Preloaded chromatographic column packing column filling machine

Abstract

The utility model provides a pre-installed chromatographic column packing column filling machine which comprises an installation frame, a pre-installed column assembly, a column filling tool assembly and a lifting assembly. The preassembled column assembly comprises a preassembled column upper sealing cover, a preassembled column body and a preassembled column lower sealing cover. The preassembled column upper sealing cover and the preassembled column lower sealing cover are used for sealing openings in the two opposite ends of the preassembled column body respectively. The column assembling tool assembly comprises a tool column pipe and an exhaust structure, the tool column pipe is connected with the pre-assembling column body, the lifting assembly, the tool column pipe and the pre-assembling column body are sequentially arranged from top to bottom, and the exhaust structure is used for exhausting air brought by a sealing cover on the pre-assembling column; the lifting assembly is detachably connected with the preassembled column upper sealing cover and used for driving the preassembled column upper sealing cover to move till the screen is immersed in the solution of the tool column pipe. Different from the prior art, the device can be used for filling a stationary phase of a high-capacity preloaded chromatographic column, the problem that bubbles exist at the head of the chromatographic column can be solved, and the column filling effect is improved.

Description

Technical Field

[0001] The utility model relates to the field of chromatography column production equipment, in particular to a column packing machine for pre-packed chromatography column fillers. Background Art

[0002] Prepacked chromatography columns are delivered to customers with the stationary phase pre-installed within the column, eliminating the need for pre-loading. During the production of these prepacked columns, the stationary phase is loaded into the column using specialized loading equipment to ensure uniform distribution of the stationary phase within the column.

[0003] Currently, existing filling equipment is designed by simulating the manual column filling process. Although it eliminates the trouble of manual column filling, it is difficult to expel the bubbles under the column head by simply shaking the column body when filling and fixing a large-capacity pre-packed chromatography column, as is done when filling a small-capacity pre-packed column. As a result, the accumulated bubbles will affect the liquid flow path during the use of the chromatography column and will also affect the column efficiency of the pre-packed chromatography column. Utility Model Content

[0004] Based on this, the purpose of the present invention is to provide a column packing machine for pre-packed chromatography column fillers to solve the deficiencies in the prior art.

[0005] To achieve the above-mentioned purpose, the present invention provides a column packing machine for pre-packed chromatography column fillers, comprising a mounting frame, a pre-packed column assembly provided on the mounting frame, a column packing tooling assembly, and a lifting assembly;

[0006] The pre-loaded column assembly includes a pre-loaded column upper cover, a pre-loaded column body, and a pre-loaded column lower cover, wherein the pre-loaded column upper cover is located above the pre-loaded column lower cover, and the pre-loaded column upper cover and the pre-loaded column lower cover are respectively used to seal the openings at opposite ends of the pre-loaded column body, and the pre-loaded column body is connected to the mounting frame via the pre-loaded column lower cover;

[0007] The column loading fixture assembly includes a fixture column tube and an exhaust structure provided on the fixture column tube. The fixture column tube is connected to the pre-loaded column body. The lifting assembly, the fixture column tube, and the pre-loaded column body are arranged in sequence from top to bottom. The exhaust structure is located at one end of the fixture column tube away from the pre-loaded column body. The exhaust structure is used to remove air brought in by the cover on the pre-loaded column.

[0008] The lifting assembly is detachably connected to the upper cover of the pre-installed column. A screen is connected to the bottom of the upper cover of the pre-installed column. The lifting assembly is used to drive the upper cover of the pre-installed column to move until the screen is immersed in the solution of the tooling column tube.

[0009] The beneficial effects of the present invention are as follows: by connecting the tooling column tube with the pre-loaded column body, and arranging the lifting assembly, the tooling column tube and the pre-loaded column body in sequence from top to bottom, the tooling column tube is used to expand the filler volume so as to carry out subsequent large-capacity filling operations. When the filling is completed, the lifting assembly drives the upper cover of the pre-loaded column to move until the screen of the upper cover of the pre-loaded column is immersed in the solution of the tooling column tube. Since the upper cover of the pre-loaded column gradually moves from the atmospheric environment to contact with the filler mixed solution, there is a risk of introducing air into the filler mixed solution, resulting in bubbles in the screen. The bubbles in the screen are removed by the exhaust structure to discharge the air brought by the upper cover of the pre-loaded column, and then the upper cover of the pre-loaded column is driven downward by the lifting assembly to complete the compacting operation of the stationary phase. Different from the prior art, it is not only possible to fill the stationary phase of a large-capacity pre-loaded chromatography column, but also to improve the problem of bubbles in the head of the chromatography column, thereby improving the column filling effect. In addition, it can also realize compacting of the stationary phase, and the operation is simple and convenient, and the filling process is stable.

[0010] Preferably, the exhaust structure includes a pipe interface and an exhaust pipe, the pipe interface is connected to the tooling column tube, the pipe interface passes through the tube wall of the tooling column tube, and one end of the exhaust pipe passes through the pipe interface and is close to the bottom of the screen.

[0011] Preferably, the exhaust structure includes a plurality of rotating tubes, a plurality of slots are provided on the tooling column tube, one end of the rotating tube passes through the slot and extends into the tooling column tube to form an extension portion, the extension portion is an arc-shaped structure, and a plurality of air holes are provided on the extension portion.

[0012] Preferably, the rotating tube is connected to an air pump.

[0013] Preferably, the plurality of rotating tubes are evenly arranged at equal angles along the circumference of the tooling column tube.

[0014] Preferably, a receiving groove is provided on the inner wall of the tooling column tube, and the extension portion is embedded in the receiving groove.

[0015] Preferably, the lifting assembly includes a lifting reducer, a lifting screw and a guide structure, the lifting screw is connected to the guide structure, and the lifting screw is connected to the lifting reducer, the guide structure is used to guide the lifting screw so that the lifting screw moves under the action of the lifting reducer, and the lifting reducer and the guide structure are both installed on the mounting bracket.

[0016] Preferably, the guide structure includes a guide column and a sleeve, the outer side of the sleeve is connected to the mounting frame, the top end of the lifting screw is connected to the lifting top plate, one end of the guide column is connected to the lifting top plate, and the other end of the guide column passes through the interior of the sleeve, and the guide column is parallel to the lifting screw.

[0017] Preferably, one end of the lifting reducer is connected to the drive motor through a first coupling, and the other end of the lifting reducer is connected to the encoder through a second coupling.

[0018] Preferably, a control assembly is provided on the mounting frame, and the lifting assembly is connected to the control assembly.

[0019] Additional aspects and advantages of the present invention will be given in part in the following description and will become apparent from the following description or learned through practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] Figure 1 A schematic structural diagram of a column packing machine for pre-packed chromatography column fillers provided in the first embodiment of the present invention;

[0021] Figure 2 A cross-sectional view of a column packing machine for pre-packed chromatography columns provided in the first embodiment of the present invention;

[0022] Figure 3 A schematic structural diagram of a column mounting tool assembly provided in the first embodiment of the present utility model;

[0023] Figure 4 A cross-sectional view of a column mounting tool assembly provided in the first embodiment of the present utility model;

[0024] Figure 5 A cross-sectional view of the exhaust structure provided in the second embodiment of the present utility model.

[0025] Description of main component symbols:

[0026] 10. Mounting frame; 21. Upper cover of pre-installed column; 22. Pre-installed column body; 23. Lower cover of pre-installed column; 24. Screen; 31. Tooling column tube; 32. Thickening plate; 33. Pipe connection; 34. Exhaust pipe; 35. Inner pressure plate; 36. Outer pressure plate; 37. Sealing nut; 38. Elastic sealing gasket; 41. Lifting reducer; 42. Lifting screw; 43. Drive motor; 44. Encoder; 45. Guide column; 46. Bushing; 47. Extended bracket; 48. Long-handled screw; 50. First mounting plate; 60. Second mounting plate; 70. Lifting top plate; 71. Lifting bottom plate; 72. Upper proximity switch; 73. Lower proximity switch; 81. Rotating tube; 82. Air hole; 91. Electric cabinet; 92. Touch screen.

[0027] The following specific embodiments will further illustrate the present invention in conjunction with the above-mentioned drawings. DETAILED DESCRIPTION

[0028] To facilitate understanding of the present invention, a more comprehensive description of the present invention will be provided below with reference to the accompanying drawings. The drawings illustrate several embodiments of the present invention. However, the present invention can be implemented in many different forms and is not limited to the embodiments described herein. Rather, these embodiments are provided to provide a more thorough and comprehensive understanding of the present invention.

[0029] It should be noted that when an element is referred to as being "fixed to" another element, it may be directly on the other element or there may be an intermediate element. When an element is referred to as being "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "left," "right," and similar expressions used herein are for illustrative purposes only.

[0030] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by those skilled in the art to which this invention pertains. The terms used herein in the specification of this invention are intended only to describe specific embodiments and are not intended to limit the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0031] See also Figures 1 to 4 , is a column packing machine for pre-packed chromatography column fillers in the first embodiment of the present invention, comprising a mounting frame 10, a pre-packed column assembly, a column packing tooling assembly and a lifting assembly.

[0032] Among them: one end of the pre-installed column assembly is connected to the mounting frame 10 through the first mounting plate 50, the other end of the pre-installed column assembly is connected to the column mounting fixture assembly, the lifting assembly is connected to the mounting frame 10 through the second mounting plate 60, the lifting assembly, the column mounting fixture assembly and the pre-installed column assembly are arranged in sequence from top to bottom. It should be noted that the pre-installed column assembly includes a pre-installed column upper cover 21, a pre-installed column body 22 and a pre-installed column lower cover 23. The pre-installed column upper cover 21 is used to seal the opening at the top of the pre-installed column body 22, and the pre-installed column lower cover 23 is used to seal The opening at the bottom of the pre-loaded column body 22, that is, the pre-loaded column upper cover 21 is located above the pre-loaded column lower cover 23, and the pre-loaded column upper cover 21 is connected to a screen 24 toward the bottom of the pre-loaded column lower cover 23. The pre-loaded column upper cover 21 is connected to the lifting assembly, and the pre-loaded column body 22 and the pre-loaded column lower cover 23 are installed on the first mounting plate 50. The first mounting plate 50 is installed on the mounting frame 10. The pre-loaded column upper cover 21 is pressed into the top of the pre-loaded column body 22 through the lifting assembly, and the sealing operation of the opening at the top of the pre-loaded column body 22 is realized.

[0033] In this embodiment, the column loading tooling assembly includes a tooling column tube 31 and an exhaust structure provided on the tooling column tube 31. The tooling column tube 31 is connected to the pre-loaded column body 22, and the central axis of the tooling column tube 31 is on the same straight line as the central axis of the pre-loaded column body 22. The tooling column tube 31 is located above the pre-loaded column body 22, and the pre-loaded column body 22 is provided on the first mounting plate 50. The exhaust structure is used to remove the air brought by the cover 21 on the pre-loaded column. The exhaust structure is located at one end of the tooling column tube 31 away from the pre-loaded column body 22. It can be explained that the setting of the tooling column tube 31 can expand the packing volume, realizing the large-capacity filling operation of the pre-loaded column body 22, and, during the filling process, the tooling column tube 31 is filled with water, which is formed by the precipitation and stratification of the filler mixed solution. The lifting component drives the pre-loaded column upper cover 21 from the atmospheric environment to the tooling column tube 31, and there is a risk of bringing in air. In order to solve this problem, the exhaust structure is arranged near the liquid level in the tooling column tube 31, and the screen 24 on the pre-loaded column upper cover 21 is immersed in the water in the tooling column tube 31. If air is brought in, bubbles will be formed on the screen 24, and the exhaust structure can discharge the bubbles.

[0034] It should be noted that a thickening plate 32 is integrally connected to the inner wall of the tooling column tube 31, and the tooling column tube 31 and the thickening plate 32 are integrally formed. The bottom of the thickening plate 32 is flush with the bottom of the tooling column tube 31, and the top of the thickening plate 32 is located at the upper end of the tooling column tube 31 and below the exhaust structure. The setting of the thickening plate 32 can reduce the diameter of the opening of the tooling column tube 31, and an O-ring is provided on the upper cover 21 of the pre-installed column. When the upper cover 21 of the pre-installed column is pressed down to the bottom of the exhaust structure, the O-ring on the upper cover 21 of the pre-installed column fits with the side wall of the thickening plate 32.

[0035] In this embodiment, the exhaust structure includes a pipe interface 33 and an exhaust pipe 34. The pipe interface 33 is sealed with the tooling column tube 31 through a first sealing structure. The pipe interface 33 passes through the closure of the tooling column tube 31 so that one end of the exhaust pipe 34 passes through the pipe interface 33 and is close to the bottom of the screen 24, thereby removing bubbles on the screen 24.

[0036] The first sealing structure includes an inner pressure plate 35, an outer pressure plate 36, a sealing nut 37 and an elastic sealing gasket 38. An opening is opened on the tooling column tube 31, and the inner pressure plate 35 and the outer pressure plate 36 are respectively located on two opposite sides of the opening, and the inner pressure plate 35 is located inside the tooling column tube 31, and the outer pressure plate 36 is located outside the tooling column tube 31. The elastic sealing gasket 38 is located between the outer pressure plate 36 and the outer wall of the tooling column tube 31. The inner pressure plate 35, the outer pressure plate 36 and the elastic sealing gasket 38 are all provided with a through groove. A limiting ring is provided around the end of the pipe interface 33 located inside the tooling column tube 31, and a thread is provided on the end of the pipe interface 33 away from the limiting ring. The end of the pipe interface 33 away from the limiting ring passes through the through grooves on the inner pressure plate 35, the elastic sealing gasket 38 and the outer pressure plate 36 in sequence, and is threadedly connected to the sealing nut 37, thereby sealing the pipe interface 33 to the tooling column tube 31.

[0037] It should be noted that the exhaust pipe 34 is sealed with the pipe interface 33 through an O-ring, and the exhaust pipe 34 is manually pushed in or pulled out of the pipe interface 33. It can be understood that the end of the exhaust pipe 34 away from the tooling column tube 31 is connected to the vacuum pump.

[0038] In this embodiment, the lifting assembly includes a lifting reducer 41, a lifting screw 42 and a guide structure. The lifting screw 42 is connected to the guide structure. The lifting reducer 41 is installed on the mounting frame 10 through a second mounting plate 60. One end of the lifting reducer 41 is connected to the drive motor 43 through a first coupling, and the other end of the lifting reducer 41 is connected to the encoder 44 through a second coupling. The top of the lifting screw 42 is connected to a lifting top plate 70, and the guide structure is connected to the lifting screw 42 through the lifting top plate 70, so that under the action of the lifting reducer 41, the lifting screw 42 rises or falls with the drive of the servo motor, wherein the guide structure guides the lifting screw 42, and the encoder 44 is used to accurately control the position.

[0039] In this embodiment, a control component is provided on the mounting frame 10, and the control component includes a start button, an emergency stop button, a touch screen 92 and an electrical cabinet 91. The start button, the emergency stop button, the touch screen 92, the lifting reducer 41, the drive motor 43 and the encoder 44 in the lifting component are all connected to the electrical cabinet 91.

[0040] In this embodiment, the guide structure includes a guide column 45 and a sleeve 46. Holes are provided on the second mounting plate 60 and the mounting frame 10. The outer side of the sleeve 46 is inserted into the holes of the second mounting plate 60 and the mounting frame 10. One end of the guide column 45 is connected to the lifting top plate 70, and the other end of the guide column 45 passes through the interior of the sleeve 46 and is connected to the lifting bottom plate 71. The guide column 45 is parallel to the lifting screw 42. It should be noted that an upper proximity switch 72 and a lower proximity switch 73 are provided on the guide column 45. The upper proximity switch 72 is located above the lower proximity switch 73. The upper proximity switch 72 and the lower proximity switch 73 are respectively located on opposite sides of the shaft sleeve 46. When the lifting assembly descends to the lowest point, the upper proximity switch 72 touches the top of the second mounting plate 60. When the lifting assembly rises to the highest point, the lower proximity switch 73 touches the bottom of the mounting plate. The upper proximity switch 72 and the lower proximity switch 73 are both connected to the electrical cabinet 91. The upper proximity switch 72 and the lower proximity switch 73 are both used to control the start and stop of the lifting switch. When the upper proximity switch 72 or the lower proximity switch 73 touches the second mounting plate 60, the lifting assembly is controlled to stop working.

[0041] In this embodiment, the lifting assembly is connected to the pre-installed column upper cover 21 through an extended bracket 47. Specifically, the extended bracket 47 is located between the lifting screw 42 and the tooling column tube 31, one end of the extended bracket 47 is connected to the lifting base plate 71, and the other end of the extended bracket 47 is detachably connected to the pre-installed column upper cover through a long-handled screw 48. When the pre-installed column upper cover 21 descends to the inside of the pre-installed column body 22, the long-handled screw 48 can be loosened from the top to loosen the pre-installed column upper cover 21.

[0042] In a specific embodiment, the stationary phase mixed solution is poured into the pre-loaded column body 22 from the tooling column tube 31, and after the stationary phase mixed solution is stratified, the upper cover 21 of the pre-loaded column is driven by the lifting assembly to move to near the liquid surface in the tooling column tube 31. At this time, the screen 24 just enters the water in the tooling column tube 31, and then the bubbles in the screen 24 are discharged through the exhaust structure, and then the upper cover 21 of the pre-loaded column is driven to continue to descend by the lifting assembly to squeeze out the excess liquid in the stationary phase mixed solution until the upper cover 21 of the pre-loaded column is completely pressed into the pre-loaded column body 22. At this time, the column loading of the pre-loaded column assembly is completed.

[0043] In the specific implementation, by connecting the tooling column tube 31 with the pre-loaded column body 22, and placing the lifting assembly, the tooling column tube 31 and the pre-loaded column body 22 in order from top to bottom, the tooling column tube 31 is used to expand the filler volume so as to perform large-capacity filling operations later. When the filling is completed, the lifting assembly drives the pre-loaded column upper cover 21 to move until the screen 24 of the pre-loaded column upper cover 21 is immersed in the solution of the tooling column tube 31. Since the pre-loaded column upper cover 21 gradually moves from the atmospheric environment to contact with the filler mixed solution, there is a risk of air being brought in. The risk in the filler mixed solution causes bubbles to exist in the screen 24. The bubbles in the screen 24 are removed by the exhaust structure to discharge the air brought by the upper cover 21 of the pre-loaded column, and then the upper cover 21 of the pre-loaded column is driven downward by the lifting component to complete the compacting operation of the stationary phase. Different from the existing technology, it can not only load the stationary phase of a large-capacity pre-loaded chromatography column, but also improve the problem of bubbles in the head of the chromatography column, thereby improving the column loading effect. In addition, it can also realize the compaction of the stationary phase, and the operation is simple and convenient, and the loading process is stable.

[0044] It should be noted that the above implementation process is only for illustrating the feasibility of the present application, but it does not mean that the pre-loaded chromatography column filler column packing machine of the present application has only the above-mentioned only implementation process. On the contrary, as long as the pre-loaded chromatography column filler column packing machine of the present application can be implemented, it can be included in the feasible implementation plan of the present application.

[0045] Please refer to 5, which is a pre-loaded chromatography column packing machine in the second embodiment of the present invention. The difference between the exhaust structure in this embodiment and the exhaust structure in the first embodiment is that: the exhaust structure includes multiple rotating tubes 81, and multiple slots are provided on the tooling column tube 31. One end of the rotating tube 81 passes through the slot and extends into the tooling column tube 31 to form an extension portion. The extension portion is an arc-shaped structure, and a number of air holes 82 are provided on the extension portion. The extension portion is located near the liquid level in the tooling column tube 31, and the other end of the rotating tube 81 away from the extension portion is connected to the vacuum pump.

[0046] It should be noted that multiple rotating tubes 81 are evenly arranged at equal angles along the circumference of the tooling column tube 31, and a receiving groove is provided on the inner wall of the tooling column tube 31. When there is no need to discharge the bubbles on the screen 24, the extension part is embedded in the receiving groove. When the bubbles on the screen 24 need to be discharged, the vacuum pump is operated, and then the rotating tube 81 is rotated to drive the extension part to rotate, so that the extension part sweeps across the bottom of the screen 24, thereby discharging the bubbles on the screen 24 through the air holes 82 on the extension part.

[0047] It should be pointed out that the implementation principle and some technical effects of the pre-loaded chromatography column packing machine provided in the second embodiment of the present invention are the same as those of the first embodiment. For the sake of brief description, for matters not mentioned in this embodiment, reference can be made to the corresponding content in the first embodiment.

[0048] Throughout this specification, reference to terms such as "one embodiment," "some embodiments," "examples," "specific examples," or "some examples" means that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0049] The above-described embodiments merely represent several implementation methods of the present invention. While the descriptions are relatively specific and detailed, they should not be construed as limiting the scope of the present invention. It should be noted that a person skilled in the art would be able to make various modifications and improvements without departing from the scope of the present invention, and these modifications and improvements fall within the scope of protection of the present invention. Therefore, the scope of protection of the present invention shall be determined by the appended claims.

Claims

1. A column packing machine for pre-packed chromatography column fillers, characterized in that, It includes a mounting frame, a pre-installed column assembly, a column installation tooling assembly and a lifting assembly arranged on the mounting frame; The pre-loaded column assembly includes a pre-loaded column upper cover, a pre-loaded column body, and a pre-loaded column lower cover, wherein the pre-loaded column upper cover is located above the pre-loaded column lower cover, and the pre-loaded column upper cover and the pre-loaded column lower cover are respectively used to seal the openings at opposite ends of the pre-loaded column body, and the pre-loaded column body is connected to the mounting frame via the pre-loaded column lower cover; The column loading fixture assembly includes a fixture column tube and an exhaust structure provided on the fixture column tube. The fixture column tube is connected to the pre-loaded column body. The lifting assembly, the fixture column tube, and the pre-loaded column body are arranged in sequence from top to bottom. The exhaust structure is located at one end of the fixture column tube away from the pre-loaded column body. The exhaust structure is used to remove air brought in by the cover on the pre-loaded column. The lifting assembly is detachably connected to the upper cover of the pre-installed column. A screen is connected to the bottom of the upper cover of the pre-installed column. The lifting assembly is used to drive the upper cover of the pre-installed column to move until the screen is immersed in the solution of the tooling column tube.

2. The pre-packed chromatography column packing machine according to claim 1, characterized in that The exhaust structure includes a pipe interface and an exhaust pipe, the pipe interface is connected to the tooling column tube, the pipe interface passes through the tube wall of the tooling column tube, one end of the exhaust pipe passes through the pipe interface and is close to the bottom of the screen.

3. The pre-packed chromatography column packing machine according to claim 1, characterized in that The exhaust structure includes multiple rotating tubes, multiple slots are opened on the tooling column tube, one end of the rotating tube passes through the slot and extends into the tooling column tube to form an extension part, the extension part is an arc-shaped structure, and a plurality of air holes are opened on the extension part.

4. The pre-packed chromatography column packing machine according to claim 3, characterized in that The rotating tube is connected to the air pump.

5. The pre-packed chromatography column packing machine according to claim 3, characterized in that, The plurality of rotating tubes are evenly arranged at equal angles along the circumference of the tooling column tube.

6. The pre-packed chromatography column packing machine according to claim 3, characterized in that, A receiving groove is provided on the inner wall of the tooling column tube, and the extension portion is embedded in the receiving groove.

7. The pre-packed chromatography column packing machine according to claim 1, characterized in that, The lifting assembly includes a lifting reducer, a lifting screw and a guide structure. The lifting screw is connected to the guide structure, and the lifting screw is connected to the lifting reducer. The guide structure is used to guide the lifting screw so that the lifting screw moves under the action of the lifting reducer. The lifting reducer and the guide structure are both installed on the mounting frame.

8. The pre-packed chromatography column packing machine according to claim 7, characterized in that, The guide structure includes a guide column and a sleeve. The outer side of the sleeve is connected to the mounting frame. The top end of the lifting screw is connected to the lifting top plate. One end of the guide column is connected to the lifting top plate, and the other end of the guide column passes through the interior of the sleeve. The guide column is parallel to the lifting screw.

9. The pre-packed chromatography column packing machine according to claim 7, characterized in that, One end of the lifting reducer is connected to the drive motor through a first coupling, and the other end of the lifting reducer is connected to the encoder through a second coupling.

10. The pre-packed chromatography column packing machine according to claim 1, characterized in that: A control component is provided on the installation frame, and the lifting component is connected to the control component.

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