Virus liquid treatment, clarification and filtration device
Through the high-pressure homogenization chamber and cooling mechanism combined with the filtration device, the problems of low production efficiency and high energy consumption in the treatment of virus fluid are solved, and large-scale efficient and uniform processing and filtration of virus fluid are achieved, ensuring product quality.
Patent Information
- Application Number
- CN202422339295.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-09-25
- Publication Date
- 2025-08-12
- Estimated Expiration
- 2034-09-25
AI Technical Summary
The prior art has problems of low production efficiency, high energy consumption and uneven processing in large-scale virus fluid treatment, especially in freeze-thaw and ultrasonic crushing methods.
The high-pressure homogenization chamber is combined with a cooling mechanism and a filtering mechanism, and the virus liquid is homogenized through the high-pressure homogenization chamber, and the virus liquid is cooled and filtered by cooling coils and thermal copper tubes to ensure that the virus liquid does not deteriorate during the filtration process.
It realizes large-scale efficient production of virus fluid, reduces energy consumption, and ensures uniform treatment and quality of virus fluid, and improves production efficiency.
Smart Images
Figure CN223214090U_ABST
Abstract
Description
Technical Field
[0001] The utility model relates to the technical field of virus liquid treatment, in particular to a virus liquid treatment and clarification filtering device. Background Art
[0002] Cell disruption technology involves the use of external forces to disrupt the cell membrane and cell wall, releasing cellular contents, including the target product. This technology is fundamental for separating and purifying non-secreted biochemicals synthesized within cells (such as proteins and nucleic acids). It is widely used in molecular biology, biochemistry, drug development, environmental analysis, as well as in biology, medicine, and pharmacy.
[0003] Freeze-thaw and ultrasonic disruption are two commonly used cell disruption methods. The freezing and thawing processes in freeze-thaw disruption require a long time, especially in large-scale production, which affects overall production efficiency and makes it difficult to achieve uniform freezing and thawing. In large-scale applications, the freeze-thaw process typically requires a large amount of energy for cooling, making energy consumption particularly problematic. Ultrasonic disruption generates heat, requiring an ice bath or other methods to control the liquid temperature. Furthermore, the propagation characteristics of ultrasonic waves can lead to uneven treatment of the viral solution, especially in large-scale processing, where localized over- or undertreatment may occur, affecting the quality of the final product. Furthermore, equipment scalability can also be a concern for large-scale production. Therefore, a viral solution treatment and clarification filtration device is proposed. Utility Model Content
[0004] The purpose of the utility model is to provide a virus liquid treatment and clarification filtering device to solve the problem of low efficiency in large-scale production in the prior art.
[0005] To achieve the above-mentioned objectives, the utility model provides the following technical solutions: A virus liquid treatment and clarification filtration device comprises a high-pressure homogenization chamber, an inlet end and an outlet end are fixedly mounted on the high-pressure homogenization chamber, a connecting pipe is connected to the outlet end, a cooling mechanism is provided on the high-pressure homogenization chamber, the cooling mechanism comprises a heat-insulating jacket fixedly mounted on the high-pressure homogenization chamber, an installation inlet is fixedly mounted on the upper end of the heat-insulating jacket, an installation outlet is fixedly mounted on the lower end of the heat-insulating jacket, a cooling coil is arranged in the heat-insulating jacket, a docking pipe is arranged at the end of the cooling coil, a filtering mechanism is connected to the connecting pipe, the filtering mechanism comprises a filtering chamber connected to the end of the connecting pipe, a sealing end cap is provided at the upper end of the filtering chamber, a cooling liquid port is opened on the side wall of the filtering chamber, two groups of mounting seats are fixedly mounted in the filtering chamber, a coarse filter screen and a fine filter screen are sequentially arranged on the two groups of mounting seats, a filter screen frame is provided on both the coarse filter screen and the fine filter screen, a heat-conducting copper pipe is arranged between the filter screen frames, and the heat-conducting copper pipe has good thermal conductivity.
[0006] Preferably, the thermal insulation jacket is provided with an installation notch, and the inlet end and the outlet end both pass through the thermal insulation jacket through the installation notch, so that the thermal insulation jacket can play a role of heat insulation.
[0007] Preferably, heat transfer fluid is stored inside the heat insulation jacket, and the cooling coil is immersed in the heat transfer fluid.
[0008] Preferably, one end of the cooling coil extends out of the insulation jacket through an installation inlet, and the other end of the cooling coil extends out of the insulation jacket through an installation outlet. One end of the docking pipe is connected to the cooling coil, and the other end of the docking pipe is connected to the filter cavity. The cooling coil is coiled on the high-pressure homogenization cavity.
[0009] Preferably, a feed port is provided on the sealing end cover, and a discharge port is provided at the bottom of the filter cavity.
[0010] Preferably, a thread is provided in the sealing end cover, and the sealing end cover is mounted on the filter cavity through the thread.
[0011] Preferably, one end of the connecting pipe is connected to the high-pressure homogenization chamber, and the other end of the connecting pipe is connected to the filter chamber. The filter rack is installed in the filter chamber through the mounting seat, and the coarse filter and the fine filter are both installed in the filter chamber through the filter rack. The coarse filter and the fine filter can filter the virus liquid.
[0012] Compared with the prior art, the beneficial effects of the present invention are:
[0013] In the present application, the coolant can be passed into the cooling coil. After the coolant enters the cooling coil, it will exchange heat with the high-pressure homogenization chamber, thereby reducing the temperature of the virus liquid in the high-pressure homogenization chamber. At the same time, the coolant in the cooling coil will enter the filter chamber, so that the cooling water flows through the outer wall of the heat-conducting copper tube, thereby cooling the virus liquid during the filtration process, preventing the virus liquid from deteriorating, and facilitating large-scale production of the virus liquid.
[0014] In this application, the virus liquid discharged from the outlet end will enter the filter cavity, and the virus liquid will pass through the coarse filter and the fine filter in turn, thereby filtering the virus liquid, and the sealed end cap can be unscrewed. After unscrewing the sealed end cap, the coarse filter, the thermal copper tube and the fine filter can be taken out in turn, which is convenient for cleaning the filter. At the same time, when the coolant enters the filter cavity, the thermal copper tube will separate the virus liquid from the cooling water to prevent the cooling water from mixing into the virus liquid. BRIEF DESCRIPTION OF THE DRAWINGS
[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;
[0016] Figure 2 It is a schematic diagram of the local structure of the utility model;
[0017] Figure 3 This is a schematic diagram of the cooling mechanism of the present utility model;
[0018] Figure 4 This is a schematic diagram of the filtering mechanism of the present invention.
[0019] Numbers in the figure: 1. High-pressure homogenizing chamber; 2. Inlet end; 3. Outlet end; 4. Connecting pipe; 5. Cooling mechanism; 501. Installation inlet; 502. Thermal insulation jacket; 503. Cooling coil; 504. Installation notch; 505. Installation outlet; 506. Docking pipe; 6. Filter mechanism; 601. Sealing end cover; 602. Filter chamber; 603. Coolant port; 604. Coarse filter; 605. Filter rack; 606. Thermal copper tube; 607. Fine filter; 608. Mounting seat; 609. Feed port; 610. Discharge port. DETAILED DESCRIPTION
[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.
[0021] like Figure 1 and Figure 2 As shown, the utility model provides a technical solution for a virus liquid treatment and clarification filtration device, comprising a high-pressure homogenization chamber 1, on which an inlet end 2 and an outlet end 3 are fixedly mounted, the outlet end 3 being connected to a communication pipe 4, a cooling mechanism 5 being provided on the high-pressure homogenization chamber 1, and a filtering mechanism 6 being connected to the communication pipe 4, through which the homogenized virus liquid can be filtered, and during the homogenization and filtration process, the cooling mechanism 5 can cool the virus liquid to prevent the virus liquid from deteriorating.
[0022] like Figure 2 and Figure 3 As shown, the cooling mechanism 5 includes a thermal insulation jacket 502 fixedly mounted on the high-pressure homogenization chamber 1, an installation inlet 501 fixedly mounted on the upper end of the thermal insulation jacket 502, an installation outlet 505 fixedly mounted on the lower end of the thermal insulation jacket 502, a cooling coil 503 is provided in the thermal insulation jacket 502, a docking pipe 506 is provided at the end of the cooling coil 503, an installation notch 504 is opened on the thermal insulation jacket 502, and both the inlet end 2 and the outlet end 3 pass through the thermal insulation jacket 502 through the installation notch 504.
[0023] Specifically, the coolant can be passed into the cooling coil 503. After entering the cooling coil 503, the coolant will exchange heat with the high-pressure homogenization chamber 1, thereby reducing the temperature of the virus liquid in the high-pressure homogenization chamber 1. At the same time, the coolant in the cooling coil 503 will enter the filter chamber 602, so that the cooling water flows through the outer wall of the heat-conducting copper tube 606, thereby cooling the virus liquid during the filtration process to prevent the virus liquid from deteriorating.
[0024] like Figure 2 and Figure 4 As shown, the filtering mechanism 6 includes a filtering cavity 602 connected to the end of the communicating pipe 4, a sealing end cap 601 is provided at the upper end of the filtering cavity 602, a cooling liquid port 603 is provided on the side wall of the filtering cavity 602, two sets of mounting seats 608 are fixedly installed in the filtering cavity 602, a coarse filter screen 604 and a fine filter screen 607 are provided on the two sets of mounting seats 608 in sequence, a filter frame 605 is provided on the coarse filter screen 604 and the fine filter screen 607, a heat-conducting copper tube 606 is provided between the filter frames 605, a feed port 609 is provided on the sealing end cap 601, and a discharge port 610 is provided at the bottom of the filtering cavity 602.
[0025] Specifically, the virus liquid discharged from the outlet port 3 will enter the filter cavity 602, and the virus liquid will pass through the coarse filter 604 and the fine filter 607 in sequence, thereby filtering the virus liquid, and the sealing end cap 601 can be unscrewed. After unscrewing the sealing end cap 601, the coarse filter 604, the thermal copper tube 606 and the fine filter 607 can be taken out in sequence to facilitate cleaning of the filter. At the same time, when the coolant enters the filter cavity 602, the thermal copper tube 606 will separate the virus liquid from the cooling water to prevent the cooling water from mixing into the virus liquid.
[0026] Working principle: When in use, the virus liquid is transported to the high-pressure homogenization chamber 1 through the inlet port 2. The interior of the high-pressure homogenization chamber 1 has a specially designed geometric shape. Under the action of the booster mechanism, the high-pressure solution passes through the homogenization chamber quickly. The material will be subjected to mechanical forces such as high-speed shearing, high-frequency oscillation, cavitation and convection impact and corresponding thermal effects at the same time. The mechanical force and chemical effects caused by this can induce changes in the physical, chemical and structural properties of the material macromolecules, and ultimately achieve a homogenization effect. The homogenized virus liquid will be discharged through the outlet port 3. The virus liquid discharged from the outlet port 3 will enter the filter chamber 602. The virus liquid will pass through the coarse filter 604 and the fine filter 607 in turn, thereby filtering the virus liquid, and the coolant can be passed into the cooling coil 503 for cooling. After the liquid enters the cooling coil 503, it will exchange heat with the high-pressure homogenization chamber 1, thereby reducing the temperature of the virus liquid in the high-pressure homogenization chamber 1. Since one end of the docking pipe 506 is connected to the cooling coil 503, and the other end of the docking pipe 506 is connected to the filter chamber 602, the coolant in the cooling coil 503 will enter the filter chamber 602. When the coolant enters the filter chamber 602, the heat-conducting copper tube 606 will separate the virus liquid from the cooling water, and the cooling water will flow through the outer wall of the heat-conducting copper tube 606, thereby cooling the virus liquid during the filtration process to prevent the virus liquid from deteriorating. After use, the sealing end cap 601 can be unscrewed. After unscrewing the sealing end cap 601, the coarse filter 604, the heat-conducting copper tube 606 and the fine filter 607 can be taken out in turn to facilitate cleaning of the filter.
[0027] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.
Claims
1. A virus liquid treatment and clarification filtration device, comprising a high-pressure homogenization chamber (1), wherein an inlet end (2) and an outlet end (3) are fixedly mounted on the high-pressure homogenization chamber (1), and a communication pipe (4) is connected to the outlet end (3), characterized in that: The high-pressure homogenizing chamber (1) is provided with a cooling mechanism (5), the cooling mechanism (5) comprising a heat-insulating jacket (502) fixedly mounted on the high-pressure homogenizing chamber (1), a mounting inlet (501) fixedly mounted on the upper end of the heat-insulating jacket (502), a mounting outlet (505) fixedly mounted on the lower end of the heat-insulating jacket (502), a cooling coil (503) disposed within the heat-insulating jacket (502), a docking pipe (506) disposed at the end of the cooling coil (503), a filtering mechanism (6) connected to the connecting pipe (4), the filtering mechanism (6) comprising The invention comprises a filter chamber (602) connected to the end of the communication pipe (4), wherein a sealing end cover (601) is provided at the upper end of the filter chamber (602), a cooling liquid port (603) is provided on the side wall of the filter chamber (602), two groups of mounting seats (608) are fixedly installed in the filter chamber (602), a coarse filter (604) and a fine filter (607) are provided on the two groups of mounting seats (608) in sequence, a filter frame (605) is provided on each of the coarse filter (604) and the fine filter (607), and a heat-conducting copper pipe (606) is provided between the filter frames (605).
2. The virus liquid treatment and clarification filtration device according to claim 1, characterized in that: The heat-insulating jacket (502) is provided with a mounting notch (504), and both the inlet end (2) and the outlet end (3) pass through the heat-insulating jacket (502) via the mounting notch (504).
3. The virus liquid treatment and clarification filtration device according to claim 2, characterized in that: The inner side of the heat-insulating jacket (502) stores heat-conducting liquid, and the cooling coil (503) is immersed in the heat-conducting liquid.
4. The virus liquid treatment and clarification filtration device according to claim 3, characterized in that: One end of the cooling coil (503) extends out of the heat-insulating jacket (502) through the installation inlet (501), and the other end of the cooling coil (503) extends out of the heat-insulating jacket (502) through the installation outlet (505). One end of the docking pipe (506) is connected to the cooling coil (503), and the other end of the docking pipe (506) is connected to the filter chamber (602).
5. The virus liquid treatment and clarification filtration device according to claim 4, characterized in that: A feed port (609) is provided on the sealing end cover (601), and a discharge port (610) is provided at the bottom of the filter cavity (602).
6. The virus liquid treatment and clarification filtration device according to claim 1, characterized in that: The sealing end cover (601) is provided with a thread, and the sealing end cover (601) is mounted on the filter cavity (602) via the thread.
7. The virus liquid treatment and clarification filtration device according to claim 1, characterized in that: One end of the communication pipe (4) is connected to the high-pressure homogenization chamber (1), and the other end of the communication pipe (4) is connected to the filter chamber (602). The filter frame (605) is installed in the filter chamber (602) via the mounting seat (608). The coarse filter (604) and the fine filter (607) are both installed in the filter chamber (602) via the filter frame (605).