Cold insulation type antibody preservation box capable of being marked

Abstract

The utility model belongs to the technical field of biological sample preservation, and particularly relates to a markable cold insulation type antibody preservation box which comprises an upper box body and a lower box body, the upper box body is detachably fixed with the lower box body through a buckle mechanism, ice blocks used for cold insulation of the upper box body are arranged in a cavity of the lower box body, and the upper box body and the lower box body are detachably fixed through a buckle mechanism. Grids with the top periphery capable of being marked are fixedly installed in the upper box body, an antibody storage tube is inserted into the inner wall of each grid in a sliding mode, the inner bottom wall of each grid is provided with an automatic snap fastener mechanism extending into the lower box body, and the automatic pop-up action of the antibody storage tubes is achieved through the automatic snap fastener mechanisms. According to the cold insulation type antibody storage box capable of being marked, the serial numbers on the antibody storage tubes correspond to the serial number marks in a one-to-one mode, so that the target antibody storage tubes can be conveniently found, marking and marking can be facilitated, mistakes are not prone to being taken out, and the cold insulation type antibody storage box is easy to return after being used.

Description

Technical Field

[0001] The utility model relates to the technical field of biological sample preservation, in particular to a markable cold-keeping antibody preservation box. Background Art

[0002] Antibodies are core tools and reagents commonly used in biological research and medical experiments, involving a variety of experiments such as protein immunoblotting, enzyme-linked immunosorbent assay, immunoprecipitation, immunofluorescence, and flow cytometry. Their stability and activity are directly related to the accuracy of experimental results. Antibodies are extremely sensitive to temperature, and improper storage will lead to antibody denaturation and reduced titer. In the existing technology, the storage conditions for antibodies are mainly low-temperature freezing (-20°C to -80°C) or refrigeration (2-8°C). Laboratories usually use cell freezing boxes to store antibodies, which have the following technical defects:

[0003] 1. Insufficient temperature control. Insufficient temperature control may occur in the following situations: (1) when searching for the target antibody; (2) from finding the target antibody to before use; (3) during the preparation of the antibody to the target concentration; (4) from the use of the antibody to the time it is returned to the refrigerator. In the above situations, the antibody is out of temperature control and is very likely to be repeatedly frozen and thawed, accelerating its degradation.

[0004] 2. Difficulty in labeling: There is a lack of labeling area on the storage container, and the storage position of the antibody tube is not fixed, making it difficult to quickly find it. During the search process, other non-target antibodies may be temporarily out of temperature control, and it is easy to take the wrong antibody due to human error.

[0005] Therefore, there is an urgent need for a storage device with a simple structure, convenient labeling, and the ability to effectively maintain antibody stability. This device should be able to withstand the influence of external temperature fluctuations to a certain extent, while providing a relatively stable storage environment for the antibodies to ensure the activity and stability of the antibodies during storage and transportation. By labeling and fixing the antibody storage location, the possibility of incorrect antibody removal can be reduced, thereby improving work efficiency. Utility Model Content

[0006] Based on the existing technical problems, the utility model proposes a markable cold-keeping antibody storage box.

[0007] The utility model provides a markable cold-keeping antibody storage box, which comprises an upper box body and a lower box body.

[0008] The upper box body is detachably fixed to the lower box body through a snap mechanism.

[0009] Ice cubes for keeping the upper box body cold are arranged in the cavity of the lower box body.

[0010] The interior of the upper box body is fixedly installed with a markable grid, and the inner wall of each grid is slidably plugged with an antibody storage tube.

[0011] The inner bottom wall of each grid is provided with an automatic snap mechanism extending into the lower box body, and the antibody storage tube is automatically ejected by the automatic snap mechanism.

[0012] Preferably, the snap mechanism includes an L-shaped slot opened on the bottom surface of the upper box body, and an elastic snap is fixedly installed on the edge of the upper surface of the lower box body and is snapped into the L-shaped slot. When disassembling, the top of the elastic snap is pressed inward until the elastic snap is disengaged from the outer end notch of the L-shaped slot.

[0013] Through the above technical solution, the snap mechanism can facilitate the replacement of ice cubes in the lower box at any time.

[0014] Preferably, number marks are provided on the upper surface of the edge of the upper box body.

[0015] Through the above technical solution, the grid can be marked with a two-dimensional coordinate system so that each grid has a unique number, which facilitates the management of the antibody storage tubes and prevents confusion.

[0016] Preferably, a label adapted to the top edge of the grid is fixedly connected to the top outer surface of the antibody storage tube, and an adhesive layer is provided on the inner surface of the label.

[0017] Through the above technical solution, each antibody storage tube is marked in the corresponding grid, so that each antibody storage tube corresponds to its own unique grid, preventing the problem of difficult identification.

[0018] Preferably, the adhesive layer is a two-layer structure, and the upper surface of the first layer and the lower surface of the second layer are adhered to each other.

[0019] The above technical solution facilitates the necessary labeling of the biological sample in each antibody storage tube.

[0020] Preferably, the first layer comprises PET, acrylic adhesive and PET from bottom to top, and the second layer comprises PET, acrylic pressure-sensitive adhesive and coated paper from bottom to top.

[0021] The coated paper can be marked with a pen, and the PET in the lower part of the first layer structure of the adhesive layer can be torn off to stick to the marked coated paper, and the PET in the lower part of the second layer structure can be torn off to stick to the label area.

[0022] Preferably, the automatic snap button mechanism includes an outer sleeve installed at the center of the inner bottom wall of the grid, the inner wall of the outer sleeve is slidably connected to the inner sleeve, the inner bottom wall of the outer sleeve is fixedly installed with a spring that always bounces the inner sleeve upward, and the top of the inner sleeve is slidably connected to a pressure rod.

[0023] The top inner wall of the outer sleeve is fixedly connected with a guide fixed groove, and the inner wall of the guide fixed groove is slidably inserted with a guide movable groove whose wall thickness is at least twice the wall thickness of the guide fixed groove. The inner walls of multiple guide fixed grooves are fixed in a circular array on the outer surface of the inner sleeve, and the bottom of the guide fixed groove and the top of the guide movable groove are both provided with bevels.

[0024] A pressing block adapted to the oblique opening is fixedly mounted on the bottom surface of the pressing rod, and the pressing block and the oblique opening are in a semi-engaged state before each pressing;

[0025] A guide block is fixedly mounted on the outer surface of the pressing block to prevent the pressing rod from rotating in the circumferential direction. The inner side wall of the guide fixed groove is provided with a guide groove slidably connected to the two side surfaces of the guide block.

[0026] Through the above technical solution, the pressing principle of a ballpoint pen is adopted to facilitate the taking out of the antibody storage tube.

[0027] Preferably, a box cover is provided on the top of the upper box body, a digital thermometer is magnetically attracted to the side of the box cover by a magnet, and a probe of the digital thermometer is movably inserted into the center of the box cover.

[0028] Through the above technical solution, the temperature inside the upper box can be monitored in real time, preventing the antibody storage tube from losing temperature and causing difficult-to-detect problems.

[0029] The beneficial effects of the present invention are:

[0030] 1. By setting the number on the antibody storage tube to correspond to the number mark one by one, it is not only easy to find the target antibody storage tube, but also easy to identify and mark, not easy to take the wrong one, and easy to return it to its place after use.

[0031] 2. By arranging ice cubes in the cavity of the lower box body for keeping the upper box body cold, the antibody storage tubes in the box body at room temperature can be kept cold, preventing the problem of biological samples becoming ineffective due to loss of temperature.

[0032] 3. By setting up an automatic snap mechanism, it is possible to quickly take out the antibody storage tube, increase the speed of taking out, and reduce the time the entire box is placed at room temperature due to difficulty in taking out. BRIEF DESCRIPTION OF THE DRAWINGS

[0033] Figure 1 This is a schematic diagram of a markable cold-keeping antibody storage box proposed in the present invention;

[0034] Figure 2 This is a three-dimensional diagram of the overall appearance of a markable cold-keeping antibody storage box proposed in the present invention;

[0035] Figure 3This is a three-dimensional diagram of the buckle mechanism of a markable cold-keeping antibody storage box proposed in the present invention;

[0036] Figure 4 This is a top view of the interior of the upper box body of a markable cold-keeping antibody storage box proposed in the present invention;

[0037] Figure 5 A top view of the mark and label of a markable cold-keeping antibody storage box proposed in the present invention;

[0038] Figure 6 This is a three-dimensional diagram of a label for a markable cold-keeping antibody storage box proposed in the present invention;

[0039] Figure 7 This is an exploded view of the automatic snap mechanism of a markable cold-keeping antibody storage box proposed in the present invention;

[0040] Figure 8 This is a stereoscopic diagram of the assembly of the automatic snap mechanism of a markable cold-keeping antibody storage box proposed by the present invention.

[0041] In the figure: 1. Upper box body; 11. L-shaped slot; 12. Elastic buckle; 2. Lower box body; 3. Grid; 31. Label; 32. Adhesive layer; 321. PET; 322. Acrylic glue; 323. Acrylic pressure-sensitive adhesive; 324. Coated paper; 4. Antibody storage tube; 41. Outer sleeve; 42. Inner sleeve; 43. Spring; 44. Pressure rod; 45. Fixed guide groove; 46. Moving guide groove; 47. Pressure block; 48. Guide block; 49. Guide groove; 5. Number mark; 6. Box cover; 61. Digital thermometer. DETAILED DESCRIPTION

[0042] The technical solutions in the embodiments of the present invention will be described clearly and completely below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments.

[0043] Reference Figures 1-8 , a labelable cold storage antibody box, such as Figure 1-Figure 2 As shown, it includes an upper box body 1 and a lower box body 2.

[0044] In order to facilitate the connection and quick disassembly between the upper box body 1 and the lower box body 2, as shown in FIG. Figure 1 as well as Figure 3 As shown, the upper box body 1 is detachably fixed to the lower box body 2 through a snap mechanism.

[0045] Specifically, quick installation and removal are achieved as follows: the snap mechanism includes an L-shaped slot 11 formed on the bottom surface of the upper box body 1, and an elastic snap 12 fixedly mounted on the edge of the upper surface of the lower box body 2, which snaps into the L-shaped slot 11. To remove the ice cubes, the top of the elastic snap 12 is pressed inward until it disengages from the outer end of the L-shaped slot 11. The snap mechanism allows for easy replacement of ice cubes in the lower box body 2.

[0046] By arranging ice cubes for keeping the upper box body 1 cold in the cavity of the lower box body 2, the antibody storage tube 4 in the box body at room temperature can be kept cold, preventing the problem of biological sample failure caused by loss of temperature.

[0047] In order to facilitate the unique identification of biological antibodies, such as Figure 4-Figure 5 As shown, first, a readable grid 3 is fixedly mounted within the interior of the upper housing 1. An antibody storage tube 4 is slidably inserted into the inner wall of each grid 3. Next, numbered markings 5 ​​are provided on the upper edge of the upper housing 1. The grids 3 can be labeled using a two-dimensional coordinate system, giving each grid 3 a unique number. This facilitates the management of the antibody storage tubes 4 and prevents confusion. For example, if numerical markings are used horizontally and alphabetical markings are used vertically within the rectangular housing, each antibody storage tube 4 within each grid 3 will be uniquely labeled.

[0048] By setting the numbers on the antibody storage tubes 4 to correspond to the number marks 5 one by one, it is not only easy to find the target antibody storage tubes 4, but also easy to identify and mark, making it difficult to take the wrong one and easy to return it to its place after use.

[0049] To prevent confusion during placement, a label 31 is fixedly attached to the top outer surface of the antibody storage tube 4, matching the top edge of the grid 3. Each antibody storage tube 4 is then labeled within its corresponding grid 3, ensuring that each tube 4 corresponds to its own unique grid 3 and preventing identification issues. Furthermore, a numbered marker 5 can be provided protruding outward from the top edge of the grid 3. Two sides of the label 31 are then hollowed out to fit within the protruding numbered marker 5. This way, when the antibody storage tube 4 is placed within the grid 3, any mismatched numbered markers 5 will be lifted upward.

[0050] In order to facilitate the necessary writing and labeling of the biological antibodies in each antibody storage tube 4, as shown in FIG. Figure 6 As shown, an adhesive layer 32 is provided on the inner surface of the label 31. The adhesive layer 32 is a two-layer structure, with the upper surface of the first layer and the lower surface of the second layer adhered to each other. This facilitates the necessary labeling of the biological sample in each antibody storage tube 4.

[0051] Specifically, label writing is achieved as follows: the first layer comprises PET 321 , acrylic adhesive 322 and PET 321 from bottom to top, and the second layer comprises PET 321 , acrylic pressure-sensitive adhesive 323 and coated paper 324 from bottom to top.

[0052] The coated paper 324 can be marked with a pen. The PET 321 in the lower middle portion of the first layer structure of the adhesive layer 32 can be torn off to adhere to the marked coated paper 324. The PET 321 in the lower middle portion of the second layer structure can be torn off to adhere to the label 31 area.

[0053] In order to achieve the effect of keeping the box cool and monitoring the temperature at the same time, Figure 1 and Figure 2 As shown, first, ice cubes are placed in the cavity of the lower box body 2 to keep the upper box body 1 cold. A lid 6 is then placed on the top of the upper box body 1. The lid 6 can be made of a transparent acrylic sheet, allowing the interior to be observed without having to lift the lid 6. A digital thermometer 61 is magnetically attached to the side of the lid 6, with the probe of the digital thermometer 61 removably plugged into the center of the lid 6. When the container needs to be frozen in a freezer or refrigerator, the digital thermometer 61 can be removed. When the entire container needs to be taken out for use, it is magnetically attached to the lid 6 again, and the probe is then inserted into the center hole. A Xiboer (home appliance) brand digital thermometer can be used for the digital thermometer 61. The temperature range can reach as low as -50 degrees Celsius. This allows for real-time monitoring of the temperature within the upper box body 1, preventing the antibody storage tube 4 from losing temperature, which can be difficult to detect.

[0054] In order to facilitate the rapid removal of the antibody storage tube 4, Figure 1 as well as Figure 7-Figure 8 As shown, the inner bottom wall of each grid 3 is provided with an automatic snap mechanism extending into the lower box body 2, and the antibody storage tube 4 is automatically ejected by the automatic snap mechanism.

[0055] Specifically, it is achieved as follows: the automatic snap button mechanism includes an outer sleeve 41 installed at the center of the inner bottom wall of the grid 3, the inner wall of the outer sleeve 41 is slidably connected with an inner sleeve 42, the inner bottom wall of the outer sleeve 41 is fixedly installed with a spring 43 that always bounces the inner sleeve 42 upward, and the top of the inner sleeve 42 is slidably connected with a pressure rod 44.

[0056] The top inner wall of the outer sleeve 41 is fixedly connected with a guide fixed groove 45, and the inner wall of the guide fixed groove 45 is slidably inserted with a guide movable groove 46 whose wall thickness is at least twice the wall thickness of the guide fixed groove 45. The inner walls of multiple guide fixed grooves 45 are fixed in a circular array on the outer surface of the inner sleeve 42, and the bottom of the guide fixed groove 45 and the top of the guide movable groove 46 are both beveled.

[0057] A pressing block 47 adapted to the oblique opening is fixedly mounted on the bottom surface of the pressing rod 44 , and the pressing block 47 and the oblique opening are in a semi-engaged state before each pressing.

[0058] A guide block 48 is fixedly mounted on the outer surface of the pressing block 47 to prevent the pressing rod 44 from rotating in the circumferential direction. The inner sidewall of the guide groove 45 is provided with guide grooves 49 that are slidably connected to the two sides of the guide block 48. The pressing principle of a ballpoint pen is adopted to facilitate the removal of the antibody storage tube 4.

[0059] The specific steps are as follows: a. When the lower surface of the antibody storage tube 4 presses the pressure rod 44 downward, the pressure rod 44 drives half of the bevel of the pressure block 47 to contact half of the bevel of the guide groove 46, and at the same time, the guide block 48 is inserted into the guide groove 49;

[0060] b. The pressing block 47 pushes the guide groove 46 downward, thereby driving the inner sleeve 42 to slide downward;

[0061] c. Since only half of the oblique opening of the pressing block 47 contacts half of the oblique opening of the movable guide groove 46, when the oblique opening of the movable guide groove 46 slides to the bottom oblique opening of the fixed guide groove 45, a force is applied to the movable guide groove 46 to rotate circumferentially in the direction c, causing the oblique opening of the movable guide groove 46 to rotate circumferentially along the oblique opening of the bottom of the fixed guide groove 45, completing the placement of the antibody storage tube 4.

[0062] When the antibody storage tube 4 needs to be taken out, the above steps ac are followed, causing the movable guide groove 46 to rotate again until it slides to the gap between adjacent fixed guide grooves 45, so that the spring 43 pushes the antibody storage tube 4 upward.

[0063] If the antibody storage tube 4 with the matching number mark 5 is not returned to its original position in the grid 3 and is pushed upward, the pressing block 47 at the bottom of the current antibody storage tube 4 cannot be pressed down and the tube will not return to its original position smoothly, thereby reminding the user that the current antibody storage tube 4 is not in the correct position.

[0064] By providing the automatic snap mechanism, the antibody storage tube 4 can be quickly taken out, the speed of taking out can be increased, and the time for the entire box to be placed at room temperature due to difficulty in taking out can be reduced.

[0065] The above is only a preferred specific implementation method of the present invention, but the protection scope of the present invention is not limited to this. Any technician familiar with the technical field within the technical scope disclosed by the present invention can make equivalent replacements or changes based on the technical solution and utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A markable cold-keeping antibody storage box, comprising an upper box body (1) and a lower box body (2); Its characteristics are: The upper box body (1) is detachably fixed to the lower box body (2) via a snap mechanism; Ice cubes for keeping the upper box body (1) cold are provided in the cavity of the lower box body (2); The upper surface of the edge of the upper box body (1) is provided with a number mark (5), and an identifiable grid (3) is fixedly installed inside the upper box body (1), and an antibody storage tube (4) corresponding to the number mark (5) is slidably inserted into the inner wall of each grid (3); The inner bottom wall of each grid (3) is provided with an automatic snap mechanism extending into the lower box body (2), and the antibody storage tube (4) is automatically ejected by the automatic snap mechanism.

2. The labelable cold-keeping antibody storage box according to claim 1, characterized in that: The snap mechanism comprises an L-shaped slot (11) provided on the bottom surface of the upper box body (1), and an elastic snap (12) is fixedly mounted on the edge of the upper surface of the lower box body (2) and snapped into the L-shaped slot (11). When disassembling, the top of the elastic snap (12) is pressed inward until the elastic snap (12) is separated from the outer end notch of the L-shaped slot (11).

3. The labelable cold-keeping antibody storage box according to claim 1, characterized in that: A label (31) adapted to the top edge of the grid (3) is fixedly connected to the top outer surface of the antibody storage tube (4), and an adhesive layer (32) is provided on the inner surface of the label (31).

4. The labelable cold-keeping antibody storage box according to claim 3, characterized in that: The adhesive layer (32) is a two-layer structure, with the upper surface of the first layer and the lower surface of the second layer being adhered to each other.

5. The labelable cold-keeping antibody storage box according to claim 4, characterized in that: The first layer comprises, from bottom to top, PET (321), acrylic adhesive (322), and PET (321); the second layer comprises, from bottom to top, PET (321), acrylic pressure-sensitive adhesive (323), and coated paper (324); The coated paper (324) can be marked with a pen, and the PET (321) in the lower middle portion of the first layer structure of the adhesive layer (32) can be torn off to adhere to the marked coated paper (324), and the PET (321) in the lower middle portion of the second layer structure can be torn off to adhere to the label (31) area.

6. The labelable cold-keeping antibody storage box according to claim 1, characterized in that: The automatic snap mechanism comprises an outer sleeve (41) mounted at the center of the inner bottom wall of the grid (3), an inner sleeve (42) being slidably inserted into the inner wall of the outer sleeve (41), a spring (43) for always pushing the inner sleeve (42) upwards being fixedly mounted on the inner bottom wall of the outer sleeve (41), and a pressure rod (44) being slidably sleeved on the top of the inner sleeve (42); The top inner wall of the outer sleeve (41) is fixedly connected with a guide fixed groove (45), and the inner wall of the guide fixed groove (45) is slidably connected with a guide movable groove (46) whose wall thickness is at least twice the wall thickness of the guide fixed groove (45), and the inner walls of the plurality of guide fixed grooves (45) are fixed in an annular array on the outer surface of the inner sleeve (42), and the bottom of the guide fixed groove (45) and the top of the guide movable groove (46) are both provided with bevels; A pressing block (47) adapted to the oblique opening is fixedly mounted on the bottom surface of the pressing rod (44), and the pressing block (47) and the oblique opening are in a semi-engaged state before each pressing. A guide block (48) is fixedly mounted on the outer surface of the pressure block (47) to prevent the pressure rod (44) from rotating in the circumferential direction. The inner side wall of the guide groove (45) is provided with a guide groove (49) that is slidably connected to the two side surfaces of the guide block (48).

7. The labelable cold-keeping antibody storage box according to claim 1, characterized in that: A box cover (6) is provided on the top of the upper box body (1), and a digital thermometer (61) is magnetically attracted to the side of the box cover (6) through a magnet, and a probe of the digital thermometer (61) is movably inserted into the center of the box cover (6).

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