In-vitro micro-tissue drug metabolism detection device

Abstract

The utility model relates to the technical field of medical detection equipment, in particular to an in-vitro micro-tissue drug metabolism detection device. Comprising an incubation chamber, a printing terminal and an auxiliary assembly, a temperature control assembly is arranged at the top of the incubation chamber, the auxiliary assembly comprises a first conveyor, a second conveyor, a sorting robot, a sample pool and a detection component, the incubation chamber is used for incubating samples, the incubated samples are placed on the first conveyor to be conveyed, and after being detected by the detection component, the samples are sent to the printing terminal. After detection, samples can be rapidly placed on the second conveyor to be conveyed, finally, the samples are placed into the sample pools at different positions through the sorting robot according to feedback information of the control system, the printing terminal can print and output detection data, then the in-vivo microenvironment can be simulated, the in-vivo metabolic process of drugs can be accurately simulated, and the in-vivo microenvironment can be simulated. Moreover, preliminary detection and rapid transfer of samples can be realized, and the detection efficiency can be improved.

Description

Technical Field

[0001] The utility model relates to the technical field of medical detection equipment, in particular to an in vitro micro-tissue drug metabolism detection device. Background Art

[0002] Drug metabolism refers to the process by which drugs are converted into metabolites through enzymatic reactions in the body. This process is crucial for evaluating the efficacy and safety of drugs.

[0003] Traditional drug metabolism research usually relies on in vivo experiments, but this method is time-consuming, costly and raises ethical issues. In recent years, the development of in vitro microtissue technology has provided a new approach for drug metabolism research. In vitro microtissue drug metabolism detection devices can effectively conduct drug metabolism research by co-incubating drugs with in vivo microtissue components (such as liver microsomes), providing important support for new drug research and development.

[0004] However, in the detection devices under the existing technology, samples are mostly manually transported multiple times before incubation detection, which takes a long time and is inefficient. It is difficult to achieve automatic and efficient incubation detection, and it is inconvenient to use. Utility Model Content

[0005] The purpose of the present invention is to provide an in vitro microtissue drug metabolism detection device, which is designed to simulate the in vivo microenvironment, accurately simulate the metabolic process of drugs in the body, and realize preliminary detection and rapid transfer of samples, thereby improving detection efficiency.

[0006] To achieve the above objectives, the present invention provides an in vitro microtissue drug metabolism detection device, comprising an incubation chamber and a printing terminal, wherein a temperature control component is provided on the top of the incubation chamber, the printing terminal is provided on the rear side of the incubation chamber, and further comprising auxiliary components;

[0007] The auxiliary components include a first conveyor, a second conveyor, a sorting robot, a sample pool, and a detection component. The first conveyor is fixedly connected to the incubation chamber and is located on the right side of the incubation chamber. The sorting robot is located on the discharge side of the second conveyor. The sample pool is arranged in a ring outside the sorting robot. The detection component is arranged on the side of the incubation chamber close to the first conveyor.

[0008] Wherein, the temperature control component adopts central air conditioning.

[0009] The detection component includes a first detection platform and a spectrum detector. The first detection platform is arranged on one side of the first conveyor. The spectrum detector is arranged on the first detection platform and is electrically connected to the printing terminal.

[0010] Wherein, the auxiliary component also includes a first indicator light and a second indicator light. The first indicator light is electrically connected to the printing terminal and fixed on the top of the shell of the printing terminal; the second indicator light is fixedly installed on the top of the incubation chamber.

[0011] The utility model discloses an in vitro micro-tissue drug metabolism detection device, wherein a temperature control component is arranged on the top of the incubation chamber, a printing terminal is arranged on the rear side of the incubation chamber, a first conveyor is installed on one side of the incubation chamber, a second conveyor is arranged on the rear side of the first conveyor, a sorting robot is located on the discharge side of the second conveyor, a sample pool is arranged in a ring outside the sorting robot, a detection component is arranged on the side of the incubation chamber close to the first conveyor, a humidity control and gas control system is provided in the incubation chamber, which can maintain a constant incubation environment, and the temperature is controlled by the temperature control component. The incubation chamber is used for sample incubation, and the incubated sample is placed on the first conveyor for transportation, and then after being detected by the detection component, the detected sample can be quickly placed on the second conveyor for transportation, and finally the sorting robot puts the sample into the sample pool at different positions according to the feedback information of the control system, and the printing terminal can print out the detection data, thereby realizing the simulation of the in vivo microenvironment, accurately simulating the metabolic process of the drug in the body, and realizing preliminary detection and rapid transfer of the sample, which is conducive to improving the detection efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art.

[0013] Figure 1 It is a schematic diagram of the overall structure of the in vitro microtissue drug metabolism detection device of the first embodiment of the present utility model.

[0014] Figure 2 This is a front view of the in vitro microtissue drug metabolism detection device according to the first embodiment of the present invention.

[0015] Figure 3 It is a schematic diagram of the overall structure of the in vitro microtissue drug metabolism detection device according to the second embodiment of the present invention.

[0016] In the figure: 101-incubation chamber, 102-printing terminal, 103-temperature control component, 104-first conveyor, 105-second conveyor, 106-sorting robot, 107-sample pool, 108-first detection table, 109-spectrometer, 201-first indicator light, 202-second indicator light. DETAILED DESCRIPTION

[0017] The embodiments of the present invention are described in detail below, and examples of the embodiments are shown in the accompanying drawings. The embodiments described below with reference to the accompanying drawings are exemplary and are intended to be used to explain the present invention, but should not be understood as limiting the present invention.

[0018] Example 1:

[0019] like Figure 1 and Figure 2 As shown, Figure 1 This is a schematic diagram of the overall structure of the in vitro microtissue drug metabolism detection device. Figure 2 1 is a front view of an in vitro microtissue drug metabolism detection device. The present invention provides an in vitro microtissue drug metabolism detection device, comprising an incubation chamber 101, a printing terminal 102, and auxiliary components. A temperature control component 103 is provided on the top of the incubation chamber 101. The auxiliary components include a first conveyor 104, a second conveyor 105, a sorting robot 106, a sample pool 107, and a detection component. The detection component includes a first detection table 108 and a spectrometer 109. The aforementioned scheme can simulate the in vivo microenvironment, accurately simulate the metabolic process of drugs in the body, and achieve preliminary detection and rapid transfer of samples, thereby improving detection efficiency. It can be understood that the aforementioned scheme can simulate the in vivo microenvironment, accurately simulate the metabolic process of drugs in the body, and achieve preliminary detection and rapid transfer of samples, thereby improving detection efficiency.

[0020] In this embodiment, a temperature control component 103 is set on the top of the incubation chamber 101, and the printing terminal 102 is set on the rear side of the incubation chamber 101. The incubation chamber 101 is used for sample incubation, and the temperature control component 103 set on the top is used for temperature control. A humidity control and gas control system are set inside to maintain a constant incubation environment. A humidifier can be used for humidity control. The printing terminal 102 is used for printing and outputting detection data. The device adopts an external control cabinet for overall equipment operation control.

[0021] The first conveyor 104 is fixedly connected to the incubation chamber 101 and is located on the right side of the incubation chamber 101. The second conveyor 105 is arranged at the rear side of the first conveyor 104. The sorting robot 106 is located on the discharge side of the second conveyor 105. The sample pool 107 is arranged in an annular manner on the outside of the sorting robot 106. The detection component is arranged on the side of the incubation chamber 101 close to the first conveyor 104. The left side frame of the first conveyor 104 is fixed to the lower side of the discharge port of the incubation chamber 101 by bolts for sample testing and feeding. The second conveyor 105 is used for rapid transportation of samples after testing. The sorting robot 106 is a multi-axis industrial robot fixed to the ground by bolts. A clamp is installed on its front working head for sample clamping. The detection component is arranged on the side of the incubation chamber 101 close to the first conveyor 104 for performing the first sample test.

[0022] Secondly, the temperature control component 103 uses a central air conditioner. The temperature control component 103 is used to control the temperature in the incubation chamber 101 to provide a good sample incubation environment. The use of central air conditioning will facilitate aesthetic design. At the same time, the working principle and setting structure of central air conditioning are existing technologies that can be directly selected and will not be described in detail here.

[0023] Finally, the first inspection platform 108 is positioned on one side of the first conveyor 104; the optical spectrum detector 109 is positioned on the first inspection platform 108 and electrically connected to the printing terminal 102. The first inspection platform 108 is placed directly on the ground, and the optical spectrum detector 109 is placed directly on the first inspection platform 108 and electrically connected to the printing terminal 102 via a cable. The printing terminal 102 is electrically connected to an external control cabinet via a cable. The optical spectrum detector 109 can be used for the initial sample testing.

[0024] When the present invention is used to simulate the in vivo microenvironment, accurately simulate the metabolic process of drugs in the body, and realize preliminary detection and rapid transfer of samples, which is beneficial to improving the detection efficiency, the incubation chamber 101 is used for sample incubation. During the detection, the staff places the incubated sample on the first conveyor 104 for transportation, and then the operator or the external automatic operation robot cooperates with the detection component to perform the detection. The detected sample can be quickly placed on the second conveyor 105 for transportation. Finally, the sorting robot 106 puts the sample into the sample pool 107 at different positions for centralized collection according to the feedback information and action control of the control system to complete the detection. The printing terminal 102 can print out the detection data, thereby realizing the simulation of the in vivo microenvironment, accurately simulate the metabolic process of drugs in the body, and realize preliminary detection and rapid transfer of samples, which is beneficial to improving the detection efficiency.

[0025] Example 2:

[0026] like Figure 3 As shown, Figure 3 20 is a schematic diagram of the overall structure of an in vitro microtissue drug metabolism detection device. Based on the first embodiment, the utility model provides an in vitro microtissue drug metabolism detection device, and the auxiliary component further includes a first indicator light 201 and a second indicator light 202.

[0027] The first indicator light 201 is electrically connected to the printing terminal 102 and fixed to the top of the housing of the printing terminal 102; the second indicator light 202 is fixedly installed on the top of the incubation chamber 101. The first indicator light 201 is fixed to the top housing of the printing terminal 102 by bolts and is electrically connected to the internal controller of the printing terminal 102 via a cable. The second indicator light 202 is also bolted to the top of the incubation chamber 101 and is electrically connected to the external control cabinet via a cable when in operation.

[0028] In this embodiment, the first indicator light 201 is used to indicate the working status of the printing terminal 102, so that the working status of the printing terminal 102 can be known at a certain distance from a distance. The second indicator light 202 is used to indicate the working status of the incubation chamber 101, so that the working status of the incubation chamber 101 can be known at a certain distance from a distance.

[0029] The above disclosure is merely one or more preferred embodiments of the present application and is not intended to limit the scope of the present application. A person skilled in the art will understand that all or part of the processes of the above embodiments and equivalent changes made in accordance with the claims of the present application are still within the scope of the present application.

Claims

1. An in vitro microtissue drug metabolism detection device, comprising an incubation chamber and a printing terminal, wherein a temperature control component is provided on the top of the incubation chamber and the printing terminal is provided at the rear side of the incubation chamber, characterized in that: Also included are auxiliary components; The auxiliary components include a first conveyor, a second conveyor, a sorting robot, a sample pool and a detection component. The first conveyor is fixedly connected to the incubation chamber and is located on the right side of the incubation chamber. The second conveyor is arranged on the rear side of the first conveyor. The sorting robot is located on the discharge side of the second conveyor. The sample pool is arranged in a ring outside the sorting robot. The detection component is arranged on the side of the incubation chamber close to the first conveyor.

2. The in vitro microtissue drug metabolism detection device according to claim 1, characterized in that: The temperature control component adopts central air conditioning.

3. The in vitro microtissue drug metabolism detection device according to claim 1, wherein: The detection component includes a first detection platform and a spectrum detector. The first detection platform is arranged on one side of the first conveyor. The spectrum detector is arranged on the first detection platform and is electrically connected to the printing terminal.

4. The in vitro microtissue drug metabolism detection device according to claim 1, wherein: The auxiliary component further includes a first indicator light and a second indicator light. The first indicator light is electrically connected to the printing terminal and fixed on the top of the shell of the printing terminal; the second indicator light is fixedly installed on the top of the incubation chamber.

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