon dioxide in the sample chamber 31 moves towards the fifth liquid pipe 48.
[0043] When the liquid carbon dioxide and ethanol need to be repeatedly replaced by liquid penetration for more thorough penetration and replacement of ethanol.
[0044] After replacing the ethanol in the sample with liquid carbon dioxide, the mixed liquid is discharged to the waste liquid storage tank 2 through the fifth liquid pipe 48 and the fourth liquid pipe 47 by using the micro pump 46. Due to the small size of the sample, most of the ethanol is removed during the first replacement process, and the utilization rate of liquid carbon dioxide is low during the subsequent replacement processes.
[0045] Again, introduce liquid carbon dioxide through the first liquid pipe 41, adjust the second electric three-way valve 45, and use the micro pump 46 to make the liquid carbon dioxide flow sequentially along the fifth liquid pipe 48 to the third liquid pipe 44, the first electric three-way valve 42 and the second liquid pipe 43, so that the liquid carbon dioxide continuously circulates and penetrates with the sample. After several cycles, use the second electric three-way valve 45 to drain the liquid into the waste liquid storage tank 2, and then discharge the liquid carbon dioxide through the first liquid pipe 41, so as to reduce the replacement times, reduce the consumption of liquid carbon dioxide, and lower the cost.
[0046] Meanwhile, the content not detailedly described in this specification belongs to the prior art well known to those skilled in the art.
[0047] It should be noted that, in this article, relational terms such as first and second are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or sequence between these entities or operations. Moreover, the term "comprising", "including" or any other variant thereof is intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements not only includes those elements, but also includes other elements not expressly listed, or further includes elements inherent to such process, method, article or device.
[0048] Although the embodiments of the present invention have been shown and described, for those of ordinary skill in the art, it can be understood that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principle and spirit of the present invention. The scope of the present invention is defined by the appended claims and their equivalents.
Claims
1. A sample dryer, comprising a dryer (1), a waste liquid storage tank (2) is arranged on the dryer (1), and a pressure regulating valve and a heat exchanger are arranged inside the dryer (1), characterized in that, It also includes a vibration mechanism and a circulating stirring mechanism. The vibration mechanism is arranged inside the dryer (1), and the circulating stirring mechanism is arranged outside the vibration mechanism.
2. The sample dryer according to claim 1, wherein: The vibration mechanism includes a sample chamber (31), and a number of notches are provided at the bottom end of the sample chamber (31).
3. The sample dryer according to claim 2, wherein: An organic reagent container (36) is arranged inside the sample chamber (31). A number of micro-holes (37) are provided on the outer side of the organic reagent container (36). A heat insulation plate (392) is provided at the bottom end of the organic reagent container (36), and a number of springs (34) are provided on the lower side of the heat insulation plate (392).
4. The sample dryer according to claim 3, wherein: A micro electromagnetic vibrator (35) is provided at the bottom end of the heat insulation plate (392). A fixed circular plate (33) is provided at the bottom end of the spring (34). A number of fixed cylinders (32) are provided at the bottom end of the fixed circular plate (33), and the fixed cylinders (32) are fitted with the notches at the bottom end of the sample chamber (31). A pick-up and placement fixing block (38) is provided on the outer side of the organic reagent container (36), and a hole is provided on the pick-up and placement fixing block (38). A sample cage (391) is arranged inside the organic reagent container (36), and a sample port and a second notch are provided on the sample cage (391). A sample cover (39) is threadedly connected to the sample chamber (31).
5. The sample dryer according to claim 4, characterized in that: The circulating stirring mechanism includes a second liquid pipe (43) and a fifth liquid pipe (48). The second liquid pipe (43) is connected to the side wall of the sample chamber (31) at an angle of 30 degrees, and the fifth liquid pipe (48) is connected to the bottom end of the sample chamber (31) at an angle of 30 degrees. A micro pump (46) is provided on the outer side of the fifth liquid pipe (48).
6. The sample dryer according to claim 5, wherein: The circulating stirring mechanism further includes a first liquid pipe (41). One end of the first liquid pipe (41) is connected to a liquid storage tank outside the dryer (1), and a first electric three-way valve (42) is connected to the end of the first liquid pipe (41) close to the sample chamber (31). The middle part of the circulating stirring mechanism is connected to the second liquid pipe (43), and the end of the first electric three-way valve (42) away from the first liquid pipe (41) is connected to a third liquid pipe (44).
7. A sample dryer according to claim 6, characterized in that: The end of the third liquid pipe (44) away from the first electric three-way valve (42) is connected to a second electric three-way valve (45), and the end of the second electric three-way valve (45) away from the third liquid pipe (44) is connected to a fourth liquid pipe (47).