PRP preparation device

Abstract

The PRP preparation device comprises a pipe body, an upper cover, a lower cover and a sealing plug, the pipe body comprises an upper section pipe, a middle pipe and a lower section pipe, the upper cover and the upper section pipe are matched to form an upper cavity, the upper cover can move up and down so that the upper cover can be switched between a first position and a second position, and the upper cover is provided with a liquid injection and suction hole, a liquid suction pipe and a sealing piece; the lower cover is matched with the lower section pipe to form a lower cavity, and the lower cover can move up and down to adjust the volume of the lower cavity; the sealing plug is used for controlling opening and closing of the liquid injection and suction hole and the liquid suction pipe; the part, located in the upper cavity, of the pipette has a set length, and the set length enables the pipette to be located in the platelet-poor plasma layer and keep a gap with the platelet-rich plasma layer when the pipette is located at the second position, and enables the port of the pipette to be located outside the platelet-rich plasma when the port of the pipette is located at the first position. By applying the device, the PRP concentration can be directly adjusted in the preparation device, and the damage to platelets can be avoided when the PRP is extracted.

Description

Technical Field

[0001] The utility model relates to the technical field of medical devices, in particular to a PRP preparation device. Background Art

[0002] With the advancement of medical technology, platelet-rich plasma (PRP) therapy has emerged. Platelet-rich plasma (PRP) is a platelet concentrate obtained by centrifuging autologous whole blood. It contains a large number of growth factors and proteins. Injecting an appropriate concentration of PRP into the area in need of treatment can rapidly stop bleeding, relieve pain, and accelerate wound healing, making it extremely valuable in aesthetic medicine, wound therapy, and osteoarthritis treatment. Currently, PRP is typically processed from drawn autologous whole blood using a platelet-rich plasma (PRP) prep apparatus. This process involves centrifuging the prep apparatus containing the autologous whole blood, separating the blood from top to bottom into a platelet-poor plasma layer, a platelet-rich plasma layer (commonly known as the buffy coat), and a red blood cell layer. A Luer connector, syringe, and other accessories are then used to draw a predetermined amount of platelet-poor plasma (PPP) and platelet-rich plasma, respectively. The two are then mixed and shaken together in an external container to obtain the desired PRP concentration.

[0003] However, because PPP and PRP need to be separately pipetted into the preparation device and then shaken to mix, these PRP preparation devices and methods pose a high risk of infection. Furthermore, current PRP preparation devices and methods also have limited applicability and are prone to platelet damage. Utility Model Content

[0004] Based on this, it is necessary to provide a PRP preparation device to address the above technical problems.

[0005] The utility model provides a PRP preparation device, comprising:

[0006] The pipe body comprises an upper pipe section, a middle pipe section and a lower pipe section which are connected in sequence, wherein the inner diameters of the upper pipe section and the lower pipe section are both larger than the inner diameter of the middle pipe section;

[0007] An upper cover is provided on the upper tube and the two cooperate to form an upper cavity. The upper cover is provided with injection and suction holes, a suction tube and a sealing member. The injection and suction holes and the suction tube both connect the upper cavity with the outside. The sealing member and the suction tube both extend into the upper cavity.

[0008] a lower cover, which is disposed on the lower tube and the two cooperate to form a lower cavity, wherein the lower cover can be displaced up and down relative to the lower tube to adjust the volume of the lower cavity; and

[0009] A sealing plug is provided on the upper cover and is used to control the opening and closing of the injection and suction holes and the pipette;

[0010] The upper cover is movable up and down relative to the upper tube so as to switch between a first position and a second position. When the upper cover is in the first position, the sealing member is separated from the middle tube. When the upper cover is in the second position, the sealing member seals the middle tube to isolate the upper chamber from the lower chamber.

[0011] The portion of the pipette located in the upper cavity has a set length, and the set length is configured so that the port of the pipette can be located in the platelet-poor plasma layer when the upper cover is in the first position and the tube body is upright, so that the port of the pipette can be kept spaced from the platelet-rich plasma layer when the upper cover is in the second position and the tube body is upright, and so that the port of the pipette can be located outside the shaken platelet-rich plasma when the upper cover is in the second position and the tube body is inverted.

[0012] Applying this application has the following beneficial effects:

[0013] 1. The volume of the lower chamber can be adjusted by moving the lower cover up and down relative to the lower tube, and thus the volume of the blood preparation device can be adjusted accordingly. This can expand the application range of the blood preparation device and reduce unnecessary blood waste.

[0014] 2. After centrifugation and stratification, the volume of the lower chamber can be changed by shifting the lower cover to allow the platelet-rich plasma layer to rise to the upper chamber. The middle tube is then sealed with a seal to completely separate the platelet-poor plasma layer and the platelet-rich plasma layer from the red blood cell layer. Platelet-poor plasma can then be extracted through a pipette according to the required concentration to adjust the platelet-poor plasma to platelet-rich plasma to an appropriate ratio. The platelet-rich plasma of the required concentration can be obtained by mixing and shaking the two. This avoids mixing operations outside the preparation device and reduces the risk of infection.

[0015] 3. The preparation device can be inverted to extract platelet-rich plasma. Since the pipette port is located outside the shaken platelet-rich plasma, the pipette connected to the outside can balance the air pressure. A syringe without a needle can be used to extract the shaken platelet-rich plasma through the injection and aspiration ports, avoiding damage to platelets and contamination caused by needle insertion. Furthermore, inverting the preparation device makes it easier to completely extract the platelet-rich plasma, avoiding residual waste.

[0016] In one embodiment, the set length is L, the height of the upper cavity when the upper cover is in the second position is H, and L and H satisfy the following relationship:

[0017] In one embodiment, the upper cover is threadedly connected to the upper tube, and the upper cover is displaced up and down relative to the upper tube by a screwing action. The screwing action achieves the upper cover's up and down displacement relative to the upper tube. On the one hand, the circumferential screwing action is less likely to cause vibration of the tube body, thereby preventing the effect on the plasma stratification after centrifugation. On the other hand, the threaded connection easily meets sealing requirements.

[0018] In one embodiment, the upper cover includes an upper cover plate and an upper screw cap formed into an integral structure. The injection and aspiration holes, the aspiration tube, and the sealing member are all provided on the upper cover plate. The upper screw cap is provided with an internal thread, and the upper cover is screwed onto the exterior of the upper tube via the upper screw cap. The upper cover is screwed onto the exterior of the upper tube via the upper screw cap, facilitating the screwing operation.

[0019] In one embodiment, the lower cover is threadedly connected to the lower tube, and the lower cover is displaced up and down relative to the lower tube by a screwing action. The screwing action achieves the up and down displacement of the lower cover relative to the lower tube. On the one hand, the circumferential screwing action is less likely to cause vibration of the tube body, thereby preventing the effect on the plasma stratification after centrifugation. On the other hand, the threaded connection easily meets the sealing requirements.

[0020] In one embodiment, the lower cover includes a lower cover plate and a lower screw cap formed into an integral structure. The lower screw cap is provided with an internal thread, and the lower cover is screwed onto the exterior of the lower tube section via the lower screw cap. The lower cover is screwed onto the exterior of the lower tube section via the lower screw cap, facilitating the screwing operation.

[0021] In one embodiment, the lower cover further includes a push block fixedly disposed in the lower screw cap, the push block being slidably disposed inside the lower tube section, and an outer surface of the push block being in contact with an inner wall of the lower tube section.

[0022] In one embodiment, the upper tube section is provided with graduated lines, each of which represents the volume of the space within the upper chamber below the corresponding graduated line. The graduated lines facilitate observation of the amount of platelet-rich plasma and platelet-poor plasma, and facilitate determination of the amount of platelet-poor plasma to be aspirated.

[0023] In one embodiment, the tube body is made of a transparent material, and a convex structure is formed inside the middle tube. The convex structure inside the middle tube can create a visual magnification effect, making it easier for an operator to observe the concentration state of platelets from outside the middle tube.

[0024] In one embodiment, the intermediate tube forms a central lumen, with the upper, intermediate, and lower lumens coaxially arranged. The seal is a sealing shaft extending downward through the middle of the upper cover. The upper lumen includes an upper main lumen and an upper transition lumen located below the upper main lumen, with the upper transition lumen gradually decreasing in width from top to bottom. The lower lumen includes a lower main lumen and a lower transition lumen located above the lower main lumen, with the lower transition lumen gradually increasing in width from top to bottom. The upper, intermediate, and lower transition lumen are sequentially connected. Thus, when the upper cover is screwed on, the seal rotates about its own axis while following the upper cover's upward and downward movement, thereby reducing disturbance to the platelet-rich plasma.

[0025] In one embodiment, the sealing member is detachably connected to the upper cover or formed into an integral structure;

[0026] The sealing member is inserted into the middle cavity to seal the middle tube when the upper cover is in the second position;

[0027] Alternatively, the inner diameter of the bottom of the upper transition chamber is larger than the inner diameter of the middle chamber and a step surface is formed therebetween. When the upper cover is in the second position, the sealing member abuts against the step surface to seal the middle tube. BRIEF DESCRIPTION OF THE DRAWINGS

[0028] Figure 1 A schematic diagram of the external structure of the preparation device provided in this application;

[0029] Figure 2 This is an exploded view of the preparation device;

[0030] Figure 3 A longitudinal cross-sectional view of the preparation device when the upper cover is in the first position and the lower cover is in a relatively lower position;

[0031] Figure 4 A longitudinal cross-sectional view of the preparation device when the upper cover is in the first position and the lower cover is relatively positioned upward;

[0032] Figure 5 A longitudinal cross-sectional view of the preparation device when the upper cover is in the second position and the lower cover is relatively positioned upward;

[0033] Figure 6 A longitudinal cross-sectional view of the preparation device when it is inverted to extract platelet-rich plasma;

[0034] Figure 7 The figure is a flowchart of the operation of using the preparation device.

[0035] Figure numerals: 1. upper tube; 2. middle tube; 20. step surface; 21. convex structure; 3. lower tube; 4. upper cover; 40. upper cover plate; 400. injection and suction holes; 41. upper screw cap; 42. suction tube; 43. sealing member; 44. sealing ring; 5. lower cover; 50. lower cover plate; 51. lower screw cap; 52. push block; 6. sealing plug; 7. upper cavity; 70. upper main cavity; 71. upper transition cavity; 8. middle cavity; 9. lower cavity; 90. lower main cavity; 91. lower transition cavity. DETAILED DESCRIPTION

[0036] To make the above-mentioned objects, features, and advantages of the present invention more clearly understood, the following detailed description of specific embodiments of the present invention is provided in conjunction with the accompanying drawings. The following description sets forth many specific details to facilitate a full understanding of the present invention. However, the present invention can be implemented in many other ways than those described herein, and those skilled in the art may make similar modifications without departing from the scope of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0037] In the description of the present invention, it should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "clockwise", "counterclockwise", "axial", "radial", "circumferential" and the like to indicate orientations or positional relationships based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation to the present invention.

[0038] Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Thus, a feature specified as "first" or "second" may explicitly or implicitly include at least one such feature. In the description of this utility model, "plurality" means at least two, such as two, three, etc., unless otherwise specifically defined.

[0039] In this utility model, unless otherwise specified or limited, the terms "installed," "connected," "connect," "fixed," etc. should be understood in a broad sense. For example, they can refer to fixed connection, detachable connection, or integration; mechanical connection, electrical connection; direct connection, or indirect connection through an intermediate medium; internal communication between two components, or interaction between two components, unless otherwise specified. Those skilled in the art will understand the specific meanings of the above terms in this utility model based on specific circumstances.

[0040] In the present invention, unless otherwise expressly specified or limited, when a first feature is "above" or "below" a second feature, it may mean that the first and second features are in direct contact, or the first and second features are in indirect contact through an intermediary. Furthermore, when a first feature is "above," "above," or "above" a second feature, it may mean that the first feature is directly above or diagonally above the second feature, or simply means that the first feature is at a higher level than the second feature. When a first feature is "below," "below," or "below" a second feature, it may mean that the first feature is directly below or diagonally below the second feature, or simply means that the first feature is at a lower level than the second feature.

[0041] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0042] The required PRP concentration varies in different treatment plans. For example, in medical aesthetics, a PRP concentration multiple of 2-3 times is preferred; in wound treatment, a PRP concentration multiple of about 4 times is preferred; and in osteoarthritis treatment, a PRP concentration multiple of about 6 times is preferred. After the existing PRP preparation device is centrifuged, in order to obtain the platelet-rich plasma of the required concentration, it is necessary to use accessories such as Luer connectors and syringes to draw a certain amount of platelet-poor plasma and platelet-rich plasma respectively, and then mix the two in an external container and shake them to obtain the platelet-rich plasma of the required concentration. The operation of drawing platelet-poor plasma and platelet-rich plasma into an external container for mixing increases the probability of infection.

[0043] During the aspiration process, there is only one opening for the syringe to draw out the platelet-poor plasma and platelet-rich plasma. Due to the combined effects of atmospheric pressure and the surface tension of the liquid molecules, it is difficult to draw out the platelet-poor plasma and platelet-rich plasma with just the syringe. A needle is required to complete the aspiration process, and this needle can damage the platelets in the platelet-rich plasma. Furthermore, this aspiration method inevitably leaves some platelet-poor plasma and platelet-rich plasma remaining in the preparation device.

[0044] In addition, different treatment plans require different amounts of platelet-rich plasma, and accordingly, different amounts of autologous whole blood samples. However, existing PPP preparation devices can only process a fixed amount of autologous whole blood, and their application range is limited.

[0045] To solve the above problems, the first aspect of the present application provides a PRP preparation device, such as Figure 1 and Figure 2 As shown in the figure, the preparation device includes a tube body, an upper cover 4, a lower cover 5 and a sealing plug 6. The upper cover 4 is provided with a liquid injection and aspiration hole 400, a liquid aspiration tube 42 and a sealing member 43. The tube body includes an upper tube 1, an intermediate tube 2 and a lower tube 3 which are connected in sequence. When autologous whole blood is injected into the tube body, it can flow in the upper tube 1, the intermediate tube 2 and the lower tube 3. The inner diameters of the upper tube 1 and the lower tube 3 are both larger than the inner diameter of the intermediate tube 2. Figure 3 and Figure 4 As shown in the figure, the upper cover 4 is arranged on the upper section of the tube 1 and the two cooperate to form an upper cavity 7. The injection and suction holes 400 and the suction tube 42 both connect the upper cavity 7 with the outside. The sealing plug 6 is arranged on the upper cover 4 and is used to control the opening and closing of the injection and suction holes 400 and the suction tube 42.

[0046] Combine Figure 4 and Figure 5 As shown, the lower cover 5 is arranged on the lower tube 3 and the two cooperate to form the lower cavity 9. The lower cover 5 can be displaced up and down relative to the lower tube 3 to adjust the volume of the lower cavity 9. The lower cover 5 can be displaced up and down relative to the lower tube 3 to adjust the volume of the lower cavity 9, and then the volume of the preparation device can be adjusted. The volume of the preparation device can be adjusted accordingly according to the target blood volume required for the treatment plan, which can expand the application range of the preparation device and reduce unnecessary blood waste. At the same time, the upper cover 4 can be displaced up and down relative to the upper tube 1 to switch the upper cover 4 between the first position and the second position. The sealing member 43 and the pipette 42 are both extended into the upper cavity 7. The sealing member 43 is separated from the middle tube 2 when the upper cover 4 is in the first position, and is sealed in the middle tube 2 when the upper cover 4 is in the second position to isolate the upper cavity 7 from the lower cavity 9.

[0047] The portion of the pipette 42 in this embodiment located in the upper chamber 7 has a set length, and the set length is configured so that the port of the pipette 42 is located in the platelet-poor plasma layer when the upper cover 4 is in the first position and the tube body is placed upright. After centrifugal stratification, the platelet-rich plasma layer can be raised to the upper chamber 7 by shifting the lower cover 5 to change the volume of the lower chamber 9. Then, by sealing the intermediate tube 2 with the seal 43, the platelet-poor plasma layer and the platelet-rich plasma layer can be completely separated from the red blood cell layer. After observing and determining the amount of platelet-rich plasma obtained after centrifugal stratification, the required amount of platelet-poor plasma can be deduced based on the required concentration of platelet-rich plasma. The platelet-poor plasma is drawn through the pipette 42 so that the platelet-poor plasma and platelet-rich plasma in the upper chamber 7 reach the required ratio. The two are mixed and shaken to obtain the platelet-rich plasma of the required concentration. Avoiding mixing operations outside the preparation device reduces the risk of infection.

[0048] It is easy to understand that the pipette 42 is used to aspirate platelet-poor plasma, that is, the pipette 42 cannot extend into the platelet-rich plasma layer after stratification. Therefore, the set length is also configured to ensure that the end of the pipette 42 is spaced apart from the platelet-rich plasma layer when the upper cover 4 is in the second position and the pipette body is placed upright.

[0049] In addition, if Figure 6 As shown in , the set length is also configured so that when the upper cover 4 is in the second position and the tube body is inverted, the end of the pipette 42 can be located outside the shaken platelet-rich plasma. In this way, after the platelet-poor plasma and platelet-rich plasma are mixed and shaken, the preparation device can be inverted to extract the platelet-rich plasma. Because the end of the pipette 42 is located outside the shaken platelet-rich plasma, the pipette 42 connected to the outside can balance the air pressure. A syringe without a needle can be used to extract the shaken platelet-rich plasma through the injection and aspiration port 400, avoiding damage to platelets and contamination caused by needle insertion. At the same time, the inverted preparation device makes it easier to completely extract the platelet-rich plasma, avoiding residual waste.

[0050] The "upright placement" described in this embodiment refers to placing the preparation device with the "upper cover 4 on the upper side and the lower cover 5 on the lower side"; the "inverted placement" described in this embodiment refers to placing the preparation device with the "upper cover 4 on the lower side and the lower cover 5 on the upper side".

[0051] Specifically in this embodiment, Figure 5 As shown in , the set length is L, the height of the upper cavity 7 when the upper cover 4 is in the second position is H, and L and H satisfy the following relationship: In other optional embodiments, L and H satisfy the following relationship: That's it. The above relationship is obtained through deduction and experiment, and its principle is explained as follows: As mentioned above, after the required amount of platelet-rich plasma of the required concentration is clear, the corresponding amount of autologous whole blood sample has been roughly determined, and the corresponding tube volume is also roughly determined. In this case, after centrifugal stratification and allowing the platelet-rich plasma layer to enter the upper chamber 7, the height position of the platelet-rich plasma layer in the upper tube 1 and the height position of the platelet-poor plasma layer in the upper tube 1 can be deduced to obtain similar data. After the preparation device is inverted, the height position of the mixed and shaken platelet-rich plasma of the required concentration in the upper tube 1 can also be deduced to obtain similar data. Through multiple experiments, the relationship between the above-mentioned set length L and the height dimension H of the upper chamber 7 when the upper cover 4 is in the second position can be obtained.

[0052] The upper cover 4 in this embodiment is threadedly connected to the upper tube 1, and the upper cover 4 is displaced up and down relative to the upper tube 1 by the screwing action of the thread. The upper cover 4 is displaced up and down relative to the upper tube 1 by the screwing operation. On the one hand, the screwing operation along the circumferential direction is not easy to cause vibration of the tube body, avoiding affecting the stratified plasma after centrifugation; on the other hand, the threaded connection is easy to meet the sealing requirements. Specifically, the upper cover 4 in this embodiment includes an upper cover plate 40 and an upper screw cap 41 formed as an integral structure. The injection and aspiration holes 400, the pipette 42 and the sealing member 43 are all provided on the upper cover plate 40. The upper screw cap 41 is provided with an internal thread. The upper cover 4 is screwed onto the outside of the upper tube 1 through the upper screw cap 41. The upper cover 4 is screwed onto the outside of the upper tube 1 through the upper screw cap 41 to facilitate the screwing operation.

[0053] To achieve a threaded connection, the upper tube section 1 in this embodiment has external threads on its outer wall that mate with the internal threads of the upper screw cap 41. In other alternative embodiments, the upper cover 4 can also be designed as a cylindrical structure with external threads on the outer surface of the cylindrical structure and internal threads on the inner wall of the upper tube section 1 that mate with the external threads of the aforementioned structure. In this case, due to the greater height of the cylindrical structure, the depth of the injection / suction hole 400 is greater.

[0054] Similar to the structural design of the upper cover 4, the lower cover 5 in this embodiment is threadedly connected to the lower tube 3, and the lower cover 5 is displaced up and down relative to the lower tube 3 through the screwing action. The lower cover 5 is displaced up and down relative to the lower tube 3 by the screwing operation. On the one hand, the screwing operation along the circumferential direction is less likely to cause vibration of the tube body, avoiding affecting the plasma stratification after centrifugation; on the other hand, the threaded connection easily meets the sealing requirements. Specifically, the lower cover 5 in this embodiment includes a lower cover plate 50 and a lower screw cap 51 formed as an integral structure. The lower screw cap 51 is provided with an internal thread, and the exterior of the lower tube 3 is provided with an external thread. The lower cover 5 is screwed onto the exterior of the lower tube 3 through the lower screw cap 51. The lower cover 5 is screwed onto the exterior of the lower tube 3 through the lower screw cap 51, which facilitates the screwing operation.

[0055] Furthermore, the lower cover 5 in this embodiment also includes a push block 52 fixedly disposed in the lower screw cap 51. The push block 52 is slidably disposed inside the lower tube 3, and the outer surface of the push block 52 is in contact with the inner wall of the lower tube 3. Optionally, the push block 52 can be made of a material having a certain elastic deformation ability. For example, the push block 52 can be a rubber block so that it can fit tightly with the inner wall of the lower tube 3 and provide a good sealing effect for the plasma. The push block 52 in this embodiment is fixedly secured to the lower cover plate 50. Optionally, the push block 52 and the lower cover plate 50 can also be integrally formed.

[0056] Since the lower chamber 9 is formed by the cooperation of the lower tube 3 and the lower cover 5, in an embodiment in which the push block 52 is not provided, the volume of the lower chamber 9 can also be changed by the up and down displacement of the lower cover plate 50 and the lower screw cap 51. The lower cover 5 in this embodiment adopts the solution of providing the push block 52, which is more convenient for the overall size design of the tube body, thereby making the preparation device as a whole easier to operate and hold. The specific description is as follows: when the lower cover 5 adopts the solution of not providing the push block 52, the lower chamber 9 is formed by the cooperation of the lower cover plate 50 and the lower knob cap in the lower cover 5 and the lower tube 3; when the lower cover 5 adopts the solution of providing the push block 52, the lower chamber 9 is formed by the cooperation of the push block 52 in the lower cover 5 and the lower tube 3. After the maximum design volume and the minimum design volume of the lower chamber 9 are set, the length dimension of the lower tube 3 in the solution of providing the push block 52 will be designed to be longer, which is easier to operate and hold.

[0057] In this embodiment, scale lines are provided on the upper tube 1 to indicate the volume of the space below the corresponding scale line within the upper chamber 7. The scale lines facilitate observation of the amount of platelet-rich plasma and platelet-poor plasma, and facilitate determination of the amount of platelet-poor plasma to be aspirated.

[0058] The tube body in this embodiment is made of a transparent material, and a convex structure 21 is formed inside the intermediate tube 2. By forming the convex structure 21 inside the intermediate tube 2, a visual magnification effect can be achieved through the convex structure 21, which makes it easier for the operator to observe the concentrated state of the platelets from the outside of the intermediate tube 2. The tube body in this embodiment is made of glass. In other optional embodiments, the tube body can also be made of transparent plastic materials such as polypropylene. The convex structure 21 refers to the wall thickness of the intermediate tube 2 having the characteristic of "relatively thicker in the middle and relatively thinner on the upper and lower sides" along the height direction of the tube body, thereby forming the intermediate tube 2 into a structure similar to a "magnifying glass", thereby achieving a visual magnification effect.

[0059] In this embodiment, the intermediate tube 2 is formed with a central lumen 8, with the upper lumen 7, the central lumen 8, and the lower lumen 9 coaxially arranged. The seal 43 is a sealing shaft extending downward through the middle of the upper cover 4. As the upper cover 4 is tightened, the seal 43 rotates about its own axis while following the upper cover 4's upward and downward movement, minimizing disturbance of the platelet-rich plasma.

[0060] Furthermore, the upper chamber 7 in this embodiment includes an upper main chamber 70 and an upper transition chamber 71 located below the upper main chamber 70, with the upper transition chamber 71 gradually decreasing in width from top to bottom. The lower chamber 9 includes a lower main chamber 90 and a lower transition chamber 91 located above the lower main chamber 90, with the lower transition chamber 91 gradually increasing in width from top to bottom. The upper transition chamber 71, the intermediate chamber 8, and the lower transition chamber 91 are sequentially connected. The above-described configuration of the tubular body facilitates the sealing operation between the seal 43 and the intermediate chamber 8. Furthermore, the inner walls of the upper transition chamber 71 and the lower transition chamber 91 are designed with inclined surfaces, which prevents the platelet-rich plasma layer from dispersing during its upward displacement to the upper chamber 7 after centrifugation.

[0061] like Figures 1 to 5 As shown in , in this embodiment, the inner diameters of the upper main body cavity 70 and the lower main body cavity 90 are identical, the upper transition cavity 71 and the lower transition cavity 91 are roughly symmetrical with respect to the intermediate cavity 8, and the wall thickness of the upper tube 1 and the wall thickness of the lower tube 3 are roughly the same. Therefore, the wall of the upper tube 1 has substantially the same contour as the upper cavity 7, and the wall of the lower tube 3 has substantially the same contour as the lower cavity 9. It should be noted that in other optional embodiments, the outer contour of the tube body can be directly designed as a columnar shape, as long as the upper cavity 7, the intermediate cavity 8, and the lower cavity 9 meet the aforementioned characteristics. The wall thickness of the tube body can be varied.

[0062] like Figure 2 As shown in FIG, the sealing member 43 in this embodiment is detachably connected to the upper cover 4, and the sealing member 43 is provided through the upper cover plate 40. A sealing ring 44 can be provided between the sealing member 43 and the upper cover plate 40 for sealing. In other optional embodiments, the sealing member 43 can also be integrally formed with the upper cover 4.

[0063] like Figure 5 As shown in FIG, in this embodiment, the sealing member 43 is designed to be compatible with the middle cavity 8. When the upper cover 4 is in the second position, the sealing member 43 is inserted into the middle cavity 8 to seal the middle tube 2. Figure 3 As shown in the figure, the bottom inner diameter of the upper transition chamber 71 is larger than the inner diameter of the middle chamber 8 and a step surface 20 is formed between the two. In other optional embodiments, the diameter of the sealing member 43 can also be designed to be larger than the inner diameter of the middle chamber 8, so that the sealing member 43 can abut against the step surface 20 to close the middle tube 2 when the upper cover 4 is in the second position.

[0064] like Figure 7 As shown in , the operating instructions for using the preparation device are as follows:

[0065] S100: With the sealing member 43 and the intermediate tube 2 kept separated, the sealing plug 6 is opened and the blood to be treated is injected into the tube body through the injection and aspiration holes 400;

[0066] S200: Close the sealing plug 6 and place the preparation device into a centrifuge for centrifugation, so that the blood in the tube is separated from the top to the bottom into a platelet-poor plasma layer, a platelet-rich plasma layer and a red blood cell layer; inject autologous whole blood and close the sealing plug 6. Figure 3 As shown in .

[0067] S300: Adjust the position of the lower cover 5 relative to the tube body to push the platelet-rich plasma layer into the upper chamber 7; the cross-sectional view of the preparation device after this step is completed is as follows Figure 4 As shown in .

[0068] S400: Aspirating the platelet-poor plasma layer through the pipette 42 until the platelet-poor plasma and platelet-rich plasma reach a target ratio;

[0069] S500: Adjust the upper cover 4 to the second position relative to the tube body so that the seal 43 seals the middle tube 2; the cross-sectional view of the preparation device after this step is completed is as follows Figure 5 As shown in .

[0070] S600: Shake the platelet-poor plasma layer and the platelet-rich plasma layer in the upper chamber 7 and turn the preparation device upside down; the cross-sectional view of the preparation device during this step is as shown in FIG. Figure 6 As shown in . It should be noted that in this step, either the platelet-poor plasma layer and the platelet-rich plasma layer in the upper chamber 7 are first shaken and then the preparation device is inverted; or the preparation device is first inverted and then the platelet-poor plasma layer and the platelet-rich plasma layer in the upper chamber 7 are shaken and then mixed. In this case, inverting the preparation device first and then shaking can save time waiting for the preparation device to rest.

[0071] S700: Open the sealing plug 6 and extract the shaken platelet-rich plasma through the injection and aspiration hole 400.

[0072] In other optional embodiments, before injecting the blood to be treated into the tube body through the injection / aspiration port 400 in step S100, a step S10 may be further included: adjusting the position of the lower cover 5 relative to the tube body to adjust the internal volume of the tube body to match the amount of blood to be treated. Step S10 allows the volume of the preparation device to be adjusted accordingly based on the target blood volume required for the treatment plan, thereby expanding the application range of the preparation device and reducing unnecessary blood waste.

[0073] Furthermore, after step S100, step S110 may be included: adjusting the position of the lower cover 5 relative to the tube body to adjust the volume of the lower chamber 9. In other words, the lower cover 5 position adjustment operation can be performed after the autologous whole blood is injected into the tube body, thereby achieving the purpose of "adjusting the volume of the preparation device according to the target blood volume required by the treatment plan." Furthermore, by moving the lower cover 5 downward and upward after the autologous whole blood is injected into the tube body, the volume of the lower chamber 9 can be changed, thereby ensuring a more efficient flow of the autologous whole blood within the tube body.

[0074] It is easy to understand that both step S10 and step S100 may be adopted in one operation, or only one of them may be adopted.

[0075] The technical features of the above-mentioned embodiments can be combined arbitrarily. In order to make the description concise, not all possible combinations of the technical features in the above-mentioned embodiments are described. However, as long as there is no contradiction in the combination of these technical features, they should be considered to be within the scope of this specification.

[0076] The above-described embodiments merely represent several implementations of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the utility model patent. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the concept of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present utility model patent shall be determined by the appended claims.

Claims

1. A PRP preparation device, characterized in that: The preparation device comprises: A pipe body comprising an upper pipe section (1), an intermediate pipe section (2) and a lower pipe section (3) which are connected in sequence, wherein the inner diameters of the upper pipe section (1) and the lower pipe section (3) are both larger than the inner diameter of the intermediate pipe section (2); An upper cover (4) is arranged on the upper tube (1) and the two cooperate to form an upper chamber (7). The upper cover (4) is provided with a liquid injection and suction hole (400), a liquid suction tube (42) and a sealing member (43). The liquid injection and suction hole (400) and the liquid suction tube (42) both connect the upper chamber (7) with the outside. The sealing member (43) and the liquid suction tube (42) both extend into the upper chamber (7); A lower cover (5) is disposed on the lower tube (3) and the two cooperate to form a lower chamber (9), wherein the lower cover (5) can be displaced up and down relative to the lower tube (3) to adjust the volume of the lower chamber (9); and A sealing plug (6) is provided on the upper cover (4) and is used to control the opening and closing of the liquid injection and suction holes (400) and the liquid suction tube (42); The upper cover (4) can be displaced up and down relative to the upper tube (1) so as to switch the upper cover (4) between a first position and a second position; the sealing member (43) is separated from the middle tube (2) when the upper cover (4) is in the first position, and seals the middle tube (2) to isolate the upper chamber (7) from the lower chamber (9) when the upper cover (4) is in the second position; The portion of the pipette (42) located in the upper chamber (7) has a set length, and the set length is configured so that when the upper cover (4) is in the first position and the tube body is upright, the port of the pipette (42) can be located in the platelet-poor plasma layer, when the upper cover (4) is in the second position and the tube body is upright, the port of the pipette (42) can be kept spaced from the platelet-rich plasma layer, and when the upper cover (4) is in the second position and the tube body is inverted, the port of the pipette (42) can be located outside the platelet-rich plasma in a shaken state.

2. The preparation device according to claim 1, characterized in that The set length is L, the height dimension of the upper cavity (7) when the upper cover (4) is in the second position is H, and L and H satisfy the following relationship:

3. The preparation device according to claim 1, characterized in that The upper cover (4) is threadedly connected to the upper tube (1), and the upper cover (4) is displaced up and down relative to the upper tube (1) by a screwing action of the thread.

4. The preparation device according to claim 3, characterized in that The upper cover (4) comprises an upper cover plate (40) and an upper screw cap (41) formed as an integral structure; the liquid injection and suction holes (400), the liquid suction tube (42) and the sealing member (43) are all provided on the upper cover plate (40); the upper screw cap (41) is provided with an internal thread; and the upper cover (4) is screwed onto the outside of the upper tube (1) via the upper screw cap (41).

5. The preparation device according to claim 1, characterized in that The lower cover (5) is threadedly connected to the lower tube (3), and the lower cover (5) is displaced up and down relative to the lower tube (3) by a screwing action of the thread.

6. The preparation device according to claim 5, characterized in that The lower cover (5) comprises a lower cover plate (50) and a lower screw cap (51) formed into an integral structure. The lower screw cap (51) is provided with an internal thread. The lower cover (5) is screwed onto the outside of the lower section pipe (3) through the lower screw cap (51).

7. The preparation device according to claim 6, characterized in that The lower cover (5) further comprises a push block (52) fixedly arranged in the lower screw cap (51), the push block (52) being slidably arranged inside the lower tube (3), and the outer surface of the push block (52) being in contact with the inner wall of the lower tube (3).

8. The preparation device according to claim 1, characterized in that The upper tube (1) is provided with scale lines, and the scale lines are used to represent the volume value of the space below the position of the corresponding scale lines in the upper cavity (7).

9. The preparation device according to claim 1, characterized in that The tube body is made of a transparent material, and a convex structure (21) is formed inside the intermediate tube (2).

10. The preparation device according to any one of claims 1 to 9, characterized in that The intermediate tube (2) is formed with an intermediate cavity (8), the upper cavity (7), the intermediate cavity (8) and the lower cavity (9) are coaxially distributed, and the sealing member (43) is a sealing shaft extending downward through the middle of the upper cover (4); The upper chamber (7) comprises an upper main chamber (70) and an upper transition chamber (71) located below the upper main chamber (70), and the upper transition chamber (71) gradually decreases in width from top to bottom; the lower chamber (9) comprises a lower main chamber (90) and a lower transition chamber (91) located above the lower main chamber (90), and the lower transition chamber (91) gradually increases in width from top to bottom, and the upper transition chamber (71), the intermediate chamber (8) and the lower transition chamber (91) are connected in sequence.

11. The preparation device according to claim 10, characterized in that The sealing member (43) and the upper cover (4) are detachably connected or form an integral structure; The sealing member (43) is inserted into the middle cavity (8) to seal the middle tube (2) when the upper cover (4) is in the second position; Alternatively, the bottom inner diameter of the upper transition chamber (71) is greater than the inner diameter of the intermediate chamber (8) and a step surface (20) is formed between the two, and the sealing member (43) abuts against the step surface (20) to seal the intermediate tube (2) when the upper cover (4) is in the second position.

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