Filtering equipment for doxorubicin hydrochloride liposome injection

Abstract

The utility model relates to filtering equipment for doxorubicin hydrochloride lipidosome injection, which belongs to the technical field of filtering equipment and comprises a filtering shell, a sealing cover is attached to the upper end face of the filtering shell, a driving shaft is rotatably connected to the center of the inside of the sealing cover, a first scraping plate and a second scraping plate are connected to the outer wall of the driving shaft, and the first scraping plate and the second scraping plate are arranged on the outer wall of the driving shaft. The lower end of the driving shaft is fixedly connected with a connecting plate, and the tail end of the connecting plate is fixedly connected with a cleaning rod. The filter has the advantages that the filter frame is connected with the positioning rods on the supporting plate in a clamped mode through the positioning grooves, the sealing cover is directly detached when the filter needs to be detached, the filter frame in the filter can be directly taken, and when the filter frame needs to be replaced or cleaned, only the sealing cover needs to be detached, so that the filter can be replaced or cleaned. The filter frame can be easily taken out from the equipment without disassembling other complex parts, so that the operation time is greatly saved, the working efficiency is improved, the operation process becomes simple and visual, and the operation difficulty is reduced.

Description

Technical Field

[0001] The utility model relates to the technical field of filtering equipment, in particular to filtering equipment for doxorubicin hydrochloride liposome injection. Background Art

[0002] Injectable solutions refer to sterile solutions of drugs for injection into the body, as well as sterile powders or concentrated solutions for preparation into solutions or suspensions prior to use. Doxorubicin hydrochloride liposome injection is a type of injectable solution. It is a liposome preparation in which doxorubicin hydrochloride is encapsulated in liposomes containing methoxypolyethylene glycol on the surface. This process is called pegylation, which protects the liposomes from recognition by the mononuclear phagocyte system, thereby prolonging their circulation. During production, the injectable solution requires the use of a filtration device for extraction and storage.

[0003] Traditional filtration equipment usually uses a single-layer filter plate for filtration. Although this design can remove impurities to a certain extent, due to the fixed filter pore size, the filtration effect on impurity particles of different sizes is limited. In particular, for the removal of small particle impurities, a single-layer filter plate often cannot achieve the ideal filtration effect, resulting in the injection solution still containing a large number of particles, and easily causing the filter plate to be clogged during filtration, affecting the filtration effect. Since the filter plate is usually fixed inside the equipment, the entire equipment or complex components need to be disassembled for cleaning, which not only increases the difficulty of operation, but may also cause damage to the equipment or affect the filtration effect. In response to the above situation, we have launched a filtration equipment for doxorubicin hydrochloride liposome injection. Utility Model Content

[0004] The purpose of the utility model is to provide a filtering device for doxorubicin hydrochloride liposome injection to solve the problem of low filtering effect proposed in the above background technology.

[0005] The technical solution of the utility model is:

[0006] A filter housing, wherein the upper end surface of the filter housing is fitted with a sealing cover, a drive shaft is rotatably connected to the inner center of the sealing cover, a first scraper and a second scraper are connected to the outer wall of the drive shaft, a connecting plate is fixedly connected to the lower end of the drive shaft, and a cleaning rod is fixedly connected to the end of the connecting plate;

[0007] The inner wall of the filter housing is fixedly connected to a support plate, the upper end surface of the support plate is fixedly connected to a positioning rod, and the upper end surface of the support plate is fitly connected to a filter frame, the inner wall of the filter frame is fixedly connected to a first filter plate, and the inner wall of the filter frame is provided with a second filter plate above the first filter plate.

[0008] Furthermore, the first scraper is located on the upper end surface of the first filter plate, and the second scraper is located on the lower end surface of the first filter plate, and the first scraper and the second scraper are gear-shaped structures.

[0009] The driving shaft rotates through the rocker to rotate the first scraper and the second scraper, and the gear-shaped first scraper and the second scraper are respectively attached to the upper and lower surfaces of the first filter plate, which can more comprehensively scrape off impurities or residues on the surface of the filter plate during rotation to avoid blockage.

[0010] Furthermore, a discharge port is provided at the lower end of the filter housing, and the cleaning rod is located at and closely connected to the inner wall of the discharge port.

[0011] The cleaning rod rotates along the inner wall of the discharge port, which can effectively remove the material attached to the inner wall, ensure the thoroughness of the cleaning, prevent the material from accumulating or forming a blockage in the discharge port, and avoid production interruption or reduced production efficiency due to material blockage.

[0012] The present invention provides a filtering device for doxorubicin hydrochloride liposome injection through improvement, which has the following improvements and advantages compared with the prior art:

[0013] First: In the present invention, the filter holes of the second filter plate are larger than those of the first filter plate, so that the second filter plate removes large particles of impurities first, and the first filter plate can focus more on removing smaller and more difficult-to-handle particles in the subsequent filtering process, thereby improving the efficiency of the entire filtering process. The first scraper and the second scraper with a gear-shaped structure are respectively attached to the upper and lower surfaces of the first filter plate, which can more comprehensively scrape off impurities or residues on the surface of the filter plate during rotation to avoid blockage. When the drive shaft rotates, it drives the connecting plate and the cleaning rod to rotate, and then the cleaning rod rotates along the inner wall of the discharge port, which can effectively remove materials attached to the inner wall, ensure the thoroughness of cleaning, prevent materials from accumulating or forming blockages in the discharge port, and avoid production interruptions or reduced production efficiency due to material blockage.

[0014] Secondly, in the present invention, the filter frame is connected to the positioning rod on the support plate through the positioning groove. When disassembly is required, the sealing cover is directly removed and the internal filter frame can be directly taken out. When the filter frame needs to be replaced or cleaned, only the sealing cover needs to be removed to easily remove the filter frame from the equipment without the need to disassemble other complex components, which greatly saves operation time, improves work efficiency, makes the operation process simple and intuitive, and reduces the difficulty of operation. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] The present invention will be further explained below in conjunction with the accompanying drawings and Examples:

[0016] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0017] Figure 2 This is a schematic diagram of the internal connection structure of the filter housing of the utility model;

[0018] Figure 3 It is a schematic diagram of the connection structure of the filter frame of the utility model.

[0019] Explanation of the accompanying drawings: 1. Filter housing; 2. Sealing cover; 201. Drive shaft; 202. First scraper; 203. Second scraper; 204. Connecting plate; 205. Cleaning rod; 3. Discharge port; 4. Support plate; 401. Positioning rod; 402. Filter frame; 403. First filter plate; 404. Positioning groove; 5. First locking block; 6. Threaded bolt; 7. Second locking block; 8. Rocker; 9. Feed port; 10. Second filter plate. DETAILED DESCRIPTION

[0020] The following will be combined with the Figures 1 to 3 This utility model is described in detail, and the technical solutions in the embodiments of this utility model are clearly and completely described. Obviously, the embodiments described are only some of the embodiments of this utility model, not all of them. Based on the embodiments of this utility model, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this utility model.

[0021] The utility model provides a filtering device for doxorubicin hydrochloride liposome injection through improvement. Figure 1-Figure 3 As shown, it includes a filter housing 1, the upper end surface of the filter housing 1 is attached to a sealing cover 2, the inner center of the sealing cover 2 is rotatably connected to a drive shaft 201, the outer wall of the drive shaft 201 is connected to a first scraper 202 and a second scraper 203, the lower end of the drive shaft 201 is fixedly connected to a connecting plate 204, and the end of the connecting plate 204 is fixedly connected to a cleaning rod 205;

[0022] The inner wall of the filter housing 1 is fixedly connected to a support plate 4, the upper end surface of the support plate 4 is fixedly connected to a positioning rod 401, and the upper end surface of the support plate 4 is fittedly connected to a filter frame 402, and the inner wall of the filter frame 402 is fixedly connected to a first filter plate 403, and the inner wall of the filter frame 402 is located above the first filter plate 403 and is provided with a second filter plate 10, the filter hole of the second filter plate 10 is larger than the first filter plate 403, the first scraper 202 is located on the upper end surface of the first filter plate 403, and the second scraper 203 is located on the lower end surface of the first filter plate 403, and the first scraper 202 and the second scraper 203 are gear-shaped structures, and the lower end surface of the filter frame 402 is provided with a positioning groove 404 that is engaged with the positioning rod 401.

[0023] In this embodiment, the filter housing 1 injects the doxorubicin hydrochloride liposome injection, and then passes through the second filter plate 10 inside the filter frame 402 to perform the first step of filtration, and then passes through the first filter plate 403 again. Since the filter pores of the second filter plate 10 are larger than those of the first filter plate 403, the second filter plate 10 removes large particles of impurities first, and the first filter plate 403 can focus more on removing smaller and more difficult-to-process particles in the subsequent filtration process, thereby improving the efficiency of the entire filtration process. The pre-filtration of the second filter plate 10 can ensure that the impurities are not contaminated. The first filter plate 403 is protected from direct impact by large particles of impurities, thereby extending its service life. The driving shaft 201 is rotated through the rocker 8 to realize the rotation of the first scraper 202 and the second scraper 203. The first scraper 202 and the second scraper 203 of the gear-shaped structure are respectively attached to the upper and lower surfaces of the first filter plate 403, which can more comprehensively scrape impurities or residues on the surface of the filter plate during the rotation process to avoid clogging. The gear-shaped structure can provide a more uniform scraping force, reduce the possibility of missed scraping, and thus improve the overall The efficiency of the filtration process and the rotation of the scraper driven by the rocker 8 are relatively simple to operate, do not require complex mechanical structures or maintenance processes, and help reduce the difficulty of operation and maintenance costs. When the drive shaft 201 rotates, it drives the connecting plate 204 and the cleaning rod 205 to rotate, and then the cleaning rod 205 rotates along the inner wall of the discharge port 3, which can effectively remove the material attached to the inner wall, ensure the thoroughness of the cleaning, prevent the material from accumulating or forming a blockage in the discharge port 3, and avoid the production interruption or reduction of production efficiency caused by material blockage. Finally, the filter frame 402 is connected to the positioning rod 401 on the support plate 4 through the positioning groove 404. When it needs to be disassembled, the sealing cover 2 is directly removed, and the internal filter frame 402 can be directly taken out. When the filter frame 402 needs to be replaced or cleaned, only the sealing cover 2 needs to be removed, and the filter frame 402 can be easily removed from the equipment without removing other complex components, which greatly saves operation time and improves work efficiency. The operation process becomes simple and intuitive, and the operation difficulty is reduced.

[0024] In a preferred embodiment, a rocker 8 is provided at the top of the drive shaft 201, and a feed port 9 is provided on one side of the rocker 8 at the upper end of the sealing cover 2. The rotation of the scraper is driven by the rocker 8. The operation is relatively simple and does not require a complex mechanical structure or maintenance process, which helps to reduce the difficulty of operation and maintenance costs. The feed port 9 is used for the entry of the injection liquid.

[0025] In a preferred embodiment, a discharge port 3 is provided at the lower end of the filter housing 1, and the cleaning rod 205 is located in close contact with the inner wall of the discharge port 3. The cleaning rod 205 rotates along the inner wall of the discharge port 3, which can effectively remove the material attached to the inner wall, ensure the thoroughness of the cleaning, prevent the material from accumulating or forming a blockage in the discharge port 3, and avoid production interruption or reduced production efficiency due to material blockage.

[0026] In a preferred embodiment, a second locking block 7 is fixedly connected to the opening of the outer wall of the filter housing 1, and a first locking block 5 is fixedly connected to the outer wall of the sealing cover 2. A threaded bolt 6 is provided inside the first locking block 5. The sealing cover 2 is attached to the second locking block 7 through the first locking block 5, and the threaded bolt 6 is rotated to achieve the installation and disassembly of the sealing cover 2.

[0027] The above description of the disclosed embodiments will enable one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be readily apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention is not limited to the embodiments shown herein but is intended to conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A filtration device for doxorubicin hydrochloride liposome injection, characterized in that: The invention comprises a filter housing (1), wherein the upper end surface of the filter housing (1) is fitted with a sealing cover (2), a driving shaft (201) is rotatably connected to the inner center of the sealing cover (2), a first scraper (202) and a second scraper (203) are connected to the outer wall of the driving shaft (201), a connecting plate (204) is fixedly connected to the lower end of the driving shaft (201), and a cleaning rod (205) is fixedly connected to the end of the connecting plate (204); The inner wall of the filter housing (1) is fixedly connected to a support plate (4), the upper end surface of the support plate (4) is fixedly connected to a positioning rod (401), and the upper end surface of the support plate (4) is fittedly connected to a filter frame (402), the inner wall of the filter frame (402) is fixedly connected to a first filter plate (403), and the inner wall of the filter frame (402) is provided with a second filter plate (10) above the first filter plate (403).

2. A filtering device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: A discharge port (3) is provided at the lower end of the filter housing (1), and the cleaning rod (205) is located and is closely connected to the inner wall of the discharge port (3).

3. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: The lower end surface of the filter frame (402) is provided with a positioning groove (404) which is snap-connected with the positioning rod (401).

4. The filtration device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: The first scraper (202) is located on the upper end surface of the first filter plate (403), and the second scraper (203) is located on the lower end surface of the first filter plate (403), and the first scraper (202) and the second scraper (203) are gear-shaped structures.

5. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: The filter holes of the second filter plate (10) are larger than those of the first filter plate (403).

6. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: A rocker (8) is provided at the top end of the driving shaft (201), and a feed port (9) is provided on one side of the rocker (8) at the upper end of the sealing cover (2).

7. The filtering device for doxorubicin hydrochloride liposome injection according to claim 1, characterized in that: A second locking block (7) is fixedly connected to the opening of the outer wall of the filter housing (1), and a first locking block (5) is fixedly connected to the outer wall of the sealing cover (2). A threaded bolt (6) is provided inside the first locking block (5).

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