Noninvasive hemodynamics simulation device and test system

Abstract

The utility model discloses a noninvasive hemodynamics simulation device and a noninvasive hemodynamics test system, and the noninvasive hemodynamics simulation device comprises two excitation signal input terminals which are used for inputting external excitation signals; comprising two signal output terminals and is used for outputting a simulated blood flow body impedance change signal to the outside; the two excitation signal input terminals are electrically connected with the signal processing module; the two signal output terminals are electrically connected with the signal processing module; the signal processing module is used for converting an excitation signal input from the excitation signal input terminal into a body impedance change signal caused by simulating blood flow; the two signal output terminals are used for outputting body impedance change signals caused by simulated blood flow to the outside. The output body impedance change signal caused by simulated blood flow is more flexible to regulate and control, and the space is larger.

Description

Technical Field

[0001] The utility model relates to the technical field of non-invasive hemodynamic simulation, and particularly relates to a non-invasive hemodynamic simulation device and a test system. Background Technique

[0002] The population suffering from cardiovascular diseases in our country has always been high. According to the "Report on Cardiovascular Health and Diseases in China 2022", there are as many as 330 million cardiovascular disease patients in our country. Compared with other diseases, the mortality rate caused by cardiovascular-related diseases is the highest, and the number of patients is still increasing so far, accounting for more than 40% of the total number of deaths from diseases among residents. Therefore, it is crucial to promote the research and development of a hemodynamic parameter monitoring system. Hemodynamic parameters are necessary criteria for the clinical monitoring and diagnosis of cardiovascular disease patients, and are used to study the changes in circulatory system parameters such as blood flow volume, flow rate, and peripheral resistance under physiological and pathological conditions. Among them, cardiac output is a key parameter for evaluating the efficiency of the circulatory system and an important evaluation criterion for measuring the strength of the heart's ejection ability.

[0003] The measurement method of non-invasive cardiac output is to apply a high-frequency alternating current excitation to both ends of the chest cavity, collect the voltage amplitude at both ends of the excitation, and calculate the impedance change in the chest cavity due to the change in cardiac output, so as to obtain the cardiac output parameter of the human body. Compared with the gold standard thermodilution method, the method of measuring cardiac output by thoracic impedance method is an essential clinical means for hemodynamic monitoring due to its non-invasiveness. Therefore, the accuracy and safety of its measurement equipment are crucial.

[0004] The Chinese pharmaceutical industry standard "YY / T 1078-2008" for non-invasive hemodynamic monitoring by thoracic impedance method in direct impedance rheograph puts forward specific requirements for the accuracy detection and safety of the parameters of the monitoring instrument. At present, the common method for testing and detecting equipment on the market is still to use a simple digital-to-analog converter to output a signal for testing, and it cannot test the output current; the resistance range that can be simulated by foreign testing equipment is very small and cannot meet the requirements of industry standards.

[0005] How to design a non-invasive hemodynamic simulation device for various tests of non-invasive hemodynamic devices is a technical problem to be solved. Summary of the Invention

[0006] The technical solution of the utility model overcomes the shortcomings of the prior art and proposes a non-invasive hemodynamic simulation device similar to a human body resistance simulation model that can accurately generate a changing output signal in real time according to the input excitation. By designing an excitation signal input terminal and a signal processing device, the non-invasive hemodynamic simulation device can better simulate the human blood flow change model, is a precise hemodynamic simulation device, and can provide a more refined input signal adjustment mechanism.

[0007] The technical solution for solving the above technical problems in this application is a non-invasive hemodynamic simulation device, which is used to output a signal of the body impedance change caused by the simulated blood flow; it includes two excitation signal input terminals for inputting external excitation signals; it includes two signal output terminals for outputting the signal of the body impedance change caused by the simulated blood flow to the outside; the two excitation signal input terminals are electrically connected to the signal processing module; the two signal output terminals are electrically connected to the signal processing module; the signal processing module is used to convert the excitation signal input from the excitation signal input terminal into a signal of the body impedance change caused by the simulated blood flow; the two signal output terminals are used to output the signal of the body impedance change caused by the simulated blood flow to the outside.

[0008] The signal processing module includes: a rectification circuit, a main control MCU, an analog-to-digital conversion circuit, a signal modulation circuit, and a signal output circuit; the two excitation signal input terminals are electrically connected to the rectification circuit to input an AC excitation signal to the rectification circuit; the rectification circuit is electrically connected to the main control MCU, the main control MCU is electrically connected to the analog-to-digital conversion circuit, the analog-to-digital conversion circuit is electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit; the signal output circuit is electrically connected to the two signal output terminals to output the signal of the body impedance change caused by the simulated blood flow to the outside.

[0009] The above non-invasive hemodynamic simulation device further includes a voltage stabilization circuit; the voltage stabilization circuit is electrically connected to the rectification circuit and the analog-to-digital conversion circuit.

[0010] The above non-invasive hemodynamic simulation device further includes an overcurrent detection circuit; the voltage stabilization circuit is electrically connected to the overcurrent detection circuit, and the overcurrent detection circuit is electrically connected to the main control MCU.

[0011] The above non-invasive hemodynamic simulation device further includes a sine wave generating circuit; the main control MCU is electrically connected to the sine wave generating circuit, both the sine wave generating circuit and the analog-to-digital conversion circuit are electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit.

[0012] The above rectification circuit is a high-speed rectification circuit, including a dual operational amplifier balanced high-speed rectification circuit.

[0013] The above voltage stabilization circuit includes an RMS-DC integrated chip for converting the rectified signal into a DC effective value.

[0014] The above sine wave generating circuit is used to output a sine wave with the same frequency as the excitation.

[0015] The technical solution for solving the above-mentioned technical problems in the present application can also be a non-invasive hemodynamic testing system, comprising the above-mentioned non-invasive hemodynamic simulation device, two excitation signal input terminals of the non-invasive hemodynamic simulation device, which are used for electrical connection to an external excitation signal source; two signal output terminals of the non-invasive hemodynamic simulation device are electrically connected to the non-invasive hemodynamic detection device to be tested, and output simulated blood flow body impedance change signals to the non-invasive hemodynamic detection device.

[0016] Compared with the prior art, one of the beneficial effects of the present invention is that the two excitation signal input terminals provide a reference excitation source for the simulation, thereby making the output signal of the body impedance change caused by the simulated blood flow more flexible and with a larger space for regulation.

[0017] Compared with the prior art, one of the beneficial effects of the present invention is that the signal processing module provides rich signal conversion and change possibilities for the input excitation signal and control signal.

[0018] Compared with the prior art, one of the beneficial effects of the present invention is that the voltage stabilizing circuit provides a stable voltage reference for the voltage stabilizing circuit, making the output signal more stable and having a higher resolution when performing precise control.

[0019] Compared with existing technologies, one of the benefits of this invention is that the overcurrent detection circuit provides protection for the noninvasive hemodynamic simulation device, preventing excessive current from entering the system circuit, primarily preventing excessive current from flowing through the entire system signal chain. This reduces the risk of overcurrent to the noninvasive hemodynamic simulation device and the risk of excessive current to the noninvasive hemodynamic device within the noninvasive hemodynamic testing system.

[0020] Compared with the prior art, one of the beneficial effects of the present invention is that the overcurrent detection circuit provides protection for the non-invasive hemodynamic simulation device to prevent excessive current from entering the main control MCU, and the output can be more stable and reliable when the excitation source fluctuates.

[0021] Compared with the prior art, one of the beneficial effects of the present invention is that the sine wave generating circuit provides a signal reference for the output signal; the sine wave with the same frequency as the output excitation is output, and the signal output consistency is better.

[0022] Compared with the existing technology, one of the beneficial effects of the present invention is that the non-invasive hemodynamic testing system is based on the above-mentioned non-invasive hemodynamic testing system and can provide a more accurate and close to real body impedance change signal caused by simulated blood flow. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 This is a schematic diagram of a non-invasive hemodynamic simulation device. Figure 1 ;

[0024] Figure 2 is a schematic block diagram of a non-invasive hemodynamic simulation device Figure 2 ;

[0025] Figure 3 is a schematic block diagram of a non-invasive hemodynamic simulation device Figure 3 ;

[0026] Figure 4 is a partial schematic block diagram of a non-invasive hemodynamic simulation device Figure 1 ;

[0027] Figure 5 is a partial schematic block diagram of a non-invasive hemodynamic simulation device Figure 2 ;

[0028] Figure 6 is a schematic block diagram of a non-invasive hemodynamic test system;

[0029] Figure 7 is a partial schematic block diagram of a non-invasive hemodynamic simulation device Figure 3 . Detailed implementation manners

[0030] The following further details the content of the present utility model in conjunction with each attached drawing.

[0031] As used herein, the term "prepared from" is synonymous with "comprising". The term "comprising" as used herein, "having", "containing" or any other variation thereof, is intended to cover non-exclusive inclusion. For example, a composition, step, method, article or device comprising the listed elements need not be limited to those elements, but may include other elements not expressly listed or elements inherent to such composition, step, method, article or device. The connecting phrase "consisting of" excludes any unstated element, step or component.

[0032] If used in a claim, this phrase will make the claim closed, excluding materials other than those described, except for conventional impurities associated therewith. When the phrase "consisting of" appears in a clause of the claim body rather than immediately following the subject, it only limits the elements described in that clause; other elements are not excluded from the above claim as a whole. When a quantity, concentration, or other value or parameter is expressed as a range, a preferred range, or a range defined by a series of upper preferred values and lower preferred values, this should be understood to specifically disclose all ranges formed by any pairing of any range upper limit or preferred value with any range lower limit or preferred value, whether or not the range is separately disclosed.

[0033] For example, when the range "1 to 5" is disclosed, the described range should be interpreted as including the ranges "1 to 4", "1 to 3", "1 to 2", "1 to 2 and 4 to 5", "1 to 3 and 5", etc. When a numerical range is described herein, unless otherwise stated, the range is intended to include its end values and all integers and fractions within the range. The singular form includes plural objects of discussion, unless the context clearly indicates otherwise. "Optional" or "any one" means that the matter or event described thereafter may or may not occur, and this description includes the case where the event occurs and the case where the event does not occur. Approximating language in the specification and claims is used to modify quantities, indicating that the present utility model is not limited to the specific quantity, but also includes modified parts that are close to the quantity and acceptable without causing relevant fundamental functional changes. Accordingly, modifying a numerical value with "about", "approximately", etc. means that the present utility model is not limited to the exact numerical value. In some examples, the approximating language may correspond to the accuracy of the instrument for measuring the numerical value. In the specification and claims of the present application, range limitations can be combined and / or interchanged, and if not otherwise stated, these ranges include all sub-ranges contained therein. In addition, the indefinite articles "a" and "an" before elements or components of the present utility model do not limit the quantity requirement (i.e., the number of occurrences) of the elements or components. Therefore, "a" or "an" should be interpreted as including one or at least one, and the singular form of elements or components also includes the plural form, unless the quantity is clearly indicated as the singular form above.

[0034] Such as Figure 1 , an embodiment of a non-invasive hemodynamic simulation device for outputting a signal of the change in body impedance caused by simulated blood flow; including two excitation signal input terminals, excitation signal input terminal A and signal output terminal B for external excitation signal input; including two signal output terminals, signal output terminal A and signal output terminal B for outputting the signal of the change in body impedance caused by simulated blood flow to the outside; the two excitation signal input terminals are electrically connected to the signal processing module; the two signal output terminals are electrically connected to the signal processing module; the signal processing module is used to convert the excitation signal input from the excitation signal input terminal into a signal of the change in body impedance caused by simulated blood flow; the two signal output terminals are used to output the signal of the change in body impedance caused by simulated blood flow to the outside.

[0035] Such as Figure 2, An embodiment of a non-invasive hemodynamic simulation device. The signal processing module includes: a rectifier circuit, a main control MCU, an analog-to-digital conversion circuit, a signal modulation circuit, and a signal output circuit; two excitation signal input terminals are electrically connected to the rectifier circuit to input an AC excitation signal to the rectifier circuit; the rectifier circuit is electrically connected to the main control MCU, the main control MCU is electrically connected to the analog-to-digital conversion circuit, the analog-to-digital conversion circuit is electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit; the signal output circuit is electrically connected to two signal output terminals to output a signal of the body impedance change caused by the simulated blood flow to the outside.

[0036] As Figure 3 , An embodiment of a non-invasive hemodynamic simulation device further includes a voltage stabilization circuit; the voltage stabilization circuit is electrically connected to the rectifier circuit and the analog-to-digital conversion circuit.

[0037] As Figure 3 , An embodiment of a non-invasive hemodynamic simulation device further includes an overcurrent detection circuit; the voltage stabilization circuit is electrically connected to the overcurrent detection circuit, and the overcurrent detection circuit is electrically connected to the main control MCU.

[0038] As Figure 7 , The overcurrent detection circuit includes a shutdown input stage, i.e., an input terminal, an input stage switch circuit, and a current detection circuit; the shutdown input stage is electrically connected to the input stage switch circuit, the current detection circuit is electrically connected to the main control MCU, and the MCU judges the magnitude of the current to determine whether there is overcurrent; if there is overcurrent, a switch control signal is output to the input stage switch circuit through the shutdown input stage to control the cut-off of the input of the excitation signal. If there is no overcurrent, the current value is displayed on the screen.

[0039] As Figure 3 , An embodiment of a non-invasive hemodynamic simulation device further includes a sine wave generation circuit; the main control MCU is electrically connected to the sine wave generation circuit, and both the sine wave generation circuit and the analog-to-digital conversion circuit are electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit.

[0040] As Figure 3 , An embodiment of a non-invasive hemodynamic simulation device, the above rectifier circuit is a high-speed rectifier circuit, including a dual-op amp balanced high-speed rectifier circuit.

[0041] As Figure 4 , An embodiment of a non-invasive hemodynamic simulation device, the above voltage stabilization circuit includes an RMS-DC integrated chip for converting the rectified signal into a DC effective value. As Figure 5 , An embodiment of a non-invasive hemodynamic simulation device, the above sine wave generation circuit is used to output a sine wave with the same frequency as the excitation.

[0042] As Figure 6, an embodiment of a non-invasive hemodynamic testing system, including the above-mentioned non-invasive hemodynamic simulation device. The two excitation signal input terminals of the non-invasive hemodynamic simulation device are electrically connected to an external excitation signal source; the two signal output terminals of the non-invasive hemodynamic simulation device are electrically connected to the non-invasive hemodynamic detection device to be tested, and output a simulated body impedance change signal of blood flow to the non-invasive hemodynamic detection device. An external control signal is input to the signal processing module, and the signal control module performs more accurate and refined control on the simulated body impedance change signal of blood flow output to the non-invasive hemodynamic detection device to be tested according to the signals input from the excitation signal input terminals A and B. The non-invasive hemodynamic detection device is used to measure hemodynamic parameters such as cardiac output.

[0043] In this application, according to the accuracy detection standard requirements of non-invasive hemodynamic parameters, referring to the current research and development status of non-invasive hemodynamic simulation technologies at home and abroad, and combining with the human blood pressure signal waveform, a non-invasive hemodynamic simulation device based on the thoracic impedance method is designed, which can real-time simulate the impedance change of the human chest caused by the ejection of blood during ventricular systole, and is used to detect the accuracy and safety of non-invasive hemodynamic monitoring devices.

[0044] In the prior art, non-invasive hemodynamic simulation devices mainly adopt the electrophysiological signal simulation method. The electrophysiological signal simulation method directly uses a digital-to-analog converter to simulate the human vascular pressure electrical signal and inputs the signal to the acquisition end of the monitoring instrument. It cannot perform refined transformation and control on the simulated body impedance change signal of blood flow. It can only be a fixed signal frequency, magnitude and mode, and cannot perform a more realistic hemodynamic simulation according to the set rules.

[0045] The above are only embodiments of this application, and do not limit the scope of this application. Any equivalent structure or equivalent process transformation made using the content of the application specification and drawings, or directly or indirectly applied in other related technical fields, is equally included in the scope of protection of this application.

Claims

1. A non-invasive hemodynamic simulation device, characterized in that: Used to output a signal simulating the change in body impedance caused by blood flow; Includes two excitation signal input terminals for external excitation signal input; It includes two signal output terminals for outputting a signal simulating a change in blood flow and body impedance; The two excitation signal input terminals are electrically connected to the signal processing module; The two signal output terminals are electrically connected to the signal processing module; The signal processing module is used to convert the excitation signal input from the excitation signal input terminal into a body impedance change signal simulating blood flow; The two signal output terminals are used to output signals of body impedance changes caused by simulated blood flow.

2. The non-invasive hemodynamic simulation device according to claim 1, characterized in that: The signal processing module includes: rectifier circuit, main control MCU, analog-to-digital conversion circuit, signal modulation circuit, and signal output circuit; The two excitation signal input terminals are electrically connected to the rectifier circuit to input an AC excitation signal to the rectifier circuit; The rectifier circuit is electrically connected to the main control MCU, the main control MCU is electrically connected to the analog-to-digital conversion circuit, the analog-to-digital conversion circuit is electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit; The signal output circuit is electrically connected to the two signal output terminals and outputs a body impedance change signal simulated by blood flow to the outside.

3. The non-invasive hemodynamic simulation device according to claim 2, characterized in that: Also includes a voltage stabilizing circuit; The voltage stabilizing circuit is electrically connected to the rectifier circuit, and the voltage stabilizing circuit is electrically connected to the analog-to-digital conversion circuit.

4. The non-invasive hemodynamic simulation device according to claim 3, characterized in that: It also includes an overcurrent detection circuit; the voltage stabilizing circuit is electrically connected to the overcurrent detection circuit, and the overcurrent detection circuit is electrically connected to the main control MCU.

5. The non-invasive hemodynamic simulation device according to claim 2, characterized in that: Also included is a sine wave generating circuit; The main control MCU is electrically connected to the sine wave generating circuit, the sine wave generating circuit and the analog-to-digital conversion circuit are both electrically connected to the signal modulation circuit, and the signal modulation circuit is electrically connected to the signal output circuit.

6. The non-invasive hemodynamic simulation device according to claim 2, characterized in that: The rectifier circuit is a high-speed rectifier circuit, including a dual-op-amp balanced high-speed rectifier circuit.

7. The non-invasive hemodynamic simulation device according to claim 3, characterized in that: The voltage stabilizing circuit includes an RMS-DC integrated chip for converting a rectified signal into a direct current effective value.

8. The non-invasive hemodynamic simulation device according to claim 5, characterized in that: The sine wave generating circuit is used to output a sine wave with the same frequency as the excitation.

9. A non-invasive hemodynamic testing system, characterized in that: The non-invasive hemodynamic simulation device comprises the non-invasive hemodynamic simulation device according to any one of claims 1 to 8, wherein the two excitation signal input terminals of the non-invasive hemodynamic simulation device are used for electrical connection to an external excitation signal source; The two signal output terminals of the non-invasive hemodynamic simulation device are electrically connected to the non-invasive hemodynamic detection device to be tested, and output simulated blood flow body impedance change signals to the non-invasive hemodynamic detection device.

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