Efficient vacuum emulsification device for liposome biological agent

Abstract

The utility model discloses an efficient vacuum emulsification device for a liposome biological agent, and belongs to the technical field of stirring equipment. The device comprises an emulsifying tank body and a homogenizing assembly arranged in the emulsifying tank body, and the emulsifying tank body is connected with a vacuum pump; the homogenizing assembly comprises a homogenizer and a homogenizing cutting blade arranged on the homogenizer, the homogenizer is connected with a homogenizing shaft in a sleeving manner, the homogenizer is in a three-dimensional spiral shape, an included angle a is formed between the homogenizer and the homogenizing cutting blade arranged on the same side as the homogenizer, and a homogenizing blade is arranged at the edge position of the homogenizing cutting blade and is an inclined blade. The raw materials of the mixed lipidosome biological agent are cut and stirred through the homogenizing assembly in the emulsifying tank body, formation and uniform distribution of the lipidosome biological agent are promoted, the emulsifying tank body is vacuumized through the vacuum pump, the content of bubbles and oxygen generated in the processing process of the raw materials of the lipidosome biological agent by the homogenizing assembly is reduced, and the processing efficiency of the lipidosome biological agent is improved. The stability and the shelf life of the liposome biological preparation are improved.

Description

Technical Field

[0001] The utility model belongs to the technical field of stirring equipment, in particular to a high-efficiency vacuum emulsification device for liposome biological preparations. Background Art

[0002] A liposome is an artificial membrane. In water, the hydrophilic heads of phospholipid molecules insert into the water, while the hydrophobic tails of the liposomes extend into the air. Upon agitation, they form a spherical bilayer of lipid molecules, ranging in diameter from 25 to 1000 nm. Liposomes can be used for genetic engineering or pharmaceutical preparation, leveraging their ability to fuse with cell membranes to deliver drugs into cells. Biological definition: When amphiphilic molecules such as phospholipids and sphingolipids are dispersed in an aqueous phase, the hydrophobic tails of the molecules tend to aggregate, avoiding the aqueous phase, while the hydrophilic heads are exposed to the aqueous phase, forming closed vesicles with a bilayer structure, called liposomes. Pharmaceutical definition: Liposomes are microscopic vesicles formed by encapsulating drugs within a lipid bilayer.

[0003] In the process of using liposome technology for biological preparations, the raw materials of liposome biological preparations need to be put into an emulsification container in a certain proportion, and the stirring system is started to make the stirring paddle rotate in the emulsification container. The raw materials need to be broken up and stirred, gradually mixed and formed into liposomes.

[0004] During the stirring process of the prior art, the raw materials of the liposome biological preparation are not stirred uniformly, resulting in poor emulsification efficiency and quality of the formed liposome biological preparation, uneven distribution of the liposome biological preparation, and waste of resources. Utility Model Content

[0005] 1. Technical problems to be solved by the utility model

[0006] The utility model aims to solve the problem that the existing stirring system stirs the raw materials of liposome biological preparation unevenly, resulting in poor content and quality of the formed liposome biological preparation and uneven distribution of the liposome biological preparation.

[0007] 2. Technical solution

[0008] In order to achieve the above-mentioned purpose, the technical solution provided by the present utility model is:

[0009] The utility model discloses a high-efficiency vacuum emulsification device for liposome biological preparations, comprising an emulsification tank body and a homogenization component arranged in the emulsification tank body, wherein the emulsification tank body is connected to a vacuum pump so as to form a vacuum in the emulsification tank body; the homogenization component comprises a homogenizer and homogenization slices arranged at the outer edge of the homogenizer and staggered up and down, the homogenizer is sleeved and connected to a homogenization shaft, the homogenizer is in a three-dimensional spiral shape, the homogenizer forms an angle a with the homogenization slices arranged on the same side, a homogenization blade is arranged at the edge of the homogenization slice, the homogenization blade is an oblique blade, and the homogenization blade is arranged on different surfaces of the adjacent homogenization slices on the same side, so that the homogenization blade can cut the raw materials of the liposome biological preparations inside and outside the homogenization slices.

[0010] Preferably, the angle a ranges from 90° to 150°.

[0011] Preferably, the shape of the homogenizing blade may be a triangle, a trapezoid, a square or a rectangle.

[0012] Preferably, an emulsifying motor is further included, and the emulsifying motor drives the homogenizing shaft to rotate through a reduction device.

[0013] Preferably, the emulsification tank is connected to a feeding device and a discharging device.

[0014] Preferably, the emulsification tank is connected to a liquid level display device and a temperature display device.

[0015] Preferably, it further comprises an emulsification control system, which comprises a vacuum system and a control system.

[0016] 3. Beneficial effects

[0017] Compared with the prior art, the technical solution provided by this utility model has the following beneficial effects:

[0018] The utility model discloses a high-efficiency vacuum emulsification device for liposome biological preparations, comprising an emulsification tank body and a homogenization component arranged in the emulsification tank body, wherein the emulsification tank body is connected to a vacuum pump so as to form a vacuum in the emulsification tank body; the homogenization component comprises a homogenizer and homogenization slices arranged at the outer edge of the homogenizer and staggered up and down, the homogenizer is sleeved and connected to a homogenization shaft, the homogenizer is in a three-dimensional spiral shape, the homogenizer forms an angle a with the homogenization slices arranged on the same side, a homogenization blade is arranged at the edge of the homogenization slice, the homogenization blade is an oblique blade, and the homogenization blade is arranged on different surfaces of the adjacent homogenization slices on the same side, so that the homogenization blade can cut the raw materials of the liposome biological preparations inside and outside the homogenization slices. The homogenizing component in the emulsification tank cuts and stirs the mixed raw materials of the liposome biologic, thereby promoting the formation and uniform distribution of the liposome biologic, and the emulsification tank is evacuated by a vacuum pump, thereby reducing the bubbles and oxygen content generated during the processing of the liposome biologic raw materials by the homogenizing component, thereby improving the stability and shelf life of the liposome biologic. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 This is a schematic diagram of the overall structure of a high-efficiency vacuum emulsification device for liposome biological preparations of the present invention;

[0020] Figure 2 This is a schematic diagram of the homogenizing component structure of a high-efficiency vacuum emulsification device for liposome biological preparations of the utility model;

[0021] Figure 3 for Figure 2 A detailed view of the part at A in the middle.

[0022] Explanation of the numbers in the schematic diagram:

[0023] 100. Feeding device; 200. Emulsifying motor; 210. Homogenizing shaft; 300. Homogenizing assembly; 310. Homogenizer; 320. Homogenizing slice; 330. Homogenizing blade; 400. Emulsifying tank; 410. Liquid level display device; 420. Temperature display device; 500. Discharging device; 600. Emulsifying control system. DETAILED DESCRIPTION

[0024] In order to enable those skilled in the art to better understand the present invention, the following will clearly and completely describe the technical solutions in the embodiments of the present invention in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments in the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of this application.

[0025] It should be noted that the terms "first," "second," and the like in the specification and claims of the present application and the accompanying drawings are used to distinguish similar objects and are not necessarily used to describe a specific order or precedence. It should be understood that the numbers used in this manner are interchangeable where appropriate for the embodiments of the present application described herein. In addition, the terms "including" and "having," and any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, system, product, or apparatus comprising a series of steps or units is not necessarily limited to those steps or units explicitly listed, but may include other steps or units that are not explicitly listed or inherent to these processes, methods, products, or apparatus.

[0026] In this application, terms such as "upper," "lower," "left," "right," "front," "back," "top," "bottom," "inner," "outer," "center," "vertical," "horizontal," "transverse," and "longitudinal" indicate positions or locations based on the positions or locations shown in the accompanying drawings. These terms are primarily intended to better describe this application and its embodiments and are not intended to limit the devices, elements, or components indicated to having a specific orientation, or to being constructed or operated in a specific orientation.

[0027] Furthermore, some of the above terms may be used to express other meanings besides indicating a position or location. For example, the term "on" may also be used to indicate a dependency or connection in certain circumstances. Those skilled in the art will understand the specific meanings of these terms in this application based on the specific circumstances.

[0028] Furthermore, the terms "installed," "disposed," "provided with," "connected," "connected," and "socketed" should be interpreted broadly. For example, they can refer to fixed connections, removable connections, or integral structures; mechanical connections or electrical connections; direct connections, indirect connections through an intermediary, or internal communication between two devices, elements, or components. Those skilled in the art will understand the specific meanings of these terms in this application based on the specific circumstances.

[0029] It should be noted that, in the absence of conflict, the embodiments and features of the embodiments in this application can be combined with each other. The present application will be described in detail below with reference to the accompanying drawings and in combination with the embodiments.

[0030] Example 1

[0031] Refer to the attached Figure 1-3, a high-efficiency vacuum emulsification device for liposome biological preparations in this embodiment includes an emulsification tank body 400, which is used to stir and emulsify the raw materials of the liposome biological preparation to form a liposome biological preparation. The emulsification tank body 400 is made of 316L stainless steel material with high strength and corrosion resistance. The interior of the emulsification tank body 400 is smooth and has no dead corners, which is convenient for cleaning and disinfection. The emulsification tank body 400 is connected to a feeding device 100 and a discharging device 500. The feeding device 100 includes a feeding hopper and a visual hole. The feeding hopper is used to input the raw materials of the liposome biological preparation into the emulsification tank body 400, and the visual hole is used to observe the inventory of the raw materials of the input liposome biological preparation, so as to facilitate the timely addition of new raw materials of the liposome biological preparation. The discharging device 500 is used to discharge the liposome biological preparation after production, so as to facilitate subsequent quality inspection and analysis to ensure that the product meets the quality standards.

[0032] The emulsification tank body 400 is connected to a liquid level display device 410 and a temperature display device 420. A liquid static pressure sensor is installed at the bottom of the emulsification tank body 400. The liquid static pressure sensor monitors the amount of material in the emulsification tank body 400 and displays it through the external liquid level display device 410, allowing staff to observe the inventory of the emulsification tank body 400 in real time. A temperature sensor is provided in the emulsification tank body 400 to monitor the temperature in the emulsification tank body 400. The temperature sensor displays the monitored temperature in the emulsification tank body 400 through the external temperature display device 420, allowing staff to monitor the emulsification temperature in real time.

[0033] The emulsification tank 400 is provided with a homogenizing component 300 for stirring and emulsifying the raw materials of the liposome biological preparation put in. The homogenizing component 300 includes a homogenizer 310 and homogenizing slices 320 arranged at the outer edge of the homogenizer 310 and staggered up and down. The homogenizer 310 is sleeved and connected with a homogenizing shaft 210. The homogenizer 310 is in a three-dimensional spiral shape. The rotation of the homogenizing shaft 210 drives the homogenizer 310 and the homogenizing slices 320 to rotate, cutting and stirring the raw materials of the liposome biological preparation in the emulsification tank 400, improving the formation and uniform distribution of the liposome biological preparation and improving product efficiency. The homogenizer 310 forms an angle a with the homogenizing slices 320 arranged on the same side, and the angle a ranges from 90° to 150°. When the angle a is less than 90°, the homogenizing slices 320 are rotated along with the homogenizer. During the rotation of the homogenizer 310, only the raw materials of the liposome biologics close to the homogenizing axis 210 can be stirred and cut. When the angle a is greater than 150°, the homogenized slice 320 can only stir and cut the raw materials of the liposome biologics away from the homogenizer 310 during the rotation of the homogenizer 310. A homogenizing blade 330 is provided at the edge of the homogenized slice 320. The shape of the homogenizing blade 330 can be a triangle, a trapezoid, a square or a rectangle, which is used to cut the mixed raw materials of the liposome biologics. The homogenizing blade 330 is a bevel blade, and the homogenizing blade 330 is provided on different surfaces of the adjacent homogenized slices 320 on the same side, so that the homogenizing blade 330 cuts the raw materials of the liposome biologics inside and outside the homogenized slice 320, thereby improving the formation and uniform distribution of the liposome biologics and improving product efficiency.

[0034] The emulsifying motor 200 is further included. The emulsifying motor 200 drives the homogenizing shaft 210 to rotate through a reduction device. The rotation of the homogenizing shaft 210 drives the homogenizing component 300 to rotate, thereby cutting and stirring the raw materials of the liposome biological preparation.

[0035] It also includes an emulsification control system 600, which includes a vacuum system and a control system. The vacuum system includes a vacuum pump, a vacuum pipeline and a vacuum control system. The vacuum pump is connected to the emulsification tank 400 through a vacuum pipeline to evacuate the emulsification tank 400. The vacuum control system can monitor and adjust the vacuum degree in real time, reduce the bubbles and oxygen content generated by the homogenization component 300 during the stirring of the raw materials of the liposome biological preparation, and improve the stability and shelf life of the liposome biological preparation; the control system realizes precise control of parameters such as stirring speed, stirring time, vacuum degree, temperature, etc., and is equipped with safety protection devices, such as overload protection, overheating protection, etc., to ensure the safe operation of the device. The emulsification control system 600 is a prior art and will not be described in detail here.

[0036] The above-mentioned embodiments only express a certain implementation method of the utility model, and the description thereof is relatively specific and detailed, but it cannot be understood as limiting the scope of the patent of the utility model. It should be pointed out that for ordinary technicians in this field, several variations and improvements can be made without departing from the concept of the utility model, which all fall within the scope of protection of the utility model. Therefore, the scope of protection of the utility model patent shall be based on the attached claims.

Claims

1. A high-efficiency vacuum emulsification device for liposome biological preparations, characterized by: The invention comprises an emulsification tank (400) and a homogenizing assembly (300) arranged in the emulsification tank (400), wherein the emulsification tank (400) is connected to a vacuum pump so as to form a vacuum in the emulsification tank (400); The homogenizing component (300) includes a homogenizer (310) and homogenizing slices (320) arranged at the outer edge of the homogenizer (310) and staggered up and down. The homogenizer (310) is sleeved and connected with a homogenizing shaft (210). The homogenizer (310) is in a three-dimensional spiral shape. The homogenizer (310) forms an angle a with the homogenizing slices (320) arranged on the same side. A homogenizing blade (330) is arranged at the edge of the homogenizing slice (320). The homogenizing blade (330) is an oblique blade, and the homogenizing blade (330) is arranged on different surfaces of the adjacent homogenizing slices (320) on the same side, so that the homogenizing blade (330) cuts the raw materials of the liposome biological preparation inside and outside the homogenizing slice (320).

2. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 1, characterized in that: The angle a ranges from 90° to 150°.

3. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 2, characterized in that: The shape of the homogenizing blade (330) may be a triangle, a trapezoid, a square or a rectangle.

4. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 3, characterized in that: It also includes an emulsifying motor (200), which drives the homogenizing shaft (210) to rotate via a speed reduction device.

5. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 4, characterized in that: The emulsification tank (400) is connected to a feeding device (100) and a discharging device (500).

6. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 5, characterized in that: The emulsification tank (400) is connected to a liquid level display device (410) and a temperature display device (420).

7. The high-efficiency vacuum emulsification device for liposome biological preparations according to claim 6, characterized in that: The invention also comprises an emulsification control system (600), wherein the emulsification control system (600) comprises a vacuum system and a control system.

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