Hollow ion selective electrode based on single electrode structure

Abstract

The utility model provides a hollow ion selective electrode based on a single electrode structure, which comprises a substrate, and a first hollow hole penetrating through the substrate and a front conductive circuit are arranged on the front surface of the substrate; a back conductive circuit, a selective electrode patch and a conductive adhesive tape are arranged on the back of the substrate, and the front conductive circuit (2) is connected with the back conductive circuit (4); the selective electrode patch (42) is tightly attached to the substrate and completely covers the first hollowed-out hole (1), and the conductive adhesive tape (43) is arranged on the selective electrode patch (42), fixes the selective electrode patch (42) to the back face of the substrate and makes contact with the back face conductive circuit (4) for conduction. According to the utility model, the detection performance of the electrode is ensured, the electrode is more flexible, and the processing and use cost is reduced.

Description

Technical Field

[0001] The utility model belongs to the field of electrochemical sensors and relates to a hollow ion selective electrode based on a single electrode structure. Background Art

[0002] Electrodes are the most important sensitive components of electrochemical sensors. For ease of use, portable electrodes are provided in the prior art. These electrodes are provided on a substrate for rapid detection of biochemical molecules. The electrodes are then plugged into an analyzer interface to obtain analysis results.

[0003] The working electrode modification layer of existing portable electrodes is fixed and cannot be replaced according to the detection target. Therefore, it may cause waste during use and cause some inconvenience in the specific use of the electrode. At the same time, modifying different modification layers on the electrode surface also brings difficulties to the electrode repair and processing. The electrode processing cost is high and there are also some inconveniences in use.

[0004] All existing electrode technical solutions propose to separate the key working electrode modification layer and perform subsequent gluing and installation according to the requirements of the detection molecules. However, there are still tiny gaps in the later installed structure. When the detection liquid droplets are added to the electrode modification hole position and react with the electrode modification layer in contact, the tiny gaps between the electrode modification layer and the back of the substrate cause the electrode detection area to change and become unable to be fixed, thereby greatly affecting the stability and accuracy of the detection data; in order to transmit the electrical signal generated by the electrode patch, a ring-shaped conductive structure is set in the contact area between the electrode patch and the electrode substrate, and the electrical signal is transmitted to the electrode pin by the ring structure. The effect of this ring structure in conducting electricity and transmitting signals is also not good, which affects the sensitivity of the electrode.

[0005] In order to further overcome the above problems, this patent aims to provide a hollow hole electrode that can be freely assembled with selective electrode patches according to the requirements of the detection object, and the area of ​​the electrode detection area is fixed to ensure the accuracy and stability of the detection. Utility Model Content

[0006] In summary, the present invention provides a hollow ion-selective electrode based on a single-electrode structure, which can ensure the electrode detection performance while being more flexible, reducing processing and use costs, and opening up broader application prospects for microelectrodes.

[0007] The purpose of the utility model is to provide a hollow ion-selective electrode based on a single-electrode structure, comprising a substrate, wherein the front side of the substrate is provided with a first hollow hole penetrating the substrate and a front conductive circuit; the back side of the substrate is provided with a back conductive circuit, a selective electrode patch and a conductive tape, and the front conductive circuit is connected to the back conductive circuit; the selective electrode patch is tightly attached to the substrate and completely covers the first hollow hole, and the conductive tape is arranged on the selective electrode patch, fixing the selective electrode patch to the back side of the substrate and contacting and conducting with the back conductive circuit.

[0008] In one embodiment, the front conductive circuit partially overlaps with the back conductive circuit in the projection direction, and the front conductive circuit is provided with a plurality of conductive holes penetrating the substrate to connect the front conductive circuit with the back conductive circuit.

[0009] In one embodiment, an insulating double-sided tape is further included, and the insulating double-sided tape is attached between the selective electrode patch and the substrate. The insulating double-sided tape is provided with a second hollow hole in the projection direction of the first hollow hole.

[0010] In one embodiment, the shape of the first hollow hole is a geometric shape, such as a circle.

[0011] In one embodiment, one or more vias are provided on the front conductive circuit, and the front conductive circuit is interconnected with the back conductive circuit through the vias.

[0012] In one embodiment, the front conductive circuit includes a circuit end and a pin end connected to each other, and the pin end extends toward an edge of the substrate.

[0013] In one embodiment, the surface-modified metal layer of the front conductive circuit, the electrode detection layer, and the back conductive circuit serves as a base metal, and the metal type includes silver.

[0014] In one embodiment, the second hollow hole on the insulating double-sided tape is concentrically arranged with the first hollow hole.

[0015] In one embodiment, the conductive tape completely covers the selective electrode patch and the conductive hole.

[0016] In one embodiment, the material of the selective electrode patch includes at least one or more of carbon and metal, and the metal material includes gold, silver, platinum, bismuth, chromium, copper, and nickel.

[0017] The beneficial effects of the utility model are:

[0018] (1) The utility model digs a hole in the core detection area to form a first hollow hole, and splits the working electrode into components, which are then installed as independent electrode patches. In order to avoid the electrode patch directly contacting the back substrate to produce a tiny gap, which in turn causes the detection liquid to overflow and the electrode reaction area to change and affect the detection accuracy, an insulating double-sided tape is used to fix the inside and fill the gap, and then a conductive tape is used to fix the outside for a second time to achieve electrical signal transmission at the same time, thereby ensuring the sensitivity and accuracy of the electrode and solving the stability problem of the patch electrode.

[0019] (2) The present invention achieves the purpose of selecting different electrode modification layers according to the characteristics of the detection target by setting the core detection area of ​​the working electrode as an independent electrode patch that can be freely replaced and selected. At the same time, the material and modification layer of the independent electrode patch serving as the core detection layer can be freely replaced and used immediately after replacement, making the selection of electrode patches more diverse and achieving the purpose of detecting a variety of different biochemical molecules by replacing the electrode patch. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] The utility model is further described with reference to the accompanying drawings, but the embodiments in the accompanying drawings do not constitute any limitation to the utility model. A person skilled in the art can obtain other drawings based on the following drawings without creative work.

[0021] Figure 1 This is a front view schematic diagram of a hollow ion selective electrode based on a single electrode structure of the present invention;

[0022] Figure 2 This is a schematic diagram of the back of a hollow ion selective electrode based on a single electrode structure in this utility model. Figure 1 ;

[0023] Figure 3 This is a schematic diagram of the back of a hollow ion selective electrode based on a single electrode structure in this utility model. Figure 2 ;

[0024] Figure 4 This is a schematic diagram of the back of a hollow ion selective electrode based on a single electrode structure in this utility model. Figure 3 ;

[0025] Figure 5 This is a schematic diagram of the side structure of a hollow ion-selective electrode based on a single-electrode structure of the utility model.

[0026] Legend:

[0027] 1. First hollow hole; 2. Front conductive circuit; 22. Circuit end; 23. Pin end; 24. Through hole; 3. Back conductive circuit; 41. Insulating double-sided tape; 42. Selective electrode patch; 43. Conductive tape. DETAILED DESCRIPTION

[0028] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention will be further described in detail with reference to the following specific embodiments and the accompanying drawings.

[0029] The following is attached with the instruction manual Figure 1 -Attached Figure 5 Several examples are given to describe exemplary implementations of the present application. It should be noted that the following application scenarios are only provided to facilitate understanding of the spirit and principles of the present application, and the implementations of the present application are not limited in this respect. On the contrary, the implementations of the present application can be applied to any applicable scenario.

[0030] Example 1

[0031] As attached Figure 1 The figure shows a hollow ion-selective electrode based on a single-electrode structure provided by the present invention, comprising a PET plate electrode substrate with electrode dimensions of 12 x 35 mm and a thickness of 0.35 mm. The substrate can be made of a flexible polymer material, or conventional electrode materials such as epoxy resin, ceramic, silicon, and glass.

[0032] The front side of the substrate is provided with a first hollow hole 1 and a front conductive circuit 2 that passes through the substrate; the back side of the substrate is provided with a back conductive circuit 3, a selective electrode patch 42 and a conductive tape 43, and the front conductive circuit 2 is connected to the back conductive circuit 3; the selective electrode patch 42 is tightly attached to the substrate and completely covers the first hollow hole 1, and the conductive tape 43 is arranged on the selective electrode patch 42, fixing the selective electrode patch 42 to the back side of the substrate and contacting and conducting with the back conductive circuit 3.

[0033] This application separates the working electrode into a separate component, and the electrode patch can be processed or selected separately. The process is simpler and more convenient, and more types of modification and processing can be performed. More targets can be detected, and more targeted selections can be made according to different targets, which greatly expands the electrode detection range and detection methods.

[0034] Specifically, in order to tightly fix the electrode patch on the back of the substrate, the utility model designs a multi-layer structure, which includes an insulating double-sided tape 41, an electrode patch and a conductive tape 43. The insulating double-sided tape 41 is attached to the back of the substrate, and a hole identical to the first hollow hole 1 on the substrate is opened at the same position. After tearing off the upper backing paper on the other side, the electrode patch can be pasted and fixed. Because the double-sided tape material is insulating, it does not affect the reaction and signal transmission generated on the electrode patch. Subsequently, the conductive tape 43 is used to cover the electrode patch, and the electrode patch is fixed to the back of the substrate for the second time, and connected to the back conductive circuit 3, thereby realizing the transmission of electrical signals from the electrode patch to the conductive tape 43, the back conductive circuit 3 and the through hole 24 to the front conductive circuit 2.

[0035] It can be understood that the electrode patch is fixed on the back of the substrate. When the hollow electrode is used, the test liquid is added to the first hollow hole 1 on the front, that is, the part of the electrode patch corresponding to the first hollow hole 1 is the electrode detection area, and the electrochemical reaction area is also calculated based on this. However, when the electrode patch is in direct contact with the back of the substrate, it is impossible for the electrode patch to fit completely tightly. There will always be tiny gaps between the materials. The test liquid may overflow these tiny gaps, which will cause the area of ​​the electrode detection area to change, affecting the electrode detection results.

[0036] The metal part can be appropriately added to the contact area between the back conductive circuit 3 and the conductive tape 43, so as to maximize the contact area between the conductive circuit and the conductive tape 43, thereby increasing the conductive area, making the conductive effect better and the electrical signal transmission effect better.

[0037] In this embodiment, the front conductive circuit 2 and the back conductive circuit 3 partially overlap in the projection direction, and the front conductive circuit 2 is provided with a plurality of conductive holes 24 penetrating the substrate to connect the front conductive circuit 2 with the back conductive circuit 3.

[0038] It is understood that the conductive traces are generally filled with a metal layer within the conductive vias 24, providing electrical connection between the metal layers of the conductive traces on the front and back sides of the substrate. The number of conductive vias 24 is set to one or more, typically three, to ensure electrical connection between the front and back sides of the substrate, ensuring proper electrical signal transmission. In another embodiment, the front conductive traces 2 and the back conductive traces 3 are directly connected.

[0039] Preferably, this embodiment further includes an insulating double-sided tape 41 , which is attached between the selective electrode patch 42 and the substrate. The insulating double-sided tape 41 has a second hollow hole in the projection direction of the first hollow hole 1 .

[0040] It is understandable that, in this embodiment, preferably, the size and shape of the second hollow hole are the same as those of the first hollow hole 1, but the specific shape and size of the second hollow hole are not limited. The electrode patch is fixed on the back of the substrate. When in use, the liquid to be tested is added to the position of the first hollow hole 1 on the front. That is, the part of the electrode patch corresponding to the position of the first hollow hole 1 is the electrode detection area, and the electrochemical reaction area is also calculated based on this. However, when the electrode patch is in direct contact with the back of the substrate, it is impossible to fit completely tightly. There will always be tiny gaps between the materials. The liquid to be tested may overflow these tiny gaps, which will cause the area of ​​the electrode detection area to change, affecting the electrode detection results. By setting an insulating double-sided tape 41 between the substrate and the selective electrode patch 42, the selective electrode patch 42 is prevented from directly contacting the substrate, so that the periphery of the first hollow hole 1 remains flat, and the fluid will not leak through the gaps on the substrate during detection, thereby improving the product detection accuracy.

[0041] In this embodiment, the first hollow hole 1 is preferably circular. The shape and area of ​​the first hollow hole 1 determine the shape and size of the area on the selective electrode patch 42 for detecting the test fluid. This embodiment merely provides a preferred shape for the first hollow hole and does not limit the shape of the hollow hole.

[0042] In this embodiment, preferably, one or more vias 24 are provided on the front conductive circuit 2 , and the front conductive circuit is interconnected with the back conductive circuit 3 through the vias 24 .

[0043] It can be understood that in the embodiment of the present invention, the front conductive circuit 2 is not directly connected to the first hollow hole 1, that is, the front conductive circuit 2 of the electrode is not directly connected to the working electrode position, but is connected to the back conductive circuit 3 on the back of the electrode base through the conductive hole 24 set in the circuit end 22, and then connected to the electrode sheet subsequently loaded at the position of the first hollow hole 1 and transmits electrical signals. This not only reduces the volume of the electrode and makes the electrode surface circuit arrangement simpler, but also makes the electrical signal transmission smoother. It is also in line with the design concept of the present invention to load the working electrode separately as an electrode sheet, avoiding the disadvantage of the loaded electrode sheet affecting the electrical signal transmission due to poor contact and other reasons.

[0044] Preferably, in this embodiment, the front conductive circuit 2 includes a circuit end 22 and a pin end 23 connected to each other, and the pin end 23 extends toward the edge of the substrate.

[0045] It is understandable that the pin end 23 is arranged at the edge of the substrate to facilitate connection to the electrochemical analyzer through a standard USB interface, thereby achieving the purpose of closely docking with the USB standard interface and simplifying the docking operation of data communication with the electrochemical workstation.

[0046] In this embodiment, preferably, the surfaces of the front conductive circuit 2 , the electrode detection layer and the back conductive circuit 3 are modified with a metal layer as a base metal, and the metal type includes silver.

[0047] In this embodiment, preferably, the conductive tape 43 completely covers the selective electrode patch 42 and the conducting hole 24 .

[0048] It can be understood that the shape of the conductive tape 43 is not specifically restricted in this embodiment. By setting the conductive tape 4343 to connect the selective electrode patch 42 and the back conductive circuit 3, the detection of the droplet to be tested can be achieved. In addition, the conductive tape 43 completely covers the selective electrode patch 42, which can further fix the selective electrode patch 42 on the substrate to reduce the gap, thereby improving the detection accuracy.

[0049] In this embodiment, preferably, the material of the selective electrode patch 42 includes at least one or more of carbon and metal, and the metal material includes gold, silver, platinum, bismuth, chromium, copper, and nickel.

[0050] The selective electrode patch 42 is a gold electrode sheet with an overall thickness of 0.01-0.02mm and an overall radius of 2mm. The shape can be circular or rectangular, and can also be freely set. Its area is larger than the area of ​​the first hollow hole 1, and it can completely cover it. To save costs, the gold electrode sheet uses a copper base, which is polished and plated with bright copper, then silver, and finally gold. Only the side in contact with the base layer can be processed on a single side. For ease of use, the front conductive line 2 on the front of the base can be partially coated with ink, and then a second layer of ink can be applied to the periphery of the electrode loading area, leaving only the electrode detection layer and the area where the first hollow hole 1 and the electrode pin are located exposed. The thickness of each layer of ink is 10-20μm.

[0051] In an optional embodiment, a raised dam is provided on the periphery of the first hollow hole 1 so that the inner side of the raised dam can form a detection area for electrochemical detection. When the test liquid is dripped into the detection area, it can effectively prevent the test liquid from overflowing the electrode structure.

[0052] When the utility model is used, the pin end is first connected to the USB standard interface of the electrochemical workstation, and then solution, blood or biochemical tissue fluid is dripped into the first hollow hole 1 to perform electrochemical detection. The operation is simple, fast and convenient.

[0053] The present invention uses double-sided tape to fix the electrode patch to the greatest extent, fill the gaps, and minimize the tiny gaps generated by the electrode patch and the back substrate surface, thereby avoiding changes in the area of ​​the electrode detection area and the inability to fix it, which greatly affects the stability and accuracy of the detection data. The subsequent secondary fixation with conductive tape 43 further prevents the electrode patch from being moved by external forces, covers and protects the electrode patch, and at the same time expands the contact area between the conductive tape 43 and the electrode patch, and the contact area between the conductive tape 43 and the back conductive circuit 3 as much as possible, thereby connecting the electrode patch to the back conductive circuit 3, facilitating signal transmission, and achieving excellent results, making the electrode performance more sensitive and stable.

[0054] Example 2

[0055] The difference between this embodiment and embodiment 1 is that in this embodiment, the selective electrode patch 42 is a silver electrode sheet, which can be circular or rectangular, or can be freely set. Its area is larger than the area of ​​the first hollow hole 1 and can completely cover it.

[0056] For ease of use, the conductive circuit 2 on the front side of the substrate can be partially coated with ink, and then a second layer of ink can be coated around the first hollow hole 1, leaving only the first hollow hole 1 and the area where the pin end is located exposed. The thickness of each layer of ink is 10 to 20 μm.

[0057] Example 3

[0058] The difference between this embodiment and embodiment 1 is that in this embodiment, the selective electrode patch 42 is a platinum electrode sheet, which can be circular or rectangular, or can be freely set, and its area is larger than the area of ​​the first hollow hole 1, and can completely cover it.

[0059] Example 4

[0060] The difference between this embodiment and embodiment 1 is that, in this embodiment, the selective electrode patch 42 selects a bismuth electrode sheet, and specifically, a bismuth film can be modified on the surface of the reaction surface of the electrode sheet. The shape of the electrode sheet can be circular or rectangular, and can also be freely set. Its area is larger than the area of ​​the first hollow hole 1 and can completely cover it.

[0061] Example 5

[0062] The difference between this embodiment and embodiment 1 is that, in this embodiment, the selective electrode patch 42 selects a carbon electrode sheet, the material of which can be selected from carbon-related materials including graphene, and the shape can be circular or rectangular, or can be freely set. Its area is larger than the area of ​​the first hollow hole 1 and can completely cover it.

[0063] Example 6

[0064] The difference between this embodiment and embodiment 1 is that, in this embodiment, the selective electrode patch 42 selects a chromium electrode sheet, and specifically, a chromium film can be modified on the surface of the reaction surface of the electrode sheet. The shape of the electrode sheet can be circular or rectangular, and can also be freely set. Its area is larger than the area of ​​the first hollow hole 1 and can completely cover it.

[0065] Example 7

[0066] The difference between this embodiment and embodiment 1 is that, in this embodiment, the selective electrode patch 42 is based on a gold electrode sheet, which is modified with an active enzyme substance. The electrode sheet in contact with the electrode substrate can be modified on one side. The shape of the substrate can be circular or rectangular, and can also be freely set. Its area is larger than the area of ​​the first hollow hole 1, and it can completely cover it.

[0067] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the present invention can be implemented in other specific forms without departing from the spirit or essential features of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations that come within the meaning and range of equivalents of the claims be embraced within the present invention.

[0068] In addition, it should be understood that although this specification describes the embodiments, not each embodiment contains only one independent technical solution. This description is for clarity only. Those skilled in the art should consider the specification as a whole. The technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art. Technical details not described in detail in this utility model can be implemented by any existing technology in the art. In particular, all technical features not described in detail in this utility model can be implemented by any existing technology.

Claims

1. A hollow ion-selective electrode based on a single-electrode structure, comprising a substrate, characterized in that: The front surface of the base is provided with a first hollow hole (1) penetrating the base and a front conductive circuit (2); The back of the substrate is provided with a back conductive circuit (3), a selective electrode patch (42) and a conductive tape (43); the front conductive circuit (2) is connected to the back conductive circuit (3); the selective electrode patch (42) is tightly attached to the substrate and completely covers the first hollow hole (1); the conductive tape (43) is arranged on the selective electrode patch (42), fixes the selective electrode patch (42) to the back of the substrate, and is in contact and conductive with the back conductive circuit (3).

2. The hollow ion selective electrode based on a single electrode structure according to claim 1, characterized in that: The front conductive circuit (2) and the back conductive circuit (3) partially overlap in the projection direction, and the front conductive circuit (2) is provided with a plurality of conductive holes (24) penetrating the substrate to connect the front conductive circuit (2) and the back conductive circuit (3).

3. The hollow ion selective electrode based on a single electrode structure according to claim 1, characterized in that: It also includes an insulating double-sided tape (41), which is attached between the selective electrode patch (42) and the substrate, and the insulating double-sided tape (41) is provided with a second hollow hole in the projection direction of the first hollow hole (1).

4. The hollow ion selective electrode based on a single electrode structure according to claim 2, characterized in that: The shape of the first hollow hole (1) is geometric.

5. The hollow ion selective electrode based on a single electrode structure according to claim 4, characterized in that: One or more conducting holes (24) are provided on the front conductive circuit (2), and the front conductive circuit is interconnected with the back conductive circuit (3) through the conducting holes (24).

6. The hollow ion selective electrode based on a single electrode structure according to claim 4, characterized in that: The front conductive circuit (2) comprises a circuit end (22) and a pin end (23) connected to each other, and the pin end (23) extends toward the edge of the substrate.

7. The hollow ion selective electrode based on a single electrode structure according to claim 1, characterized in that: The surfaces of the front conductive circuit (2), the electrode detection layer and the back conductive circuit (3) are modified with a metal layer as a base metal, and the metal type includes silver.

8. The hollow ion selective electrode based on a single electrode structure according to claim 3, characterized in that: The second hollow hole on the insulating double-sided tape (41) is arranged concentrically with the first hollow hole (1).

9. The hollow ion selective electrode based on a single electrode structure according to claim 5, characterized in that: The conductive tape (43) completely covers the selective electrode patch (42) and the conductive hole (24).

10. The hollow ion selective electrode based on a single electrode structure according to claim 1, characterized in that: The selective electrode patch (42) is a carbon electrode patch or a metal electrode patch, and the metal material is one of gold, silver, platinum, bismuth, chromium, copper, and nickel.

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