Biopharmaceutical high-mixing-degree gas mixing device

Abstract

The utility model discloses a high-mixing-degree gas mixing device for biopharmacy, which is characterized in that bending quick connectors are arranged at two ends of a mixing column along the length direction of the mixing column, one end of the mixing column is connected with a static mixer, and the static mixer is arranged between the mixing column and the bending quick connectors; an air hole disc is arranged between the uniform mixing column and the static mixer, the first end of the air hole disc is tightly connected with the uniform mixing column through a sealing gasket, and the second end of the air hole disc is tightly connected with an adjacent bending quick connector through a conical connecting pipe; a gas mixing tank is formed in the static mixer, and a gas injection valve is movably connected to the gas mixing tank. According to the utility model, the static mixer is additionally arranged, and the fineness of split-flow gas and liquid is increased through the synergistic effect of the gas hole disc and the gas mixing pool arranged in the static mixer, so that the gas mixing effect of target liquid is stronger, and the gas mixing process of viscous fluid is effectively improved; in addition, the pore plate can eliminate large bubbles and buffer fluid to be fully and uniformly mixed, so that the gas mixing uniformity and reproducibility are improved.

Description

Technical Field

[0001] The utility model relates to a machine for uniformly mixing gas and liquid, in particular to a high-mixing-degree gas mixing device for biopharmaceuticals, belonging to the technical field of biopharmaceutical research and development and production. Background Art

[0002] Gas mixing devices are often used in biomedical research and development to mix the feed liquid in the cracking process. The mixing columns in existing gas mixing devices mostly use gas injection to mix the feed liquid. The gas is directly supplied to the mixing column, thereby using the rising gas to mix the liquid.

[0003] However, after long-term use, direct gas mixing in viscous fluids can lead to increased randomness in diffusion. Large bubbles rising and mixing alone, coupled with tumbling bubbles, can result in poor uniformity and reproducibility in liquid mixing. Therefore, it is necessary to develop a high-mixing gas mixing device for biopharmaceuticals to improve mixing uniformity and reproducibility. Summary of the Invention

[0004] The purpose of the present invention is to solve the above problems and provide a high-mixing gas mixing device for biopharmaceuticals to solve the problem of low liquid mixing due to tumbling of bubbles in the mixing column and improve the mixing processing performance.

[0005] The technical solution of the present utility model is a high-mixing gas mixing device for biopharmaceuticals, comprising a mixing column, each end of which is provided with a bend quick connector along its length, and a fastener is provided between the bend quick connector and the mixing column. The device is characterized in that one end of the mixing column is also connected to a static mixer, which is positioned between the mixing column and the bend quick connector via the fastener. A perforated disc is positioned between the mixing column and the static mixer, the first end of the perforated disc being tightly connected to the mixing column via a sealing gasket, and the second end of the perforated disc being tightly connected to the adjacent bend quick connector via a tapered connecting tube. An air mixing tank is formed within the static mixer, to which an air injection valve is movably connected.

[0006] Furthermore, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, a disk rim is provided on the periphery of the upper part of the air hole disk, a sleeve portion is provided on the lower part of the air hole disk, and a plurality of exhaust holes are provided in the center of the air hole disk.

[0007] Furthermore, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, a sealing groove for installing the sealing gasket is opened inside the disk edge.

[0008] Furthermore, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, a docking groove for clamping and fixing the tapered connecting tube is provided on the sleeve portion.

[0009] Furthermore, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, several of the exhaust holes are evenly distributed layer by layer in a circular shape, and the aperture of the inner layer exhaust holes is smaller than the aperture of the outer layer exhaust holes.

[0010] Preferably, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, the fastener is a hollow cylindrical pin, and a retaining member is connected to the outer side of the fastener.

[0011] Preferably, in the above-mentioned high-mixing degree gas mixing device for biopharmaceuticals, the bending quick connector is arranged in a snap-on ° bend.

[0012] By adopting the technical solution of the present invention, after the feed liquid enters the mixing column, gas is continuously and stably injected into the mixing column through the gas injection valve, and a static mixer is used to assist in mixing the feed liquid and the gas supply inside the mixing column. The fineness of the injected gas diversion is effectively controlled by the air hole disk, thereby eliminating large bubbles and improving the uniformity of bubble tumbling, so that the diffusion randomness of the gas-liquid mixture in the viscous fluid is effectively reduced, thereby maintaining the uniformity and reproducibility of the gas-liquid mixing.

[0013] Compared with the existing technology, after adopting the technical solution of the utility model, a static mixer is added, and the synergistic effect of the air hole disk and the air mixing pool inside the static mixer is used to increase the fineness of the diverted gas and liquid, so that the air mixing effect of the target liquid is stronger, the mixing efficiency is improved, and the air mixing effect of viscous fluids is effectively improved. The air hole disk eliminates large bubbles and buffers the fluid to fully mix, thereby improving the uniformity and reproducibility of air mixing.

[0014] In addition, the present invention is composed of a plurality of individual components and adopts modular assembly, and each component can be directly replaced, thus saving maintenance time. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a structural diagram of the utility model;

[0016] Figure 2 This is a side structural diagram of the present utility model;

[0017] Figure 3 for Figure 2 Schematic diagram of vertical section;

[0018] Figure 4 for Figure 2 (Schematic diagram of the transverse section of the stomata disc when viewed from above);

[0019] Figure 5 This is a schematic diagram of the main structure of the air hole disk of the utility model;

[0020] Figure 6AA is a schematic cross-sectional view of the air hole disk of the present invention;

[0021] Figure 7 This is a schematic diagram of the top view of the air hole disk of the utility model.

[0022] The meanings of the reference numerals in the figure are: 1-mixing column, 2-conical connecting pipe, 3-static mixer, 4-air hole disk, 41-disc edge, 42-sleeve connection part, 43-sealing groove, 44-docking groove, 45-exhaust hole, 5-sealing gasket, 6-air injection valve, 7-fastener, 8-bending quick connector, 9-locking piece. DETAILED DESCRIPTION

[0023] The following further illustrates the technical solution of the present invention with reference to the accompanying drawings to make it easier to understand and grasp. The components involved, such as the sealing gasket 5, the air injection valve 6, the fastener 7, and the retaining member 9, are commonly used components commonly known to those skilled in the art, and there are no special requirements for them in this application.

[0024] like Figures 1 to 4 As shown, the utility model provides a high-mixing degree gas mixing device for biopharmaceuticals, including a mixing column 1, wherein both ends of the mixing column 1 along its length direction are provided with bending quick connectors 8, and fasteners 7 are provided between the bending quick connectors 8 and the mixing column 1.

[0025] According to the technical solution of the present utility model, one end of the mixing column 1 is also connected to a static mixer 3, which is positioned between the mixing column 1 and the bend quick connector 8 via the fastener 7. A perforated disc 4 is positioned between the mixing column 1 and the static mixer 3. The first end of the perforated disc 4 is tightly connected to the mixing column 1 via a sealing gasket 5, and the second end of the perforated disc 4 is tightly connected to the adjacent bend quick connector 8 via a tapered connecting tube 2. The interior of the static mixer 3 forms an air mixing tank, which is movably connected to an air injection valve 6.

[0026] Preferably, if Figures 5 to 7 As shown, in the above structure: a disc edge 41 is provided on the periphery of the upper portion of the pore disc 4, a sleeve portion 42 is provided on the lower portion of the pore disc 4, and a plurality of exhaust holes 45 are provided in the center portion of the pore disc 4.

[0027] Specifically, in the structure of the above-mentioned air hole disk 4 , a sealing groove 43 is opened inside the disk edge 41 , and the sealing gasket 5 is installed through the sealing groove 43 .

[0028] Specifically, in the structure of the above-mentioned air hole disk 4 , a docking groove 44 is provided on the sleeve portion 42 , and the conical connecting pipe 2 is fixed by being clamped through the docking groove 44 .

[0029] More specifically, in the structure of the above-mentioned pore plate 4, several of the exhaust holes 45 are evenly distributed layer by layer in a circular shape, and the aperture of the inner layer exhaust holes 45 is smaller than the aperture of the outer layer exhaust holes 45. The evenly distributed exhaust holes 45 can effectively divert the fine density of gas and liquid, eliminate large bubbles and buffer the fluid to achieve sufficient mixing of gas and liquid.

[0030] Preferably, in the above structure: the fastener 7 is a hollow cylindrical pin, the hollow cylindrical pin has a simple structure, strong bearing capacity, good variable load and impact performance, and the outer side of the fastener 7 is connected to a locking piece 9, which can fix the installation position of the mixing column 1 through the locking piece 9, making it convenient for disassembly and assembly.

[0031] Preferably, in the above structure: the bending quick connector 8 is set in a 90° snap-on bending configuration. The snap-on configuration has a wide fastening surface, high firmness, and is not easy to fall off. Even if the mixed liquid pressure is large, it can withstand it, thereby ensuring the stability of the pipe connection; the bending quick connector 8 with a 90° bending design can reduce the bending of the hose to be connected in some special structures, continuously ensure unobstructed liquid transportation in the hose, and ensure the continuous and stable progress of the gas mixing operation.

[0032] In the technical solution of this utility model, the static mixer 3 with the air hole disk 4 is provided to assist the mixing column 1 in efficiently and evenly mixing the gas and liquid, which is the technical key of this case. Figure 3 The focus of the exhibition is on the relevant components involved in the gas mixing device. Figures 5 to 7 The detailed structure of the air-perforated disk 4 is shown. Based on actual process requirements, components of appropriate specifications (for example, matching specifications and models between the mixing column 1, air-perforated disk 4, and static mixer 3) can be directly selected to improve overall mixing efficiency. Components such as the sealing gasket 5, air injection valve 6, fastener 7, and retaining member 9 can be conventionally configured by a person skilled in the art based on existing techniques. This application does not impose any special requirements on their model selection or combination.

[0033] In this way, by adopting the technical solution of the present invention, after the feed liquid enters the mixing column 1, gas is continuously and stably injected into the mixing column 1 through the gas injection valve 6, and the static mixer 3 is used to assist in mixing the feed liquid and the gas supply inside the mixing column 1, and the fineness of the injected gas diversion is effectively controlled by the air hole disk 4, thereby eliminating large bubbles, improving the uniformity of bubble tumbling, and effectively reducing the diffusion randomness of the gas-liquid mixture in the viscous fluid, thereby maintaining the uniformity and reproducibility of the gas-liquid mixing.

[0034] From the above description, it can be found that compared with the existing technology, after adopting the technical solution of the utility model, a static mixer is added, and the synergistic effect of the air hole disk and the air mixing pool inside the static mixer is used to increase the fineness of the diverted gas and liquid, so that the air mixing effect of the target liquid is stronger, the mixing efficiency is improved, and the air mixing process of viscous fluids is effectively improved. The air hole disk is used to eliminate large bubbles and buffer the fluid to fully mix, thereby improving the uniformity and reproducibility of air mixing; moreover, the utility model is composed of multiple separate components and adopts modular assembly. Each component can be directly replaced, saving maintenance time.

[0035] The above describes the technical solution, working process and implementation effect of the utility model in detail. It should be noted that what is described is only a typical example of the utility model. In addition, the utility model can also have many other specific implementation methods. Any technical solution formed by equivalent replacement or equivalent transformation falls within the scope of protection required by the utility model.

Claims

1. A high-mixing gas mixing device for biopharmaceuticals, comprising a mixing column (1), wherein both ends of the mixing column (1) along the length direction are provided with bending quick connectors (8), characterized in that: A fastener (7) is provided between the bending quick connector (8) and the mixing column (1); wherein, one end of the mixing column (1) is also connected to a static mixer (3), and the static mixer (3) is provided between the mixing column (1) and the bending quick connector (8) through the fastener (7); an air hole disk (4) is provided between the mixing column (1) and the static mixer (3), the first end of the air hole disk (4) is tightly connected to the mixing column (1) through a sealing gasket (5), and the second end of the air hole disk (4) is tightly connected to the adjacent bending quick connector (8) through a conical connecting pipe (2); an air mixing pool is formed inside the static mixer (3), and an air injection valve (6) is movably connected to the air mixing pool.

2. A high-mixing gas mixing device for biopharmaceuticals according to claim 1, characterized in that: The upper periphery of the pore disk (4) is provided with a disk edge (41), the lower portion of the pore disk (4) is provided with a sleeve portion (42), and the central portion of the pore disk (4) is provided with a plurality of exhaust holes (45).

3. A high-mixing gas mixing device for biopharmaceuticals according to claim 2, characterized in that: A sealing groove (43) for installing the sealing gasket (5) is provided inside the disk rim (41).

4. The high-mixing gas mixing device for biopharmaceuticals according to claim 2, characterized in that: The sleeve portion (42) is provided with a docking groove (44) for clamping and fixing the tapered connecting pipe (2).

5. The high-mixing gas mixing device for biopharmaceuticals according to claim 2, characterized in that: The plurality of exhaust holes (45) are evenly distributed layer by layer in a circular shape, and the aperture of the exhaust holes (45) in the inner layer is smaller than the aperture of the exhaust holes (45) in the outer layer.

6. The high-mixing gas mixing device for biopharmaceuticals according to claim 1, characterized in that: The fastener (7) is a hollow cylindrical pin.

7. A high-mixing gas mixing device for biopharmaceuticals according to claim 1 or 6, characterized in that: The outer sides of the fasteners (7) are connected to latching pieces (9).

8. The high-mixing gas mixing device for biopharmaceuticals according to claim 1, characterized in that: The bending quick connector (8) is arranged in a snap-fit ​​90° bend.

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