Autoantibody detection membrane strip

Abstract

The utility model relates to the technical field of antibody detection articles, and discloses an autoantibody detection membrane strip which comprises a bottom membrane, a soft edge strip is fixedly connected to the upper surface of the bottom membrane, a transparent soft membrane is fixedly connected to the upper surface of the soft edge strip, a rubber ring is fixedly connected to the front side of the upper surface of the transparent soft membrane, and the rubber ring is fixedly connected to the rear side of the upper surface of the transparent soft membrane. The upper surface of the transparent soft film is provided with a serum dripping opening located in the inner side of the rubber ring, and the upper surface of the rubber ring adheres to a cover film. According to the utility model, by arranging the bottom membrane, the soft edge strip, the transparent soft membrane, the cover membrane and the rubber ring, when the cover membrane and the rubber ring are adhered together, the interior of the whole bottom membrane is sealed by the transparent soft membrane, the cover membrane and the rubber ring, so that moist steam in the external environment cannot enter the interior of the whole bottom membrane to generate hydrolysis reaction with the nitrocellulose membrane; therefore, the problem that the nitrocellulose membrane is easy to hydrolyze and lose efficacy when exposed in an open environment is avoided, and the service life of the whole bottom membrane is greatly prolonged.

Description

Technical Field

[0001] The utility model relates to the technical field of antibody detection products, and more specifically, to an autoantibody detection membrane strip. Background Art

[0002] Antibodies are proteins produced by the immune system that can recognize and bind to foreign substances such as viruses and bacteria, thereby helping the body resist disease. Antibody testing is a medical test that helps doctors determine the patient's disease and assess the severity of the disease by detecting the level of antibodies in the blood.

[0003] According to a search, a test strip for combined detection of multiple hepatitis IgM antibodies, with publication number CN207114555U, solves the problem of traditional antibody test strips that they can only detect one IgM antibody at a time by providing multiple hepatitis IgM antibody detection membrane blocks and coated linear antigens. However, this design still has the following problems:

[0004] The nitrocellulose test membrane block is not protected, and the nitrocellulose itself is prone to aging and easily absorbs moisture in the air to undergo hydrolysis. This makes the entire test membrane strip unable to be stored in an indoor environment for a long time, greatly reducing the service life of the test membrane strip, so it needs to be improved. Utility Model Content

[0005] In order to overcome the deficiencies of the prior art, the utility model provides an autoantibody detection membrane strip, which has the advantage of a long service life.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solution: an autoantibody detection membrane strip, comprising a base membrane, a soft edge strip fixedly connected to the upper surface of the base membrane, a transparent soft membrane fixedly connected to the upper surface of the soft edge strip, a rubber ring fixedly connected to the front side of the upper surface of the transparent soft membrane, a serum dripping port located inside the rubber ring on the upper surface of the transparent soft membrane, a cover membrane adhered to the upper surface of the rubber ring, a pull strip fixedly connected to the left surface of the cover membrane, and the other end of the cover membrane fixedly connected to the right surface of the soft edge strip.

[0007] As an optimal technical solution of the present invention, the upper surface of the base film is fixedly connected to a nitrocellulose membrane, and the right end of the inner surface of the soft edge strip is fixedly connected to a No. 4 spacer, a No. 3 spacer, a No. 2 spacer and a No. 1 spacer in sequence from front to back, and the No. 1 spacer, the No. 2 spacer, the No. 3 spacer and the No. 4 spacer are all fixedly connected to the upper surface of the base film, and the No. 1 spacer, the No. 2 spacer, the No. 3 spacer and the No. 4 spacer are all fixedly connected to the outer surface of the nitrocellulose membrane.

[0008] As an optimal technical solution of the present invention, the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis A IgM antibody detection membrane block located between the soft edge strip and the No. 1 spacer strip, and the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis A IgM antibody quality control membrane block located on the right side of the hepatitis A IgM antibody detection membrane block.

[0009] As an optimal technical solution of the present invention, the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis B IgM antibody detection membrane block located between the No. 1 spacer and the No. 2 spacer, and the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis B IgM antibody quality control membrane block located on the right side of the hepatitis B IgM antibody detection membrane block.

[0010] As an optimal technical solution of the present invention, the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis C IgM antibody detection membrane block located between the No. 2 spacer and the No. 3 spacer, and the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis C IgM antibody quality control membrane block located on the right side of the hepatitis C IgM antibody detection membrane block.

[0011] As an optimal technical solution of the present invention, the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis D IgM antibody detection membrane block located between the No. 3 spacer and the No. 4 spacer, and the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis D IgM antibody quality control membrane block located on the right side of the hepatitis D IgM antibody detection membrane block.

[0012] As an optimal technical solution of the present invention, the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis E IgM antibody detection membrane block located between the No. 4 spacer and the soft edge bar, and the upper surface of the nitrocellulose membrane is fixedly connected to a hepatitis E IgM antibody quality control membrane block located on the right side of the hepatitis E IgM antibody detection membrane block.

[0013] Compared with the prior art, the beneficial effects of the present invention are as follows:

[0014] 1. The utility model is provided with a base film, a soft edge strip, a transparent soft film, a cover film and an rubber ring. When the cover film and the rubber ring are adhered together, the interior of the entire base film will be sealed by the transparent soft film, the cover film and the rubber ring. At this time, the humid water vapor in the external environment cannot enter the interior of the entire base film to produce a hydrolysis reaction with the nitrocellulose membrane, thereby avoiding the problem of the nitrocellulose membrane being easily hydrolyzed and failing when exposed to an open environment, and greatly improving the service life of the entire base film.

[0015] 2. The utility model is provided with a transparent soft film, a serum drop port, a nitrocellulose membrane, a No. 1 spacer and a hepatitis A IgM antibody detection membrane block. When the serum is dropped onto the nitrocellulose membrane, the serum will gradually diffuse inside the nitrocellulose membrane and eventually spread to various places inside the nitrocellulose membrane. However, the parallel arrangement of the hepatitis A IgM antibody detection membrane block, the hepatitis B IgM antibody detection membrane block, the hepatitis C IgM antibody detection membrane block, the hepatitis D IgM antibody detection membrane block and the hepatitis E IgM antibody detection membrane block makes the length of the entire nitrocellulose membrane relatively short, which shortens the time for the serum to diffuse into the entire nitrocellulose membrane, thereby avoiding the long length of the nitrocellulose membrane caused by the serial arrangement of the antibody detection membrane blocks, greatly reducing the time required for antibody detection and improving the speed of antibody detection. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 This is a schematic diagram of the structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the structure of the rubber ring of the utility model;

[0018] Figure 3 This is a schematic diagram of the structure of the nitrocellulose membrane of the utility model;

[0019] Figure 4 This is a schematic cross-sectional view of the utility model;

[0020] Figure 5 for Figure 4 Schematic diagram of the locally enlarged structure at point A in the middle.

[0021] In the figure: 1. Base film; 2. Soft edge strip; 3. Transparent soft film; 4. Cover film; 5. Pull strip; 6. Rubber ring; 7. Serum drop port; 8. Nitrocellulose membrane; 9. Spacer No. 1; 10. Spacer No. 2; 11. Spacer No. 3; 12. Spacer No. 4; 13. Hepatitis A IgM antibody test membrane block; 14. Hepatitis A IgM antibody quality control membrane block; 15. Hepatitis B IgM antibody test membrane block; 16. Hepatitis B IgM antibody quality control membrane block; 17. Hepatitis C IgM antibody test membrane block; 18. Hepatitis C IgM antibody quality control membrane block; 19. Hepatitis D IgM antibody test membrane block; 20. Hepatitis D IgM antibody quality control membrane block; 21. Hepatitis E IgM antibody test membrane block; 22. Hepatitis E IgM antibody quality control membrane block. DETAILED DESCRIPTION

[0022] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0023] like Figures 1 to 5 As shown, the utility model provides an autoantibody detection membrane strip, including a base membrane 1, a soft edge strip 2 is fixedly connected to the upper surface of the base membrane 1, a transparent soft membrane 3 is fixedly connected to the upper surface of the soft edge strip 2, a rubber ring 6 is fixedly connected to the front side of the upper surface of the transparent soft membrane 3, a serum drop port 7 is opened on the upper surface of the transparent soft membrane 3 and is located inside the rubber ring 6, a cover membrane 4 is adhered to the upper surface of the rubber ring 6, a pull strip 5 is fixedly connected to the left surface of the cover membrane 4, and the other end of the cover membrane 4 is fixedly connected to the right surface of the soft edge strip 2.

[0024] When the cover film 4 and the rubber ring 6 are adhered together, the serum drop port 7 will be closed by the transparent soft film 3, the cover film 4 and the rubber ring 6. At this time, external moisture cannot enter the interior of the base film 1 through the serum drop port 7, thereby preventing the nitrocellulose membrane 8 from absorbing moisture in the air and starting to hydrolyze.

[0025] Among them, the upper surface of the base film 1 is fixedly connected with the nitrocellulose membrane 8, and the right end of the inner surface of the soft edge strip 2 is fixedly connected with the No. 4 spacer 12, the No. 3 spacer 11, the No. 2 spacer 10 and the No. 1 spacer 9 from front to back, and the No. 1 spacer 9, the No. 2 spacer 10, the No. 3 spacer 11 and the No. 4 spacer 12 are all fixedly connected to the upper surface of the base film 1, and the No. 1 spacer 9, the No. 2 spacer 10, the No. 3 spacer 11 and the No. 4 spacer 12 are all fixedly connected to the outer surface of the nitrocellulose membrane 8.

[0026] The first spacer 9 , the second spacer 10 , the third spacer 11 and the fourth spacer 12 serve to separate the nitrocellulose membrane 8 .

[0027] Among them, the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis A IgM antibody detection membrane block 13 located between the soft edge strip 2 and the No. 1 spacer strip 9, and the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis A IgM antibody quality control membrane block 14 located on the right side of the hepatitis A IgM antibody detection membrane block 13.

[0028] The hepatitis A IgM antibody detection membrane block 13 can detect the hepatitis A IgM antibody in the serum, while the hepatitis A IgM antibody quality control membrane block 14 plays a role in determining whether the detection result of the hepatitis A IgM antibody detection membrane block 13 is valid.

[0029] Among them, the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis B IgM antibody detection membrane block 15 located between the No. 1 spacer 9 and the No. 2 spacer 10, and the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis B IgM antibody quality control membrane block 16 located on the right side of the hepatitis B IgM antibody detection membrane block 15.

[0030] The hepatitis B IgM antibody detection membrane block 15 can detect the hepatitis B IgM antibody in the serum, while the hepatitis B IgM antibody quality control membrane block 16 plays a role in determining whether the detection result of the hepatitis B IgM antibody detection membrane block 15 is valid.

[0031] Among them, the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis C IgM antibody detection membrane block 17 located between the No. 2 spacer 10 and the No. 3 spacer 11, and the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis C IgM antibody quality control membrane block 18 located on the right side of the hepatitis C IgM antibody detection membrane block 17.

[0032] The hepatitis C IgM antibody detection membrane block 17 can detect the hepatitis C IgM antibody in the serum, while the hepatitis C IgM antibody quality control membrane block 18 plays a role in determining whether the detection result of the hepatitis C IgM antibody detection membrane block 17 is valid.

[0033] Among them, the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis D IgM antibody detection membrane block 19 located between the No. 3 spacer 11 and the No. 4 spacer 12, and the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis D IgM antibody quality control membrane block 20 located on the right side of the hepatitis D IgM antibody detection membrane block 19.

[0034] The hepatitis D IgM antibody detection membrane block 19 can detect the hepatitis D IgM antibody in the serum, while the hepatitis D IgM antibody quality control membrane block 20 plays a role in determining whether the detection result of the hepatitis D IgM antibody detection membrane block 19 is valid.

[0035] Among them, the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis E IgM antibody detection membrane block 21 located between the No. 4 spacer 12 and the soft edge strip 2, and the upper surface of the nitrocellulose membrane 8 is fixedly connected to the hepatitis E IgM antibody quality control membrane block 22 located on the right side of the hepatitis E IgM antibody detection membrane block 21.

[0036] The hepatitis E IgM antibody detection membrane block 21 can detect the hepatitis E IgM antibody in the serum, while the hepatitis E IgM antibody quality control membrane block 22 plays a role in determining whether the detection result of the hepatitis E IgM antibody detection membrane block 21 is valid.

[0037] The working principle and use process of this utility model:

[0038] When it is necessary to test various antibodies in the serum, the tester first pinches the pull strip 5 and separates the cover film 4 from the adhesive ring 6. At this time, the serum drop port 7 will be exposed. The tester then samples the patient's blood and prepares serum. The serum is then dripped onto the nitrocellulose membrane 8 through the serum drop port 7. The cover film 4 is then re-covered to cover the adhesive ring 6 and the base film 1 is left to stand for twenty minutes.

[0039] During these twenty minutes, the serum will gradually diffuse inside the nitrocellulose membrane 8. If hepatitis antibodies exist in the patient's serum, when the hepatitis antibodies in the serum come into contact with the hepatitis A IgM antibody detection membrane block 13, the hepatitis B IgM antibody detection membrane block 15, the hepatitis C IgM antibody detection membrane block 17, the hepatitis D IgM antibody detection membrane block 19 and the hepatitis E IgM antibody detection membrane block 21, the hepatitis antibodies will combine with the antigens in the antibody detection membrane block and appear as a red line. After the red line appears, the antigens in the antibody detection membrane block will also move with the serum and eventually combine with the antibodies in the corresponding antibody quality control membrane block, and then appear as another red line. Only when the corresponding antibody quality control membrane block also shows a red line can the test results of the antibody detection membrane block be considered valid.

[0040] It should be noted that, in this document, related terms such as first and second are used only to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any actual relationship or order between these entities or operations. Moreover, the terms "comprises," "comprising," or any other variations thereof are intended to cover non-exclusive inclusion, such that a process, method, article, or apparatus that includes a list of elements includes not only those elements but also other elements not explicitly listed, or elements inherent to such process, method, article, or apparatus.

[0041] Although the embodiments of the present invention have been shown and described, it will be understood by those skilled in the art that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. An autoantibody detection membrane strip, comprising a base membrane (1), characterized in that: The upper surface of the base film (1) is fixedly connected to a soft edge strip (2), the upper surface of the soft edge strip (2) is fixedly connected to a transparent soft film (3), the front side of the upper surface of the transparent soft film (3) is fixedly connected to a rubber ring (6), the upper surface of the transparent soft film (3) is provided with a serum droplet (7) located inside the rubber ring (6), the upper surface of the rubber ring (6) is adhered to a cover film (4), the left surface of the cover film (4) is fixedly connected to a pull strip (5), and the other end of the cover film (4) is fixedly connected to the right surface of the soft edge strip (2).

2. The autoantibody detection membrane strip according to claim 1, characterized in that: The upper surface of the base film (1) is fixedly connected to a nitrocellulose membrane (8), and the right end of the inner surface of the soft edge strip (2) is fixedly connected to a No. 4 spacer (12), a No. 3 spacer (11), a No. 2 spacer (10) and a No. 1 spacer (9) in sequence from front to back. The No. 1 spacer (9), the No. 2 spacer (10), the No. 3 spacer (11) and the No. 4 spacer (12) are all fixedly connected to the upper surface of the base film (1), and the No. 1 spacer (9), the No. 2 spacer (10), the No. 3 spacer (11) and the No. 4 spacer (12) are all fixedly connected to the outer surface of the nitrocellulose membrane (8).

3. The autoantibody detection membrane strip according to claim 2, characterized in that: The upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis A IgM antibody detection membrane block (13) located between the soft edge strip (2) and the No. 1 spacer strip (9), and the upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis A IgM antibody quality control membrane block (14) located on the right side of the hepatitis A IgM antibody detection membrane block (13).

4. The autoantibody detection membrane strip according to claim 2, characterized in that: The upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis B IgM antibody detection membrane block (15) located between the No. 1 spacer (9) and the No. 2 spacer (10), and the upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis B IgM antibody quality control membrane block (16) located on the right side of the hepatitis B IgM antibody detection membrane block (15).

5. The autoantibody detection membrane strip according to claim 2, characterized in that: The upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis C IgM antibody detection membrane block (17) located between the second spacer (10) and the third spacer (11), and the upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis C IgM antibody quality control membrane block (18) located on the right side of the hepatitis C IgM antibody detection membrane block (17).

6. The autoantibody detection membrane strip according to claim 2, characterized in that: The upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis D IgM antibody detection membrane block (19) located between the third spacer (11) and the fourth spacer (12), and the upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis D IgM antibody quality control membrane block (20) located on the right side of the hepatitis D IgM antibody detection membrane block (19).

7. The autoantibody detection membrane strip according to claim 2, characterized in that: The upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis E IgM antibody detection membrane block (21) located between the No. 4 spacer bar (12) and the soft edge bar (2), and the upper surface of the nitrocellulose membrane (8) is fixedly connected to a hepatitis E IgM antibody quality control membrane block (22) located on the right side of the hepatitis E IgM antibody detection membrane block (21).

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