Positive pressure filter pressing device and chemical synthesis workstation

Abstract

The utility model discloses a positive pressure filter pressing device and chemical synthesis workstation, wherein the positive pressure filter pressing device comprises a base, a positive pressure component and a filter module, the filter module is arranged in the positive pressure component, the base is arranged below the positive pressure component, and the base and the positive pressure component form a cavity for accommodating a filtrate collector. According to the positive pressure filter pressing device and the chemical synthesis work station, the defect that time and labor are wasted in manual filtering operation can be overcome, and the situation of cross contamination can be avoided.

Description

Technical Field

[0001] The utility model relates to the technical field of chemical experimental equipment, in particular to a positive pressure filtration device and a chemical synthesis workstation. Background Art

[0002] High-throughput chemical synthesis is an efficient, rapid and high-yield chemical synthesis method. By using high-throughput and automation technologies, it can simultaneously process thousands of different reactions, greatly improving the yield and efficiency of compounds. This method is widely used in many fields such as medicine, materials science, chemical biology, and organic chemistry, accelerating the R & D process of new materials or new drugs. Compared with traditional manual synthesis methods, high-throughput synthesis has the characteristics of higher automation, standardization and no need for multiple operators, reducing the cost and risk of chemical experiments.

[0003] In the process of high-throughput chemical synthesis, how to obtain filtrates or filter cakes in multiple systems through filtration is a crucial step in many chemical reaction experimental schemes. However, manual operation for separate filtration and sub-packaging of each system is time-consuming and laborious, not meeting the requirements of high-throughput synthesis for automation, standardization and no need for multiple operators.

[0004] In summary, there is an urgent need for a positive pressure filtration device and a chemical synthesis workstation to solve the problems existing in the related technologies. Content of the Utility Model

[0005] In view of the above problems, the utility model discloses a positive pressure filtration device, which includes a base, a positive pressure component and a filtration module. The filtration module is arranged in the positive pressure component, and the base is arranged below the positive pressure component, and the two form a cavity for accommodating a filtrate collector.

[0006] Preferably, the positive pressure component includes a bearing plate, a sealing cover and a joint; the bearing plate is provided with a filtration module, the filtration module is hermetically provided with a sealing cover, and a cavity is formed between the two. The joint penetrates through the sealing cover and communicates with the cavity.

[0007] Preferably, the sealing cover includes a first cover plate, a second cover plate and a sealing ring; the first cover plate is provided with an installation hole for installing the joint; the second cover plate is provided with an opening whose size matches the size of the filtration module; the sealing ring is circumferentially arranged on the first cover plate, and the second cover plate is connected to the first cover plate and clamps the sealing ring.

[0008] Preferably, the first cover plate is further provided with a clamping member, and the outer side of the clamping member is provided with an external tooth structure.

[0009] Preferably, the base and the bearing plate are connected by a pillar, and both between the base and the pillar and between the bearing plate and the pillar are connected by a pin and fixed by a setscrew.

[0010] Preferably, scale lines are also provided on the struts.

[0011] Preferably, the filtering module includes a plurality of funnel-shaped filtering units. Loading holes are provided on the bearing plate. The filtering module is arranged on the bearing plate and the necks of the filtering units penetrate through the loading holes.

[0012] Preferably, the bearing plate is provided with a stop block and a ball plunger screw, and the two are combined to clamp the filtering module.

[0013] Preferably, the sealing cover is also provided with an air baffle.

[0014] This application also discloses a chemical synthesis workstation, which includes a platform and the above-mentioned positive pressure filtration device. The positive pressure filtration device is installed on the platform through a cushion seat. A moving assembly, a pipette tip, a liquid storage assembly, and a reaction area are installed on the platform. A liquid transfer assembly and a jaw assembly are installed on the moving assembly.

[0015] The beneficial effects of this application compared with the prior art are as follows:

[0016] (1) Through the technical solution of the present utility model, a positive pressure filtration device is provided. During use, the filtering module is loaded into the positive pressure assembly, and the filtrate collector is set up. Then, an automated liquid dispensing device is used to load the solution to be filtered into the filtering module. At this time, gas is introduced into the positive pressure assembly. Since the internal pressure is greater than the external atmospheric pressure at this time, the solution flows into the filtrate collector after being filtered by the filtering module. Since this device uses positive pressure filtration instead of negative pressure, the filtrate collector will not be adsorbed in the positive pressure filtration device due to the action of atmospheric pressure and cannot be taken out.

[0017] (2) Through the technical solution of the present utility model, the filtering module includes a plurality of funnel-shaped filtering units. After transferring multiple portions of mixed liquid obtained from high-throughput chemical experiments to the filtering units through a liquid transfer device, each portion of the mixed liquid can be separately collected by selecting a filtrate collector (such as a collection plate) corresponding to the number of filtering units, which can avoid cross-contamination and also solve the time-consuming and laborious drawbacks of manual operation.

[0018] (3) Through the technical solution of the present utility model, the sealing cover includes a first cover plate, a second cover plate, and a sealing ring. By clamping the sealing ring between the first cover plate and the second cover plate, a sealing cover with good sealing performance is obtained. When this sealing cover is installed and connected to the bearing plate carrying the filtering module, the sealing ring provided on the first cover plate just fits with the filtering module, forming a relatively sealed environment between the sealing cover and the filtering module. When gas is introduced into the sealing cover through a connector, due to the difference in internal and external atmospheric pressures, the mixed liquid in the filtering module filters out from the neck of the filtering unit under the action of air pressure and is received by the filtrate collector below.

[0019] (4) Through the technical solution of the present utility model, the base is connected to the bearing plate through columns. The base and the columns, as well as the bearing plate and the columns, are connected by pins and fixed by setscrews. A scale is also provided on the columns. Therefore, the distance between the base and the bearing plate can be adjusted according to experimental requirements (such as the height of the filtrate collector).

[0020] In the following, the optimal embodiments for implementing the present application will be described in more detail with reference to the accompanying drawings, so as to easily understand the features and advantages of the present application. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] In order to more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings required for the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings in the following description are only some embodiments of the present invention. For those of ordinary skill in the art, other drawings can be obtained based on these drawings without creative efforts.

[0022] Figure 1 Schematic diagram of the positive pressure filtration device of the present application embodiment arranged in a chemical synthesis workstation;

[0023] Figure 2 Overall structure schematic diagram of the positive pressure filtration device of the present application embodiment (loaded with a collection plate);

[0024] Figure 3 For Figure 1 Explosion schematic diagram of the positive pressure filtration device (loaded with a collection plate);

[0025] Figure 4 For Figure 1 Schematic diagram of the structure of the air baffle in the positive pressure filtration device arranged on the first cover plate;

[0026] Figure 5 For Figure 1 Schematic diagram of the structure of the filtration module;

[0027] Figure 6 For Figure 5 Cross-sectional schematic diagram of the filtration module along the A-A plane;

[0028] Among them, 1. Positive pressure filtration device, 1.1 - Base, 1.2 - Positive pressure component, 1.2.1 - Connector, 1.2.2 - Clamping member, 1.2.3 - First cover plate, 1.2.4 - Sealing ring, 1.2.5 - Second cover plate, 1.2.6 - Bearing plate, 1.3 - Filtration module, 1.4 - Filtrate collector, 1.5 - Column, 1.6 - Air baffle, 1.7 - Filtration unit, 1.8 - Stop block, 2 - Platform, 3 - Moving component, 4 - Pipetting head, 5 - Liquid storage component, 6 - Reaction zone, 7 - Pipetting component, 8 - Claw component. Detailed Implementation Modes

[0029] It should be noted that, without conflict, the embodiments in this application and the features in the embodiments can be combined with each other. The following further describes this application in detail with reference to the drawings and specific embodiments.

[0030] In the embodiments of this application, if there are directional indications such as up, down, left, right, front, back... they are only used to explain the relative positional relationship and movement conditions between components in a specific posture as shown in the drawings. If this specific posture changes, the directional indications will also change accordingly.

[0031] In addition, in this application, the descriptions involving "first", "second", etc. are only for descriptive purposes and cannot be understood as indicating or implying their relative importance or implicitly specifying the quantity of the indicated technical features. Thus, the features defined with "first" and "second" may explicitly or implicitly include at least one such feature.

[0032] Embodiment 1, refer to Figure 1 , this application discloses a chemical synthesis workstation, including a platform 2 and a positive pressure filtration device 1. The positive pressure filtration device 1 is installed on the platform 2 through a pad base. A moving component 3, a pipette tip 4, a liquid storage component 5, and a reaction area 6 are installed on the platform 2. A pipetting component 7 and a gripper component 8 are installed on the moving component 3. The pipetting component 7 is controlled by the moving component 3 to move for pipetting. After pipetting, positive pressure filtration is performed by the positive pressure filtration device.

[0033] Please refer to Figure 2 and Figure 3 , this application embodiment also provides a positive pressure filtration device 1, including a base 1.1, a positive pressure component 1.2, and a filtration module 1.3. The filtration module 1.3 is arranged inside the positive pressure component 1.2. The base 1.1 is arranged below the positive pressure component 1.2, and a cavity for placing a filtrate collector 1.4 is formed between them. In high-throughput chemical experiments, the filtrate collector 1.4 is generally a 24-well, 48-well, or 96-well collection plate, etc., and the number of its wells matches the filtration module.

[0034] The positive pressure component 1.2 includes a bearing plate 1.2.6, a sealing cover, and a connector 1.2.1 (the connector is a flare fitting); the filtration module 1.3 is arranged on the bearing plate 1.2.6, and a sealing cover is hermetically arranged on the filtration module 1.3, and a cavity is formed between them. The connector 1.2.1 penetrates through the sealing cover and communicates with the cavity. The connector 1.2.1 is used to connect to an external gas source (such as an air compressor, etc.) to deliver gas into the sealing cover to form a positive pressure environment.

[0035] Refer to Figure 5 and Figure 6, the filtering module 1.3 includes a plurality of funnel-shaped filtering units 1.7. The bearing plate 1.2.6 is provided with bearing holes, and the filtering module 1.3 is arranged on the bearing plate 1.2.6, and the necks of the filtering units 1.7 penetrate through the bearing holes. After transferring multiple portions of the mixed solution obtained from high-throughput chemical experiments to the filtering units through a pipetting device, each portion of the mixed solution can be separately collected after filtration by selecting a filtrate collector 1.4 (such as a collection plate) corresponding to the number of filtering units, which can avoid cross-contamination and greatly reduce the time-consuming and laborious disadvantages of manual operation.

[0036] Furthermore, referring to Figure 3 and Figure 4 , the sealing cover includes a first cover plate 1.2.3, a second cover plate 1.2.5 and a sealing ring 1.2.4; the first cover plate 1.2.3 is provided with mounting holes for mounting joints; the second cover plate 1.2.5 is provided with an opening whose size matches the size of the filtering module 1.3 (when the sealing cover is pressed onto the filtering module 1.3, the filtering module 1.3 can just pass through the opening of the second cover plate and contact the sealing ring on the first sealing cover); the sealing ring 1.2.4 is circumferentially arranged on the first cover plate 1.2.3, and the second cover plate 1.2.5 is connected to the first cover plate 1.2.3 and clamps the sealing ring 1.2.4. A sealing cover with good sealing performance is formed among the first cover plate 1.2.3, the second cover plate 1.2.5 and the sealing ring. It should be noted that when the first cover plate and the second cover plate clamp the sealing ring, there is still a part of the sealing ring exposed. When this sealing cover is installed and connected to the bearing plate carrying the filtering module, the exposed part of the sealing ring just fits with the edge of the filtering module, forming a relatively sealed environment between the sealing cover and the filtering module. When gas is introduced into the sealing cover through the joint, due to the difference in internal and external atmospheric pressures, the mixed solution in the filtering module is filtered out from the neck of the filtering unit under the action of air pressure and is received by the filtrate collector below. It should be elaborated that the material of the sealing ring includes one of rubber, latex and silica gel.

[0037] Furthermore, the first cover plate 1.2.3 is further provided with a clamping member 1.2.2, and the outer side of the clamping member 1.2.2 is provided with an external tooth structure. By setting the clamping member and an external tooth structure on its outer side, it is convenient to be grabbed by a manipulator (or a clamping claw, a clamping claw assembly), which is beneficial to improving the automation of filtration using the device of the present application.

[0038] Further, the base 1.1 is connected to the bearing plate 1.2.6 through the support column 1.5. The base 1.1 and the support column 1.5, as well as the bearing plate 1.2.6 and the support column 1.5, are connected by pins and fixed by setscrews. It should be noted that, in order to prevent the situation where the bearing plate suddenly drops significantly under the action of gravity due to the failure of the setscrew caused by mechanical fatigue, etc., in this application, a boss is also provided on the support column, and the boss is used to maintain the minimum distance between the base and the bearing plate.

[0039] Further, a scale line is also provided on the support column. When in use, the experimenter can judge and adjust the distance between the bearing plate and the base according to the reading of the scale line.

[0040] Further, the bearing plate 1.2.6 is provided with a stopper 1.8 and a ball plunger setscrew, and the two are combined to clamp the filtration module. In order to meet the automation requirements and facilitate the transfer of the filtration module or the sealing cover, the filtration module, the sealing cover and the bearing plate only touch each other and no fixing measures are taken. During the use of the device, the filtration may inevitably shift, which may cause cross-contamination of the filtrate filtered by each filtration unit. Therefore, a combination of a stopper and a ball plunger setscrew is used to clamp the filtration module and limit its displacement.

[0041] Further, refer to Figure 4 , the sealing cover is also provided with a gas baffle 1.6. The gas baffle is arranged at the joint communication place and is used to disperse the air flow to avoid too strong air pressure at the joint.

[0042] Working principle: Install the base on the platform through the cushion seat, install the bearing plate, place the filtration module on the bearing plate and clamp the filtration module through the stopper and the ball plunger setscrew; Connect the first cover plate, the second cover plate and the sealing ring in sequence to form a sealing cover, install the joint, and place it on the platform; When filtration is required, start the moving component to drive the liquid transfer component to move in the X, Y, and Z axes. The liquid transfer component reaches the pipetting head to pick up the pipette tip, and then sucks the reaction liquid from the liquid storage component into the reaction area for reaction. After that, replace the pipette tip and suck different reaction liquids from the liquid storage component and add them to the reaction area for reaction. After the reaction is completed, move the solution to the filtration module through the liquid transfer component, move the sealing cover with the joint to the filtration module and press it tightly through the jaw component, inflate through the joint and generate positive pressure in the sealing cover, and the solution is filtered under the action of positive pressure and collected by the filtrate collector, and the filter residue or precipitate remains in the filtration module.

[0043] The above further describes the present application with the help of specific embodiments. However, it should be understood that the specific description here should not be construed as a limitation on the essence and scope of the present application. Various modifications made by those of ordinary skill in the art to the above embodiments after reading this specification all fall within the scope protected by the present application.

Claims

1. A positive pressure filter press device, characterized in that, It includes a base (1.1), a positive pressure component (1.2), and a filtration module (1.3). The filtration module (1.3) is arranged inside the positive pressure component (1.2), and the base (1.1) is arranged below the positive pressure component (1.2), and the two form a cavity for placing a filtrate collector (1.4).

2. The positive pressure filtration device according to claim 1, characterized in that, The positive pressure component (1.2) includes a bearing plate (1.2.6), a sealing cover, and a connector (1.2.1); a filtration module (1.3) is arranged on the bearing plate (1.2.6), a sealing cover is hermetically arranged on the filtration module (1.3), and a cavity is formed between the two, and the connector (1.2.1) penetrates through the sealing cover and communicates with the cavity.

3. The positive pressure filter press device according to claim 2, characterized in that, The sealing cover includes a first cover plate (1.2.3), a second cover plate (1.2.5), and a sealing ring (1.2.4); an installation hole for installing the connector (1.2.1) is arranged on the first cover plate (1.2.3); the second cover plate (1.2.5) is provided with an opening whose size matches the size of the filtration module (1.3); the sealing ring (1.2.4) is circumferentially arranged on the first cover plate (1.2.3), and the second cover plate (1.2.5) is connected to the first cover plate (1.2.3) and clamps the sealing ring (1.2.4).

4. The positive pressure filtration device according to claim 3, characterized in that, The first cover plate (1.2.3) is further provided with a clamping handle (1.2.2), and an external tooth structure is arranged on the outside of the clamping handle (1.2.2).

5. The positive pressure filter press device according to claim 2, characterized in that, The base (1.1) and the bearing plate (1.2.6) are connected by a support column (1.5). The base (1.1) and the support column (1.5), and the bearing plate (1.2.6) and the support column (1.5) are connected by pins and fixed by setscrews.

6. The positive pressure filter press device according to claim 5, wherein, A scale line is further arranged on the support column (1.5).

7. The positive pressure filtration device according to claim 2, wherein The filtration module (1.3) includes a number of funnel-shaped filtration units (1.7). A bearing hole is arranged on the bearing plate (1.2.6). The filtration module (1.3) is arranged on the bearing plate (1.2.6), and the neck of the filtration unit (1.7) penetrates through the bearing hole.

8. The positive pressure filtration device according to claim 2, characterized in that, The bearing plate (1.2.6) is provided with a stop block (1.8) and a ball detent, and the two are combined to clamp the filtration module (1.3).

9. The positive pressure filter press device according to claim 2, characterized in that The sealing cover is further provided with a gas blocking piece (1.6).

10. A chemical synthesis workstation, characterized in that, It includes a platform (2) and the positive pressure filtration device according to any one of claims 1-9. The positive pressure filtration device is installed on the platform (2) through a mounting seat. A moving component (3), a pipetting head (4), a liquid storage component (5), and a reaction zone (6) are installed on the platform (2). A pipetting component (7) and a jaw component (8) are installed on the moving component (3).

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