Mass spectrometry system and chip target plate

Abstract

The utility model relates to a mass spectrum system and a chip target plate. A plurality of detection holes used for containing samples to be detected are formed in one side face of the chip target plate. If the number of the detection holes is larger than 96, the target plate is a large-flux chip target plate, the large-flux detection requirement is met, and the detection efficiency can be improved. Besides, the inner wall of each detection hole is a hydrophilic surface, and the area, except the detection holes, on the side surface is a hydrophobic layer, so that the holes are clear during sample preparation, the sample application amount is restrained, cross contamination between hole sites can be effectively avoided, the crystallization uniformity between the holes can be improved, and the nanoliter-level detection requirements of nucleic acid genes can be met; besides, on the premise that the surface area size of the chip target plate is not increased, the diameter D of each detection hole is effectively limited, the number of the detection holes can be increased as much as possible so as to realize large flux, and meanwhile, due to the fact that the distance S1 between every two adjacent detection holes is large enough, the holes are clear during sample preparation, and the crystallization uniformity between the holes is improved.

Description

Technical Field

[0001] The present application relates to the field of mass spectrometry detection technology, and in particular to a mass spectrometry system and a chip target plate. Background Art

[0002] Mass spectrometers include, but are not limited to, matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS), which consists of matrix-assisted laser desorption ionization and time-of-flight ion separation technology. Analyte molecules and organic acid substances (matrix) in a liquid solution system form co-crystals on a chip target plate. The chip target plate containing the matrix and analyte is first excited by a laser pulse in an ion source, and then the charge is indirectly transferred to the analyte molecules wrapped in the matrix, so that the analyte molecules become charged ions that fly in a linear flight tube without field. The detection and identification of different analyte ions are achieved by detecting the time when different ions arrive at the detector.

[0003] Nucleic acid mass spectrometry is the abbreviation for biological mass spectrometers when matrix-assisted laser desorption ionization time-of-flight mass spectrometry is applied to nucleic acid genetic testing. To implement a nucleic acid mass spectrometry detection platform, a chip target plate capable of simultaneously loading both the matrix and the analyte is required.

[0004] The development of chip target plates in related technologies is still immature, usually with a flux of 48 and 96. When the flux needs to be increased, for example, to achieve a flux of 384, in order to avoid mutual interference between detection holes and affect the detection quality, the surface size of the target plate needs to be increased proportionally. As a result, the detection operation cannot be completed in a detection chamber with unchanged volume size, and the user's demand for a large-throughput chip target plate cannot be met, that is, the detection efficiency cannot be improved. Summary of the Invention

[0005] Based on this, it is necessary to overcome the defects of the existing technology and provide a mass spectrometry system and chip target plate, which can achieve high throughput while ensuring the detection quality, thereby helping to improve the detection efficiency.

[0006] A chip target plate, wherein one side surface of the chip target plate is formed with multiple detection holes for installing samples to be tested, the inner walls of the detection holes are set as a hydrophilic surface, and the area outside the detection holes on the side surface is provided with a hydrophobic layer; the diameter D of the detection holes is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes is ≥ 1 mm.

[0007] In one embodiment, the number of the detection holes is greater than or equal to 96; the detection holes are arranged in a rectangular array with m columns and n rows; wherein 10≤m≤30, 10≤n≤30.

[0008] In one embodiment, the chip target plate is configured as a rectangular plate, the width of the chip target plate is 15 mm to 25 mm, and the length of the chip target plate is 25 mm to 35 mm.

[0009] In one embodiment, the distance S2 between the detection hole close to the edge of the chip target plate and the edge of the chip target plate is set to 1 mm to 3 mm.

[0010] In one embodiment, the inner wall of the detection hole is provided with a hydrophilic coating or a hydrophilic film layer, or the chip target plate is made of a hydrophilic material.

[0011] In one embodiment, the hydrophobic layer is configured as a hydrophobic coating layer or a hydrophobic film layer, or the chip target plate is made of a hydrophobic material.

[0012] In one embodiment, one side surface of the chip target plate is further formed with one or more calibration holes for installing standard samples.

[0013] In one embodiment, the calibration holes are arranged in sequence and at intervals in the middle part of the bottom of the chip target plate; the center line of each calibration hole is parallel to the bottom edge of the chip target plate; the spacing S3 between the calibration holes close to the side edge of the chip target plate and the side edge of the chip target plate is set to 6mm-9mm.

[0014] In one embodiment, a code and / or identifier is provided on the side of the chip target plate.

[0015] A mass spectrometry system comprises the chip target plate and a mass spectrometry detector. The chip target plate can be detachably placed in a detection chamber of the mass spectrometry detector.

[0016] The above-mentioned mass spectrometry system and chip target plate, since the inner wall of the detection hole is set as a hydrophilic surface and the area outside the detection hole on the side is set as a hydrophobic layer, can achieve clear pores during sample preparation, constrain the size of the sample spotting, fix and unify the crystal morphology, effectively avoid cross-contamination between the wells, effectively improve the uniformity of crystallization between the wells, and meet the nanoliter-level detection requirements of nucleic acid genes; in addition, the diameter D of the detection hole is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes is ≥ 1 mm. That is, under the premise that the surface area size of the chip target plate is not increased, the size of the diameter D of the detection hole is effectively limited, and the number of detection holes can be increased as much as possible to achieve high throughput, for example, to meet the scenario application of 384 matrix prefabrication. At the same time, because the spacing S1 between adjacent detection holes is large enough, it can further achieve clear pores during sample preparation, constrain the size of the sample spotting, fix and unify the crystal morphology, effectively avoid cross-contamination between the wells, and improve the uniformity of crystallization between the wells. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] Figure 1 This is a schematic structural diagram of a chip target plate according to an embodiment of the present application.

[0018] Figure 2 This is a diagram of the chip target plate in the naked eye after the spotting process is completed in one embodiment of the present application.

[0019] Figure 3 This is a schematic diagram of the crystallization state of six randomly selected points on a chip target plate observed under a microscope according to an embodiment of the present application.

[0020] 10. Chip target plate; 11. Detection hole; 12. Calibration hole; 13. Coding. DETAILED DESCRIPTION

[0021] To make the above-mentioned objects, features, and advantages of the present application more clearly understood, the specific embodiments of the present application are described in detail below with reference to the accompanying drawings. The following description sets forth many specific details to facilitate a full understanding of the present application. However, the present application can be implemented in many other ways than those described herein, and those skilled in the art can make similar improvements without violating the scope of the present application. Therefore, the present application is not limited to the specific embodiments disclosed below.

[0022] As described in the background technology, the chip target plate in the prior art cannot achieve a large flux, that is, it cannot achieve a flux greater than 96. The inventors have found that the reason for this problem is that when the number of detection holes is increased on the chip target plate with almost unchanged surface area, the spacing between adjacent detection holes will be reduced, resulting in mutual interference and contamination of samples in adjacent detection holes, and uneven crystallization of the hole positions of each detection hole.

[0023] Based on the above reasons, the present application provides a mass spectrometry system and chip target plate, which can achieve high throughput while ensuring detection quality, thereby being conducive to improving detection efficiency.

[0024] See Figure 1 , Figure 1 A schematic structural diagram of a chip target plate 10 according to an embodiment of the present application is shown. An embodiment of the present application provides a chip target plate 10, wherein a plurality of detection holes 11 for mounting samples to be tested are formed on one side surface of the chip target plate 10. Specifically, the number of detection holes 11 is greater than or equal to 96. The inner wall of the detection hole 11 is set as a hydrophilic surface, and the area outside the detection hole 11 on the side is provided with a hydrophobic layer. In addition, the diameter D of the detection hole 11 is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes 11 is ≥ 1 mm.

[0025] The above-mentioned chip target plate 10, since the number of detection holes 11 is greater than 96, is a high-throughput chip target plate 10, which meets the user's detection needs for high-throughput chip target plates 10, thereby improving the detection efficiency; in addition, since the inner wall of the detection hole 11 is set as a hydrophilic surface, the area outside the detection hole 11 on the side is set as a hydrophobic layer, so that the holes can be clearly distinguished during sample preparation, the size of the sample spotting amount can be restricted, the crystal morphology can be fixed and unified, and cross contamination between the holes can be effectively avoided. The uniformity of crystallization between the holes is effectively improved, and the detection needs of nucleic acid genes at the nanoliter level can be met; in addition, the detection hole The diameter D of the detection holes 11 is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes 11 is ≥ 1 mm. That is, under the premise that the surface area of ​​the chip target plate 10 does not increase, the size of the diameter D of the detection holes 11 is effectively limited, and the number of detection holes 11 can be increased as much as possible to achieve high throughput, for example, to meet the scenario application of 384 matrix prefabrication. At the same time, because the spacing S1 between adjacent detection holes 11 is large enough, it can further achieve clear pores during sample preparation, restrict the size of the sample spotting amount, fix and unify the crystal morphology, effectively avoid cross contamination between pores, and improve the uniformity of crystallization between pores.

[0026] See also Figure 1 In some embodiments, each detection hole 11 is formed on one side surface of the chip target plate 10 by various methods including but not limited to laser etching, liquid corrosion, tool milling, mold stamping, etc., and can be flexibly adjusted and set according to actual needs, which is not limited here.

[0027] See also Figure 1 In some embodiments, the detection hole 11 includes but is not limited to regular shapes such as circular holes, elliptical holes, polygonal holes, and other irregular shapes. Among them, the polygonal holes include but are not limited to triangles, quadrilaterals, pentagons, hexagons, etc.

[0028] See also Figure 1 In one embodiment, the detection holes 11 are arranged in a rectangular array with m columns and n rows, where 10≤m≤30 and 10≤n≤30. Thus, the number of detection holes 11 is between 100 and 900, meeting the requirements of high-throughput detection.

[0029] See also Figure 1 In some embodiments, m and n are independently set, including but not limited to various values ​​such as 10, 12, 15, 16, 18, 20, 22, 24, 25, 26, 28, and 30. In this embodiment, based on the actual application requirements of nucleic acid mass spectrometry, m is set to 16 and n is set to 24, that is, the chip target plate 10 is set to simultaneously meet the detection throughput of 384, thereby enabling the detection operation of 384 samples to be performed simultaneously.

[0030] See also Figure 1 In some embodiments, the chip target plate 10 includes but is not limited to regular-shaped plates such as polygonal plates, circular plates, or elliptical plates, as well as other irregular-shaped plates.

[0031] See also Figure 1 In a specific embodiment, the chip target plate 10 is a rectangular plate, and the width of the chip target plate 10 is 15 mm to 25 mm, specifically, for example, 15 mm, 18 mm, 20 mm, 22 mm, 25 mm, etc. In addition, the length of the chip target plate 10 is 25 mm to 35 mm, specifically, for example, 25 mm, 28 mm, 30 mm, 32 mm, 35 mm, etc.

[0032] See also Figure 1 In one embodiment, the distance S2 between the detection hole 11 near the edge of the chip target plate 10 and the edge of the chip target plate 10 is set to 1 mm to 3 mm. When the distance S2 is set within this range, the side surface of the chip target plate 10 can be fully and effectively utilized, while also avoiding the increased processing accuracy and difficulty of the chip target plate 10 caused by an excessively small distance S2, thereby facilitating mass production of the chip target plate 10.

[0033] Specifically, the spacing S2 includes, but is not limited to, various values ​​such as 1 mm, 1.5 mm, 2 mm, 2.5 mm, or 3 mm. Of course, the spacing S2 can also be set to any value greater than 3 mm or less than 1 mm according to actual needs. When the spacing S2 is greater than 3 mm, and the larger the value, the surface utilization rate of the chip target plate 10 will be reduced; when the spacing S2 is less than 1 mm, and the smaller the value, the processing accuracy requirements and processing difficulty of the chip target plate 10 will increase, and the chip target plate 10 will be easily scrapped.

[0034] In one embodiment, the inner wall of the detection hole 11 is provided with a hydrophilic coating or a hydrophilic film layer, or the chip target plate 10 is made of a hydrophilic material.

[0035] In some embodiments, when a hydrophilic coating is provided on the inner wall of the detection hole 11, the inner wall of the detection hole 11 can be set as a hydrophilic surface. The hydrophilic coating includes, but is not limited to, being provided on the inner wall of the detection hole 11 by various means such as adhesive fixation, 3D printing, and spraying.

[0036] In some embodiments, when a hydrophilic coating layer is provided on the inner wall of the detection hole 11 , the inner wall of the detection hole 11 can be set as a hydrophilic surface.

[0037] In some embodiments, when the chip target plate 10 is made of a hydrophilic material, the inner wall of the detection hole 11 can also be set as a hydrophilic surface.

[0038] In some embodiments, the inner wall surface of the detection hole 11 is subjected to a hydrophilic treatment, which can also achieve the inner wall of the detection hole 11 being set as a hydrophilic surface.

[0039] In one embodiment, the hydrophobic layer is configured as a hydrophobic coating layer or a hydrophobic film layer, or the chip target plate 10 is made of a hydrophobic material.

[0040] In some embodiments, when the hydrophobic layer is configured as a hydrophobic coating, the hydrophobic coating is disposed on the surface of the chip target plate 10 in various ways including but not limited to bonding, 3D printing, and spraying.

[0041] In some embodiments, when the hydrophobic layer is configured as a hydrophobic coating layer, the hydrophobic coating layer is, for example, formed by coating on the surface of the chip target plate 10 .

[0042] In some embodiments, when the chip target plate 10 is made of a hydrophobic material, the hydrophobic coating layer and the chip target plate 10 are configured as an integrated structure, for example.

[0043] The hydrophobic material includes but is not limited to at least one selected from wax, polydimethylsiloxane, polystyrene, alkyl ketene dimer, polymethacrylate and photoresist.

[0044] See also Figure 1 In one embodiment, one or more calibration holes 12 for receiving standard samples are formed on one side of the chip target plate 10. Thus, before the mass spectrometer performs a detection and analysis step on the sample to be tested, the standard sample disposed in the calibration hole 12 is used to sample and test the standard sample in the calibration hole 12, thereby calibrating the mass spectrometer and improving the detection accuracy of the sample to be tested. This provides a mass calibration function.

[0045] The content of each component of the standard sample is known, and the mass spectrometer detects the standard sample and automatically calibrates according to the detection results.

[0046] The number of calibration holes 12 includes, but is not limited to, one, two, three, five, or other numbers. A greater number of calibration holes 12, i.e., repeated sampling and testing of the standard sample, can improve calibration accuracy and provide a more reliable reference. In this embodiment, the number of calibration holes 12 is, for example, five, and each calibration hole 12 is arranged on the chip target plate 10 at equal or unequal intervals.

[0047] See also Figure 1In one embodiment, the calibration holes 12 are sequentially spaced apart in the middle of the bottom of the chip target plate 10. The center line of the calibration holes 12 is parallel to the bottom edge of the chip target plate 10. The spacing S3 between the calibration holes 12 near the side edge of the chip target plate 10 and the side edge of the chip target plate 10 is set to 6 mm to 9 mm.

[0048] See also Figure 1 In some embodiments, the calibration hole 12 includes, but is not limited to, regular shapes such as a circular hole, an elliptical hole, a polygonal hole, and other irregular shapes. Polygonal holes include, but are not limited to, triangles, quadrilaterals, pentagons, hexagons, and the like. Specifically, the calibration hole 12 has the same shape and size as the detection hole 11, and both are, for example, circular holes.

[0049] See also Figure 1 In some embodiments, the spacing between two adjacent calibration holes 12 is set, for example, with reference to the spacing between two adjacent detection holes 11. The sizes of the two are specifically the same, but of course they can also be different. They can be flexibly adjusted and set according to actual needs.

[0050] See also Figure 1 In a specific embodiment, the detection holes 11 are arranged in a rectangular array of 16 columns and 24 rows, and the calibration holes 12 are arranged in a row of 5 holes at the bottom of the rectangular array. In addition, the spacing S1 between two adjacent columns of detection holes 11 and the spacing S1 between two adjacent rows of detection holes 11 are both set to 1 mm, for example. In addition, the spacing S2 between the detection holes 11 in the first row from top to bottom and the top edge of the chip target plate 10 is, for example, 1.5 mm, and the spacing S2 between the detection holes 11 in the first row from left to right and the left edge of the chip target plate 10 is, for example, 1.5 mm. In addition, the spacing S3 between the calibration holes 12 close to the left edge of the chip target plate 10 and the left edge of the chip target plate 10 is, for example, 7.5 mm, and the spacing S3 between the calibration holes 12 close to the right edge of the chip target plate 10 and the right edge of the chip target plate 10 is, for example, 7.5 mm.

[0051] See also Figure 1 In one embodiment, a code 13 and / or a marker is provided on the side of the chip target plate 10. Thus, the code 13 and / or the marker can be used to trace the chip target plate 10 and quickly obtain various information about the chip target plate 10, including but not limited to the number, diameter, spacing S1, spacing S2, spacing S3 of the detection holes 11, the type and quantity of the standard samples, the production date, the manufacturer, and the production batch.

[0052] The code 13 includes but is not limited to a QR code, a digital code 13, a barcode 13, etc. The identifier includes but is not limited to a text identifier, a pattern identifier, a digital identifier, a trademark identifier, etc.

[0053] See also Figures 1 to 3 , using a spotting device to pre-form the matrix on Figure 1 On the chip target plate 10 of the 384+5 specification shown, the sample volume is controlled to be 0.09 μL, and under the microscope, each well position is observed to have a uniform and full matrix point with a size and crystal morphology consistency of more than 98%. Figure 2 The morphological structure diagram of the chip target plate 10 in the naked eye state after the spotting procedure is completed is shown. Figure 3 The figure shows the crystallization state of six randomly selected points on the chip target plate 10 observed under a microscope.

[0054] See also Figures 1 to 3 In one embodiment, a mass spectrometry system includes the chip target plate 10 of any of the above embodiments and a mass spectrometry detector. The chip target plate 10 can be detachably placed in a detection chamber of the mass spectrometry detector.

[0055] The above-mentioned mass spectrometry system, since the number of detection holes 11 is greater than 96, that is, a high-throughput chip target plate 10, meets the user's detection needs for a high-throughput chip target plate 10, thereby improving the detection efficiency; in addition, since the inner wall of the detection hole 11 is set as a hydrophilic surface, and the area outside the detection hole 11 on the side is set as a hydrophobic layer, it can achieve clear pores during sample preparation, restrict the size of the sample spot, fix and unify the crystal morphology, effectively avoid cross-contamination between pores, effectively improve the uniformity of crystallization between pores, and meet the detection needs of nucleic acid genes at the nanoliter level; in addition, the detection hole 1 The diameter D of the detection holes 11 is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes 11 is ≥ 1 mm. That is, under the premise that the surface area of ​​the chip target plate 10 does not increase, the size of the diameter D of the detection holes 11 is effectively limited, and the number of detection holes 11 can be increased as much as possible to achieve high throughput, for example, to meet the scenario application of 384 matrix prefabrication. At the same time, because the spacing S1 between adjacent detection holes 11 is large enough, it can further achieve clear pores during sample preparation, restrict the size of the sample spotting amount, fix and unify the crystal morphology, effectively avoid cross contamination between pores, and improve the uniformity of crystallization between pores.

[0056] In the description of this application, it should be understood that if the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential", etc. appear, the orientation or position relationship indicated by these terms is based on the orientation or position relationship shown in the accompanying drawings, which is only for the convenience of describing this application and simplifying the description, and does not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on this application.

[0057] In addition, if the terms "first" or "second" appear, these terms are used for descriptive purposes only and should not be understood to indicate or imply relative importance or implicitly specify the number of technical features indicated. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include at least one of such features. In the description of this application, if the term "plurality" appears, "plurality" means at least two, for example, two, three, etc., unless otherwise specifically defined.

[0058] In this application, unless otherwise specified or limited, the terms "mounted," "connected," "connected," "fixed," etc., should be interpreted broadly. For example, these terms may refer to fixed connections, removable connections, or integration; mechanical connections or electrical connections; direct connections or indirect connections through an intermediary; and internal communication between two components or interaction between two components, unless otherwise specified. Those skilled in the art will understand the specific meanings of these terms in this application based on the specific circumstances.

[0059] In this application, unless otherwise expressly specified or limited, if a first feature is described as being "above" or "below" a second feature, or similar descriptions, this may mean that the first and second features are in direct contact, or that the first and second features are in indirect contact through an intermediate medium. Furthermore, when a first feature is described as being "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is described as being "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0060] It should be noted that if an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. If an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. If any, the terms "vertical", "horizontal", "upper", "lower", "left", "right" and similar expressions used in this application are for illustrative purposes only and do not represent the only embodiment.

[0061] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0062] The above-described embodiments merely represent several implementation methods of the present application. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the patent application. It should be noted that a person of ordinary skill in the art may make various modifications and improvements without departing from the spirit of the present application, and these modifications and improvements fall within the scope of protection of the present application. Therefore, the scope of protection of the present patent application shall be determined by the appended claims.

Claims

1. A chip target plate, characterized in that: A plurality of detection holes for mounting samples to be tested are formed on one side surface of the chip target plate, the inner wall of the detection hole is set as a hydrophilic surface, and the area outside the detection hole on the side is provided with a hydrophobic layer; the diameter D of the detection hole is ≤ 0.5 mm, and the spacing S1 between adjacent detection holes is ≥ 1 mm; a code and / or identifier is provided on the side surface of the chip target plate; wherein, the inner wall of the detection hole is provided with a hydrophilic coating or a hydrophilic coating layer, and the chip target plate is made of a hydrophobic material; or, the chip target plate is made of a hydrophilic material, and the hydrophobic layer is set as a hydrophobic coating or a hydrophobic coating layer.

2. The chip target plate according to claim 1, characterized in that: The number of the detection holes is greater than or equal to 96; the detection holes are arranged in a rectangular array with m columns and n rows; wherein 10≤m≤30, 10≤n≤30.

3. The chip target plate according to claim 2, characterized in that: The chip target plate is configured as a rectangular plate, the width of the chip target plate is 15 mm to 25 mm, and the length of the chip target plate is 25 mm to 35 mm.

4. The chip target plate according to claim 3, characterized in that: The distance S2 between the detection hole close to the edge of the chip target plate and the edge of the chip target plate is set to 1 mm to 3 mm.

5. The chip target plate according to claim 1, characterized in that: The hydrophilic coating is bonded, 3D printed, or sprayed onto the inner wall of the detection hole; or, the hydrophilic coating layer is formed by plating on the inner wall of the detection hole.

6. The chip target plate according to claim 1, characterized in that: The hydrophobic coating is bonded, 3D printed, or sprayed on the surface of the chip target plate; or, the hydrophobic coating layer is formed on the surface of the chip target plate by plating.

7. The chip target plate according to claim 1, characterized in that: One or more calibration holes for installing standard samples are also formed on one side surface of the chip target plate.

8. The chip target plate according to claim 7, characterized in that: The calibration holes are sequentially and spaced apart in the middle of the bottom of the chip target plate.

9. The chip target plate according to claim 8, characterized in that: The center line of each calibration hole is parallel to the bottom edge of the chip target plate; the spacing S3 between the calibration hole close to the side edge of the chip target plate and the side edge of the chip target plate is set to 6mm-9mm.

10. A mass spectrometry system, characterized in that The mass spectrometry system includes the chip target plate according to any one of claims 1 to 9, and also includes a mass spectrometry detector, and the chip target plate can be detachably placed in a detection chamber of the mass spectrometry detector.

Images