Liquid chromatography-mass spectrometer for real-time drug analysis

Abstract

The utility model provides a liquid chromatography-mass spectrometer for real-time drug analysis, belongs to the technical field of liquid chromatography-mass spectrometers, and aims to solve the problems that during detection, a large number of sample tubes are inserted into a support frame in the instrument one by one, the operation is troublesome, time-consuming and labor-consuming, the later taking is troublesome, and the detection speed and efficiency of the instrument are slowed down. The auxiliary locking assembly is fixedly mounted in the instrument main body; the bearing assembly is inserted into the instrument body in a sliding mode and makes contact with the auxiliary locking assembly. The sample tube fixing mechanism is inserted into the bearing assembly; the control mechanism is connected with the sample tube fixing mechanism; the internal threaded rod can push the clamping ring to slide towards the inner side at the same time, the clamping ring makes contact with the sample tube and clamps and fixes the sample tube, the sample tube and the loading assembly are fixedly connected together, the sample tube is rapidly and simply taken and placed, and after detection is completed, multiple sets of sample tubes can be rapidly separated.

Description

Technical Field

[0001] The utility model belongs to the technical field of liquid chromatography-mass spectrometry instruments, and more specifically, relates to a liquid chromatography-mass spectrometry instrument for real-time drug analysis. Background Art

[0002] Liquid spectrometry is mainly used in research in industries such as drug metabolism and pharmacokinetic research, and clinical pharmacology research. During use, the components of the sample separated by liquid chromatography enter the mass spectrometer detector in turn, and each component is ionized in the ion source to produce ions with a certain charge and different mass numbers; different ions have different movement behaviors in the electromagnetic field, and the mass analyzer is used to separate the ions according to different mass-to-charge ratios to obtain a mass spectrum arranged in order of mass-to-charge ratio; before detection, a large number of sample tubes need to be placed inside the machine. The number of sample tubes is large, and they need to be inserted one by one into the support frame inside the instrument, which is troublesome, time-consuming and labor-intensive. It is also more troublesome to take them out later, which slows down the detection speed and efficiency of the instrument. Utility Model Content

[0003] In order to solve the above technical problems, the present invention provides a liquid chromatography-mass spectrometry instrument for real-time drug analysis to solve the problem raised in the above background technology that during detection, there are a large number of sample tubes, which need to be inserted one by one into the support frame in the instrument, which is troublesome, time-consuming and labor-intensive. It is also more troublesome to take them out later, which slows down the detection speed and efficiency of the instrument.

[0004] The utility model provides a liquid chromatography-mass spectrometry instrument for real-time drug analysis, which is achieved by the following specific technical means:

[0005] A liquid spectrometer for real-time drug analysis comprises: an instrument body, an auxiliary locking assembly, a carrying assembly, a sample tube fixing mechanism and a control mechanism; the instrument body as a whole is a rectangular parallelepiped structure; the auxiliary locking assembly is fixedly installed inside the instrument body; the carrying assembly is slidably inserted into the instrument body and contacts the auxiliary locking assembly; the sample tube fixing mechanism is inserted inside the carrying assembly; the control mechanism is connected to the sample tube fixing mechanism; the sample tube fixing mechanism comprises: a support frame and an auxiliary support plate; the support frame is a square frame structure, and a slide groove is opened on the inner side of the support frame; the auxiliary support plate is fixedly installed inside the support frame.

[0006] In at least some embodiments, the auxiliary locking assembly includes: a fixed plate, a spring, an insertion rod and a control plate; the fixed plate is a rectangular structure with a hollow interior, and the surface of the fixed plate is fixedly connected to the fixed plate; the spring is installed inside the fixed plate; the insertion rod is a T-shaped structure as a whole, and the bottom of the insertion rod is slidably inserted into the interior of the fixed plate. The insertion rod can limit the load-bearing assembly, and the spring can elastically support the insertion rod; one side of the control plate is slidably inserted into the interior of the fixed plate and fixedly connected to the insertion rod.

[0007] In at least some embodiments, the carrying assembly includes: a carrying box and a limiting card slot; the carrying box is a rectangular structure with a groove on the top, the carrying box is slidably inserted into the interior of the instrument body, and the carrying box is used to carry the sample tube; the limiting card slot is opened at the bottom of the carrying box.

[0008] In at least some embodiments, the sample tube fixing mechanism further includes: a driving frame, a clamping plate and a clamping ring; the driving frame as a whole is a U-shaped structure, and one side of the driving frame is slidably connected to the auxiliary support plate; both ends of the clamping plate are slidably installed in the inside of the slide groove opened on the inner side of the support frame; the clamping ring as a whole is an arc-shaped structure, and one side of the clamping ring is fixedly connected to the clamping plate, and the clamping plate and the clamping ring can play a role in assisting in clamping and fixing the sample tube.

[0009] In at least some embodiments, the control mechanism includes: an outer rod, a sliding plate and a threaded rod; the outer rod is a rectangular structure with a T-shaped slot inside, and a square slot is provided on the top of the outer rod; the sliding plate is a T-shaped structure, and the sliding plate is slidably installed inside the T-shaped slot of the outer rod, driving one end of the frame to slide through the slot of the outer rod and be fixedly connected to the sliding plate; the surface of the threaded rod is provided with threads in opposite directions, and the threaded rod is rotated to be inserted into the interior of the outer rod and threadedly connected to the sliding plate, and the rotation of the threaded rod can control the sliding plate to slide.

[0010] Compared with the prior art, the present invention has the following beneficial effects:

[0011] The utility model is provided with a sample tube fixing mechanism and a control mechanism inside. A plurality of clamping rings are provided inside the sample tube fixing mechanism. When taking a sample tube, the sample tube is placed in the middle area of ​​the clamping ring. The threaded rod inside the control mechanism is rotated. The plurality of threads on the surface of the threaded rod in opposite directions push the clamping ring to slide inward at the same time. The clamping ring contacts the sample tube and clamps it. The sample tube is tightly connected to the carrier assembly, so that the sample tube can be taken and placed quickly and simply. After the test is completed, the clamping ring is released and the plurality of sample tubes can be quickly separated. BRIEF DESCRIPTION OF THE DRAWINGS

[0012] Figure 1 It is a schematic structural diagram of the main body axis side view of the present utility model.

[0013] Figure 2 This utility model Figure 1 A is a schematic diagram of the local enlarged structure.

[0014] Figure 3 It is a schematic cross-sectional structural diagram of the auxiliary locking assembly of the present utility model.

[0015] Figure 4 It is a bottom view structural diagram of the load-bearing assembly of the present invention.

[0016] Figure 5 It is a schematic diagram of the exploded structure of the sample tube fixing mechanism of the present utility model.

[0017] Figure 6 It is a schematic cross-sectional structural diagram of the control mechanism of the present utility model.

[0018] In the figure, the corresponding relationship between the component names and the drawing numbers is as follows:

[0019] 1. Instrument body; 2. Auxiliary locking assembly; 201. Fixing plate; 202. Spring; 203. Insert rod; 204. Control panel; 3. Carrying assembly; 301. Carrying box; 302. Limiting slot; 4. Sample tube fixing mechanism; 401. Support frame; 402. Auxiliary support plate; 403. Drive frame; 404. Clamp; 405. Clamp ring; 5. Control mechanism; 501. Outer rod; 502. Sliding plate; 503. Threaded rod. DETAILED DESCRIPTION

[0020] The following is a further detailed description of the embodiments of the present invention in conjunction with the accompanying drawings and examples.

[0021] Example 1:

[0022] As attached Figure 1 To the attached Figure 6 As shown:

[0023] The utility model provides a liquid spectrometer for real-time drug analysis, comprising: an instrument body 1, an auxiliary locking assembly 2, a carrying assembly 3, a sample tube fixing mechanism 4 and a control mechanism 5; the instrument body 1 is a rectangular parallelepiped structure as a whole; the auxiliary locking assembly 2 is fixedly installed inside the instrument body 1; the carrying assembly 3 is slidably inserted into the instrument body 1 and contacts the auxiliary locking assembly 2; the sample tube fixing mechanism 4 is inserted inside the carrying assembly 3; the control mechanism 5 is connected to the sample tube fixing mechanism 4; the sample tube fixing mechanism 4 comprises: a support frame 401 and an auxiliary support plate 402; the support frame 401 is a square frame structure, and a slide groove is opened on the inner side of the support frame 401; the auxiliary support plate 402 is fixedly installed inside the support frame 401.

[0024] like Figure 3 As shown, the auxiliary locking assembly 2 includes: a fixed plate 201, a spring 202, an insertion rod 203 and a control plate 204; the fixed plate 201 is a rectangular structure with a hollow interior, and the surface of the fixed plate 201 is fixedly connected to the fixed plate 201; the spring 202 is installed inside the fixed plate 201; the insertion rod 203 is a T-shaped structure as a whole, and the bottom of the insertion rod 203 is slidably inserted into the interior of the fixed plate 201, the insertion rod 203 can limit the bearing assembly 3, and the spring 202 can elastically support the insertion rod 203; one side of the control plate 204 is slidably inserted into the interior of the fixed plate 201 and fixedly connected to the insertion rod 203.

[0025] like Figure 4As shown, the carrying assembly 3 includes: a carrying box 301 and a limiting slot 302; the carrying box 301 is a rectangular structure with a groove on the top, and the carrying box 301 is slidably inserted into the inside of the instrument body 1. The carrying box 301 is used to carry the sample tube; the limiting slot 302 is opened at the bottom of the carrying box 301.

[0026] like Figure 5 As shown, the sample tube fixing mechanism 4 also includes: a driving frame 403, a clamping plate 404 and a clamping ring 405; the driving frame 403 is a U-shaped structure as a whole, and one side of the driving frame 403 is slidably connected to the auxiliary support plate 402; both ends of the clamping plate 404 are slidably installed in the inside of the slide groove opened on the inner side of the support frame 401; the clamping ring 405 is an arc-shaped structure as a whole, and one side of the clamping ring 405 is fixedly connected to the clamping plate 404. The clamping plate 404 and the clamping ring 405 can play a role in assisting in clamping and fixing the sample tube.

[0027] like Figure 6 As shown, the control mechanism 5 includes: an outer rod 501, a sliding plate 502 and a threaded rod 503; the outer rod 501 is a rectangular structure with a T-shaped sliding groove inside, and a square sliding groove is provided on the top of the outer rod 501; the sliding plate 502 is a T-shaped structure, and the sliding plate 502 is slidably installed inside the T-shaped sliding groove of the outer rod 501, driving one end of the frame 403 to slide through the sliding groove of the outer rod 501 and be fixedly connected to the sliding plate 502; the surface of the threaded rod 503 is provided with threads in opposite directions, and the threaded rod 503 is rotated to be inserted into the interior of the outer rod 501 and threadedly connected to the sliding plate 502. The rotation of the threaded rod 503 can control the sliding plate 502 to slide.

[0028] The specific usage and function of this embodiment are as follows:

[0029] In the present invention, when in use, the control panel 204 controls the insertion rod 203 to be pressed down, the insertion rod 203 is pulled out of the limit slot 302, contacts the limit, pulls the carrier box 301 out of the inside of the instrument body 1, drives the sample tube fixing mechanism 4 to be pulled out of the inside of the carrier box 301 through the control mechanism 5, and places the clamp ring 405 on the surface of the support plate filled with sample tubes, controls the clamp ring 405 to slide down, so that the sample tube is in the middle position of the clamp ring 405, and then rotates the threaded rod 503, the surface of the threaded rod 503 Multiple sets of threads push the sliding plates 502 to slide simultaneously, and the sliding plates 502 drive the frame 403, the clamping plate 404 and the clamping ring 405 to slide inward. The clamping ring 405 clamps and fixes the sample tubes, quickly completing the removal of multiple sets of sample tubes. The sample tube fixing mechanism 4 is relocated to the inside of the instrument body 1 for analysis. After the analysis is completed, the sample tube is reinserted into the surface of the sample support plate, and the threaded rod 503 is rotated to control the clamping ring 405 to separate and contact the clamping state to complete the separation of the sample pipeline.

[0030] In this article, there are several points to note:

[0031] 1. The drawings of the embodiments of the present disclosure only relate to the structures related to the embodiments of the present disclosure. Other structures may refer to conventional designs.

[0032] 2. In the absence of conflict, the embodiments of the present disclosure and the features therein may be combined with each other to form new embodiments.

[0033] The above are only specific embodiments of the present disclosure, but the scope of protection of the present disclosure is not limited thereto. Any changes or substitutions that can be easily conceived by a person skilled in the art within the technical scope disclosed in this disclosure should be included in the scope of protection of the present disclosure. Therefore, the scope of protection of the present disclosure should be based on the scope of protection of the claims.

Claims

1. A liquid chromatography-mass spectrometry instrument for real-time drug analysis, comprising: An instrument body (1), an auxiliary locking assembly (2), a carrying assembly (3), a sample tube fixing mechanism (4) and a control mechanism (5); the instrument body (1) is a rectangular parallelepiped structure as a whole; it is characterized in that the auxiliary locking assembly (2) is fixedly installed inside the instrument body (1); the carrying assembly (3) is slidably inserted into the instrument body (1) and contacts with the auxiliary locking assembly (2); the sample tube fixing mechanism (4) is inserted into the carrying assembly (3); the control mechanism (5) is connected to the sample tube fixing mechanism (4); the sample tube fixing mechanism (4) comprises: a support frame (401) and an auxiliary support plate (402); the support frame (401) is a square frame structure, and a slide groove is opened on the inner side of the support frame (401); the auxiliary support plate (402) is fixedly installed inside the support frame (401).

2. The liquid chromatography-mass spectrometry instrument for real-time drug analysis according to claim 1, characterized in that: The auxiliary locking assembly (2) comprises: a fixed plate (201), a spring (202), an insertion rod (203) and a control plate (204); the surface of the fixed plate (201) is fixedly connected to the fixed plate (201); the spring (202) is installed inside the fixed plate (201); the insertion rod (203) is a T-shaped structure as a whole, and the bottom of the insertion rod (203) is slidably inserted into the interior of the fixed plate (201); one side of the control plate (204) is slidably inserted into the interior of the fixed plate (201) and is fixedly connected to the insertion rod (203).

3. The liquid chromatography-mass spectrometry instrument for real-time drug analysis according to claim 1, characterized in that: The carrying assembly (3) comprises: a carrying box (301) and a limiting card slot (302); the carrying box (301) is a rectangular parallelepiped structure with a groove on the top, and the carrying box (301) is slidably inserted into the interior of the instrument body (1); the limiting card slot (302) is provided at the bottom of the carrying box (301).

4. The liquid chromatography-mass spectrometry instrument for real-time drug analysis according to claim 1, characterized in that: The sample tube fixing mechanism (4) further comprises: a driving frame (403), a clamping plate (404) and a clamping ring (405); the driving frame (403) is a U-shaped structure as a whole, and one side of the driving frame (403) is slidably connected to the auxiliary support plate (402); both ends of the clamping plate (404) are slidably mounted inside a slide groove provided on the inner side of the support frame (401); the clamping ring (405) is an arc-shaped structure as a whole, and one side of the clamping ring (405) is fixedly connected to the clamping plate (404).

5. The liquid chromatography-mass spectrometry instrument for real-time drug analysis according to claim 4, characterized in that: The control mechanism (5) comprises: an outer rod (501), a sliding plate (502) and a threaded rod (503); the outer rod (501) is a rectangular parallelepiped structure with a T-shaped sliding groove provided inside, and a square sliding groove is provided on the top of the outer rod (501); the sliding plate (502) is a T-shaped structure, and the sliding plate (502) is slidably mounted inside the T-shaped sliding groove of the outer rod (501), driving one end of the frame (403) to slide through the sliding groove of the outer rod (501) and be fixedly connected to the sliding plate (502); the surface of the threaded rod (503) is provided with threads in opposite directions, and the threaded rod (503) is rotatably inserted into the interior of the outer rod (501) and is threadedly connected to the sliding plate (502).

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