Medical intermediate reaction device convenient for discharging and purifying

Abstract

The utility model discloses a medical intermediate reaction device convenient for discharging and purifying, which comprises a mixing box, wherein a feeding hopper is arranged at the top end of the mixing box; the temperature control mechanism is fixedly arranged in the mixing box and used for achieving the purification effect by controlling the temperature, a stepping motor is fixedly installed in the middle of the top end of the mixing box, a stirring shaft is rotatably installed in the middle of the inner top wall of the mixing box, and the top end of the stirring shaft is fixedly connected with the output end of the stepping motor; a plurality of uniformly distributed stirring pieces are fixedly arranged on the surface of the stirring shaft. Compared with the prior art, the mixing efficiency of reactants can be improved, the solubility of the reactants is adjusted by controlling the temperature after the reaction is finished, the situation that impurities and purified products are dissolved again due to the fact that the solubility of the reactants is improved after the reactants leave the mixing box is prevented, the filtered impurities can be cleaned, and the purity of the purified products is improved. Meanwhile, the service life of the filter plate can be prolonged.

Description

Technical Field

[0001] The utility model relates to the field of pharmaceutical intermediates, in particular to a pharmaceutical intermediate reaction device which can prevent the re-fusion of purified products and impurities, can clean the impurities, can increase the service life of the filter plate, and is convenient for discharging and purification. Background Art

[0002] Pharmaceutical intermediates are chemical raw materials or products used in the pharmaceutical synthesis process. These products do not require a pharmaceutical production license and can be produced in ordinary chemical plants. As long as they meet certain quality standards, they can be used in pharmaceutical synthesis. During the synthesis of pharmaceutical intermediates, it is often necessary to purify the synthesized or extracted compounds to obtain a single compound or a class of compounds with the same structural core. The pharmaceutical production process requires extremely high purity, necessitating the separation of impurities from the raw materials.

[0003] Currently, most pharmaceutical intermediate reaction devices control the temperature to reduce the solubility to separate the purified product from the impurities. However, after the reaction is completed, from leaving the reaction box to the device for separating the purified product from the impurities, the purified product and impurities may be mixed again due to temperature deviation, resulting in purification failure. In addition, most reaction devices take measures to collect and clean the impurities, which is not convenient for the next use. At the same time, the impact force generated by the reactants on the filter plate may reduce the service life of the filter plate.

[0004] Based on the above problems, the utility model provides a pharmaceutical intermediate reaction device which is convenient for discharging and purification. Utility Model Content

[0005] The purpose of the utility model is to provide a pharmaceutical intermediate reaction device that is convenient for discharging and purifying materials, so as to solve the problems raised in the above background technology.

[0006] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: a pharmaceutical intermediate reaction device that is convenient for discharging and purifying, comprising:

[0007] A mixing box, with a feed hopper provided on the top of the mixing box;

[0008] The temperature control mechanism is fixedly arranged inside the mixing box and is used to achieve a purification effect by controlling the temperature. A stepper motor is fixedly installed in the middle of the top of the mixing box, and a stirring shaft is rotatably installed in the middle of the inner top wall of the mixing box. The top of the stirring shaft is fixedly connected to the output end of the stepper motor, and a plurality of evenly distributed stirring members are fixedly arranged on the surface of the stirring shaft. The temperature control mechanism includes a temperature controller fixedly installed on the left side of the mixing box, and a plurality of evenly distributed constant temperature tubes that do not affect each other are fixedly arranged on the left side of the inner wall of the mixing box. The plurality of constant temperature tubes are electrically connected to the temperature controller, and a connection is fixedly arranged on the bottom end of the mixing box. Taking over the pipe one, the bottom end of the mixing box is provided with a connecting pipe two symmetrically distributed with the connecting pipe one, the connecting pipe one and the connecting pipe two are fixedly provided with a control pump body, the top of the control pump body is fixedly connected to the bottom end of the mixing box, the bottom ends of the connecting pipe one and the connecting pipe two are fixedly connected to the purification box, the middle part of the inner wall of the purification box is fixedly provided with a partition, the partition divides the interior of the purification box into two inner chambers, the connecting pipe two and the connecting pipe one are respectively located at the top ends of the corresponding inner chambers, the two inner chambers of the purification box are respectively provided with filter plates directly below the connecting pipe two and the connecting pipe one, and the purification box is provided with a discharge port at the bottom end of the two inner chambers;

[0009] The bottom end of the temperature controller is fixedly connected to a temperature transfer tube, the top of the purification box is fixedly provided with a thermometer, and a constant temperature plate is provided on the left side of the inner wall of the inner chamber of the purification box on the left side, and the constant temperature plate is electrically connected to the bottom end of the temperature transfer tube.

[0010] Furthermore, the two inner chambers of the purification box are fixedly installed with a fixed plate, and a collection box is provided on the top of the fixed plate. Two symmetrically distributed electric telescopic rods are fixedly installed on the side of the interior of the purification box away from the fixed plate and above the filter plate. The output end of the electric telescopic rod is fixedly connected to a push plate, and the bottom end of the push plate is in contact with the upper surface of the filter plate. A cover plate is fixedly provided on the interior of the purification box above the two electric telescopic rods. The front end of the purification box is located on both sides of the partition and is hinged with a door body, and the door body is parallel to the horizontal position of the collection box.

[0011] Furthermore, four fixed blocks are fixedly arranged inside the purification box, two of which are fixedly arranged at the back end of the fixed plate, and the other two fixed blocks are fixedly arranged on the back side of the inner wall of the purification box. The four fixed blocks are parallel to each other, and two symmetrically distributed first sleeves are fixedly arranged on the fixed blocks. A second sleeve is slidably penetrated inside the first sleeve, and a reset spring is fixedly connected between the first sleeve and the second sleeve. The top end of the second sleeve is fixedly connected to the bottom end of the filter plate.

[0012] Furthermore, waterproof sealing rings are provided at the joints between the two door bodies, the purification box and the partition.

[0013] Furthermore, a protective cover is fixedly provided on the top of the mixing box outside the stepping motor.

[0014] Furthermore, a glass window is provided at the front end of the mixing box.

[0015] Compared with the prior art, the beneficial effects of the present invention are:

[0016] 1. After the reactants enter the mixing box, start the stepper motor to drive the internal stirring shaft to rotate, and then use the stirring element to stir the reactants evenly to mix them. At the same time, start the thermostat to control the thermostatic tube to increase the temperature inside the mixing box to improve its reaction efficiency. After the reaction is completed, lower the temperature inside the mixing box through the thermostat to reduce the solubility and separate the impurities from the required purified products. Then check the external temperature on the thermometer. The internal temperature of the purification box is consistent with the external temperature. If it is lower than the temperature of the reactants in the mixing box, start the control pump to move the reactants from the connecting pipe to the mixing box. The first one is drawn into the inner chamber on the right side of the purification box, and impurities are filtered out through the filter plate, and the purified product flows out through the discharge port. If the temperature on the thermometer is higher than the stable temperature of the reactants in the temperature controller, the thermostat is first started to lower the temperature of the constant temperature plate through the temperature transfer tube until the temperature of the inner chamber on the left side of the purification box is consistent with that of the mixing box. Then the control pump is started to draw the reactants from the connecting pipe 2 into the inner chamber on the left side of the purification box, and then it is filtered and purified, which improves the practicality of the overall device and prevents the re-dissolution of reactants and impurities due to inaccurate temperature control, resulting in purification failure.

[0017] 2. After the purification of the reactants is completed, impurities will remain on the upper surface of the filter plate, which is inconvenient for the next use. Start the electric telescopic rod and push the push plate to push the impurities into the collection box. Then the staff can open the door and take out the collection box, which improves the practicality of the entire device.

[0018] 3. A return spring is provided. When the reactants flow into the purification box, a certain impact force will be generated on the filter plate. The return spring will buffer the impact of the impact force on the filter plate, thereby increasing the service life of the filter plate. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] Figure 1 It is a schematic diagram of the three-dimensional structure of the utility model;

[0020] Figure 2 This is a schematic diagram of the internal structure of the mixing box of the utility model;

[0021] Figure 3 This is a schematic diagram of the internal structure of the purification box of the present utility model;

[0022] Figure 4This is a schematic diagram of the internal structure of the sleeve of the present invention.

[0023] In the figure: 1. mixing box; 2. temperature controller; 3. protective cover; 4. feed hopper; 5. glass window; 6. control pump body; 7. connecting pipe 1; 8. purification box; 9. partition; 10. door body; 11. connecting pipe 2; 12. thermometer; 13. temperature transfer pipe; 14. constant temperature pipe; 15. temperature control mechanism; 16. return spring; 17. stirring element; 18. stirring shaft; 19. stepping motor; 20. discharge port; 21. first sleeve; 22. push plate; 23. electric telescopic rod; 24. cover plate; 25. filter plate; 26. constant temperature plate; 27. collecting box; 28. fixing plate; 29. ​​fixing block; 30. second sleeve. DETAILED DESCRIPTION

[0024] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0025] Example 1: Please refer to Figures 1 to 3 , a pharmaceutical intermediate reaction device that is convenient for discharging and purification, comprising:

[0026] The mixing box 1 has a feed hopper 4 at the top thereof, which provides conditions for materials to enter the mixing box 1 .

[0027] The temperature control mechanism 15 is fixedly arranged inside the mixing box 1, and is used to achieve a purification effect by controlling the temperature. A stepper motor 19 is fixedly installed in the middle of the top of the mixing box 1, and a stirring shaft 18 is rotatably installed in the middle of the inner top wall of the mixing box 1. The top of the stirring shaft 18 is fixedly connected to the output end of the stepper motor 19, and a plurality of evenly distributed stirring members 17 are fixedly arranged on the surface of the stirring shaft 18. The temperature control mechanism 15 includes a temperature controller 2 fixedly installed on the left side of the mixing box 1, and a plurality of evenly distributed constant temperature tubes 14 that do not affect each other with the stirring members 17 are fixedly arranged on the left side of the inner wall of the mixing box 1. The plurality of constant temperature tubes 14 are all electrically connected to the temperature controller 2. A connecting pipe 1 7 is fixedly arranged at the bottom end of the mixing box 1, and a connecting pipe 2 11 symmetrically distributed with the connecting pipe 1 7 is provided at the bottom end of the mixing box 1. The connecting pipe 1 7 and A control pump body 6 is fixedly provided on the connecting pipe 2 11, and the top of the control pump body 6 is fixedly connected to the bottom end of the mixing box 1, and the bottom ends of the connecting pipe 1 7 and the connecting pipe 2 11 are fixedly connected to the purification box 8. A partition 9 is fixedly provided in the middle of the inner wall of the purification box 8, and the partition 9 divides the interior of the purification box 8 into two inner chambers. The connecting pipe 2 11 and the connecting pipe 1 7 are respectively located at the top ends of the corresponding inner chambers. The two inner chambers of the purification box 8 are located directly below the connecting pipe 2 11 and the connecting pipe 1 7. A filter plate 25 is provided. The bottom ends of the two inner chambers of the purification box 8 are both provided with a discharge port 20. The bottom end of the temperature controller 2 is fixedly connected to the temperature transfer tube 13, and the top end of the purification box 8 is fixedly provided with a thermometer 12. A constant temperature plate 26 is provided on the left side of the inner wall of the inner chamber of the purification box 8 on the left side, and the constant temperature plate 26 is electrically connected to the bottom end of the temperature transfer tube 13.

[0028] Through the above features, after the reactants enter the mixing box 1, the stepper motor 19 is started to drive the internal stirring shaft 18 to rotate, and then the reactants are stirred evenly by the stirring member 17 to mix them. At the same time, the thermostat 2 is started to control the constant temperature tube 14 to increase the temperature inside the mixing box 1, thereby improving its reaction efficiency. After the reaction is completed, the temperature inside the mixing box 1 is lowered by the thermostat 2 to reduce the solubility and separate the impurities from the required purified product. Then, the external temperature on the thermometer 12 is checked, and the internal temperature of the purification box 8 is consistent with the external temperature. If it is lower than the temperature of the reactants in the mixing box 1, the control pump body 6 is started to pump the reactants from the connection. The pipe 1 is connected to the inner chamber on the right side of the purification box 8, and the impurities are filtered out through the filter plate 25. The purified product flows out through the discharge port 20. If the temperature on the thermometer 12 is higher than the stability of the reactants in the temperature controller 2, the temperature controller 2 is first started to lower the temperature of the constant temperature plate 26 through the temperature transfer pipe 13 until the temperature of the inner chamber on the left side of the purification box 8 is consistent with that of the inside of the mixing box 1. Then, the control pump body 6 is started to draw the reactants from the connecting pipe 2 11 into the inner chamber on the left side of the purification box 8, and then it is filtered and purified, thereby improving the practicality of the overall device and preventing the reactants and impurities from dissolving again due to inaccurate temperature control, which may result in purification failure.

[0029] In this embodiment, a protective cover 3 is fixedly provided on the top end of the mixing box 1 outside the stepping motor 19 . The protective cover 3 can provide a certain protection effect for the stepping motor 19 .

[0030] In this embodiment, a glass window 5 is provided at the front end of the mixing box 1 . The glass window 5 makes it easy to see the reaction conditions inside the mixing box 1 .

[0031] Example 2: Please refer to Figures 1 to 4 , a pharmaceutical intermediate reaction device that is convenient for discharging and purification, the difference from Example 1 is that, the two inner chambers of the purification box 8 are fixedly installed with a fixed plate 28, and a collection box 27 is provided on the top of the fixed plate 28. The inside of the purification box 8 is away from the fixed plate 28 and is located above the filter plate 25. Two symmetrically distributed electric telescopic rods 23 are fixedly installed, and the output end of the electric telescopic rod 23 is fixedly connected to the push plate 22. The bottom end of the push plate 22 is in contact with the upper surface of the filter plate 25. The inside of the purification box 8 is located above the two electric telescopic rods 23 and is fixed with a cover plate 24. The front end of the purification box 8 is located on both sides of the partition 9 and is hinged with a door body 10. The door body 10 is horizontally parallel to the collection box 27.

[0032] Through the above features, after the purification of the reactants is completed, impurities will remain on the upper surface of the filter plate 25, which is inconvenient for the next use. The electric telescopic rod 23 is started, and the push plate 22 is pushed to push the impurities into the collection box 27. Then the staff can open the door 10 to take out the collection box 27, thereby improving the practicality of the overall device.

[0033] In this embodiment, four fixed blocks 29 are fixedly arranged inside the purification box 8, of which two majority fixed blocks 29 are fixedly arranged at the back end of the fixed plate 28, and the other two fixed blocks 29 are fixedly arranged on the back side of the inner wall of the purification box 8. The four fixed blocks 29 are parallel to each other, and two symmetrically distributed first sleeves 21 are fixedly arranged on the fixed blocks 29. A second sleeve 30 is slidably penetrated inside the first sleeve 21. A return spring 16 is fixedly connected between the first sleeve 21 and the second sleeve 30, and the top end of the second sleeve 30 is fixedly connected to the bottom end of the filter plate 25.

[0034] Through the above features, a return spring 16 is provided. After the reactant flows into the purification box 8, a certain impact force will be generated on the filter plate 25. The return spring 16 will buffer the impact of the impact force on the filter plate 25, thereby increasing the service life of the filter plate 25.

[0035] In this embodiment, waterproof sealing rings are provided at the joints between the two door bodies 10 and the purification box 8 and the partition 9. The provision of waterproof sealing rings can improve the airtightness of the interior.

[0036] The above is only a preferred specific implementation method of the present invention, but the protection scope of the present invention is not limited to this. Any technician familiar with the technical field within the technical scope disclosed by the present invention can make equivalent replacements or changes based on the technical solution and utility model concept of the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A pharmaceutical intermediate reaction device that is convenient for discharging and purification, characterized by: include, A mixing box (1), wherein a feed hopper (4) is provided at the top of the mixing box (1); A temperature control mechanism (15) is fixedly arranged inside the mixing box (1) and is used to achieve a purification effect by controlling the temperature. A stepper motor (19) is fixedly installed in the middle of the top of the mixing box (1). A stirring shaft (18) is rotatably installed in the middle of the inner top wall of the mixing box (1). The top of the stirring shaft (18) is fixedly connected to the output end of the stepper motor (19). The surface of the stirring shaft (18) is fixedly provided with a plurality of evenly distributed stirring elements (17). The temperature control mechanism (15) includes a temperature controller (2) fixedly arranged on the left side of the mixing box (1). A plurality of evenly distributed constant temperature tubes (14) that do not affect each other and the stirring elements (17) are fixedly provided on the left side of the inner wall of the mixing box (1). The plurality of constant temperature tubes (14) are all electrically connected to the temperature controller (2). A connecting pipe (1) is fixedly provided at the bottom end of the mixing box (1). 7), the bottom end of the mixing box (1) is provided with a connecting pipe 2 (11) symmetrically distributed with the connecting pipe 1 (7), the connecting pipe 1 (7) and the connecting pipe 2 (11) are fixedly provided with a control pump body (6), the top end of the control pump body (6) is fixedly connected to the bottom end of the mixing box (1), the bottom ends of the connecting pipe 1 (7) and the connecting pipe 2 (11) are fixedly connected with a purification box (8), the middle part of the inner wall of the purification box (8) is fixedly provided with a partition (9), the partition (9) divides the interior of the purification box (8) into two inner chambers, the connecting pipe 2 (11) and the connecting pipe 1 (7) are respectively located at the top end of the corresponding inner chambers, the two inner chambers of the purification box (8) are both provided with filter plates (25) directly below the connecting pipe 2 (11) and the connecting pipe 1 (7), and the bottom ends of the two inner chambers of the purification box (8) are both provided with discharge ports (20); The bottom end of the temperature controller (2) is fixedly connected to a temperature transfer tube (13), the top end of the purification box (8) is fixedly provided with a thermometer (12), and a constant temperature plate (26) is provided on the left side of the inner wall of the inner chamber of the purification box (8) on the left side, and the constant temperature plate (26) is electrically connected to the bottom end of the temperature transfer tube (13).

2. A pharmaceutical intermediate reaction device that is convenient for discharge and purification according to claim 1, characterized in that: The two inner chambers of the purification box (8) are fixedly installed with a fixed plate (28), and a collection box (27) is provided at the top of the fixed plate (28). Two symmetrically distributed electric telescopic rods (23) are fixedly installed on the side of the interior of the purification box (8) away from the fixed plate (28) and located above the filter plate (25). The output end of the electric telescopic rod (23) is fixedly connected to a push plate (22), and the bottom end of the push plate (22) is in contact with the upper surface of the filter plate (25). A cover plate (24) is fixedly provided on the interior of the purification box (8) above the two electric telescopic rods (23). The front end of the purification box (8) is located on both sides of the partition (9) and is hinged with a door body (10). The door body (10) is parallel to the horizontal position of the collection box (27).

3. A pharmaceutical intermediate reaction device that is convenient for discharge and purification according to claim 2, characterized in that: Four fixed blocks (29) are fixedly arranged inside the purification box (8), wherein two of the majority of the fixed blocks (29) are fixedly arranged at the back end of the fixed plate (28), and the other two fixed blocks (29) are fixedly arranged at the back side of the inner wall of the purification box (8). The four fixed blocks (29) are parallel to each other. Two symmetrically distributed first sleeves (21) are fixedly arranged on the fixed blocks (29), and a second sleeve (30) is slidably penetrated inside the first sleeve (21). A reset spring (16) is fixedly connected between the first sleeve (21) and the second sleeve (30), and the top end of the second sleeve (30) is fixedly connected to the bottom end of the filter plate (25).

4. A pharmaceutical intermediate reaction device that is convenient for discharge and purification according to claim 2, characterized in that: Waterproof sealing rings are provided at the joints between the two door bodies (10), the purification box (8) and the partition (9).

5. A pharmaceutical intermediate reaction device that is convenient for discharge and purification according to claim 1, characterized in that: A protective cover (3) is fixedly provided on the top end of the mixing box (1) and located outside the stepping motor (19).

6. A pharmaceutical intermediate reaction device that is convenient for discharge and purification according to claim 1, characterized in that: A glass window (5) is provided at the front end of the mixing box (1).

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