Integrated external circulation pipeline and blood purification equipment

Abstract

The utility model provides an integrated external circulation pipeline and blood purification equipment, and relates to the technical field of blood purification, the integrated external circulation pipeline comprises a box body and an artery pipeline area, a vein pipeline area and a plasma pipeline area which are arranged on the box body, the artery pipeline area comprises a blood sampling input end, a blood sampling pump input end, a blood sampling pump output end and a blood sampling output end, the blood sampling input end is in liquid communication with the input end of the blood sampling pump through a first pipeline; the output end of the blood sampling pump is in liquid communication with the blood sampling output end through a second pipeline; the vein pipeline area comprises a bubble catcher, a blood return input end, a transfusion pump input end, a transfusion pump output end and a blood return output end, the blood return input end is connected with the bubble catcher through a third pipeline, the bubble catcher is communicated with the transfusion pump input end through a fourth pipeline, and the transfusion pump output end is connected with the blood return output end through a fifth pipeline. In the embodiment of the invention, the pipeline connection work can be simplified, so that the probability of connection errors of workers can be effectively reduced.

Description

Technical Field

[0001] The present application relates to the technical field of blood purification, and in particular to an integrated external circulation pipeline and blood purification equipment. Background Art

[0002] In the related art, the extracorporeal circulation circuit is a medium used to maintain the flow of blood outside the body in the field of blood purification. The extracorporeal circulation circuit is powered by different pumps to complete the extracorporeal circulation of blood, and then return the blood to the human body. In the clinical treatment process, there are different treatment modes for blood purification, such as plasma exchange, plasma adsorption, etc., which involve a variety of specifications and different models of extracorporeal circulation blood circuits, which are used in series or parallel to achieve different treatment functions and purposes. However, the current extracorporeal circulation circuit connections mostly rely on manual connection by medical staff to achieve different treatment modes, which puts a huge workload on medical staff; at the same time, due to the large number of pipeline interfaces, errors are easy to occur, which poses risks to patients in clinical applications; in addition, multiple connections of the pipelines also make the blood purification equipment pipelines messy and affect the appearance. Utility Model Content

[0003] The present application aims to solve at least one of the technical problems existing in the prior art. To this end, the present application proposes an integrated external circulation pipeline and blood purification device, which can effectively simplify pipeline connection and reduce the probability of pipeline connection errors.

[0004] In one aspect, an embodiment of the present application provides an integrated external circulation pipeline, comprising a box body and an arterial pipeline area, a venous pipeline area, and a plasma pipeline area provided on the box body, wherein:

[0005] The arterial line area includes a blood sampling input end, a blood sampling pump input end, a blood sampling pump output end and a blood sampling output end, the blood sampling input end is in liquid communication with the blood sampling pump input end via a first line, and the blood sampling pump output end is in liquid communication with the blood sampling output end via a second line;

[0006] The venous line area includes a bubble trap, a return blood input end, a return infusion pump output end, and a return blood output end, wherein the return blood input end and the bubble trap are connected via a third line, the bubble trap is connected to the return infusion pump input end via a fourth line, and the return infusion pump output end and the return blood output end are connected via a fifth line;

[0007] The plasma pipeline area includes a plasma input end, a plasma pump input end, a plasma pump output end, an adsorption input end and an adsorption output end. The plasma input end is liquid-connected to the plasma pump input end through a sixth pipeline, the plasma pump output end is liquid-connected to the adsorption input end through a seventh pipeline, and the adsorption output end is liquid-connected to the bubble trap through an eighth pipeline.

[0008] Furthermore, the plasma pipeline area includes a control valve group and a waste liquid output end, the adsorption output end is liquid-connected to the waste liquid output end through the waste liquid pipeline, and the control valve group is used to control the opening and closing of the eighth pipeline and / or the waste liquid pipeline.

[0009] Furthermore, it also includes a liquid pump input end, which is connected to the seventh pipeline liquid through a circulating liquid pipeline, and the control valve group is also used to control the on-off of the circulating liquid pipeline.

[0010] Furthermore, at least one of the first pipeline, the second pipeline and the fifth pipeline is provided with a filter and a pressure detection device.

[0011] Furthermore, the adsorption input end includes a first connection end and a second connection end, and the end of the seventh pipeline away from the plasma pump output end has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end, and the second branch is liquid-connected to the second connection end; the adsorption output end includes a third connection end and a fourth connection end, and the end of the eighth pipeline away from the bubble trap has a third branch and a fourth branch arranged in parallel, the third branch is liquid-connected to the third connection end, and the fourth branch is liquid-connected to the fourth connection end.

[0012] Furthermore, the adsorption input end includes a first connection end and a second connection end, and the end of the seventh pipeline away from the plasma pump output end has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end, and the second branch is liquid-connected to the second connection end; the adsorption output end includes a third connection end and a fourth connection end, the third connection end is liquid-connected to the bubble trap through the eighth pipeline, and the fourth connection end is liquid-connected to the first connection end through a series pipeline.

[0013] Furthermore, the bubble catcher is provided with an exhaust hole, the integrated external circulation pipeline further includes an exhaust end, and the exhaust hole is connected to the exhaust end through the exhaust pipeline.

[0014] Furthermore, it also includes an anticoagulant pipeline area, which includes an anticoagulant input end, an anticoagulant pump input end and an anticoagulant pump output end. The anticoagulant input end is connected to the anticoagulant pump input end through a first anticoagulant pipeline liquid, and the anticoagulant pump output end is connected to the second pipeline through a second anticoagulant pipeline liquid.

[0015] Furthermore, the bubble trap includes a shell having an inclined surface, and a projection of the output end of the third pipeline in the vertical direction is located on the inclined surface.

[0016] Another embodiment of the present application provides a blood purification device, comprising a plasma separation device and the aforementioned integrated external circulation pipeline, wherein the plasma separation device has an input port, and the input port is in liquid communication with the blood sampling output end via a pipeline.

[0017] Furthermore, the plasma separation device includes a centrifugal plasma separator or a plasma separator.

[0018] It can be seen from the above technical solutions that the embodiments of the present application have at least the following beneficial effects:

[0019] In the integrated pipeline provided in the embodiments of the present application, the arterial, venous, and plasma lines are pre-installed on the box body, and some of the lines are pre-connected. During use, the plasma exchange device, blood collection pump, and other equipment can be directly connected to the interfaces of the arterial, venous, and plasma lines in the integrated external circulation pipeline, thereby reducing the workload of pipeline connection. At the same time, since some of the lines are pre-connected, the pipeline connection work can be simplified, thereby effectively reducing the probability of connection errors by the staff. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, the drawings described below are only some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative labor.

[0021] Figure 1 A schematic diagram of the connection of an integrated external circulation pipeline provided in one embodiment of the present application;

[0022] Figure 2 for Figure 1 An application diagram of the integrated external circulation pipeline shown;

[0023] Figure 3 A schematic diagram of the connection of an integrated external circulation pipeline provided in another embodiment of the present application;

[0024] Figure 4 for Figure 3 An application diagram of the integrated external circulation pipeline shown;

[0025] Figure 5 A schematic diagram of the connection of an integrated external circulation pipeline provided in yet another embodiment of the present application;

[0026] Figure 6 for Figure 5 An application schematic diagram of an integrated external circulation pipeline is shown.

[0027] Reference numerals:

[0028] a, first pipeline; b, second pipeline; c, third pipeline; d, fourth pipeline; e, fifth pipeline; f, sixth pipeline; g, seventh pipeline; h, eighth pipeline; i, waste liquid pipeline; j, circulating liquid pipeline; k, series pipeline;

[0029] 1. Plasma separation device; 2. Waste liquid container; 3. Blood collection pump; 4. Return pump; 5. Plasma pump; 6. Adsorption column; 7. Liquid pump; 8. Connecting pipes; 9. Anticoagulant pump; 10. Eluent bag; 11. Equilibration liquid bag; 12. Saline bag; 13. Exhaust bag; 14. Anticoagulant bag; 15. Perfusion column;

[0030] 110, blood sampling input terminal; 120, blood sampling pump input terminal; 130, blood sampling pump output terminal; 140, blood sampling output terminal;

[0031] 210, bubble trap; 220, blood return input; 230, reinfusion pump input; 240, reinfusion pump output; 250, blood return output;

[0032] 310, plasma input; 320, plasma pump input; 330, plasma pump output; 340, adsorption input; 341, first connection; 342, second connection; 350, adsorption output; 351, third connection; 352, fourth connection; 360, waste liquid output; 370, control valve group; 371, first control valve; 372, second control valve; 373, third control valve; 374, fourth control valve; 381, circulating liquid input; 382, ​​liquid pump input; 383, liquid pump output; 391, first interface; 392, second interface.

[0033] 410, exhaust end;

[0034] 510, anticoagulant input terminal; 520, anticoagulant pump input terminal; 530, anticoagulant pump output terminal. DETAILED DESCRIPTION

[0035] The following will be combined with the drawings in the embodiments of this application to clearly and completely describe the technical solutions in the embodiments of this application. Obviously, the embodiments described are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of this application.

[0036] See also Figure 1As shown, one embodiment of the present application discloses an integrated external circulation circuit for use in blood purification treatment. Specifically, the integrated external circulation circuit includes a box body and an arterial circuit area, a venous circuit area, and a plasma circuit area provided on the box body.

[0037] in:

[0038] The arterial pipeline area includes a blood collection input end 110, a blood collection pump input end 120, a blood collection pump output end 130 and a blood collection output end 140. The blood collection input end 110 is liquid-connected to the blood collection pump input end 120 through a first pipeline a, and the blood collection pump output end 130 is liquid-connected to the blood collection output end 140 through a second pipeline b.

[0039] The venous line area includes a bubble trap 210, a blood return input end 220, a reinfusion pump input end 230, a reinfusion pump output end 240 and a blood return output end 250. The blood return input end 220 and the bubble trap 210 are connected through a third line c, the bubble trap 210 and the reinfusion pump input end 230 are connected through a fourth line d, and the reinfusion pump output end 240 and the blood return output end 250 are connected through a fifth line e.

[0040] The plasma pipeline area includes a plasma input end 310, a plasma pump input end 320, a plasma pump output end 330, an adsorption input end 340 and an adsorption output end 350. The plasma input end 310 is liquid-connected to the plasma pump input end 320 through the sixth pipeline f, the plasma pump output end 330 is liquid-connected to the adsorption input end 340 through the seventh pipeline g, and the adsorption output end 350 is liquid-connected to the bubble trap 210 through the eighth pipeline h.

[0041] In the integrated pipeline provided in the embodiment of the present application, the arterial pipeline area, venous pipeline area, and plasma pipeline area are pre-installed on the box body, and some pipelines are pre-connected. During use, the plasma exchange device, blood collection pump 3, and other equipment can be directly connected to the interfaces of each pipeline area, thereby reducing the workload of pipeline connection. At the same time, since some pipelines are pre-connected, the pipeline connection work can be simplified, thereby effectively reducing the probability of connection errors by personnel.

[0042] In one embodiment of the present application, the arterial pipeline area is connected to the human body's venous blood through the blood sampling input end 110, and is connected to the plasma separation device 1 through the blood sampling output end 140; the venous pipeline area is connected to the plasma separation device 1 through the return blood input end 220, and is connected to the human body's return blood line through the return blood output end; the plasma pipeline area is connected to the plasma separation device 1 through the plasma input end 310, and is connected to the venous pipeline area through the loop pipeline.

[0043] In some embodiments of the present application, the plasma separation device includes a centrifugal plasma separator or a plasma separator.

[0044] In this embodiment, the plasma separation device 1 includes a blood cell outlet and a plasma outlet. The circuit piping includes a sixth pipe f, a seventh pipe g, and an eighth pipe h. One end of the sixth pipe f is in fluid communication with the plasma outlet via a pipe, and the other end of the sixth pipe f is in fluid communication with the input of the plasma pump 5 or a collection pump. One end of the seventh pipe g is in fluid communication with the output of the plasma pump 5 or the collection pump, and the other end of the seventh pipe g is in fluid communication with the adsorption input 340. One end of the eighth pipe h is in fluid communication with the adsorption output 350, and the other end is in fluid communication with the bubble trap 210. An adsorption device can be connected between the adsorption input 340 and the adsorption output 350 to adsorb toxic substances in the plasma.

[0045] See also Figure 1 and Figure 2 As shown, in a possible embodiment, when blood purification is performed using an integrated external circulation pipeline, an adsorption column 6 is connected between the adsorption input end 340 and the adsorption output end 350 .

[0046] Further, see Figure 1 and Figure 2 As shown, the plasma pipeline area includes a control valve group 370 and a waste liquid output terminal 360. The adsorption output terminal 350 is in liquid communication with the waste liquid output terminal 360 via the waste liquid pipeline i. The control valve group 370 is used to control the opening and closing of the eighth pipeline h and / or the waste liquid pipeline i. The waste liquid output terminal 360 is used to connect to the waste liquid container 2 via a pipeline.

[0047] In one possible embodiment, the control valve assembly 370 is used to control the opening and closing of the eighth pipeline h and the waste liquid pipeline i. Thus, when the eighth pipeline h is in an open state and the waste liquid pipeline i is in a closed state, plasma flowing through the adsorption column 6 can flow from the adsorption output end 350 into the eighth pipeline h and then to the bubble trap 210, where it can mix with blood cells before returning to the human body through the blood return output end. When the eighth pipeline h is in a closed state and the waste liquid pipeline i is in an open state, plasma or liquid flowing through the adsorption column 6 can flow from the adsorption output end 350 through the waste liquid pipeline i and be discharged from the waste liquid output end 360 to a waste liquid collection device.

[0048] See also Figure 1 and Figure 2 The integrated external circulation pipeline includes a first interface 391 and a second interface 392. The first interface 391 is connected to the eighth pipeline h, and the second interface 392 is connected to the bubble trap 210. The first interface 391 and the second interface 392 are connected by a connecting pipeline 8.

[0049] See also Figure 1 and Figure 2As shown, in some embodiments of the present application, the integrated external circulation pipeline further includes a liquid pump input terminal, which is in fluid communication with the seventh pipeline g via the circulating liquid pipeline j. The control valve assembly 370 is also used to control the on / off state of the circulating liquid pipeline j. When the circulating liquid pipeline j is in a flow state, external circulating liquid can be input into the seventh pipeline g via the liquid pump input terminal and flow from the adsorption input terminal 340 to the adsorption column 6. The liquid pump input terminal 382 is used to input the circulating liquid.

[0050] In one possible implementation, see Figure 1 The integrated external circulation pipeline further includes a circulating liquid input end 381 and a liquid pump input end 382. The circulating liquid input end 381 is used to input circulating liquid, and a liquid pump 7 is connected between the liquid pump input end 382 and the liquid pump output end 383 to transport the circulating liquid to the circulating liquid pipeline j.

[0051] In this embodiment, the circulating liquid input end 381 is in liquid communication with the saline bag 12 , the balancing liquid bag 11 and the eluent bag 10 . The saline bag 12 contains saline, the balancing liquid bag 11 contains balancing liquid, and the eluent bag 10 contains eluent.

[0052] In some embodiments of the present application, at least one of the first pipeline a, the second pipeline b, and the fifth pipeline e is provided with a filter and a pressure detection device.

[0053] In one possible embodiment, the first pipeline a, the second pipeline b, and the fifth pipeline e are respectively provided with a filter and a pressure detection device. Specifically, the first pipeline a is provided with a filter and a pressure detection device, the filter is used to filter the blood in the first pipeline a, and the pressure detection device is used to detect the fluid pressure in the first pipeline a; the second pipeline b is provided with a filter and a pressure detection device, the filter is used to filter the blood in the second pipeline b, and the pressure detection device is used to detect the fluid pressure in the second pipeline b; the fifth pipeline e is provided with a filter and a pressure detection device, the filter is used to filter the blood in the fifth pipeline e, and the pressure detection device is used to detect the fluid pressure in the fifth pipeline e.

[0054] See also Figure 3 and Figure 4 In some embodiments of the present application, the adsorption input end 340 includes a first connection end 341 and a second connection end 342, and the end of the seventh pipeline g away from the plasma pump output end 330 has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end 341, and the second branch is liquid-connected to the second connection end 342; the adsorption output end 350 includes a third connection end 351 and a fourth connection end 352, and the end of the eighth pipeline h away from the bubble trap 210 has a third branch and a fourth branch arranged in parallel, the third branch is liquid-connected to the third connection end 351, and the fourth branch is liquid-connected to the fourth connection end 352.

[0055] Among them, the branch 1 and the branch 2 are respectively arranged in parallel on the side of the circulating liquid pipeline j away from the liquid pump 7, wherein the branch 1 is in liquid communication with the first branch, and the branch 2 is in liquid communication with the second branch.

[0056] Furthermore, a first waste liquid branch and a second waste liquid branch are provided at one end of the waste liquid pipeline i away from the waste liquid output end 360 . The first waste liquid branch is in liquid communication with the third connection end 351 , and the second waste liquid branch is in liquid communication with the fourth connection end 352 .

[0057] In one possible implementation, see Figure 3 and Figure 4 The control valve group 370 includes a first control valve 371, a second control valve 372, a third control valve 373, and a fourth control valve 374. The first control valve 371 is used to control the on-off of branch 1 and branch 2, the second control valve 372 is used to control the on-off of the first branch and the second branch; the third control valve is used to control the on-off of the third branch and the fourth branch; the fourth control valve 374 is used to control the on-off of the first waste liquid branch and the second waste liquid branch. Figure 5 and Figure 6 As shown, in some embodiments of the present application, the adsorption input end 340 includes a first connection end 341 and a second connection end 342, and the end of the seventh pipeline g away from the plasma pump output end 330 has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end 341, and the second branch is liquid-connected to the second connection end 342; the adsorption output end 350 includes a third connection end 351 and a fourth connection end 352, the third connection end 351 is liquid-connected to the bubble trap 210 through the eighth pipeline h, and the fourth connection end 352 is liquid-connected to the first connection end 341 through the series pipeline k.

[0058] See also Figure 1 and Figure 2 As shown, in some embodiments of the present application, the bubble trap 210 is provided with an exhaust hole, and the integrated external circulation pipeline further includes an exhaust end 410, and the exhaust hole is connected to the exhaust end 410 through the exhaust pipeline.

[0059] In this embodiment, the exhaust port 410 is used to connect to the exhaust bag 13 .

[0060] See also Figure 1 and Figure 2As shown, in some embodiments of the present application, an anticoagulant line area is further included, which includes an anticoagulant input end 510, an anticoagulant pump input end 520, and an anticoagulant pump output end 530. The anticoagulant input end 510 is in fluid communication with the anticoagulant pump input end 520 via a first anticoagulant line, and the anticoagulant pump output end 530 is in fluid communication with the second line b via a second anticoagulant line. The anticoagulant pump connects the anticoagulant pump input end 520 and the anticoagulant pump output end 530. In actual applications, an anticoagulant pump 9 is connected between the anticoagulant pump input end 520 and the anticoagulant pump output end 530.

[0061] In one possible embodiment, the anticoagulant input port 510 is in fluid communication with the anticoagulant liquid bag 14 .

[0062] In some embodiments of the present application, the bubble trap 210 includes a shell having an inclined surface, and a projection of the output end of the third pipeline c in the vertical direction is located on the inclined surface.

[0063] Another embodiment of the present application provides a blood purification device, including the above-mentioned integrated external circulation pipeline.

[0064] The following describes in detail the integrated external circulation pipeline and blood purification device of the embodiment of the present application with specific embodiments. It should be noted that the following embodiments are merely illustrative descriptions and should not be understood as limiting the embodiments of the present application.

[0065] See also Figure 1 and Figure 2 As shown, the integrated external circulation pipeline is buckled onto the blood purification equipment, and each pipeline interface is connected to the corresponding device and pump respectively. After the blood purification equipment is turned on, the blood collection pump 3 is turned on, and the venous blood in the human body passes through the arterial pipeline area, and passes through the blood collection input end 110, the first pipeline a, the blood collection pump 3, the blood collection pump output end 130, the second pipeline b, the filter screen, and the blood collection output end 140 to enter the plasma separation device 1. The plasma separation device 1 separates the plasma and blood cells into blood cells and plasma. After the blood cells are separated, they enter the bubble trap 210 through the return blood input end 220. The plasma enters the plasma pipeline area from the plasma input end 310 and is connected to the adsorption input end 340 (the second control valve 372 controls the opening and closing of the pipeline) in sequence. Then, it passes through the adsorption column 6 to enter the adsorption output end 350, and then enters the bubble trap 210 through the eighth pipeline h (the third control valve controls the opening and closing of the pipeline). After mixing with the blood cells in the bubble trap 210, it is returned to the human body through the fourth pipeline d, the return pump 4, and the fifth pipeline e.

[0066] When the adsorption column 6 needs to be regenerated, the second control valve 372 and the third control valve control pipeline are closed. The circulating liquid is connected to the liquid pump 7 through the pipeline inlet, and then connected to the adsorption input end 340, the adsorption column 6, the adsorption output end 350, the waste liquid pipeline i (controlled by the fourth control valve 374), and the waste liquid output end 360 through the circulating liquid pipeline j (controlled by the first control valve 371) and is recovered into the waste liquid tank, thereby regenerating the adsorption column 6. In this case, the adsorption column 6 is recycled for adsorption operation.

[0067] In another specific embodiment, see Figure 3 and Figure 4 As shown, the integrated circulation pipeline is buckled onto the blood purification equipment, and each pipeline interface is connected to the corresponding device and pump respectively. After the blood purification equipment is turned on, the blood collection pump 3 is turned on, and the venous blood in the human body passes through the arterial pipeline area, and passes through the blood collection input end 110, the blood collection pump 3, the filter, and the blood collection output end 140 to enter the plasma separation device 1. The plasma separation device 1 separates the plasma and blood cells. After the blood cells are separated, they enter the bubble trap 210 through the return blood input end 220. After the plasma is separated, it enters the plasma pipeline area, passes through the plasma input end 310 and the plasma pump 5 in turn, and then connects the first connection end 341 and the second connection end 342 from the first branch and the second branch respectively, wherein the first connection end 341 is connected to the adsorption column 6, the third connection end 351 and the third branch in turn, and the second connection end 342 is connected to the adsorption column 6, the fourth connection end 352 and the fourth branch in turn, and then the third branch and the fourth branch merge into the eighth pipeline h and are connected to the bubble trap 210. After mixing with the blood cells in the bubble trap 210, the blood is returned to the human body through the fourth pipeline d, the return pump 4, and the fifth pipeline e.

[0068] Among them, the branch 1 and the branch 2 are respectively arranged in parallel on the side of the circulating liquid pipeline j away from the liquid pump 7, wherein the branch 1 is in liquid communication with the first branch, and the branch 2 is in liquid communication with the second branch.

[0069] When the adsorption column 6 needs to be regenerated, the second control valve 372 and the third control valve control the pipeline to be closed. The circulating liquid is connected to the liquid pump 7 through the pipeline inlet, and then connected to the first connection end 341 and the second connection end 342 through the first branch and the second branch, respectively. After flowing through the adsorption column 6, the circulating liquid is recovered from the waste liquid pipeline i to the waste liquid container 2, thereby regenerating the adsorption column 6. In this case, the adsorption column 6 is recycled for adsorption operation.

[0070] See also Figure 5 and Figure 6As shown, in another specific embodiment, the integrated circulation pipeline is buckled onto the blood purification device, and each pipeline interface is connected to the corresponding device and pump. After the blood purification device is turned on, the blood sampling pump 3 is turned on, and the venous blood in the human body passes through the arterial pipeline area, and passes through the blood sampling input end 110, the blood sampling pump 3, the filter, and the blood sampling output end 140 to enter the plasma separation device 1. The plasma separation device 1 separates the plasma and blood cells. After the blood cells are separated, they enter the bubble trap 210 through the return blood input end 220. After the plasma is separated, it enters the plasma pipeline area, passes through the plasma input end 310 and the plasma pump 5, and is connected to the second connection end 342, the adsorption column 6, the fourth connection end 352, the series pipeline k, the first connection end 341, the perfusion column 15 and the third connection end 351 through the pipeline, and then is connected to the bubble trap 210 through the eighth pipeline h. After mixing with the blood cells in the bubble trap 210, it is returned to the human body through the fourth pipeline d, the return pump 4, and the fifth pipeline e.

[0071] When the adsorption column 6 needs to be regenerated, the second control valve 372 and the third control valve 373 are closed, the first control valve 371 and the fourth control valve 374 are opened, and the circulating liquid is connected to the liquid pump 7 through the pipeline inlet, and then connected to the second connecting end 342, the adsorption column 6, the fourth connecting end 352, the pipeline, and the waste liquid outlet through the pipeline to be recovered into the waste liquid container 2, thereby regenerating the adsorption column 6. The adsorption column 6 is recycled for adsorption operation.

[0072] In the description of this application, it should be understood that the terms "center", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", etc., indicating the orientation or position relationship, are based on the orientation or position relationship shown in the accompanying drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention.

[0073] The terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance or implicitly specifying the number of the technical features being referred to. Therefore, a feature specified as "first" or "second" may explicitly or implicitly include one or more of such features. In the description of this utility model, unless otherwise specified, "plurality" means two or more.

[0074] In the description of this utility model, it should be noted that, unless otherwise specified or limited, the terms "mounted," "connected," and "connected" should be understood broadly. For example, they may refer to fixed connections, detachable connections, or integral connections; they may refer to direct connections, indirect connections through an intermediary, or internal communication between two components. Those skilled in the art will understand the specific meanings of these terms in this utility model based on specific circumstances.

[0075] In the description of this specification, specific features, structures, materials or characteristics may be combined in an appropriate manner in any one or more embodiments or examples.

[0076] It should be understood that although the steps in the flowcharts of the accompanying drawings are shown in sequence as indicated by the arrows, these steps are not necessarily executed in the order indicated by the arrows. Unless otherwise specified herein, there is no strict order restriction on the execution of these steps, and they can be executed in other orders. Moreover, at least some of the steps in the flowcharts of the accompanying drawings may include multiple sub-steps or multiple stages, and these sub-steps or stages are not necessarily executed at the same time, but can be executed at different times, and their execution order is not necessarily sequential, but can be executed in turn or alternately with other steps or at least a portion of the sub-steps or stages of other steps.

Claims

1. Integrated external circulation pipeline, characterized by: The device comprises a box body and an arterial line area, a venous line area and a plasma line area arranged on the box body, wherein: The arterial line area includes a blood sampling input end, a blood sampling pump input end, a blood sampling pump output end and a blood sampling output end, the blood sampling input end is in liquid communication with the blood sampling pump input end via a first line, and the blood sampling pump output end is in liquid communication with the blood sampling output end via a second line; The venous line area includes a bubble trap, a return blood input end, a reinfusion pump input end, a reinfusion pump output end, and a return blood output end, wherein the return blood input end and the bubble trap are connected via a third line, the bubble trap is connected to the reinfusion pump input end via a fourth line, and the reinfusion pump output end is connected to the return blood output end via a fifth line; The plasma pipeline area includes a plasma input end, a plasma pump input end, a plasma pump output end, an adsorption input end and an adsorption output end. The plasma input end is liquid-connected to the plasma pump input end through a sixth pipeline, the plasma pump output end is liquid-connected to the adsorption input end through a seventh pipeline, and the adsorption output end is liquid-connected to the bubble trap through an eighth pipeline.

2. The integrated external circulation pipeline according to claim 1, characterized in that: The plasma pipeline area includes a control valve group and a waste liquid output end. The adsorption output end is liquid-connected to the waste liquid output end through a waste liquid pipeline. The control valve group is used to control the on-off of the eighth pipeline and / or the waste liquid pipeline.

3. The integrated external circulation pipeline according to claim 2, characterized in that: It also includes a liquid pump input end, which is in liquid communication with the seventh pipeline through a circulating liquid pipeline. The control valve group is also used to control the on-off of the circulating liquid pipeline.

4. The integrated external circulation pipeline according to claim 1, characterized in that: At least one of the first pipeline, the second pipeline, and the fifth pipeline is provided with a filter and a pressure detection device.

5. The integrated external circulation pipeline according to any one of claims 1 to 4, characterized in that: The adsorption input end includes a first connection end and a second connection end, and the end of the seventh pipeline away from the plasma pump output end has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end, and the second branch is liquid-connected to the second connection end; the adsorption output end includes a third connection end and a fourth connection end, and the end of the eighth pipeline away from the bubble trap has a third branch and a fourth branch arranged in parallel, the third branch is liquid-connected to the third connection end, and the fourth branch is liquid-connected to the fourth connection end.

6. The integrated external circulation pipeline according to any one of claims 1 to 4, characterized in that: The adsorption input end includes a first connection end and a second connection end, and the end of the seventh pipeline away from the plasma pump output end has a first branch and a second branch arranged in parallel, the first branch is liquid-connected to the first connection end, and the second branch is liquid-connected to the second connection end; the adsorption output end includes a third connection end and a fourth connection end, the third connection end is liquid-connected to the bubble trap through the eighth pipeline, and the fourth connection end is liquid-connected to the first connection end through a series pipeline.

7. The integrated external circulation pipeline according to claim 1, characterized in that: It also includes an anticoagulant pipeline area, which includes an anticoagulant input end, an anticoagulant pump input end and an anticoagulant pump output end. The anticoagulant input end is liquid-connected to the anticoagulant pump input end through a first anticoagulant pipeline, and the anticoagulant pump output end is liquid-connected to the second pipeline through a second anticoagulant pipeline.

8. The integrated external circulation pipeline according to claim 1, characterized in that: The bubble trap comprises a shell having an inclined surface, and a projection of the output end of the third pipeline in the vertical direction is located on the inclined surface.

9. A blood purification device, characterized in that: It comprises a plasma separation device and an integrated external circulation pipeline as claimed in any one of claims 1 to 8, wherein the plasma separation device has an input port, and the input port is in liquid communication with the blood sampling output end through a pipeline.

10. The blood purification device according to claim 9, characterized in that: The plasma separation device includes a centrifugal plasma separator or a plasma separator.

Images