Auxiliary sampling device of liquid chromatograph-mass spectrometer

Abstract

The utility model provides an auxiliary sampling device of a liquid chromatography-mass spectrometer, and relates to the technical field of liquid chromatography-mass spectrometers. The auxiliary sampling device comprises a base; the lifting support is installed on the top of the base, and the lifting support is a two-stage lifting support; one end of the first mounting plate is mounted on the lifting bracket; the waste liquid collecting assembly is mounted on the first mounting plate; the sample storage assembly is mounted on the first mounting plate; the sample injection assembly is mounted on the first mounting plate; the second mounting plate is mounted on the lifting bracket; the sliding assembly is mounted on the second mounting plate; the automatic sampling assembly is mounted on the sliding assembly; and the cleaning assembly is communicated with the automatic sampling assembly. The sliding assembly drives the automatic sampling assembly to move, samples stored in the sample storage assembly are sucked into the automatic sampling assembly in the moving process, then the sliding assembly drives the automatic sampling assembly to move to the position above the sample injection assembly, and then the samples are fed into the liquid chromatograph-mass spectrometer through the sample injection assembly.

Description

Technical Field

[0001] The utility model relates to the technical field of liquid chromatography - mass spectrometry instruments, and particularly relates to an auxiliary sample injection device for a liquid chromatography - mass spectrometry instrument. Background Art

[0002] Liquid chromatography - mass spectrometry instruments are mainly applied to drug metabolism and pharmacokinetics research, clinical pharmacology research, development research of natural drugs (such as Chinese herbal medicines), neonatal screening, identification of proteins and peptides, residue analysis, toxicant analysis, environmental analysis - in industries such as public security, environmental protection, food, tap water, and health and epidemic prevention.

[0003] When the existing liquid chromatography - mass spectrometry instruments perform sample injection, most still rely on manual operation experience, resulting in operation errors and slow sample injection speed during the sample injection process. Summary of the Utility Model

[0004] In order to solve the above - mentioned technical problems, the utility model provides an auxiliary sample injection device for a liquid chromatography - mass spectrometry instrument. The sliding component drives the automatic sampling component to move. During the movement, the sample stored in the sample storage component is inhaled into the automatic sampling component, and then the sliding component drives the automatic sampling component to move above the sample injection component, and then it is sent into the liquid chromatography - mass spectrometry instrument through the sample injection component.

[0005] The technical solution adopted by the utility model is as follows:

[0006] An auxiliary sample injection device for a liquid chromatography - mass spectrometry instrument, comprising:

[0007] A base;

[0008] A lifting bracket, installed at the top of the base, and the lifting bracket is a two - stage lifting bracket;

[0009] A first mounting plate, one end of which is installed at the end of the first - stage lifting end of the lifting bracket;

[0010] A waste liquid collection component, installed on the first mounting plate and close to the lifting bracket;

[0011] A sample storage component, installed on the first mounting plate and located on the side of the waste liquid collection component away from the lifting bracket;

[0012] A sample injection component, installed on the first mounting plate and located on the side of the sample storage component away from the waste liquid collection component;

[0013] A second mounting plate, installed at the end of the second - stage lifting end of the lifting bracket;

[0014] A sliding component, installed on the second mounting plate;

[0015] An automatic sampling component is installed on the sliding component, and the sliding component drives the automatic sampling component to move directly above the waste liquid collection component, the sample storage component or the sample injection component;

[0016] A cleaning component is communicated with the automatic sampling component.

[0017] Optionally, the waste liquid collection component includes:

[0018] A cleaning tray, on the top of which a cleaning groove is arranged;

[0019] A waste liquid collection pipe, one end of which is communicated with the cleaning groove and the other end is communicated with an external waste water treatment device.

[0020] Optionally, the sample storage component includes:

[0021] A rotating part, installed on the first mounting plate;

[0022] A sample mounting seat, installed on the rotating part, and a plurality of sample grooves are arranged on the top of the sample mounting seat;

[0023] Wherein, the rotating part drives the sample mounting seat to rotate so that the sample groove is aligned with the syringe needle of the automatic sampling component.

[0024] Optionally, the sample injection component includes:

[0025] A rotating motor, installed on the first mounting plate;

[0026] A multi-way valve, installed on the output shaft of the rotating motor, an injection port corresponding to its chamber is arranged on the top of the multi-way valve, and the sample outlet of the multi-way valve is communicated with a liquid chromatography-mass spectrometry instrument.

[0027] Optionally, the sliding component includes:

[0028] A driving motor, installed on the second mounting plate;

[0029] A lead screw pair, installed along the length direction of the second mounting plate and located at the bottom of the second mounting plate, the automatic sampling component is installed on the nut of the lead screw pair, and the output end of the driving motor is connected with the lead screw of the lead screw pair.

[0030] Optionally, the automatic sampling component includes:

[0031] A moving seat, connected with the sliding component;

[0032] A syringe needle, installed at the bottom of the moving seat;

[0033] A negative pressure pump, installed at the bottom of the moving seat and communicated with the syringe needle.

[0034] Optionally, the cleaning component includes:

[0035] A cleaning pipeline, one end of which is communicated with the syringe, and the other end is communicated with an external liquid supply component;

[0036] A cleaning disk, which is arranged on the moving seat and coaxially arranged with the syringe. A solution storage chamber is arranged in the cleaning disk, and spraying holes communicated with the solution storage chamber are arranged on the side wall of the cleaning disk facing the syringe;

[0037] A liquid supply pipeline, one end of which is communicated with the solution storage chamber of the cleaning disk, and the other end is communicated with the external liquid supply component.

[0038] Compared with the prior art, the beneficial effects of the present utility model are:

[0039] The sliding component drives the automatic sampling component to move, and samples stored in the sample storage component are inhaled into the automatic sampling component during the movement. Then, the sliding component drives the automatic sampling component to move above the sample injection component, and then is sent into the liquid chromatography-mass spectrometry instrument through the sample injection component. Description of the Drawings

[0040] In order to more clearly illustrate the technical solutions in the embodiments of the present application or the prior art, the following will briefly introduce the drawings required for use in the description of the embodiments or the prior art. Obviously, the drawings in the following description are only some embodiments of the present application. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0041] Figure 1 It is a schematic plan view of the auxiliary sample injection device for a liquid chromatography-mass spectrometry instrument.

[0042] Figure 2 It is a schematic partial top view of the auxiliary sample injection device for a liquid chromatography-mass spectrometry instrument.

[0043] Figure 3 It is a schematic partial view of the auxiliary sample injection device for a liquid chromatography-mass spectrometry instrument.

[0044] Reference numerals:

[0045] 1. Base;

[0046] 2. Lifting bracket;

[0047] 3. First mounting plate;

[0048] 4. Waste liquid collection component; 41. Cleaning disk; 42. Cleaning tank; 43. Waste liquid collection pipe;

[0049] 5. Sample storage component; 51. Rotating part; 52. Sample mounting base; 53. Sample groove;

[0050] 6. Sampling component; 61. Rotating motor; 62. Multi-way valve; 63. Sampling port;

[0051] 7. Second mounting plate;

[0052] 8. Sliding component; 81. Driving motor; 82. Lead screw pair;

[0053] 9. Automatic sampling component; 91. Moving seat; 92. Syringe; 93. Negative pressure pump;

[0054] 10. Cleaning component; 101. Cleaning pipe; 102. Cleaning disc; 103. Solution storage chamber; 104. Spraying holes; 105. Liquid supply pipeline. Detailed implementation manners

[0055] In the following text, only some exemplary embodiments are simply described. As those skilled in the art can recognize, the described embodiments can be modified in various different ways without departing from the spirit or scope of the present invention. Therefore, the drawings and the description are considered to be exemplary in nature rather than restrictive.

[0056] In the present invention, unless otherwise clearly defined and limited, the terms "mounted", "connected", "connected with", "fixed" and other terms should be understood in a broad sense. For example, it can be a fixed connection, a detachable connection, or integrated; it can be directly connected, or indirectly connected through an intermediate medium, and it can be the internal communication of two elements or the interaction relationship between two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific situations.

[0057] In the present invention, unless otherwise clearly defined and limited, the first feature being "above" or "below" the second feature may include the direct contact between the first and second features, or may include the situation where the first and second features are not in direct contact but in contact through other features between them. Moreover, the first feature being "above", "over" and "on" the second feature includes that the first feature is directly above and obliquely above the second feature, or merely indicates that the horizontal height of the first feature is higher than that of the second feature. The first feature being "under", "beneath" and "under" the second feature includes that the first feature is directly above and obliquely above the second feature, or merely indicates that the horizontal height of the first feature is lower than that of the second feature.

[0058] The following disclosure provides many different embodiments or examples for implementing different structures of the present utility model. To simplify the disclosure of the present utility model, components and settings of specific examples are described below. Of course, they are merely examples and are not intended to limit the present utility model. In addition, the present utility model may repeat reference numerals and / or reference letters in different examples. Such repetition is for the purpose of simplicity and clarity and does not itself indicate the relationship between the various embodiments and / or settings discussed.

[0059] The embodiments of the present utility model will be described in detail below with reference to the accompanying drawings.

[0060] As Figure 1 and Figure 2 shown, the embodiments of the present utility model provide an auxiliary sample injection device for a liquid chromatography-mass spectrometry instrument, including: a base 1, a lifting bracket 2, a first mounting plate 3, a waste liquid collection assembly 4, a sample storage assembly 5, a sample injection assembly 6, a second mounting plate 7, a sliding assembly 8, an automatic sampling assembly 9, and a cleaning assembly 10. The lifting bracket 2 is installed on the top of the base 1, and the lifting bracket 2 is a two-stage lifting bracket 2. One end of the first mounting plate 3 is installed at the end of the first-stage lifting end of the lifting bracket 2. The waste liquid collection assembly 4 is installed on the first mounting plate 3 and is disposed close to the lifting bracket 2. The sample storage assembly 5 is installed on the first mounting plate 3 and is located on the side of the waste liquid collection assembly 4 away from the lifting bracket 2. The sample injection assembly 6 is installed on the first mounting plate 3 and is located on the side of the sample storage assembly 5 away from the lifting bracket 2. The second mounting plate 7 is installed at the end of the second-stage lifting end of the lifting bracket 2. The sliding assembly 8 is installed on the second mounting plate 7. The automatic sampling assembly 9 is installed on the sliding assembly 8, and the sliding assembly 8 drives the automatic sampling assembly 9 to move directly above the waste liquid collection assembly 4, the sample storage assembly 5, or the sample injection assembly 6. The cleaning assembly 10 is communicated with the automatic sampling assembly 9.

[0061] During use, the auxiliary sample injection device is placed on one side of the liquid chromatography-mass spectrometry instrument, and the height of the first mounting plate 3 is adjusted through the lifting bracket 2 so that the sample injection assembly 6 on the first mounting plate 3 is at an appropriate height, and then it is communicated with the sample tube of the liquid chromatography-mass spectrometry instrument.

[0062] The sliding component 8 first drives the automatic sampling component 9 to slide onto the sample storage component 5, and then the second-level lifting end of the lifting bracket 2 descends, enabling the automatic sampling component 9 to suck the sample in the sample storage component 5. Then the second-level lifting end of the lifting bracket 2 rises, the sliding component 8 drives the automatic sampling component 9 to be located on the sample injection component 6, the second-level lifting end of the lifting bracket 2 descends, enabling a part of the structure of the automatic sampling component 9 to extend into the sample injection component 6, and then the sample is injected into the sample injection component 6. After the sample injection is completed, the second-level lifting end of the lifting frame rises, the sliding component 8 drives the automatic sampling component 9 to slide above the waste liquid collection component 4, and then drives the automatic sampling component 9 to descend through the lifting bracket 2, enabling a part of the structure of the automatic sampling component 9 to be located in the waste liquid collection component 4, and then the cleaning component 10 is started to clean the automatic sampling component 9 to prepare for the next sample injection.

[0063] By using the auxiliary sample injection device of the present application, the sample injection accuracy of the sample is improved through automatic sampling, the manual labor intensity is reduced, and the sample injection efficiency is improved.

[0064] In one embodiment, as Figure 1 and Figure 2 shown, the waste liquid collection component 4 includes: a cleaning tray 41 and a waste liquid collection pipe 43. A cleaning groove 42 is provided at the top of the cleaning tray 41, and the size of the cleaning groove 42 is larger than the size of the syringe 92 of the automatic sampling component 9. One end of the waste liquid collection pipe 43 is communicated with the cleaning groove 42, and the other end is communicated with the waste water treatment device.

[0065] During use, the waste water generated by cleaning the automatic sample injection component 6 is first collected in the cleaning groove 42, and then the waste water is discharged into the external waste water treatment device through the waste liquid collection pipe 43 communicated with the cleaning groove 42 for centralized treatment, which can effectively avoid the problem of the waste water polluting the test bench.

[0066] In one embodiment, as Figure 1 and Figure 2 shown, the sample storage component 5 includes: a rotating member 51 and a sample mounting seat 52. The rotating member 51 is installed on the first mounting plate 3. The sample mounting seat 52 is installed on the rotating member 51, and a plurality of sample grooves 53 are provided at the bottom of the sample mounting seat 52, and the sample grooves 53 are annularly distributed along the center of the sample mounting seat 52. During use, the rotating member 51 drives the sample mounting seat 52 to rotate, so that the sample grooves 53 are aligned with the syringe 92 on the automatic sampling component 9.

[0067] The rotating member 51 in this embodiment is a motor and is installed on the first mounting plate 3. The rotation of the motor drives the sample mounting seat 52 to rotate. During actual use, the test tube containing the sample can be inserted into the sample groove 53, and the syringe 92 of the automatic sampling component 9 extends into the test tube for quantitative sampling.

[0068] In one embodiment, as Figure 1 and Figure 2 shown, the sample injection assembly 6 includes: a rotating motor 61 and a multi-way valve 62. The rotating motor 61 is installed on the first mounting plate 3. The multi-way valve 62 is connected to the output shaft of the rotating motor 61, and a sample injection port 63 that is separately communicated with each of its chambers is provided at the top of the multi-way valve 62. The sample outlet of the multi-way valve 62 is communicated with the liquid chromatography-mass spectrometry instrument.

[0069] When injecting a sample, the syringe 92 of the automatic sampling assembly 9 extends into the sample injection port 63, and the sample in the automatic sampling assembly 9 can be pushed into the corresponding chamber.

[0070] In one embodiment, as Figure 1 shown, the sliding assembly 8 includes: a driving motor 81 and a lead screw pair 82. The driving motor 81 is installed on the second mounting plate 7. The lead screw pair 82 is installed along the length direction of the second mounting plate 7 and is located at the bottom of the bottom mounting plate. The automatic sampling assembly 9 is installed on the nut of the lead screw pair 82, and the output end of the driving motor 81 is connected to the lead screw of the lead screw pair 82.

[0071] During use, the driving motor 81 drives the lead screw of the lead screw pair 82 to rotate forward and backward, so that the nut of the lead screw pair 82 moves back and forth along the axis of the lead screw, and the automatic sampling assembly 9 is located at a specified position during the movement.

[0072] In one embodiment, as Figure 1 and Figure 3 shown, the automatic sampling assembly 9 includes: a moving seat 91, a syringe 92, and a negative pressure pump 93. The moving seat 91 is connected to the nut of the lead screw pair 82. The syringe 92 is installed at the bottom of the moving seat 91. The negative pressure pump 93 is installed at the bottom of the moving seat 91 and is communicated with the syringe 92.

[0073] When sampling, the negative pressure pump 93 extracts negative pressure according to requirements, so that the sample enters the syringe 92. After the lead screw pair 82 drives it to move to a specified position, the negative pressure pump 93 discharges the pressure, so that the sample smoothly enters the sample injection assembly 6.

[0074] In one embodiment, as Figure 1 and Figure 3As shown, the cleaning assembly 10 includes: a cleaning pipe 101, a cleaning disk 102, and a liquid supply pipe 105. One end of the cleaning pipe 101 is connected to the syringe 92, and the other end is connected to an external liquid supply assembly, for flushing the inside of the syringe 92. The cleaning disk 102 is installed on the moving seat 91 and is coaxially arranged with the syringe 92. A solution storage chamber 103 is provided inside the cleaning disk 102, and spray holes 104 communicating with the solution storage chamber 103 are provided on the side wall of the cleaning disk 102 facing the syringe 92. One end of the liquid supply pipe 105 is connected to the solution storage chamber 103 of the cleaning disk 102, and the other end is connected to an external liquid supply assembly.

[0075] During use, the external liquid supply assembly supplies a cleaning agent to the liquid supply pipe 105. The cleaning agent enters the solution storage chamber 103, and then sprays out through the spray holes 104 communicating with the solution storage chamber 103. The sprayed cleaning agent flushes the outer side wall of the syringe 92.

[0076] It should be noted that during the cleaning process, the syringe 92 is located in the cleaning tank 42 of the cleaning disk 102, which is convenient for transporting the waste water after cleaning to a designated position.

[0077] Finally, it should be noted that the above are only the preferred embodiments of the present invention and are not used to limit the present invention. Although the present invention has been described in detail with reference to the foregoing embodiments, for those skilled in the art, they can still modify the technical solutions recorded in the foregoing embodiments, or perform equivalent replacements for some of the technical features. Any modifications, equivalent replacements, improvements, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.

Claims

1. An auxiliary sample injection device for a liquid chromatography-mass spectrometry instrument, characterized in that, Comprising: Base; Lifting bracket, installed on the top of the base, and the lifting bracket is a two-stage lifting bracket; First mounting plate, one end of which is installed at the end of the first-stage lifting end of the lifting bracket; Waste liquid collection assembly, installed on the first mounting plate and disposed close to the lifting bracket; Sample storage assembly, installed on the first mounting plate and located on the side of the waste liquid collection assembly away from the lifting bracket; Sampling assembly, installed on the first mounting plate and located on the side of the sample storage assembly away from the waste liquid collection assembly; Second mounting plate, installed at the end of the second-stage lifting end of the lifting bracket; Sliding assembly, installed on the second mounting plate; Automatic sampling assembly, installed on the sliding assembly, and the sliding assembly drives the automatic sampling assembly to move directly above the waste liquid collection assembly, sample storage assembly or sampling assembly; Cleaning assembly, communicated with the automatic sampling assembly.

2. The auxiliary sample injection device of the liquid chromatography-mass spectrometry instrument according to claim 1, wherein The waste liquid collection assembly includes: Cleaning tray, a cleaning groove is arranged at the top of the cleaning tray; Waste liquid collection pipe, one end of which is communicated with the cleaning groove and the other end is communicated with an external waste water treatment device.

3. The auxiliary sample injection device of the liquid chromatography-mass spectrometry instrument according to claim 1 or 2, characterized in that The sample storage assembly includes: Rotating member, installed on the first mounting plate; Sample mounting seat, installed on the rotating member, and a plurality of sample grooves are arranged at the top of the sample mounting seat; Wherein, the rotating member drives the sample mounting seat to rotate so that the sample grooves are aligned with the syringe of the automatic sampling assembly.

4. The auxiliary sample injection device of the liquid chromatography-mass spectrometry instrument according to claim 1, characterized in that The sampling assembly includes: Rotating motor, installed on the first mounting plate; Multi-way valve, installed on the output shaft of the rotating motor, a sampling port corresponding to its chamber is arranged at the top of the multi-way valve, and the sample outlet of the multi-way valve is communicated with a liquid chromatography-mass spectrometry instrument.

5. The auxiliary sample injection device of the liquid chromatography-mass spectrometry instrument according to claim 1, characterized in that, The sliding assembly includes: Drive motor, installed on the second mounting plate; Lead screw pair, installed along the length direction of the second mounting plate and located at the bottom of the second mounting plate, the automatic sampling assembly is installed on the nut of the lead screw pair, and the output end of the drive motor is connected with the lead screw of the lead screw pair.

6. The auxiliary sample introduction device of the liquid chromatography-mass spectrometry instrument according to claim 1, characterized in that, The automatic sampling assembly includes: Moving seat, connected with the sliding assembly; Syringe, installed at the bottom of the moving seat; Negative pressure pump, installed at the bottom of the moving seat and communicated with the syringe.

7. The auxiliary sample injection device of the liquid chromatography-mass spectrometry instrument according to claim 6, wherein, The cleaning assembly includes: Cleaning pipeline, one end of which is communicated with the syringe and the other end is communicated with an external liquid supply assembly; Cleaning disc, arranged on the moving seat and coaxially arranged with the syringe, a solution storage chamber is arranged in the cleaning disc, and spray holes communicated with the solution storage chamber are arranged on the side wall of the cleaning disc facing the syringe; Liquid supply pipeline, one end of which is communicated with the solution storage chamber of the cleaning disc and the other end is communicated with the external liquid supply assembly.

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