Sample analyzer device
Through the independent first and second straight grippers combined with the design of the scheduling light metering unit, the structure and layout of the sample analyzer device are optimized, and the problems of low testing efficiency and large area are solved, and higher test throughput and speed are achieved.
Patent Information
- Application Number
- CN202420524268.4
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-03-15
- Publication Date
- 2025-07-29
- Estimated Expiration
- 2034-03-15
AI Technical Summary
The existing sample analyzer devices have low testing efficiency, large area and low testing accuracy, which cannot meet the growing testing needs.
The independent first and second straight grippers are used to coordinate with the scheduling light metering unit, which are respectively responsible for the transfer of the reaction cup between different units, optimize the movement route and structural layout, reduce the transit mechanism, and improve operational convenience and overall stability.
The compact structure of the sample analyzer device is achieved, the test throughput and test speed per unit area is improved, and the complex structure and high cost problems in the prior art are solved.
Smart Images

Figure CN223166760U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the field of medical inspection and analysis equipment, and in particular, to a sample analyzer device. Background Art
[0002] The chemiluminescence immunoassay system utilizes the principles of chemiluminescence and immunoreaction to correlate the optical signal with the concentration of the substance to be measured, and analyze the content of the substance to be measured in the sample. Due to its characteristics such as high sensitivity, specificity, and wide linear range, it is being increasingly widely used. With the increase in the number of test specimens, clinical laboratories have higher and higher requirements for the volume and test throughput (throughput per unit area) of the chemiluminescence immunoassay system. The chemiluminescence immunoassay system needs to realize functions such as sample transportation, reagent storage, discharge of analysis liquids such as sample reagents, transfer of reactors, cleaning and separation, etc., and has extremely high requirements for automatic control.
[0003] At present, the test throughput of the existing immunoassay analyzers can no longer meet the increasing test volume in this field, thus seriously affecting the work efficiency of users such as doctors who need to make diagnoses based on the sample measurement results. At the same time, the main problems existing in the existing sample analyzer devices are: slow test speed and low efficiency; complex instrument structure, relatively large volume and size, and slow speed; in order to improve the test speed, usually multi-connected machines are used, resulting in a large floor area for the connection and low test accuracy. Summary of the Utility Model
[0004] The main purpose of the utility model is to provide a sample analyzer device to at least solve the problem of low test efficiency existing in the sample analyzer devices in the prior art.
[0005] To achieve the above purpose, according to one aspect of the utility model, a sample analyzer device is provided. The sample analyzer device includes a gripper unit, the gripper unit includes an independently arranged first linear gripper and a second linear gripper; a scheduling and photometry unit, a part of the scheduling and photometry unit is located on the movement track of the first linear gripper, and another part is located on the movement track of the second linear gripper; a reaction cup feeding unit, a sample addition tray, an incubation unit, and a cleaning unit, the reaction cup feeding unit and the sample addition tray are arranged on the movement track of the first linear gripper, and the incubation unit and the cleaning unit are arranged on the movement track of the second linear gripper; a reagent unit and a sample unit, the reagent unit and the sample unit are located on the outer peripheral side of the sample addition tray.
[0006] Furthermore, the movement tracks of the first linear gripper and the second linear gripper are perpendicular to each other in the horizontal direction.
[0007] Furthermore, the sample addition tray, the reaction cup feeding unit, and the scheduling and photometry unit are arranged in sequence along the movement track of the first linear gripper.
[0008] Further, the scheduling photometric unit, the incubation unit, and the cleaning unit are sequentially arranged along the movement track of the second linear gripper.
[0009] Further, at least a part of the sample addition tray, the reaction cup feeding unit, the scheduling photometric unit, the incubation unit, and the cleaning unit is located below the gripper unit.
[0010] Further, the gripper unit includes a first gripper structure and a second gripper structure arranged at intervals. The first gripper structure has a first linear gripper, and the second gripper structure has a second linear gripper. The scheduling photometric unit is arranged between the first gripper structure and the second gripper structure. The first gripper structure, the scheduling photometric unit, and the second gripper structure form an included angle area, and the reaction cup feeding unit, the incubation unit, and the cleaning unit are located inside the included angle area.
[0011] Further, the first linear gripper can transfer the reaction cup provided by the reaction cup feeding unit to the sample addition tray or the scheduling photometric unit; the first linear gripper can transfer the reaction cup between the sample addition tray and the scheduling photometric unit.
[0012] Further, the second linear gripper can transfer the reaction cup between any two of the scheduling photometric unit, the incubation unit, and the cleaning unit.
[0013] Further, the scheduling photometric unit includes a scheduling photometric disc, and the scheduling photometric disc has a plurality of cup positions arranged at circumferential intervals. At least one cup position is located on the movement track of the first linear gripper, and another cup position is located on the movement track of the second linear gripper; the scheduling photometric disc rotates to move the cup position located on the movement track of the first linear gripper to the movement track of the second linear gripper; or the scheduling photometric disc rotates to move the cup position located on the movement track of the second linear gripper to the movement track of the first linear gripper.
[0014] Further, the cup positions on the scheduling photometric disc include a plurality of outer ring cup positions arranged circumferentially and a plurality of inner ring cup positions arranged circumferentially. The inner ring cup positions are located inside the area formed by the outer ring cup positions. The outer ring cup positions and the inner ring cup positions are in one-to-one correspondence and are linearly arranged so that the outer ring cup positions and the inner ring cup positions on the same straight line are located on the movement track of the first linear gripper or the movement track of the second linear gripper.
[0015] Further, in the horizontal direction, the incubation unit is movably arranged along the vertical direction of the movement track of the second linear gripper.
[0016] Further, the sample analyzer device further includes a first cup throwing position, the first cup throwing position is arranged below the gripper unit, and the first cup throwing position is located on the movement track of the first linear gripper; a second cup throwing position, the second cup throwing position is arranged below the gripper unit, and the second cup throwing position is located on the movement track of the second linear gripper.
[0017] Further, on the movement trajectory of the first linear gripper, the first reaction cup throwing position is located between the reaction cup loading unit and the scheduling and photometry unit.
[0018] Further, the sample addition tray is rotatably arranged. Along the rotation direction of the sample addition tray, the reagent unit is located downstream of the sample unit. The sample addition tray has a plurality of cup positions. When the sample addition tray rotates, the cup positions for placing the reaction cups are successively located on the movement trajectory of the first linear gripper, below the sample unit, below the reagent unit, and on the movement trajectory of the first linear gripper.
[0019] Further, there are a plurality of cup positions provided on the sample addition tray, and the plurality of cup positions are arranged at intervals along the circumferential direction of the sample addition tray.
[0020] Applying the technical solution of the present utility model, the sample analyzer device includes a gripper unit, a scheduling and photometry unit, a reaction cup loading unit, a sample addition tray, an incubation unit, a cleaning unit, a reagent unit, and a sample unit. The gripper unit includes an independently arranged first linear gripper and a second linear gripper. The movement trajectories of the first linear gripper and the second linear gripper are perpendicular. A part of the scheduling and photometry unit is located on the movement trajectory of the first linear gripper, and another part is located on the movement trajectory of the second linear gripper. The reaction cup loading unit and the sample addition tray are arranged on the movement trajectory of the first linear gripper. The incubation unit and the cleaning unit are arranged on the movement trajectory of the second linear gripper. The reagent unit and the sample unit are located on the outer peripheral side of the sample addition tray.
[0021] As can be seen from the above, the sample analyzer device adopted in this application uses the independently arranged first linear gripper and the second linear gripper in cooperation to transfer the reaction cup between the reaction cup loading unit, the sample addition tray, the incubation unit, the photometry unit, and the cleaning unit to realize sample analysis. The first linear gripper and the second linear gripper are respectively adapted to different structures and are completely independently arranged, which is beneficial to improving the overall operation convenience, solving the problem of cooperation of multiple units and components. At the same time, the design of using the double linear grippers in cooperation with the scheduling and photometry unit solves the problems in the prior art that an additional transfer mechanism needs to be set, and the structures of the gripper and the incubation tray are complex and the cost is high. The structure and layout of the sample analyzer device of this application are more compact, the overall size of the machine is smaller, and the test throughput and test speed per unit floor area of the instrument are improved. BRIEF DESCRIPTION OF THE DRAWINGS
[0022] The accompanying drawings forming a part of this application are used to provide a further understanding of the present utility model. The schematic embodiments of the present utility model and their descriptions are used to explain the present utility model and do not constitute an improper limitation to the present utility model. In the drawings:
[0023] Figure 1 The structural schematic diagram of the sample analyzer device of the present utility model is shown.
[0024] Among them, the above-mentioned drawings include the following reference numerals:
[0025] 110, the first gripper structure; 111, the first linear gripper; 112, the first guide rail; 120, the second gripper structure; 121, the second linear gripper; 122, the second guide rail; 20, the scheduling and photometry unit; 210, the outer ring cup position; 220, the inner ring cup position; 30, the reaction cup feeding unit; 310, the transfer tray; 320, the reaction cup magazine; 40, the sampling plate; 50, the incubation unit; 60, the cleaning unit; 70, the reagent unit; 80, the sample unit; 90, the first cup discarding position; 1100, the second cup discarding position; 1200, the scanner. Detailed implementation manners
[0026] It should be noted that, without conflict, the embodiments in the present application and the features in the embodiments can be combined with each other. The following will describe the present invention in detail with reference to the drawings and in combination with the embodiments.
[0027] It should be pointed out that, unless otherwise specified, all technical and scientific terms used in the present application have the same meaning as commonly understood by those of ordinary skill in the technical field to which the present application belongs.
[0028] In the present invention, unless otherwise stated, the orientation terms such as "upper, lower, top, bottom" are generally in the direction shown in the drawings, or in the vertical, perpendicular or gravitational direction of the component itself; similarly, for ease of understanding and description, "inner, outer" refer to the inner and outer of the contour of each component itself, but the above orientation terms do not limit the present invention.
[0029] In order to solve the problems of low test efficiency, large occupied area and low test accuracy existing in the sample analyzer device of the prior art, the present embodiment provides a sample analyzer device.
[0030] As Figure 1 shown, the sample analyzer device includes a gripper unit, a scheduling and photometry unit 20, a reaction cup feeding unit 30, a sampling plate 40, an incubation unit 50, a cleaning unit 60, a reagent unit 70 and a sample unit 80. The gripper unit includes an independently arranged first linear gripper 111 and a second linear gripper 121. A part of the scheduling and photometry unit 20 is located on the movement track of the first linear gripper 111, and another part is located on the movement track of the second linear gripper 121. The reaction cup feeding unit 30 and the sampling plate 40 are arranged on the movement track of the first linear gripper 111, the incubation unit 50 and the cleaning unit 60 are arranged on the movement track of the second linear gripper 121, and the reagent unit 70 and the sample unit 80 are located on the outer peripheral side of the sampling plate 40.
[0031] Among them, the movement trajectories of the first linear gripper 111 and the second linear gripper 121 are perpendicular to each other in the horizontal direction.
[0032] Specifically, the sample analyzer device adopted in the present application uses the mutually independent first linear gripper 111 and the second linear gripper 121 to cooperate to transfer reaction cups between the reaction cup loading unit 30, the sample adding tray 40, the incubation unit 50, the photometric unit and the cleaning unit 60 to achieve sample analysis. The first linear gripper 111 and the second linear gripper 121 are respectively adapted to different structures, and the completely independent setting between the two is beneficial to improving the overall operation convenience, solving the problem of the cooperation of multiple units and components. At the same time, the design of the cooperation of the double linear grippers and the incubation block solves the problems that in the prior art, an additional transfer mechanism needs to be set and the structures of the gripper and the incubation tray are complex, resulting in the problems of large overall occupied volume and high cost in the sample analyzer device of the prior art. The structure and layout of the sample analyzer device of the present application are more compact, the overall size of the instrument is smaller, and the test throughput and test speed per unit floor area of the instrument are improved.
[0033] Among them, the first linear gripper 111 is used to transfer the reaction cups provided by the reaction cup loading unit 30 between the sample adding tray 40 and the scheduling photometric unit 20; the second linear gripper 121 transfers the reaction cups between the scheduling photometric unit 20, the incubation unit 50 and the cleaning unit 60.
[0034] Furthermore, the sample adding tray 40, the reaction cup loading unit 30, and the scheduling photometric unit 20 are sequentially arranged along the movement trajectory of the first linear gripper 111, and the scheduling photometric unit 20, the incubation unit 50, and the cleaning unit 60 are sequentially arranged along the movement trajectory of the second linear gripper 121. Such a setting effectively optimizes the movement route of the linear gripper, shortens the movement stroke of the linear gripper, thereby improving the sample detection efficiency. At the same time, the sample adding tray 40, the reaction cup loading unit 30, and the scheduling photometric unit 20 sequentially arranged along the movement trajectory of the first linear gripper 111 are convenient to be adapted to the first linear gripper 111, and there is no interference between the structures, thereby improving the overall operation stability; similarly, the scheduling photometric unit 20, the incubation unit 50, and the cleaning unit 60 sequentially arranged along the movement trajectory of the first linear gripper 111 are convenient to be adapted to the second linear gripper 121, and there is no interference between the structures, thereby improving the overall operation stability.
[0035] Further, at least a part of the sample adding tray 40, the reaction cup feeding unit 30, the scheduling and photometry unit 20, the scheduling and photometry unit 20, the incubation unit 50, and the cleaning unit 60 are located below the gripper unit. Among them, at least a part of the sample adding tray 40, at least a part of the reaction cup feeding unit 30, and at least a part of the scheduling and photometry unit 20 are located below the first linear gripper 111, and at least a part of the scheduling and photometry unit 20, at least a part of the incubation unit 50, and at least a part of the cleaning unit 60 are located below the second linear gripper 121.
[0036] The first linear gripper 111 and the second linear gripper 121 of the present application move along a linear movement trajectory, and at the same time, the first linear gripper 111 and the second linear gripper 121 can move in a direction perpendicular to the movement trajectory, that is, move along the height direction of the reaction cup, so as to grasp or place the reaction cup.
[0037] In this embodiment, the gripper unit includes a first gripper structure 110 and a second gripper structure 120 arranged at intervals. The first gripper structure 110 has a first linear gripper 111, and the second gripper structure 120 has a second linear gripper 121. The scheduling and photometry unit 20 is arranged between the first gripper structure 110 and the second gripper structure 120. The first gripper structure 110, the scheduling and photometry unit 20, and the second gripper structure 120 form an included angle area, and the reaction cup feeding unit 30, the incubation unit 50, and the cleaning unit 60 are located inside the included angle area. By arranging the reaction cup feeding unit 30, the incubation unit 50, and the cleaning unit 60 inside the included angle area, it is beneficial to realize the compactness of the overall layout of multiple structures, facilitate the rational use of space, make the overall size of the instrument smaller, and improve the test throughput and test speed per unit floor area of the instrument.
[0038] Further, the first gripper structure 110 includes a first guide rail 112 extending linearly. The first linear gripper 111 is arranged on the first guide rail 112, and the first linear gripper 111 can reciprocate along the first guide rail 112. Among them, the first linear gripper 111 is slidably arranged on the first guide rail 112. The first gripper structure 110 further includes a first driving member for driving the first linear gripper 111 to slide, and the first driving member is arranged on the first guide rail 112. The linearly extending first guide rail 112 provides limit guidance for the movement of the first linear gripper 111 and provides installation for the first linear gripper 111, facilitating the stable reciprocating movement of the first linear gripper 111.
[0039] Further, the second gripper structure 120 includes a second guide rail 122 extending linearly. The second linear gripper 121 is disposed on the second guide rail 122, and the second linear gripper 121 can reciprocate along the second guide rail 122. The second linear gripper 121 is slidably disposed on the second guide rail 122. The second gripper structure 120 further includes a second driving member for driving the second linear gripper 121 to slide, and the second driving member is disposed on the second guide rail 122. The linearly extending second guide rail 122 provides limit guidance for the movement of the second linear gripper 121 and provides installation for the second linear gripper 121, facilitating the stable reciprocating movement of the second linear gripper 121.
[0040] In this embodiment, the first linear gripper 111 can transfer the reaction cups provided by the reaction cup loading unit 30 to the sample adding tray 40 or the scheduling and photometry unit 20. That is, the movement of the first linear gripper 111 can be to transfer the reaction cups provided by the reaction cup loading unit 30 to the sample adding tray 40, or to directly move the reaction cups to the scheduling and photometry unit 20. Specifically, the movement of the first linear gripper 111 can be adaptively set according to needs. The first linear gripper 111 can transfer the reaction cups between the sample adding tray 40 and the scheduling and photometry unit 20. The second linear gripper 121 can transfer the reaction cups between any two of the scheduling and photometry unit 20, the incubation unit 50, and the cleaning unit 60 to adaptively transfer the reaction cups according to needs.
[0041] As Figure 1 shown, the scheduling and photometry unit 20 includes a scheduling and photometry disc. The scheduling and photometry disc has a plurality of cup positions arranged at circumferential intervals. At least one cup position is located on the movement track of the first linear gripper 111, and another cup position is located on the movement track of the second linear gripper 121.
[0042] Specifically, the scheduling and photometry disc is rotatably disposed. The scheduling driving member provides driving force for the rotation of the scheduling and photometry disc. The retrieval driving member is drivingly connected to the scheduling and photometry disc. The scheduling and photometry disc rotates to transfer the reaction cup placed on one of the cup positions by the first linear gripper 111 to the movement track of the second linear gripper 121, facilitating the second linear gripper 121 to grasp the reaction cup; conversely, the reaction cup placed on the cup position by the second linear gripper 121 follows the rotation of the scheduling and photometry disc and is transferred to the movement track of the first linear gripper 111 to facilitate the first linear gripper 111 to grasp the reaction cup. Among them, the scheduling driving member can be a structure such as a cylinder or a motor.
[0043] By setting the scheduling photometric unit 20, the transfer of reaction cups between the first linear gripper 111 and the second linear gripper 121 is realized, achieving the function of reaction cup transfer and improving the moving speed of the reaction cups. Moreover, the scheduling photometric unit 20 also has the effect of photometric detection, facilitating the photometry of the reaction cups placed on the scheduling photometric unit 20 by the first linear gripper 111 or the photometry of the reaction cups placed on the scheduling photometric unit 20 by the second linear gripper 121.
[0044] Further, the scheduling photometric disc rotates to move the cup positions on the moving trajectory of the first linear gripper 111 to the moving trajectory of the second linear gripper 121.
[0045] Further, the scheduling photometric disc rotates to move the cup positions on the moving trajectory of the second linear gripper 121 to the moving trajectory of the first linear gripper 111.
[0046] In this embodiment, the cup positions on the scheduling photometric disc include a plurality of outer ring cup positions 210 arranged circumferentially and a plurality of inner ring cup positions 220 arranged circumferentially. The inner ring cup positions 220 are located inside the area formed by the outer ring cup positions 210. The outer ring cup positions 210 and the inner ring cup positions 220 correspond one by one and are linearly arranged, so that the outer ring cup positions 210 and the inner ring cup positions 220 on the same straight line are located on the moving trajectory of the first linear gripper 111 or the moving trajectory of the second linear gripper 121.
[0047] Among them, the outer ring cup positions 210 are used for the first linear gripper 111 to schedule reaction cups to the second linear gripper 121. At the same time, the outer ring cup positions 210 also have the function of photometry, that is, when photometry is required, the reaction cups after incubation and cleaning are moved to the outer ring cup positions 210 of the scheduling photometric unit 20 for photometry.
[0048] Among them, the inner ring cup positions 220 are used for the second linear gripper 121 to schedule reaction cups to the first linear gripper 111.
[0049] Through the settings of the inner ring cup positions 220 and the outer ring cup positions 210, the first linear gripper 111 schedules the reaction cups to the outer ring cup positions 210 of the scheduling photometric unit 20, and the second linear gripper moves the reaction cups at the outer ring cup positions 210 to the incubation unit 50. When secondary injection is actually required, the second linear gripper 121 schedules the reaction cups to the inner ring cup positions 220 of the scheduling photometric unit 20, and the first linear gripper 111 transfers the reaction cups at the inner ring cup positions 220 to the sample addition tray 40.
[0050] The scheduling photometric unit 20 of the present application has the structural settings of the inner ring cup positions 220 and the outer ring cup positions 210. During the process of scheduling reaction cups, different operations are independently set without interference, so as to realize the synchronous operation of photometry and secondary reagent injection, which is beneficial to improving work efficiency.
[0051] Among them, the inner circle cup position 220 and the outer circle cup position 210 are arranged linearly, so that the linearly arranged inner circle cup position 220 and the outer circle cup position 210 can be located on the motion trajectory of the first linear gripper 111 or the motion trajectory of the second linear gripper 121 at the same time, making it convenient for the first linear gripper 111 or the second linear gripper 121 to move the reaction cup to the inner circle cup position 220 and the outer circle cup position 210.
[0052] like Figure 1 As shown, in the horizontal direction, the incubation unit 50 is movably arranged along the vertical direction of the movement trajectory of the second linear gripper 121 , that is, in this embodiment, the incubation unit 50 is movably arranged along the direction of the movement trajectory of the first linear gripper 111 .
[0053] Specifically, the incubation unit 50 has multiple incubation positions for placing reaction cups, and the horizontal movement trajectory of the second linear gripper 121 is perpendicular to the moving direction of the incubation unit 50, so that the second linear gripper 121 can adapt to the multiple incubation positions arranged along the moving direction of the incubation unit 50 to grab or place the reaction cup.
[0054] Furthermore, the plurality of incubation sites may be arranged in an array or non-array manner.
[0055] Furthermore, the multiple incubation position incubation units 50 may adopt a square structure, or a circular structure or a structure of other shapes.
[0056] In a specific embodiment of the present application, the incubation unit 50 adopts a square structure.
[0057] Furthermore, the movement of the incubation unit 50 may be achieved through an incubation drive structure, which may be a cylinder, a motor, or the like.
[0058] In this embodiment, the incubation block unit provides a constant temperature reaction site for the sample and reagent reaction solution. The incubation unit 50 can not only realize the incubation of the reaction solution, but also realize the incubation of the substrate after the reaction cup is cleaned.
[0059] like Figure 1 As shown, the sample analyzer device also includes a first cup throwing position 90 and a second cup throwing position 1100. The first cup throwing position 90 is arranged below the gripper unit, and the first cup throwing position 90 is located on the motion trajectory of the first linear gripper 111. The second cup throwing position 1100 is arranged below the gripper unit, and the second cup throwing position 1100 is located on the motion trajectory of the second linear gripper 121.
[0060] Specifically, a first cup discarding position 90 set on the movement track of the first linear gripper 111 corresponds to the first linear gripper 111, so that when the photometry is completed or in other cases where reaction cups are not required, the first linear gripper 111 can place the used reaction cups at the first cup discarding position 90 for cup discarding; similarly, a second cup discarding position 1100 set on the movement track of the second linear gripper 121 corresponds to the second linear gripper 121, so that when the photometry is completed or in other cases where reaction cups are not required, the second linear gripper 121 can place the used reaction cups at the second cup discarding position 1100 for cup discarding.
[0061] By setting the first cup discarding position 90 and the second cup discarding position 1100, it is convenient for the first linear gripper 111 and the second linear gripper 121 to respectively perform cup discarding operations.
[0062] Furthermore, along the movement track of the first linear gripper 111, the first cup discarding position 90 is located between the reaction cup feeding unit 30 and the scheduling photometry unit 20. This is to facilitate the first linear gripper 111 to move the reaction cups after photometry completion to the first cup discarding position 90 and move the reaction cups provided by the reaction cup feeding unit 30 to the sample adding tray 40, reducing the movement path of the first linear gripper 111, increasing the movement speed, and improving work efficiency.
[0063] Furthermore, along the movement track of the second linear gripper 121, the second cup discarding position 1100 is located between the incubation unit 50 and the cleaning unit 60. This is to facilitate the second linear gripper 121 to move the incubated or cleaned reaction cups to the second cup discarding position 1100, reducing the movement path of the second linear gripper 121, increasing the movement speed, and improving work efficiency.
[0064] It should be noted that the sample analyzer device of the present application includes an operation frame, and the gripper unit, the scheduling photometry unit 20, the reaction cup feeding unit 30, the sample adding tray 40, the incubation unit 50, the cleaning unit 60, the reagent unit 70, and the sample unit 80 are all arranged on the operation frame. The first cup discarding position 90 and the second cup discarding position 1100 are also arranged on the operation frame, and the operation frame is used to provide installation for the components participating in sample analysis.
[0065] In this embodiment, the cleaning unit 60 uses magnetic cleaning means to clean the reaction cups.
[0066] As Figure 1 shown, the sample adding tray 40 is rotatably arranged. Along the rotation direction of the sample adding tray 40, the reagent unit 70 is located downstream of the sample unit 80. The sample adding tray 40 has a plurality of cup positions. When the sample adding tray 40 rotates, the cup positions for placing reaction cups are successively located on the movement track of the first linear gripper 111, below the sample unit 80, below the reagent unit 70, and on the movement track of the first linear gripper 111.
[0067] Among them, the sample analyzer device further includes a sample loading tray 40 driving structure, which is drivingly connected to the sample loading tray 40 and provides driving force for the rotation of the sample loading tray 40. The sample loading tray 40 driving structure can be structural components such as a motor or a cylinder.
[0068] Specifically, after the reaction cup is placed in a cup position, as the sample loading tray 40 rotates, this cup position moves below the sample unit 80. The sample unit 80 adds samples into the reaction cup through a sampling needle, and then this cup position moves below the reagent unit 70, and the reagent of the reagent unit 70 adds reagents into the reaction cup.
[0069] Furthermore, there are multiple cup positions on the sample loading tray 40, and the multiple cup positions are arranged at intervals along the circumferential direction of the sample loading tray 40.
[0070] Among them, the sample unit 80, the reaction cup feeding unit 30, the reagent unit 70, and the gripper unit cooperate with different cup positions on the sample loading tray 40 respectively. And in this application, the movement cycles of the sample unit 80, the reaction cup feeding unit 30, and the reagent unit 70 are the same as the time taken for the sample loading tray 40 to rotate the distance between two cup positions. That is to say, in this application, after the sample loading tray 40 rotates the interval length between every two cup positions, the reaction cup feeding unit 30 can provide a reaction cup to a cup position on the sample loading tray 40, and the sampling needle can provide a sample into an empty reaction cup on the sample loading tray 40 once and the reagent needle can add a reagent into the reaction cup after the sample is added once. And in this application, the sample loading tray 40 can be separately provided with one or more mixing working positions, and one or more mixers are arranged. The mixing working positions can be set downstream of the sampling cup position of the reagent needle, so that after the sample loading tray 40 completes sample addition, it rotates to the next position to mix the reaction solution. Furthermore, the mixing working positions can be set upstream of the gripper unit, and after the reaction solution is mixed, the sample loading tray 40 rotates to the trajectory of the gripper unit for the next operation.
[0071] Furthermore, the sample unit 80 and the reagent unit 70 each have at least one cleaning pool.
[0072] In this embodiment, the reagent unit 70 includes a reagent tray and a reagent needle that cooperate with each other. The reagent tray and the reagent needle are in one-to-one correspondence. The reagent needle moves between the reagent tray and the sample loading tray 40, and the reagent needle can move above the cup position of the sample loading tray 40 to drain the reagent. The reagent tray is used to store reagent kits and has functions such as reagent kit scheduling, reagent kit mixing, reagent refrigeration, and reagent kit barcode information scanning or reading. And the reagent needle can drain the reagent in the reagent tray into the reaction cup on the sample loading tray 40.
[0073] In this embodiment, the sample analyzer device further includes a scanner 1200. The scanner 1200 is disposed on one side of the reagent unit 70 and is used to scan the reagent unit 70.
[0074] In this embodiment, the reaction cup loading unit 30 includes a reaction cup magazine 320 and a transfer tray 310. The transfer tray 310 is located on the movement track of the first linear gripper 111. The transfer tray 310 is connected to the reaction cup magazine 320, and the reaction cup magazine 320 supplies reaction cups to the transfer tray 310. In this application, the reaction cups in the reaction cup magazine 320 can be conveyed to the transfer tray 310 through a loading chute, and the first linear gripper 111 grabs the reaction cups on the transfer tray 310 onto the sampling tray 40.
[0075] This embodiment provides a sample detection method. The sample detection method is applied to the sample analyzer device, and the sample analyzer device has a first photometric mode.
[0076] The sample detection method includes:
[0077] Adding liquid, adding the sample and the reagent into the reaction cup on the sampling tray 40 in sequence and mixing them evenly;
[0078] Scheduling, the first linear gripper 111 transfers the reaction cup carrying the evenly mixed sample and reagent to the cup position of the scheduling photometric unit 20.
[0079] Incubating, the second linear gripper 121 moves the reaction cup on the scheduling photometric unit to the incubating unit 50 for incubation.
[0080] First cleaning, the second linear gripper 121 moves the reaction cup after incubation to the cleaning unit 60 for cleaning.
[0081] Photometric measurement, according to the obtained instruction, execute the first photometric mode, and the second linear gripper 121 moves the reaction cup after cleaning to the scheduling photometric unit 20 for photometric measurement.
[0082] Specifically, during the process of scheduling the reaction cup, the reaction cup is placed at the outer ring cup position 210 of the scheduling photometric unit 20 for transferring the cup position.
[0083] Further, in the first photometric mode, the test process of this solution takes the one-step process of sample chemiluminescence test as an example:
[0084] 1. The first linear gripper 111 schedules a reaction cup on the transfer tray 310 of the reaction cup loading unit 30 to the cup position of the sampling tray 40. The sampling tray 40 advances one cup position periodically, and the reaction cup is transferred to the position where the sample unit 80 cooperates with the sampling tray 40.
[0085] 2. The sampling needle of the sample unit 80 aspirates a preset amount of sample and discharges it into the reaction cup.
[0086] 3. The reagent unit 70 schedules the reagent kit to the reagent sampling port to facilitate the reagent needle unit to aspirate the reagent.
[0087] 4. The sampling tray 40 advances one cup position periodically, and the reaction cup is transferred to the position where the reagent unit 70 cooperates with the sampling tray 40. The reagent needle of the reagent unit 70 aspirates a certain amount of reagent from the reagent sampling port of the reagent unit 70 and discharges it into the reaction cup.
[0088] 5. The sampling tray 40 advances one cup position periodically, and the reaction cup is transferred to the reaction liquid mixing position for reaction liquid mixing.
[0089] 6. The reaction cup on the sampling tray 40 is transferred to the movement track of the first linear gripper 111, and the first linear gripper 111 transfers the reaction cup to the outer circle of the scheduling photometric disc.
[0090] 7. The scheduling photometric disc rotates one cup position to below the second linear gripper 121, and the second linear gripper 121 transfers the reaction cup to the incubation unit 50 for reaction liquid incubation.
[0091] 8. After a period of time, when the reaction liquid incubation is completed, the second linear gripper 121 transfers the reaction cup to the cleaning unit 60 for magnetic cleaning operation.
[0092] 9. After the magnetic cleaning is completed, the second linear gripper 121 directly transfers the reaction cup to the scheduling photometric unit 20 for subsequent photometric operation.
[0093] 10. For the reaction cup after photometry, the scheduling photometric disc schedules the reaction cup to below the first linear gripper 111, and the first linear gripper 111 transfers it to the first cup discarding position 90 for cup discarding, completing the entire test.
[0094] In this embodiment, the sample analyzer device also has a second photometric mode. When the second photometric mode is executed, the photometric steps include:
[0095] Execute the second photometric mode according to the obtained instruction. The second linear gripper 121 first moves the reaction cup after cleaning to the incubation unit 50 for substrate incubation, and then the second linear gripper 121 moves the reaction cup after substrate incubation to the scheduling photometric unit 20 for photometry.
[0096] It should be noted that in the second photometric measurement mode, that is, when substrate incubation is required after magnetic cleaning, in step 9, the second linear gripper 121 transfers the reaction cup to the incubation position of the incubation unit 50 first, and then performs substrate incubation after re-cleaning; after a period of time, when the substrate incubation is completed, the second linear gripper 121 transfers the reaction cup to the scheduling photometric measurement unit 20 for subsequent photometric measurement operations.
[0097] In this embodiment, after the first cleaning step, the sample detection method further includes a step of injecting secondary reagents, and the injection of secondary reagents includes:
[0098] The second linear gripper 121 moves the cleaned reaction cup to the cup position of the scheduling photometric measurement unit 20;
[0099] The scheduling photometric measurement unit 20 advances one cycle, and the first linear gripper 111 moves the reaction cup on the cup position of the scheduling photometric measurement unit 20 to the sampling tray 40;
[0100] The sampling tray 40 rotates and drives the reaction cup to move below the reagent unit 70, and the reagent unit 70 injects reagents into the reaction cup and shakes it evenly;
[0101] The first linear gripper 111 transfers the reaction cup to the cup position of the scheduling photometric measurement unit 20;
[0102] The second linear gripper 121 moves the reaction cup on the scheduling photometric measurement unit 20 to the incubation unit 50 for incubation;
[0103] For the second cleaning, the second linear gripper 121 moves the incubated reaction cup to the cleaning unit 60 for secondary cleaning.
[0104] Among them, the second linear gripper 121 places the reaction cup on the inner ring cup position 220 of the scheduling photometric measurement unit 20, and the first linear gripper 111 transfers the reaction cup to the outer ring cup position 210 of the scheduling photometric measurement unit 20.
[0105] That is, the transferred cleaned reaction cup is realized through the inner ring cup position 220 of the scheduling photometric measurement unit 20. With the cooperation of the second linear gripper 121, the inner ring cup position 220 of the scheduling photometric measurement unit 20 and the first linear gripper 111, the reaction cup is moved to the sampling tray 40, and then the above steps 1-10 are executed.
[0106] From the above description, it can be seen that the above embodiments of the present invention achieve the following technical effects:
[0107] The sample analyzer device adopted in this application uses the mutually independent first linear gripper 111 and the second linear gripper 121 to cooperate to realize the transfer of reaction cups among the reaction cup feeding unit 30, the sampling tray 40, the incubation unit 50, the photometric unit, and the cleaning unit 60, so as to realize sample analysis. The first linear gripper 111 and the second linear gripper 121 are respectively adapted to different structures, and their completely independent settings are conducive to improving the overall operation convenience, solving the problem of the coordination of multiple units and components. At the same time, the design of using the double linear grippers to cooperate and schedule the photometric unit 20 solves the problems in the prior art that an additional transfer mechanism needs to be set, and the structures of the gripper and the incubation tray are complex and costly. The structure and layout of the sample analyzer device in this application are more compact, the overall dimensions of the instrument are smaller, and the test throughput and test speed per unit floor area of the instrument are improved.
[0108] Obviously, the above-described embodiments are only a part of the embodiments of the present invention, rather than all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those of ordinary skill in the art without creative efforts shall fall within the protection scope of the present invention.
[0109] It should be noted that the terms used herein are only for describing specific embodiments, and are not intended to limit the exemplary embodiments according to the present application. As used herein, unless the context clearly indicates otherwise, the singular forms are also intended to include the plural forms. In addition, it should be understood that when the terms "comprise" and / or "include" are used in this specification, they indicate the presence of features, steps, operations, devices, components, and / or combinations thereof.
[0110] It should be noted that the terms "first", "second", etc. in the description, claims, and drawings of this application are used to distinguish similar objects, and are not necessarily used to describe a specific order or sequence. It should be understood that such data can be interchanged under appropriate circumstances so that the embodiments of the present application described here can be implemented in an order different from those illustrated or described here.
[0111] The above are only the preferred embodiments of the present invention, and are not used to limit the present invention. For those skilled in the art, the present invention can have various changes and modifications. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present invention shall be included in the protection scope of the present invention.
Claims
1. A sample analyzer device, characterized in that, Comprising: A gripper unit, including an independently arranged first linear gripper (111) and a second linear gripper (121); A scheduling and photometric measurement unit (20), a part of the scheduling and photometric measurement unit (20) is located on the movement trajectory of the first linear gripper (111), and another part is located on the movement trajectory of the second linear gripper (121); A reaction cup feeding unit (30), a sample addition tray (40), an incubation unit (50) and a cleaning unit (60), the reaction cup feeding unit (30) and the sample addition tray (40) are arranged on the movement trajectory of the first linear gripper (111), and the incubation unit (50) and the cleaning unit (60) are arranged on the movement trajectory of the second linear gripper (121); A reagent unit (70) and a sample unit (80), the reagent unit (70) and the sample unit (80) are located on the outer peripheral side of the sample addition tray (40); The sample addition tray (40), the reaction cup feeding unit (30), and the scheduling and photometric measurement unit (20) are arranged in sequence along the movement trajectory of the first linear gripper (111), and the scheduling and photometric measurement unit (20), the incubation unit (50) and the cleaning unit (60) are arranged in sequence along the movement trajectory of the second linear gripper (121).
2. The sample analyzer device according to claim 1, wherein The movement trajectories of the first linear gripper (111) and the second linear gripper (121) are perpendicular to each other in the horizontal direction.
3. The sample analyzer device according to claim 1, characterized in that, At least a part of the sample addition tray (40), the reaction cup feeding unit (30), the scheduling and photometric measurement unit (20), the incubation unit (50) and the cleaning unit (60) are located below the gripper unit.
4. The sample analyzer device according to claim 1, characterized in that, The gripper unit includes a first gripper structure (110) and a second gripper structure (120) arranged at intervals. The first gripper structure (110) has the first linear gripper (111), and the second gripper structure (120) has the second linear gripper (121). The scheduling and photometric measurement unit (20) is arranged between the first gripper structure (110) and the second gripper structure (120). The first gripper structure (110), the scheduling and photometric measurement unit (20) and the second gripper structure (120) form an angular area, and the reaction cup feeding unit (30), the incubation unit (50) and the cleaning unit (60) are located inside the angular area.
5. The sample analyzer device according to claim 1, wherein The first linear gripper (111) can transfer the reaction cup provided by the reaction cup feeding unit (30) to the sample addition tray (40) or the scheduling and photometric measurement unit (20); The first linear gripper (111) can transfer the reaction cup between the sample addition tray (40) and the scheduling and photometric measurement unit (20).
6. The sample analyzer device according to claim 1, wherein The second linear gripper (121) can transfer the reaction cup between any two of the scheduling and photometric measurement unit (20), the incubation unit (50), and the cleaning unit (60).
7. The sample analyzer device according to claim 1, wherein, The scheduling photometric unit (20) includes: A scheduling photometric disk having a plurality of cup positions circumferentially spaced apart, wherein at least one of the cup positions is on the movement trajectory of the first linear gripper (111), and another of the cup positions is on the movement trajectory of the second linear gripper (121); The scheduling photometric disk rotates to move the cup position on the movement trajectory of the first linear gripper (111) to the movement trajectory of the second linear gripper (121); or The scheduling photometric disk rotates to move the cup position on the movement trajectory of the second linear gripper (121) to the movement trajectory of the first linear gripper (111).
8. The sample analyzer device according to claim 7, characterized in that, The cup positions on the scheduling photometric disk include a plurality of outer ring cup positions (210) arranged circumferentially and a plurality of inner ring cup positions (220) arranged circumferentially. The inner ring cup positions (220) are located inside the area formed by the outer ring cup positions (210). The outer ring cup positions (210) and the inner ring cup positions (220) are in one-to-one correspondence and arranged linearly, so that the outer ring cup positions (210) and the inner ring cup positions (220) on the same straight line are on the movement trajectory of the first linear gripper (111) or the movement trajectory of the second linear gripper (121).
9. The sample analyzer device according to claim 1, characterized in that, In the horizontal direction, the incubation unit (50) is movably arranged along the vertical direction of the movement trajectory of the second linear gripper (121).
10. The sample analyzer device according to claim 1, wherein, The sample analyzer device further includes: A first cup discarding position (90) arranged below the gripper unit, and the first cup discarding position (90) is on the movement trajectory of the first linear gripper (111); A second cup discarding position (1100) arranged below the gripper unit, and the second cup discarding position (1100) is on the movement trajectory of the second linear gripper (121).
11. The sample analyzer device according to claim 10, characterized in that, Along the movement trajectory of the first linear gripper (111), the first cup discarding position (90) is located between the reaction cup feeding unit (30) and the scheduling photometric unit (20).
12. The sample analyzer device according to claim 10, characterized in that, Along the movement trajectory of the second linear gripper (121), the second cup discarding position (1100) is located between the incubation unit (50) and the cleaning unit (60).
13. The sample analyzer device according to claim 1, characterized in that, The sample addition disk (40) is rotatably arranged. Along the rotation direction of the sample addition disk (40), the reagent unit (70) is located downstream of the sample unit (80). The sample addition disk (40) has a plurality of cup positions. When the sample addition disk (40) rotates, the cup positions for placing reaction cups are successively located on the movement trajectory of the first linear gripper (111), below the sample unit (80), below the reagent unit (70), and on the movement trajectory of the first linear gripper (111).