Cooling crystallization device for beta-nicotinamide mononucleotide production

Abstract

The utility model discloses a cooling crystallization device for beta-nicotinamide mononucleotide production, and belongs to the technical field of beta-nicotinamide mononucleotide. The cooling crystallization device for beta-nicotinamide mononucleotide production comprises a crystallization kettle and a separation tank, the output end of the crystallization kettle is connected with the separation tank through a pipeline, a screening net capable of swinging is arranged in the separation tank, and the screening net is driven by a driving motor to swing in a reciprocating mode. By adopting the design that the segmented cooling jacket is matched with the spiral guide plate, accurate temperature control is realized, the crystallization yield is improved, the integrated crystallization-separation design avoids material transfer loss and improves the product yield, and the innovative swing type screening net is matched with the gas purging system, so that the residual quantity of mother liquor on the surface of a crystal is reduced; the design of the U-shaped scraper effectively prevents crystals from adhering to the wall, the elastically supported screening net structure can reduce crystal damage, and the product integrity is guaranteed.

Description

Technical Field

[0001] The utility model relates to the technical field of β-nicotinamide mononucleotide, and more specifically to a cooling crystallization device for the production of β-nicotinamide mononucleotide. Background Art

[0002] β-Nicotinamide mononucleotide (NMN) is an important pharmaceutical intermediate, and the crystallization and purification steps in its production process have a decisive impact on product quality. In the prior art, when NMN is crystallized and separated, crystallization and separation need to be carried out in different equipment. The material transfer process is prone to crystal breakage and yield loss; conventional screening devices have low separation efficiency, affecting product purity. Chinese patent publication number CN217909041U discloses a recrystallization device for β-nicotinamide mononucleotide. The crystals and mother liquor are only filtered through a simple filtration, and the residual mother liquor content on the crystal surface is high. Utility Model Content

[0003] The purpose of the present invention is to overcome the deficiencies in the prior art and to provide a cooling crystallization device for the production of β-nicotinamide mononucleotide to solve the above deficiencies.

[0004] In order to achieve the above-mentioned purpose, the technical solution provided by the present utility model is:

[0005] A cooling crystallization device for producing β-nicotinamide mononucleotide includes a crystallization kettle and a separation tank. The output end of the crystallization kettle is connected to the separation tank via a pipeline. A swingable screen is provided in the separation tank, and the screen is driven by a drive motor to swing back and forth.

[0006] Preferably, the outer wall of the crystallization kettle is provided with a segmented cooling jacket, a spiral guide plate is provided in the jacket, and an online temperature sensor group is provided in the crystallization kettle.

[0007] Preferably, a stirring assembly is provided in the crystallization kettle, and the stirring assembly includes a stirring shaft, a stirring paddle and a U-shaped scraper fitted with the inner wall of the kettle.

[0008] Preferably, the screening net is installed in the separation tank through a rotating shaft and an elastic member, one end of the screening net is connected to a driving motor, and the other end of the screening net is connected to an adjustable lifting rod.

[0009] Preferably, arc-shaped plates are provided on both sides of the sieve net to prevent crystals from splashing, and a wedge-shaped bar is provided on the sieve net, and an air injection pipe is provided inside the wedge-shaped bar.

[0010] Preferably, the separation tank is arranged vertically to the crystallization kettle, and the separation tank is provided with a crystal outlet and a liquid outlet.

[0011] The utility model is a cooling crystallization device for producing β-nicotinamide mononucleotide

[0012] Compared with the prior art, the technical solution provided by this utility model has the following beneficial effects:

[0013] The utility model adopts a segmented cooling jacket combined with a spiral guide plate design to achieve precise temperature control and improve crystallization yield. The integrated crystallization-separation design avoids material transfer loss and improves product yield. The innovative swinging screening net is combined with a gas purge system to reduce the amount of mother liquor residue on the crystal surface; the U-shaped scraper design effectively prevents crystals from sticking to the wall, and the elastically supported screening net structure can reduce crystal breakage and ensure product integrity. The combined design of the wedge bar and the air jet pipe not only improves separation efficiency but also prevents screen clogging. BRIEF DESCRIPTION OF THE DRAWINGS

[0014] Figure 1 This is an overall structural diagram of the cooling crystallization device for producing β-nicotinamide mononucleotide of the present invention;

[0015] Figure 2 This is an enlarged view of point A of the present utility model;

[0016] Figure 3 This is a structural diagram of the screening net of the present utility model;

[0017] Figure 4 This is a diagram of the filtration and separation state of the screening net of the present utility model;

[0018] Figure 5 This is a diagram of the crystal discharge state of the screening net of the utility model.

[0019] In the figure: 1. crystallization kettle; 11. segmented cooling jacket; 111. spiral guide plate; 12. stirring assembly; 121. stirring shaft; 122. stirring paddle; 123. U-shaped scraper; 2. separation tank; 21. screening net; 211. rotating shaft; 212. curved plate; 213. universal joint; 214. driving motor; 215. lifting rod; 216. wedge-shaped bar; 217. air injection pipe; 218. short shaft; 22. crystal outlet; 23. liquid outlet; 24. sliding hole; 241. elastic part. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] In order to further understand the content of the present invention, the present invention is described in detail with reference to the accompanying drawings.

[0022] Combine Figure 1-Figure 5 The cooling crystallization device for producing β-nicotinamide mononucleotide includes a crystallization kettle 1 and a separation tank 2. The output end of the crystallization kettle 1 is connected to the separation tank 2 through a pipeline. A valve is provided on the connecting pipeline between the crystallization kettle 1 and the separation tank 2. After the β-nicotinamide mononucleotide mother liquor crystallizes in the crystallization kettle 1, the remaining mother liquor and crystals are controlled by the valve and flow to the separation tank 2 under the action of gravity to separate the mother liquor and crystals.

[0023] Specifically, a segmented cooling jacket 11 is provided on the outer wall of the crystallization kettle 1, which is divided into three independent temperature control zones along the axial direction of the crystallization kettle 1. The refrigerant flow in each zone is adjusted by a PID controller to achieve gradient cooling. At the same time, a spiral guide plate 111 is provided in the segmented cooling jacket 11 to force the solution to flow along a spiral path to eliminate temperature stratification. In addition, an online temperature sensor group is distributed axially and radially on the kettle body of the crystallization kettle 1 to provide real-time feedback of temperature data.

[0024] In addition, a stirring assembly 12 is provided in the crystallization kettle 1, and the stirring assembly 12 includes a stirring shaft 121, a stirring paddle 122 and a U-shaped scraper 123. The lower end of the stirring shaft 121 is provided with a U-shaped scraper 123 that is in contact with the inner wall of the crystallization kettle 1. The stirring shaft 121 above the U-shaped scraper 123 is connected to the stirring paddle 122. The stirring shaft 121 rotates under the drive of the motor, driving the stirring paddle 122 to stir the mother liquor to avoid local supercooling. At the same time, the U-shaped scraper 123 can scrape off the mother liquor and crystals adhered to the crystallization kettle 1.

[0025] More specifically, the separation tank 2 is arranged vertically to the crystallization kettle 1, a screening net 21 is provided in the separation tank 2, a crystal outlet 22 is provided on one side of the separation tank 2, and a liquid outlet 23 is provided at the lower end of the separation tank 2. The crystals screened by the screening net 21 are discharged through the crystal outlet 22, and the remaining mother liquor is recovered from the liquid outlet 23.

[0026] It should be noted that rotating shafts 211 are symmetrically provided on both sides of the screening net 21, and a sliding hole 24 matching the rotating shaft 211 is provided on the inner wall of the separation tank 2. The rotating shaft 211 moves in the sliding hole 24, and an elastic member 241 is provided in the corresponding sliding hole 24. In this embodiment, the elastic member 241 is a spring structure, and the rotating shaft 211 fixes the position of the screening net 21 under the upper and lower support of the elastic member 241. Arc plates 212 are symmetrically provided on both sides of the screening net 21 near the elastic member 241. The arc plates 212 are used to protect the crystals from being thrown out of the screening net 21. One end of the screening net 21 is connected to a driving motor 214 through a universal shaft 213. The driving motor 214 is arranged on the outer wall of the crystallization kettle 1, and the driving motor 214 drives the two sides of the screening net 21 to swing back and forth The mother liquor and the crystals are screened. A short shaft 218 is provided at the other end of the screening net 21. The short shaft 218 passes through the crystal outlet 22 and is connected to a lifting rod 215 on the outside of the separation tank 2 through a universal shaft 213. The lifting rod 215 is connected to one end of the universal shaft 213 through a bearing. The lifting rod 215 can drive the short shaft 218 to move up and down, and the inclination angle of the two ends of the screening net 21 is controlled by the short shaft 218. Specifically, when screening is performed, one end of the screening net 21 with the short shaft 218 is higher than the other end of the screening net 21. Under the action of gravity, the mother liquor moves to the end of the separation tank 2 away from the crystal outlet 22. When discharging crystals, one end of the screening net 21 with the short shaft 218 is lower than the other end of the screening net 21, which facilitates the discharge of crystals from the crystal outlet 22.

[0027] In order to further remove the mother liquid on the surface of the crystal and improve the discharge speed of the crystals of the screening net 21, a wedge bar 216 is provided on the screening net 21, and the side of the wedge bar 216 with a higher position is close to the lifting rod 215. When the driving motor 214 rotates forward and reverse, it drives the two sides of the screening net 21 to swing, and the crystals and mother liquid are screened back and forth in the middle position of the wedge bar 216. The inclined screening net 21 and the wedge bar 216 can prevent the mother liquid from diffusing to the crystal outlet 22. An air jet 217 is provided in the wedge bar 216. The air jet 217 discharges the gas from the side with a higher position of the wedge bar 216. When the crystals are discharged, the side with a higher position of the wedge bar 216 on the screening net 21 is lowered. Figure 5 As shown, the wedge-shaped bar 216 sprays gas toward one side of the crystal outlet 22 to blow the crystals, which can blow off the mother liquid on the surface of the crystals and prevent the crystals from clogging the screening mesh 21 , thereby accelerating the crystals to pass through the wedge-shaped bar 216 and be discharged from the crystal outlet 22 .

[0028] Working process: inject the mother liquor into the crystallization kettle 1, start the segmented cooling jacket 11 for gradient cooling, and at the same time, the stirring component 12 continues to operate to ensure that the solution is evenly cooled and crystallized. After the crystallization is completed, open the connecting pipe valve to allow the crystal slurry to flow into the separation tank 2 under the action of gravity. The driving motor 214 drives the screening mesh 21 to swing back and forth. The mother liquor is discharged from the liquid outlet 23 through the screening mesh 21, and the crystals remain on the screening mesh 21. The inclination angle of the screening mesh 21 is adjusted by the lifting rod 215. At the same time, the air jet 217 sprays gas to purge the crystal surface to reduce the mother liquor residue. The screening mesh 21 is tilted to a lower position on the side of the crystal outlet 22. The crystals are discharged from the crystal outlet 22 under the action of gravity and gas blowing.

[0029] It should be noted that, in this document, relational terms such as first and second, etc., are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0030] Although the embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention.

Claims

1. A cooling crystallization device for producing β-nicotinamide mononucleotide, comprising a crystallization kettle (1) and a separation tank (2), characterized in that: The output end of the crystallization kettle (1) is connected to the separation tank (2) via a pipeline. A swingable screening net (21) is provided in the separation tank (2). The screening net (21) is driven by a driving motor (214) to swing back and forth.

2. The cooling crystallization device for producing β-nicotinamide mononucleotide according to claim 1, characterized in that: The outer wall of the crystallization kettle (1) is provided with a segmented cooling jacket (11), a spiral guide plate (111) is provided inside the jacket, and an online temperature sensor group is provided inside the crystallization kettle (1).

3. The cooling crystallization device for producing β-nicotinamide mononucleotide according to claim 1, characterized in that: The crystallization kettle (1) is provided with a stirring assembly (12), which comprises a stirring shaft (121), a stirring paddle (122), and a U-shaped scraper (123) that is in contact with the inner wall of the kettle.

4. The cooling crystallization device for producing β-nicotinamide mononucleotide according to claim 1, characterized in that: The screening net (21) is installed in the separation tank (2) via a rotating shaft (211) and an elastic member (241). One end of the screening net (21) is connected to a driving motor (214), and the other end of the screening net (21) is connected to an adjustable lifting rod (215).

5. The cooling crystallization device for producing β-nicotinamide mononucleotide according to claim 1, characterized in that: Arc plates (212) are provided on both sides of the screening net (21), a wedge-shaped strip (216) is provided on the screening net (21), and an air injection pipe (217) is provided in the wedge-shaped strip (216).

6. The cooling crystallization device for producing β-nicotinamide mononucleotide according to claim 1, characterized in that: The separation tank (2) is arranged vertically to the crystallization kettle (1), and the separation tank (2) is provided with a crystal outlet (22) and a liquid outlet (23).

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