Quantitative uniform mixing system

Abstract

The utility model relates to the technical field of biological pharmacy, in particular to a quantitative uniform mixing system. The quantitative uniform mixing system comprises a stock solution container, a liquid conveying pipeline, a conveying pump, a uniform mixing container, a stirring device, a weighing device and a control device; the conveying pump, the stirring device and the weighing device are electrically connected with the control device; an inlet of the liquid conveying pipeline is connected with the stock solution container, an outlet of the liquid conveying pipeline is connected with the uniform mixing container, and the conveying pump is arranged on the liquid conveying pipeline; stirring blades of the stirring device are arranged in the blending container, and the weighing device is arranged at the bottom of the blending container to measure the weight of the mixed liquid medicine in real time. Therefore, manual operation during liquid preparation can be reduced, meanwhile, the liquid preparation efficiency is improved, and the liquid preparation accuracy is also ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of biopharmaceuticals, and in particular to a quantitative mixing system. Background Art

[0002] Currently, when preparing raw liquids in the biopharmaceutical field, manual operation is usually adopted to transport and weigh the liquids. This process has the following problems:

[0003] 1) Subjective awareness of personnel leads to poor consistency in each liquid preparation process;

[0004] 2) Low efficiency of manual operation;

[0005] 3) Liquid distribution system of non-intelligent control cabinet. Utility Model Content

[0006] The objectives of the present invention include, for example, providing a quantitative mixing system that can reduce manual operations during liquid preparation, while improving liquid preparation efficiency and ensuring liquid preparation accuracy.

[0007] The embodiment of the present utility model can be implemented as follows:

[0008] In a first aspect, the present invention provides a quantitative mixing system, comprising:

[0009] Original liquid container, infusion pipeline, delivery pump, mixing container, stirring device, weighing device and control device;

[0010] The delivery pump, the stirring device, and the weighing device are all electrically connected to the control device;

[0011] The inlet of the infusion pipeline is connected to the raw liquid container, the outlet of the infusion pipeline is connected to the mixing container, and the delivery pump is provided on the infusion pipeline;

[0012] The stirring blades of the stirring device are arranged in the mixing container, and the weighing device is arranged at the bottom of the mixing container to measure the weight of the mixed liquid in real time.

[0013] In an optional embodiment, a temperature measuring device is further included; the temperature measuring device is arranged in the mixing container to monitor the temperature of the mixed liquid.

[0014] In an optional embodiment, a mobile frame is further included, the bottom of the weighing device is arranged on the mobile frame, and the bottom of the mixing container is arranged on the top of the weighing device.

[0015] In an optional embodiment, the mobile frame is a cart.

[0016] In an optional embodiment, the raw liquid container is a disposable raw liquid bag.

[0017] In an optional embodiment, the delivery pump is a peristaltic pump.

[0018] In an optional embodiment, the stirring device includes a stirring blade and a magnetic rotation mechanism; the magnetic rotation mechanism can drive the stirring blade to rotate by magnetic force.

[0019] In an optional embodiment, the mixing container includes a mixing tank, which is arranged on the top of the weighing device; the mixing tank has a sealed inner cavity for accommodating the medicinal liquid; and the stirring blades of the stirring device can be arranged in the inner cavity.

[0020] In an optional embodiment, the mixing tank is made of stainless steel.

[0021] In an optional embodiment, the mixing container includes a box body and a mixing bag; the mixing bag can be arranged in the box body; and the mixing blades of the stirring device can be arranged in the mixing bag.

[0022] The beneficial effects of the embodiments of the present invention include, for example:

[0023] The quantitative mixing system can reduce manual operations during liquid preparation, improve liquid preparation efficiency, and ensure the accuracy of liquid preparation.

[0024] The embodiment of the present utility model can be implemented as follows:

[0025] In a first aspect, the present invention provides a quantitative mixing system, comprising:

[0026] The quantitative mixing system of this solution includes a raw liquid container, an infusion pipeline, a delivery pump, a mixing container, a stirring device, a weighing device and a control device. The control device can control the cabinet weighing device to perform real-time weighing, and at the same time regulate the operation of the stirring device and the delivery pump; in this way, on the one hand, the liquid medicine in the mixing container can be fully stirred, and on the other hand, the liquid medicine in the mixing container can reach a preset weight to facilitate the operation of subsequent processes. In summary, the functions of the equipment are realized through the coordinated work of various devices. The main function of the high-precision quantitative mixing system is to quantitatively deliver various raw liquids to the mixing tank, automatically perform quantitative mixing operations, and also perform liquid filling operations. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following is a brief introduction to the drawings required for use in the embodiments. It should be understood that the following drawings only illustrate certain embodiments of the present invention and therefore should not be regarded as limiting the scope. For ordinary technicians in this field, other relevant drawings can be obtained based on these drawings without paying any creative work.

[0028] Figure 1 This is a schematic structural diagram of a quantitative mixing system according to a first embodiment of the present invention;

[0029] Figure 2 This is a schematic diagram of the working principle of the quantitative mixing system of Example 1 of the present utility model;

[0030] Figure 3 This is a schematic structural diagram of a quantitative mixing system according to a second embodiment of the present invention;

[0031] Figure 4 This is a schematic diagram of the working principle of the quantitative mixing system of Example 2 of the present utility model.

[0032] Icons: 11-raw liquid container; 12-infusion pipeline; 13-delivery pump; 14-weighing device; 15-control device; 16-temperature measuring device; 17-mobile frame; 100-mixing container; 110-mixing tank; 111-inner cavity; 121-box; 122-mixing bag; 200-stirring device; 210-stirring blade; 220-magnetic rotating mechanism; 21-control cabinet; 22-human-machine interface; 23-pipe rack; 24-pipe clamp; 25-electric pipe clamp valve. DETAILED DESCRIPTION

[0033] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.

[0034] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are also within the scope of protection of the present invention.

[0035] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0036] In the description of the present invention, it should be noted that if the terms "upper", "lower", "inside", "outside", etc. appear, the orientation or position relationship indicated is based on the orientation or position relationship shown in the accompanying drawings, or is the orientation or position relationship in which the utility model product is usually placed when in use. It is only for the convenience of describing the present invention and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation. Therefore, it cannot be understood as a limitation on the present invention.

[0037] In addition, the terms "first", "second", etc., if used, are merely used to distinguish and describe, and should not be understood as indicating or implying relative importance.

[0038] It should be noted that, in the absence of conflict, the features in the embodiments of the present invention can be combined with each other.

[0039] Currently, when preparing raw liquids in the biopharmaceutical field, manual operation is usually adopted to transport and weigh the liquids. This process has the following problems:

[0040] ① In the past, the entire process of liquid preparation and mixing was basically completed manually, resulting in low production efficiency.

[0041] ② In the past, the control cabinet for measurement accuracy was not perfect enough and the measurement error was still large.

[0042] ③ In the past, the level of digital information management for liquid mixing was low.

[0043] ④ In the past, the location of quantitative mixing operations was limited and the scope of application was small.

[0044] ⑤ In the past, transportation used stainless steel pipes, which were expensive and had high requirements for cleaning and sterility.

[0045] In order to improve the above technical problems, a quantitative mixing system is provided in the following embodiments.

[0046] Example 1

[0047] Please refer to Figure 1This embodiment provides a quantitative mixing system, comprising a raw liquid container 11, an infusion line 12, a delivery pump 13, a mixing container 100, a stirring device 200, a weighing device 14, and a control device 15. The delivery pump 13, stirring device 200, and weighing device 14 are all electrically connected to the control device 15; the inlet of the infusion line 12 is connected to the raw liquid container 11, and the outlet of the infusion line 12 is connected to the mixing container 100. The delivery pump 13 is disposed on the infusion line 12; the stirring blade 210 of the stirring device 200 is disposed in the mixing container 100, and the weighing device 14 is disposed at the bottom of the mixing container 100 to measure the weight of the mixed liquid in real time.

[0048] The quantitative mixing system control device 15 of this solution can control the weighing device 14 of the cabinet 21 to perform real-time weighing, and at the same time regulate the operation of the stirring device 200 and the delivery pump 13; in this way, on the one hand, the liquid medicine in the mixing container 100 can be fully stirred, and on the other hand, the liquid medicine in the mixing container 100 can be made to reach a preset weight to facilitate the operation of subsequent processes. In summary, the functions of the equipment are realized through the coordinated work of various devices. The main function of the high-precision quantitative mixing system is to quantitatively deliver various types of raw liquids to the mixing tank 110, automatically perform quantitative mixing operations, and also perform liquid filling operations.

[0049] See also Figure 1 and Figure 2 As can be seen from the figure, the quantitative mixing system also includes a chassis, which includes a control cabinet 21, an HMI human-machine interface 22 installed on the electrical box, a delivery pump 13 (a peristaltic pump in this embodiment), and a pipe rack 23. The infusion pipeline 12, delivery pump 13, and control device 15 are installed in the control cabinet 21.

[0050] In an optional embodiment, the liquid container 11 is a disposable liquid bag. Disposable liquid bags offer enhanced cleanliness, are easily replaced, and are versatile enough to improve production efficiency. During operation, only the disposable liquid bag needs to be replaced to complete the entire process, significantly improving production efficiency.

[0051] In an optional embodiment, the quantitative mixing system further includes a temperature measuring device 16 ; the temperature measuring device 16 is disposed in the mixing container 100 to monitor the temperature of the mixed liquid medicine, thereby ensuring the quality of the mixed liquid medicine.

[0052] In an optional embodiment, the quantitative mixing system further includes a mobile frame 17. The bottom of the weighing device 14 is disposed on the mobile frame 17, and the bottom of the mixing container 100 is disposed on top of the weighing device 14. Optionally, the mobile frame 17 is a cart. The mobile frame 17 facilitates the movement and transportation of the mixing container 100, thereby improving the convenience of use of the quantitative mixing system.

[0053] In an optional embodiment, the delivery pump 13 is a peristaltic pump. In an optional embodiment, the stirring device 200 includes a stirring blade 210 and a magnetic rotation mechanism 220; the magnetic rotation mechanism 220 can drive the stirring blade 210 to rotate through magnetic force.

[0054] Furthermore, a plug-in data transmission connector is provided between the mixing container 100 and the control cabinet 21 , so that the data of the stirring device 200 and the temperature measuring device 16 can be transmitted to the control device 15 in the control cabinet 21 in a timely and efficient manner.

[0055] As can also be seen from the figure, in an optional embodiment, the mixing container 100 includes a mixing tank 110, which is disposed on top of the weighing device 14; the mixing tank 110 has a sealed inner cavity 111 for containing the liquid medicine; and the stirring blade 210 of the stirring device 200 can be disposed in the inner cavity 111. In an optional embodiment, the mixing tank 110 is made of stainless steel.

[0056] Furthermore, disposable delivery pipelines can be used to ensure cleanliness during the drug delivery process and facilitate maintenance and upkeep of the entire quantitative mixing system. While ensuring the sterility and integrity of the mixing experiment, the use of disposable piping and equipment, including the stock solution bag, tubing, and filter, offers the following three advantages: affordability, which requires no cleaning or maintenance; safety, which ensures a sterile environment; and flexibility, which allows for quick replacement of materials.

[0057] When in use, the working principle and process are introduced:

[0058] Preparation: Turn on the power of the high-precision quantitative mixing system, enter the production formula and production information on the touch screen of the human-machine interface 22, install the disposable delivery pipeline between the delivery pump 13 and the pipe rack 23, and install the corresponding raw liquid bag.

[0059] The quantitative mixing operation is as follows:

[0060] First quantitative mixing work:

[0061] The initial quantitative mixing process begins. The peristaltic pump begins pumping the stock solution through the intelligent pumping system's control cabinet 21, ultimately delivering it to the mixing tank 110. Simultaneously, the high-precision weighing device 14 performs real-time weighing, and the stirring device 200 operates, beginning the quantitative mixing process. When the difference, e, between the set pumped liquid mass S and the actual pumped liquid mass M reaches the set value f, the semi-difference approximation algorithm is activated to replenish the liquid until the difference, e, falls within the specified deviation range, completing the initial quantitative mixing process. The scale is then reset to zero, preparing for the second weighing.

[0062] Secondary quantitative mixing work:

[0063] Replace the stock liquid pipeline and start the second quantitative mixing process. Just like the first quantitative mixing process, perform the corresponding pumping and weighing work to finally complete the quantitative mixing process. The subsequent quantitative mixing processes are similar until the entire quantitative mixing process is completed.

[0064] Liquid filling operations:

[0065] After the quantitative mixing operation is completed, the on-site personnel can push the stainless steel mixing tank 110 to the liquid filling position to perform the liquid filling operation. At this time, the stirring device 200 together with the stainless steel mixing tank 110 is connected to the socket on the side of the control cabinet 21 through the plug-in data transmission connector for power supply and data transmission.

[0066] Example 2

[0067] See also Figure 3 and Figure 4 The quantitative mixing system of this embodiment is substantially the same as that of the embodiment. The difference between the two is that the mixing container 100 in this embodiment includes a box body 121 and a mixing bag 122; the mixing bag 122 can be set in the box body 121; the stirring blade 210 of the stirring device 200 can be set in the mixing bag 122.

[0068] Optionally, the chassis of this embodiment lacks a pipe rack 23, but instead is equipped with a pipe clamp 24 and an electric pinch valve 25. Furthermore, the mixing bag 122 in this embodiment is a disposable storage bag, thus ensuring cleanliness throughout the mixing process. The quantitative mixing system of this embodiment does not include a mobile frame 17. The weighing device 14 is mounted on a base, which is integrated with the bottom of the chassis. Adjustable feet are provided at the bottom of the base.

[0069] Preparation: Turn on the power of the high-precision quantitative mixing system, enter the production formula and production information on the touch screen of the human-machine interface 22, install the disposable delivery pipeline between the tube clamp 24 and the electric pinch valve 25, and install the corresponding raw liquid bag.

[0070] Quantitative mixing operation:

[0071] First quantitative mixing work:

[0072] The initial quantitative mixing process begins. The peristaltic pump, controlled by the intelligent pumping system, begins pumping the stock solution, ultimately delivering it to the quantitative mixing bag 122. Simultaneously, the high-precision weighing device 14 performs real-time weighing, and the magnetic stirring device 200 operates, beginning the quantitative mixing process. When the difference, e, between the set pumped liquid mass S and the actual pumped liquid mass M reaches the set value f, the semi-difference approximation algorithm is activated to replenish the solution until the difference, e, falls within the specified deviation range, completing the initial quantitative mixing process. The scale is then reset to zero, preparing for the second weighing.

[0073] Secondary quantitative mixing work:

[0074] Replace the stock liquid pipeline and start the second quantitative mixing process. Just like the first quantitative mixing process, perform the corresponding pumping and weighing work to finally complete the quantitative mixing process. The subsequent quantitative mixing processes are similar until the entire quantitative mixing process is completed.

[0075] In summary, the embodiments of the present invention provide a quantitative mixing system, which has at least the following advantages:

[0076] ① In the past, the entire process of liquid preparation and mixing was basically completed manually, resulting in low production efficiency. Now, the quantitative mixing system can assist manual work. Only the disposable stock liquid bag needs to be manually replaced during the process, which significantly improves production efficiency.

[0077] ② In the past, the control cabinet 21 for metering accuracy was not perfect enough, and the metering error was still large. Now, the quantitative mixing system is enabled, and the anti-shake control cabinet 21 solution of the pipeline and the pump liquid algorithm solution are used to control the accuracy of the control cabinet 21, significantly reducing the metering error.

[0078] ③ In the past, the digital information management level of liquid mixing was low. Now, this quantitative mixing system uses a special quantitative mixing system control cabinet 21 software, PLC programmable control cabinet 21 and HMI human-machine interface 22, which significantly improves the digital information management level.

[0079] ④ In the past, the location of quantitative mixing operations was limited and the scope of application was small. Now this quantitative mixing system has been activated, with the addition of a mobile weighing platform and a plug-in data transmission connector. The stainless steel mixing tank 110 is lifted onto the weighing platform by on-site personnel for liquid mixing. After completion, the on-site personnel can push the stainless steel mixing tank 110 to the liquid filling position for liquid filling operations. At this time, the stirring device 200 that comes with the stainless steel mixing tank 110 is connected to the socket on the side of the control cabinet 21 through a plug-in data transmission connector for power supply and data transmission. The power supply and data transmission of the stirring device 200 that moves with the tank body can be met at different positions, significantly enhancing the applicability and flexibility of the operation.

[0080] ⑤ In the past, transportation used stainless steel pipes, which were expensive and required high cleaning and sterility standards. Now, this quantitative mixing system uses disposable liquid bags, disposable pipes, and disposable mixing bags 122. Mixing bags 122 can be directly supplied to downstream users, significantly reducing production costs and increasing convenience.

[0081] The above are only specific embodiments of the present invention, but the scope of protection of the present invention is not limited to them. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this utility model should be included in the scope of protection of the present utility model. Therefore, the scope of protection of the present utility model should be based on the scope of protection of the claims.

Claims

1. A quantitative mixing system, characterized in that: include: A raw liquid container (11), a liquid infusion pipeline (12), a delivery pump (13), a mixing container (100), a stirring device (200), a weighing device (14) and a control device (15); The delivery pump (13), the stirring device (200), and the weighing device (14) are all electrically connected to the control device (15); The inlet of the infusion pipeline (12) is connected to the raw liquid container (11), the outlet of the infusion pipeline (12) is connected to the mixing container (100), and the delivery pump (13) is arranged on the infusion pipeline (12); The stirring blade (210) of the stirring device (200) is arranged in the mixing container (100), and the weighing device (14) is arranged at the bottom of the mixing container (100) to measure the weight of the mixed liquid in real time.

2. The quantitative mixing system according to claim 1, characterized in that: It also includes a temperature measuring device (16); the temperature measuring device (16) is arranged in the mixing container (100) to monitor the temperature of the mixed liquid.

3. The quantitative mixing system according to claim 1, characterized in that: It also includes a moving frame (17), the bottom of the weighing device (14) is arranged on the moving frame (17), and the bottom of the mixing container (100) is arranged on the top of the weighing device (14).

4. The quantitative mixing system according to claim 3, characterized in that: The movable frame (17) is a cart.

5. The quantitative mixing system according to claim 1, characterized in that: The raw liquid container (11) is a disposable raw liquid bag.

6. The quantitative mixing system according to claim 1, characterized in that: The delivery pump (13) is a peristaltic pump.

7. The quantitative mixing system according to claim 1, characterized in that: The stirring device (200) comprises a stirring blade (210) and a magnetic rotation mechanism (220); the magnetic rotation mechanism (220) can drive the stirring blade (210) to rotate by magnetic force.

8. The quantitative mixing system according to any one of claims 1 to 7, characterized in that: The mixing container (100) includes a mixing tank (110), which is arranged on the top of the weighing device (14); the mixing tank (110) has a sealed inner cavity (111) for accommodating liquid medicine; and the stirring blade (210) of the stirring device (200) can be arranged in the inner cavity (111).

9. The quantitative mixing system according to claim 8, characterized in that: The mixing tank (110) is made of stainless steel.

10. The quantitative mixing system according to any one of claims 1 to 7, characterized in that: The mixing container (100) comprises a box body (121) and a mixing bag (122); the mixing bag (122) can be arranged in the box body (121); and the mixing blade (210) of the stirring device (200) can be arranged in the mixing bag (122).

Images