Multi-purpose sucker box with multiple sucker specifications

Abstract

The utility model relates to the technical field of biological medicine, in particular to a multi-purpose sucker box with multiple sucker specifications, which comprises a middle plate frame body for placing suckers, a cover body movably connected to the top end side or the bottom end side of the middle plate frame body, and a plate sealing film adhered to the top or the bottom of the middle plate frame body, a middle plate hinge assembly and a middle plate switch assembly are connected to the two opposite faces of the outer wall of the middle plate frame correspondingly, and the two middle plate hinge assemblies and the two middle plate switch assemblies are arranged diagonally. Compared with a traditional hinge type suction head box, the suction head box is more stable by adopting the same upper cover and lower cover of the suction head box and designing a hinge structure, the use function of the suction head box is not affected when part of the hinge structure is damaged, meanwhile, waste can be utilized, and certain cost is reduced; moreover, the suction head box can be flexibly matched according to actual use requirements in the actual assembly process, and the internal space of the suction head box is fully utilized, so that the requirements of convenience in use and cost reduction are met.

Description

Technical Field

[0001] The utility model relates to the technical field of biomedicine, in particular to a multi-purpose suction tip box with multiple suction tip specifications. Background Art

[0002] With the development of technology, boxed pipette tips (also known as pipette tips) have been widely used in experiments that require liquid handling. By placing the pipette tips in a tip box, the efficiency of pipette tip installation can be significantly improved. However, the current tip boxes on the market have the following defects:

[0003] 1. Currently, most pipette tip boxes on the market are hinged. In actual use, because the pipette tip boxes need to be sterilized repeatedly, the hinge structure of the existing hinged pipette tip boxes is easily damaged, which causes trouble for experimenters. At the same time, when the hinged pipette tip box lid is damaged, the pipette tip box lid (which generally does not directly contact liquid during use) cannot be recycled, which is a costly pain point.

[0004] 2. Although boxed tips are convenient to use, most tip boxes are single-sided and have limited internal storage space, which results in a smaller number of tips being accommodated. Compared with bagged tips, the same number of tips is more expensive, which can easily lead to high usage costs. Therefore, in order to save costs, most experimenters prefer to buy bagged tips and pack them themselves. Utility Model Content

[0005] The utility model provides a multi-purpose suction tip box with multiple suction tip specifications to solve the problems raised in the above background technology.

[0006] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0007] A multi-purpose pipette tip box with multiple pipette tip specifications, comprising a middle plate frame for accommodating pipette tips, a cover for movably connecting to the top or bottom side of the middle plate frame, and a sealing film for adhering to the top or bottom of the middle plate frame;

[0008] A middle plate hinge assembly and a middle plate switch assembly are respectively connected to two opposite surfaces of the outer wall of the middle plate frame, and the two middle plate hinge assemblies and the middle plate switch assemblies are respectively arranged diagonally, and the two middle plate hinge assemblies and the diagonals of the two middle plate switch assemblies are arranged to intersect each other. A matrix board for placing suction heads is fixedly connected to one end of the middle plate frame, and a plurality of first placement areas are distributed in an array on the top surface of the matrix board, and a plurality of second placement areas are distributed in an array on the bottom surface of the matrix board, and one second placement area is located between four adjacent diagonally arranged first placement areas;

[0009] The cover body includes a frame body, a cover hinge assembly for matching the middle plate hinge assembly is connected to one surface of the frame body outer wall, a cover switch assembly for matching the middle plate switch assembly is provided on the surface of the frame body outer wall opposite to the cover hinge assembly, inclined support bars are connected to the two opposite surfaces of the frame body outer wall respectively, the outer wall surface of the frame body with the inclined support bar is perpendicular to the outer wall surface with the cover hinge assembly and the cover switch assembly, and a blocking plate is fixedly connected to one end of the frame body, the blocking plate includes a short oblique plate and a long oblique plate, the long oblique plate and the two oblique support bars are parallel to each other, and the inner angle between the short oblique plate and the long oblique plate forms a V-bottom groove;

[0010] The outer perimeter of the matrix plate is slightly smaller than the outer perimeter of the middle plate frame, and an outer edge groove is provided between one end of the middle plate frame and the matrix plate, and an inner edge groove is provided at the other end of the middle plate frame, and the inner edge groove can be interference fit with the outer edge groove.

[0011] Preferably, the middle plate hinge assembly includes two middle plate hinge parts, and the two middle plate hinge parts are symmetrically arranged with the middle plate switch assembly as the symmetry axis, and each of the middle plate hinge parts includes two support platforms connected to the middle plate frame, a cylinder connected to the two support platforms at the same time, and an anti-fracture extension wall connected to the two support platforms respectively, and the anti-fracture extension wall is connected to the middle plate frame at right angles to one side of the support platform.

[0012] Preferably, the middle plate switch assembly includes a contact platform and a middle plate slide connected to the middle plate frame, the middle plate slide is arranged between the contact platform and the middle plate hinge assembly, and the middle plate slide is an arc-shaped slide and is connected to the middle position of the contact platform.

[0013] Preferably, a load-bearing platform is provided on both sides of the middle plate slide, and the two load-bearing platforms are symmetrically arranged with the middle plate slide as the symmetry axis.

[0014] Preferably, the cover switch assembly includes a notch provided on the cover, an arc-shaped spring piece provided in the notch, and a through opening provided on the arc-shaped spring piece, and the abutment platform and the middle plate slide are respectively provided in the through opening.

[0015] Preferably, the cover hinge assembly includes two cover hinge parts, each of the cover hinge parts includes an arc-shaped hook connected to the frame body, a first limiting protrusion connected to the arc-shaped hook, and a second limiting protrusion connected to the frame body, the second limiting protrusion is located on the inner side of the arc-shaped hook, the first limiting protrusion is fixedly connected to the outer wall of the arc-shaped hook, and the first limiting protrusion and the second limiting protrusion correspond to each other.

[0016] Preferably, several of the first placement areas are countersunk holes distributed in a rectangular array, and the countersunk holes penetrate the surface of the matrix plate from top to bottom, and several of the second placement areas are first sample tubes distributed in a rectangular array.

[0017] The opening surface of the first sample tube is flush with the surface of the inner sink groove of the edge.

[0018] Preferably, several of the second placement areas are first through holes distributed in a rectangular array, the first through holes penetrate the surface of the matrix board from bottom to top, and the center of the first through hole is located at the intersection of the diagonals of four adjacent first placement areas.

[0019] Preferably, several of the first placement areas are second through holes distributed in a rectangular array, the second through holes penetrate the surface of the matrix plate from top to bottom, and several of the second placement areas are second sample tubes distributed in a rectangular array, the tube mouth surface of the second sample tube is flush with the surface of the inner groove of the edge.

[0020] Preferably, several of the second placement areas are irregularly shaped holes distributed in a rectangular array, the irregularly shaped holes penetrate the surface of the matrix board from bottom to top, and the centers of the irregularly shaped holes are located at the intersection of the diagonals of four adjacent first placement areas.

[0021] By adopting the above technical solution, the beneficial effects achieved by the utility model are as follows:

[0022] In the present invention, through the cooperation of the cover hinge assembly, the cover switch assembly, the middle plate hinge assembly and the middle plate switch assembly, the middle plate slide and the arc-shaped spring piece are respectively designed in an arc shape, which can ensure that the tip box continuously changes the interference fit stress angle during the process of opening and closing the cover, thereby realizing a smooth opening and closing process of the cover, and making the switch cover structure of the tip box not easily damaged, thereby ensuring stability in use. In addition, the addition of the arc-shaped hook can also greatly reduce the stress of the interference fit during the opening and closing process of the tip box, prompting the experimenter to lightly touch the arc-shaped spring piece to realize the opening and closing process of the tip box, and also indirectly protect the switch cover structure of the tip box and avoid damage to the hinge structure of the tip box.

[0023] In the present invention, the V-bottom groove formed by the inner angle of the short inclined plate and the long inclined plate on the cover body allows the cover body to be placed on the reagent tank rack of the automated pipetting equipment by cooperating with the inclined support bar. With the help of the design of the V-bottom groove, the liquid level can be effectively maintained, smaller pipetting residues can be achieved, and the liquid can be completely aspirated, thereby realizing waste utilization and solving the problem of high costs.

[0024] In the utility model, the upper cover and the lower cover have the same specifications and structures, so the cover is simple and easy to produce by vacuum forming or injection molding, which reduces multiple working steps, saves investment in production equipment, reduces production costs, and facilitates the automatic assembly and production of the upper and lower covers. At the same time, the same specifications and structures of the upper and lower covers also facilitate production quality management.

[0025] In the present invention, the design of the middle plate of the tip box and the cover body makes it possible for the tip box proposed in this solution to achieve a smaller volume while fully protecting the tips, and to make full use of the internal space of the tip box. It is compatible with three modes of loading tips in opposite directions, loading tips in the same direction and at the same position, and loading tips in the same direction, thereby achieving the needs of convenience in use and cost reduction, and effectively reducing interference and cross-contamination between tips. When permitted, it can realize single box packaging, opposite stacking box packaging, and multiple overlapping box packaging, greatly reducing the volume and material usage of the tip box, ensuring that the production and packaging costs are greatly reduced while providing convenience in use of boxed tips.

[0026] In summary, the present invention adopts the same upper cover and lower cover of the tip box, and through the design of the hinged structure, it is more stable than the traditional hinged tip box, and when part of the hinge structure is damaged, it will not affect its use function, and it can also be used as waste to reduce a certain cost; and the tip box can be flexibly matched according to actual use needs during the actual assembly process, and the internal space of the tip box can be fully utilized, thereby achieving the needs of convenience of use and cost reduction, and effectively reducing interference and cross contamination between tips, and is safe. BRIEF DESCRIPTION OF THE DRAWINGS

[0027] Figure 1 This is a schematic diagram of the matching structure of the double covers of the tip box of the present invention.

[0028] Figure 2 This is a schematic diagram of the cross-sectional structure of the double-cover body of the tip box of the present invention from the front perspective.

[0029] Figure 3 This is a schematic diagram of the cross-sectional structure of the double-cover body of the suction tip box of the present invention from a rear perspective.

[0030] Figure 4 This is a structural diagram of the cover body of the utility model from one viewing angle.

[0031] Figure 5 This is a structural schematic diagram of the cover body of the present invention from another viewing angle.

[0032] Figure 6 for Figure 2 The enlarged structural diagram at C in FIG.

[0033] Figure 7 for Figure 3 The enlarged structural diagram at D in FIG.

[0034] Figure 8 This is a schematic structural diagram of a first embodiment of the matrix board of the present invention, wherein Figure A is a top-down stereoscopic diagram of the matrix board, and Figure B is a bottom-down stereoscopic diagram of the matrix board.

[0035] Figure 9 This is a schematic structural diagram of a second embodiment of the matrix board of the present invention, wherein Figure A is a top-down stereoscopic diagram of the matrix board, and Figure B is a bottom-down stereoscopic diagram of the matrix board.

[0036] Figure 10 This is a schematic structural diagram of the third embodiment of the matrix board of the present invention, wherein Figure A is a top-down stereoscopic diagram of the matrix board, and Figure B is a bottom-down stereoscopic diagram of the matrix board.

[0037] Figure 11 This is a schematic structural diagram of the fourth embodiment of the matrix board of the present invention, wherein Figure A is a top-down stereoscopic diagram of the matrix board, and Figure B is a bottom-down stereoscopic diagram of the matrix board.

[0038] Figure 12 This is a schematic diagram of the first matching structure of the pipette tip box cover and the plate sealing film of the present invention.

[0039] Figure 13 This is a schematic diagram of the second matching structure of the pipette tip box cover and the plate sealing film of the present invention.

[0040] Figure 14 This is a schematic diagram of the single-layer structure of the matrix board in the first state of the present invention.

[0041] Figure 15 This is a schematic diagram of the first structure of the multi-layer stacking of the tip boxes of the present invention.

[0042] Figure 16 This is a schematic diagram of the second structure of the multi-layer stacking of the tip boxes of the present invention.

[0043] In the figure: 1. Middle plate frame;

[0044] 2. Cover body; 21. Frame body;

[0045] 22. Cover hinge assembly; 221. Arc-shaped hook; 222. First limiting protrusion; 223. Second limiting protrusion;

[0046] 23. Cover switch assembly; 231. Notch; 232. Arc-shaped spring; 233. Through port;

[0047] 24. Inclined support bar; 25. Blocking plate; 251. Short inclined plate; 252. Long inclined plate;

[0048] 3. Sealing film;

[0049] 4. Middle plate hinge assembly; 41. Support platform; 42. Column; 43. Anti-fracture extension wall;

[0050] 5. Middle plate switch assembly; 51. Contact platform; 52. Middle plate slide;

[0051] 6. Matrix plate; 7. First placement area; 8. Second placement area; 9. Outer edge groove; 10. Inner edge groove; 11. Load-bearing platform; 12. Countersunk hole; 13. First sample tube; 14. First through hole; 15. Second through hole; 16. Second sample tube; 17. Special-shaped hole. DETAILED DESCRIPTION

[0052] In order to more clearly understand the above-mentioned purpose, features and advantages of the present invention, the present invention is further described below with reference to the accompanying drawings and embodiments. It should be noted that the embodiments of the present application and the features therein can be combined with each other without conflict.

[0053] In the present invention, the term "plurality" refers to two or more than two, unless otherwise expressly defined. The term "and / or" used herein includes any and all combinations of one or more of the relevant listed items. Terms such as "installation", "connection", "connection", and "fixed" should be understood in a broad sense. For example, "connection" can be a fixed connection, a detachable connection, or an integral connection; "connection" can be a direct connection or an indirect connection through an intermediate medium. For those skilled in the art, the specific meanings of the above terms in the present invention can be understood according to the specific circumstances.

[0054] It should be noted that when an element is referred to as being "assembled to," "mounted to," "fixed to," or "disposed on" another element, it may be directly on the other element or there may be an intermediate element. When an element is considered to be "connected to" another element, it may be directly connected to the other element or there may be an intermediate element. The terms "vertical," "horizontal," "upper," "lower," "left," "right," and similar expressions used herein are for illustrative purposes only and do not represent the only implementation methods.

[0055] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways than those described herein. Therefore, the present invention is not limited to the specific embodiments disclosed in the following specification. Example

[0056] like Figures 1-16As shown, the present invention provides a multi-purpose pipette tip box with multiple pipette tip specifications, including a middle plate frame 1 for placing pipette tips, a cover body 2 for movably connecting to the top side or bottom side of the middle plate frame 1, and a sealing film 3 for bonding to the top or bottom of the middle plate frame 1, wherein the cover body 2 can be used as the upper cover or lower cover of the pipette tip box, and the upper cover and the lower cover have the same specifications and structures, so as to facilitate the automated assembly and production of the cover body 2, reduce multiple processes, and reduce the cost of production equipment. At the same time, the same specifications and structures of the upper and lower covers also facilitate production quality management. It should be emphasized that the lower cover of the single-boxed pipette tip box can be replaced by the sealing film 3 for cost saving considerations, such as Figure 12-14 As shown, the sealing film 3 can be made of a sticky transparent film or a sticky opaque aluminum foil according to specific needs. After the pipette tip is used up, the sealing film 3 can also be recycled for other sealing needs in the laboratory according to actual needs, thereby reducing certain costs.

[0057] The middle plate hinge assembly 4 and the middle plate switch assembly 5 are respectively connected to the two opposite surfaces of the outer wall of the middle plate frame 1, and the two middle plate hinge assemblies 4 and the middle plate switch assembly 5 are respectively arranged diagonally, and the two middle plate hinge assemblies 4 and the diagonals of the two middle plate switch assemblies 5 are arranged crosswise. The diagonal arrangement of the two middle plate hinge assemblies 4 and the diagonal arrangement of the two middle plate switch assemblies 5 make it possible to connect two cover bodies 2 to the middle plate frame 1 at the same time, and the two connected cover bodies 2 are not facing the same side when opened, and the advantage of this design is that the cover body 2 can be adapted to the upper and lower ends of the middle plate frame 1 for use, so as to ensure that the user can place and install it according to the use requirements. A matrix plate 6 for placing suction heads is fixedly connected to one port of the middle plate frame 1, and a plurality of first placement areas 7 are distributed in an array on the top surface of the matrix plate 6, and a plurality of second placement areas 8 are distributed in an array on the bottom surface of the matrix plate 6, and a second placement area 8 is located between four first placement areas 7 arranged diagonally adjacent to each other;

[0058] The cover body 2 includes a frame body 21, and a cover hinge assembly 22 for matching the middle plate hinge assembly 4 is connected on one surface of the outer wall of the frame body 21, and a cover switch assembly 23 for matching the middle plate switch assembly 5 is provided on the outer wall of the frame body 21 opposite to the cover hinge assembly 22. Inclined support bars 24 are connected to the two opposite surfaces of the outer wall of the frame body 21 respectively. The outer wall surface of the frame body 21 having the inclined support bar 24 is perpendicular to the outer wall surface having the cover hinge assembly 22 and the cover switch assembly 23, and a blocking plate 25 is fixedly connected to one end of the frame body 21. The blocking plate 25 includes a short inclined plate 251 and a long inclined plate 252. The long inclined plate 252 is parallel to the two inclined support bars 24, and the inner angle between the short inclined plate 251 and the long inclined plate 252 forms a V-bottom groove, and the inner angle between the short inclined plate 251 and the long inclined plate 252 is about 170 degrees. Figure 5As shown, after testing, the V-bottom groove formed by the inner angle of the short inclined plate 251 and the long inclined plate 252 can achieve smaller pipetting residues as a reagent pipetting groove during actual use, ensuring thorough aspiration. In addition, the inclined support bars 24 on both sides of the cover body 2 are parallel to the long inclined plate 252, so that when the cover body 2 is placed on the reagent tank rack of the automated pipetting equipment, the V-bottom groove design can effectively maintain the liquid level, facilitating thorough aspiration.

[0059] The outer perimeter of the matrix plate 6 is slightly smaller than the outer perimeter of the middle plate frame 1, and an outer edge groove 9 is provided between one end of the middle plate frame 1 and the matrix plate 6, and an inner edge groove 10 is provided at the other end of the middle plate frame 1. The inner edge groove 10 can be interference fit with the outer edge groove 9. It should be noted here that the cooperation of the middle plate frame 1 and the matrix plate 6 together forms the middle plate of the tip box, and the middle plate of the tip box can ensure that multiple middle plates of the tip box are assembled through interference fit with the help of the design of the outer edge groove 9 and the inner edge groove 10, thereby realizing the assembly and fixation of multiple stacks of tip box middle plates, reducing the shaking of the tip matrix, wherein the multiple stacks can be three stacks, five stacks, ten stacks or even more layers, and through packaging and plastic sealing, the tips between different stacks remain relatively independent and do not interfere with each other, thereby reducing mold expenses and greatly reducing production costs.

[0060] Combine Figure 6 、 Figure 7 As shown, as a further example, the middle plate hinge assembly 4 includes two middle plate hinge parts, which are symmetrically arranged with the middle plate switch assembly 5 as the symmetry axis, and each middle plate hinge part includes two support platforms 41 connected to the middle plate frame 1, a cylinder 42 connected to the two support platforms 41 at the same time, and an anti-fracture extension wall 43 connected to the two support platforms 41 respectively, and the anti-fracture extension wall 43 is connected to the middle plate frame 1 perpendicular to one side of the support platform 41.

[0061] Specifically, in this embodiment, the connection method between the plate frame 1 and the cover body 2 is a hinge method, because it is the most convenient technical solution currently used by experimenters. However, since the existing hinge structures are generally prone to damage, after testing, we have added reinforcement ribs to the hinge structure part of the middle plate hinge assembly 4. The reinforcement ribs are anti-fracture extension walls 43, and the support platform 41 and the cylinder 42 are matched with the anti-fracture extension wall 43. The design can effectively prevent the middle plate hinge assembly 4 from being damaged due to excessive force during the assembly process of the tip box or the process of opening and closing the cover.

[0062] Combine Figure 12As shown, as a further example, the middle plate switch assembly 5 includes a contact platform 51 and a middle plate slide 52 connected to the middle plate frame 1. The middle plate slide 52 is arranged between the contact platform 51 and the middle plate hinge assembly 4, and the middle plate slide 52 is an arc-shaped slide and is connected to the middle position of the contact platform 51. Load-bearing platforms 11 are respectively provided on both sides of the middle plate slide 52, and the two load-bearing platforms 11 are symmetrically arranged with the middle plate slide 52 as the symmetry axis.

[0063] Specifically, it is understood that the current existing nozzle box opening and closing cover structures are limited by vertical stress deformation, so they are prone to wear and breakage during the frequent opening and closing of the cover by experimenters. Therefore, changing the direction of deformation stress and dispersing stress are necessary to prevent the opening and closing cover structure from being easily damaged. The arc-shaped design of the middle plate slide 52 can ensure that the interference fit stress angle is continuously changed during the opening and closing of the cover, thereby achieving a smooth opening and closing process. The abutment platform 51 and the two load-bearing platforms 11 are respectively used to limit the movement of the cover body 2 to ensure the closing stability of the cover body 2.

[0064] Combine Figure 4 、 Figure 5 、 Figure 6 and Figure 7 As shown, as a further example, the cover switch assembly 23 includes a slot 231 opened on the cover body 2, an arc-shaped spring piece 232 arranged in the slot 231, and a through-hole 233 opened on the arc-shaped spring piece 232, and the abutment platform 51 and the middle plate slide 52 are respectively arranged in the through-hole 233, and the cover hinge assembly 22 includes two cover hinge parts, each of which includes an arc-shaped hook 221 connected to the frame body 21, a first limiting protrusion 222 connected to the arc-shaped hook 221, and a second limiting protrusion 223 connected to the frame body 21, the second limiting protrusion 223 is located on the inner side of the arc-shaped hook 221, the first limiting protrusion 222 is fixedly connected to the outer wall of the arc-shaped hook 221, and the first limiting protrusion 222 and the second limiting protrusion 223 correspond to each other.

[0065] Specifically, based on the problem of changing the direction of deformation stress and dispersing stress, the arc design of the arc spring piece 232 also ensures that the interference fit stress angle can be continuously changed when the experimenter pushes and pulls the arc spring piece 232 by hand, thereby making the tip box opening and closing cover structure not easily damaged and ensuring stability in use. In addition, the addition of the arc hook 221 can also greatly reduce the interference fit stress during the opening and closing process of the tip box, so that the experimenter can open and close the tip box cover with a light touch of the arc spring piece 232, and indirectly protect the tip box opening and closing cover structure. Example

[0066] Combine Figure 8 As shown, Figure 8Figure A is a top-down stereoscopic view of the matrix plate, and Figure B is a bottom-down stereoscopic view of the matrix plate. Based on the first embodiment, several first placement areas 7 are countersunk holes 12 distributed in a rectangular array. The countersunk holes 12 penetrate the surface of the matrix plate 6 from top to bottom, and several second placement areas 8 are first sample tubes 13 distributed in a rectangular array. The tube mouth surface of the first sample tube 13 is flush with the surface of the inner edge sink groove 10.

[0067] Specifically, the design of this structure enables the tip box middle plate to achieve opposite staggered loading of the tip matrix when loading the pipette tips, wherein when the tip box middle plate is a single layer during opposite staggered loading, such as Figure 2 and Figure 3 As shown, the upper tip matrix is ​​an 8*12 arrangement with a total of 96 tips, and the lower staggered and inverted tip matrix is ​​a 9*13 arrangement with a total of 117 tips. The overall height of the upper tip matrix is ​​smaller than that of the lower tip matrix. Specifically, the upper tip matrix is ​​a 10ul pipette tip, and the lower tip matrix is ​​a 200ul pipette tip.

[0068] Furthermore, the middle plate frame 1 cooperates with the matrix plate 6 to be designed into various specifications according to the specifications of large, medium and small pipette tips, which are mainly divided into two categories, namely the middle plate of the integrated tip box containing sample tubes and the middle plate of the tip box without sample tubes. The sample tubes also have three specifications of large, medium and small according to the specifications of the tips, and the volume of the sample tubes is approximately 0.6ml, 1.1ml and 1.6ml. They are mainly reversely integrated in the first sample tube barrel 13 and the second sample tube barrel 16 at the bottom of the matrix plate 6, with a total of 96. If more sample tubes are needed, the volume of the tip box middle plate and the cover body 2 can be expanded to achieve this, so as to promote the horizontal or vertical growth of the cover body 2 or increase the number of sample tube barrels in the horizontal or vertical direction. This method is basic common sense known and applied by those skilled in the art, and this embodiment will not elaborate on this. Among them, the sample tube volumes are approximately 0.6ml, 1.1ml and 1.6ml, which correspond to the 0.5ml, 1.0ml and 1.5ml centrifuge tubes commonly used in laboratories respectively, and are designed according to the main large, medium and small tip sizes. When the tip matrix of the tip box is loaded for protection, after the tip matrix is ​​used up, the experimenter can reuse the uncontaminated 96 sample tubes for reagent addition or preparation and other operations, thereby saving costs.

[0069] Furthermore, when the outer wall of the bottom end of the countersunk hole 12 in the middle plate of the tip box is observed from the perspective of the first sample tube 13, reinforcing ribs are respectively provided on the outer walls of multiple countersunk holes 12 close to the inner wall of the middle plate frame 1. The multiple countersunk holes 12 are connected to the inner wall of the middle plate frame 1 through the reinforcing ribs, and the design of the reinforcing ribs here is to prevent the outer walls around the middle plate of the tip box from deforming under the action of injection molding or external force, thereby effectively ensuring the stability of the middle plate of the tip box. Example

[0070] Combine Figure 9As shown, Figure 9 Figure A in the middle is a top-down stereoscopic view of the matrix board, and Figure B is a bottom-up stereoscopic view of the matrix board. Based on the first embodiment, several first placement areas 7 are countersunk holes 12 distributed in a rectangular array, and the countersunk holes 12 penetrate the surface of the matrix board 6 from top to bottom. Several second placement areas 8 are first through holes 14 distributed in a rectangular array, and the first through holes 14 penetrate the surface of the matrix board 6 from bottom to top, and the center of the first through hole 14 is located at the intersection of the diagonals of the four adjacent first placement areas 7.

[0071] Specifically, the design of this structure enables the tip box middle plate to achieve the same-direction staggered loading of the tip matrix when loading the pipette tips. When the same-direction staggered loading is performed, when the tip box middle plate is a single layer, such as Figure 12 As shown, this design is for the middle plate of the tip box without sample tubes. Because the countersunk hole 12 and the first through hole 14 are both through holes, two groups of tips can be loaded in the same direction according to actual needs, and the two groups of pipette tips can have the same or different specifications. Since the inner diameter of the first through hole 14 is smaller than the inner diameter of the upper end of the countersunk hole 12, the upper end heights of the two groups of tip matrices are different after placement. Among them, the countersunk hole 12 is arranged in 9*13, and a total of 117 tips can be placed. The first through hole 14 is arranged in 8*12, and a total of 96 tips can be placed. In actual use, the tip in the first through hole 14 can be used first, and the tip in the countersunk hole 12 can be used later, thereby ensuring that the two groups of tips will not be damaged or contaminated during use.

[0072] Furthermore, when the outer wall of the bottom end of the countersunk hole 12 in the middle plate of the tip box is observed from the perspective of the first through hole 14, reinforcing ribs are respectively provided on the outer walls of multiple countersunk holes 12 close to the inner wall of the middle plate frame 1. The multiple countersunk holes 12 are connected to the inner wall of the middle plate frame 1 through the reinforcing ribs, and the reinforcing ribs here are designed to prevent the outer walls around the middle plate of the tip box from deforming under the action of injection molding or external force, thereby effectively ensuring the stability of the middle plate of the tip box. Example

[0073] Combine Figure 10 As shown, Figure 10 Figure A is a top-down perspective view of the matrix plate, and Figure B is a bottom-down perspective view of the matrix plate. Based on the first embodiment, several first placement areas 7 are second through-holes 15 distributed in a rectangular array. The second through-holes 15 penetrate the surface of the matrix plate 6 from top to bottom, and several second placement areas 8 are second sample tubes 16 distributed in a rectangular array. The tube mouth surface of the second sample tube 16 is flush with the surface of the inner edge groove 10.

[0074] Specifically, the design of this structure enables the middle plate of the tip box to achieve symmetrically staggered loading of the tip matrix when loading the pipette tips. It should be emphasized that the height of the middle plate frame 1 in this embodiment is higher than the middle plate frame 1 in Examples 2 and 3. Therefore, this type of tip box middle plate can load larger-sized pipette tips when loading in symmetrically staggered manner, such as loading 1000ul-sized tips in the second through hole 15. Therefore, this type of tip box middle plate is suitable for large-sized tips and large-sized sample tubes.

[0075] Furthermore, in order to ensure the wall thickness of the sample tube, for the integration of large-sized sample tubes, the inner wall of the second sample tube barrel 16 and the outer wall of the second sample tube barrel 16 are respectively designed to be arc surface structures that are concentric with the second through hole 15, thereby ensuring the free loading and removal of the large-sized tip matrix and effectively protecting the pipette tips. Example

[0076] Combine Figure 11 As shown, Figure 11 Figure A in the middle is a top-down stereoscopic view of the matrix board, and Figure B is a bottom-up stereoscopic view of the matrix board. Based on the first embodiment, several first placement areas 7 are second through holes 15 distributed in a rectangular array, and the second through holes 15 pass through the surface of the matrix board 6 from top to bottom. Several second placement areas 8 are special-shaped holes 17 distributed in a rectangular array, and the special-shaped holes 17 pass through the surface of the matrix board 6 from bottom to top, and the center of the special-shaped hole 17 is located at the intersection of the diagonals of the four adjacent first placement areas 7.

[0077] Specifically, the design of this structure enables the tip box middle plate to achieve unidirectional staggered loading of the tip matrix when loading the pipette tips, and this design is for the use scenario where the tip box middle plate does not require a sample tube. Therefore, the second through hole 15 and the special-shaped hole 17 are both through holes, and two groups of tips can be loaded in the same direction staggered according to actual needs. The two groups of pipette tips have different specifications, which makes the upper end heights of the two groups of head matrices different after placement, so that the experimenter can use the highly protruding pipette tips first and then the lower height pipette tips, to ensure that the two groups of tips will not be damaged or contaminated during use.

[0078] In summary, the tip box mid-plate is designed in various specifications according to the specifications of large, medium and small tips, and is mainly divided into two categories, namely, the mid-plate of the tip box with sample tubes and the mid-plate of the tip box without sample tubes. The mid-plate of the tip box with sample tubes is as follows: Figure 8 and Figure 10 As shown, the middle plate of the tip box without sample tube is as follows Figure 9 and Figure 11 shown.

[0079] It should be noted that the middle plate of the tip box can be integrated with sample tubes such as centrifuge tubes, PCR tubes, octet tubes, flow cytometry tubes, etc. according to actual needs, so that operators can conveniently process samples. The integrated sample tubes can also pre-package reagents, freeze-dried balls, sampling cotton swabs, pipette tips and other commonly used laboratory reagents or consumables, thereby further saving packaging volume and materials, and greatly reducing costs while improving convenience. Example

[0080] Combine Figure 15 As shown, on the basis of Example 3, through the design of the outer edge groove 9 and the inner edge groove 10 on the middle plate of each tip box, it can ensure that the stacked tip box middle plate is assembled through the interference fit of the outer edge groove 9 and the inner edge groove 10, and realize the multi-stack assembly and fixation of the tip box middle plate, so as to achieve the same direction and same position loading of the pipette tips in the middle plate of the tip box, make full use of the internal space of the tip box, and relatively reduce the interference and cross contamination between the tips compared with traditional stacked tips.

[0081] It is worth emphasizing that this same-direction and same-position loading method can be replaced with a sealing film 3 on the bottom middle plate frame 1 according to cost savings when it is actually used, which effectively saves costs. At the same time, when the pipette tips of multiple stacked boxes are loaded in the same direction and in the same position, because the pipette tips are conical hollow structures, the small tip part of the tip on the middle plate of the upper tip box can be inserted into the wide end part of the tip on the middle plate of the lower tip box, thereby realizing the same-direction and same-position loading, which greatly reduces the overall volume of the stacked tips. It should be noted that, because of the Figure 15 The diagram uses a 10ul pipette tip, so the small tip of the upper tip is not inserted into the wide end of the lower tip. However, this will be shown when replacing it with a larger pipette tip. Figure 16 Inverted tip part. Example

[0082] Combine Figure 16 As shown, on the basis of Example 2, when the pipette tips are loaded in opposite directions in the middle plate of the tip box, the design of the outer edge groove 9 and the inner edge groove 10 on the middle plate of each tip box can ensure that the stacked tip box middle plates are assembled through the interference fit of the outer edge groove 9 and the inner edge groove 10, thereby realizing the multi-stack assembly and fixation of the middle plates of the tip box, and under the action of gravity, no matter which group of head matrices is on the upper layer, the other group of head matrices will drop a distance and fit with the cover body 2, thereby not affecting the use of the upper head matrix and reducing the risk of damage and contamination of the lower head matrix.

[0083] It is worth emphasizing that this type of offset loading method requires a tip box middle plate with a first sample tube 13 as the base layer, and then stacks multiple tip box middle plates with first through holes 14 to ensure that the tips in the first sample tube 13 and the tips in the first through holes 14 will not contaminate each other. In actual use, the height of the cover body 2 can be adjusted by the staff according to the actual usage situation, so as to meet the use of pipette tips of different sizes. Example

[0084] Combine Figure 13 and Figure 14 As shown, when the middle plate of the tip box is used in a single layer, the sealing film 3 can be sealed at the position of the inner groove 10 at the edge of the middle plate frame 1 or at the position of the outer groove 9 at the edge of the middle plate frame 1 according to actual usage, so that the first placement area 7 and the second placement area 8 can be used to place pipette tips according to the situation, thereby achieving the needs of convenience in use and cost reduction.

[0085] In summary, the middle plate of the tip box is compatible with three methods of loading tips in opposite directions, loading tips in the same direction and at the same position, and loading tips in the same direction and staggered. In the actual assembly and production process, it can be flexibly matched according to actual use needs, and the internal space of the tip box can be fully utilized to achieve the needs of convenience and cost reduction. Compared with traditional stacked tips, the interference and cross-contamination between tips are relatively reduced, and the stacked box is compatible with filter cartridge tips, which solves the pain point that conventional stacking is not compatible with filter cartridge tips; at the same time, the overall structure of the tip box is more compact, which saves tip box materials compared with traditional tip boxes, reduces production raw material costs, and reduces packaging and transportation costs to a certain extent; at the same time, it can also make disposable tip boxes fully reused and reduce the volume occupied by boxes of tips of various specifications, which is convenient for experimenters and reduces the complicated work of purchasing and disinfecting consumables such as sample tubes and reagent tanks for experimenters, saving manpower and material resources; and multi-layer stacking is also convenient for the use of automated pipetting equipment, saving space for automated pipetting equipment and loading and unloading time of boxed tips.

[0086] It should be noted that the above-mentioned multi-layer stacking method in this article only describes the small and medium-sized medium-plate frames 1. Although it is a description of the large-sized medium-plate frames 1, its overall layout and stacking method are similar to those of the small and medium-sized medium-plate frames 1. Experimenters can flexibly match them according to actual conditions and are not limited to the illustrations in this article to ensure that the internal space of the tip box is fully utilized. Among them, for large-sized tips, due to space limitations, the opposite staggered loading proposed in Example 4 is preferably adopted to achieve the needs of convenience in use and cost reduction.

[0087] In addition, when part of the hinge structure of the middle plate of the nozzle box is damaged, it can be used as a part that is not hinged to the cover body 2, and then placed in the middle when stacking without affecting its use function, which has the effect of waste utilization.

[0088] Throughout this specification, terms such as "one embodiment," "some embodiments," and "specific embodiments" mean that the specific features, structures, materials, or characteristics described in conjunction with that embodiment or example are included in at least one embodiment or example of the present invention. In this specification, schematic representations of these terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

[0089] Although the embodiments of the present invention have been shown and described, those skilled in the art will appreciate that various changes, modifications, substitutions and variations may be made to these embodiments without departing from the principles and purpose of the present invention, and that the scope of the present invention is defined by the claims and their equivalents.

Claims

1. A multi-purpose pipette tip box with multiple pipette tip specifications, characterized in that: It comprises a middle plate frame (1) for placing a suction head, a cover (2) for being movably connected to the top end or bottom end of the middle plate frame (1), and a sealing film (3) for being bonded to the top or bottom of the middle plate frame (1); A middle plate hinge assembly (4) and a middle plate switch assembly (5) are respectively connected to two opposite surfaces of the outer wall of the middle plate frame (1), the two middle plate hinge assemblies (4) and the middle plate switch assemblies (5) are respectively arranged diagonally, and the diagonals of the two middle plate hinge assemblies (4) and the two middle plate switch assemblies (5) are arranged crosswise, a matrix plate (6) for placing suction heads is fixedly connected to one end of the middle plate frame (1), a plurality of first placement areas (7) are distributed in an array on the top surface of the matrix plate (6), a plurality of second placement areas (8) are distributed in an array on the bottom surface of the matrix plate (6), and one of the second placement areas (8) is located between four adjacent diagonally arranged first placement areas (7); The cover body (2) comprises a frame body (21), one surface of the outer wall of the frame body (21) is connected to a cover body hinge assembly (22) for matching the middle plate hinge assembly (4), a surface of the outer wall of the frame body (21) opposite to the cover body hinge assembly (22) is provided with a cover body switch assembly (23) for matching the middle plate switch assembly (5), two opposite surfaces of the outer wall of the frame body (21) are respectively connected to inclined support bars (24), and the frame body (21) has an inclined The outer wall surface of the support bar (24) is arranged perpendicularly to the outer wall surface of the cover hinge assembly (22) and the cover switch assembly (23), and a blocking plate (25) is fixedly connected to one end of the frame body (21), the blocking plate (25) comprising a short inclined plate (251) and a long inclined plate (252), the long inclined plate (252) and the two inclined support bars (24) being parallel to each other, and the inner angle between the short inclined plate (251) and the long inclined plate (252) forms a V-bottom groove; The outer perimeter of the matrix plate (6) is slightly smaller than the outer perimeter of the middle plate frame (1), and an outer edge groove (9) is provided between one end of the middle plate frame (1) and the matrix plate (6), and an inner edge groove (10) is provided at the other end of the middle plate frame (1), and the inner edge groove (10) can be interference-fitted with the outer edge groove (9).

2. The multi-purpose tip box with multiple tip specifications according to claim 1, characterized in that: The middle plate hinge assembly (4) includes two middle plate hinge parts, the two middle plate hinge parts are symmetrically arranged with the middle plate switch assembly (5) as the symmetry axis, and each middle plate hinge part includes two support platforms (41) connected to the middle plate frame (1), a cylinder (42) connected to the two support platforms (41) at the same time, and an anti-fracture extension wall (43) connected to the two support platforms (41) respectively, and the anti-fracture extension wall (43) is connected to the middle plate frame (1) at a side perpendicular to the support platform (41).

3. The multi-purpose pipette tip box with multiple pipette tip specifications according to claim 1, characterized in that: The middle plate switch assembly (5) comprises a contact platform (51) and a middle plate slide (52) connected to the middle plate frame (1); the middle plate slide (52) is arranged between the contact platform (51) and the middle plate hinge assembly (4); and the middle plate slide (52) is an arc-shaped slide and is connected to the middle position of the contact platform (51).

4. The multi-purpose tip box with multiple tip specifications according to claim 3, characterized in that: A load-bearing platform (11) is provided on both sides of the middle plate slide (52), and the two load-bearing platforms (11) are symmetrically arranged with the middle plate slide (52) as a symmetry axis.

5. The multi-purpose tip box with multiple tip specifications according to claim 3, characterized in that: The cover switch assembly (23) comprises a notch (231) provided on the cover (2), an arc-shaped spring piece (232) provided in the notch (231), and a through-hole (233) provided on the arc-shaped spring piece (232), and the abutment platform (51) and the middle plate slide platform (52) are respectively provided in the through-hole (233).

6. The multi-purpose pipette tip box with multiple pipette tip specifications according to claim 1, characterized in that: The cover hinge assembly (22) includes two cover hinge parts, each of which includes an arc-shaped hook (221) connected to the frame body (21), a first limiting protrusion (222) connected to the arc-shaped hook (221), and a second limiting protrusion (223) connected to the frame body (21), wherein the second limiting protrusion (223) is located on the inner side of the arc-shaped hook (221), the first limiting protrusion (222) is fixedly connected to the outer wall of the arc-shaped hook (221), and the first limiting protrusion (222) and the second limiting protrusion (223) correspond to each other.

7. The multi-purpose tip box with multiple tip specifications according to claim 1, characterized in that: Several of the first placement areas (7) are countersunk holes (12) distributed in a rectangular array, and the countersunk holes (12) penetrate the surface of the matrix plate (6) from top to bottom, and several of the second placement areas (8) are first sample tubes (13) distributed in a rectangular array, and the tube mouth surface of the first sample tube (13) is flush with the surface of the inner sink groove (10) of the edge.

8. The multi-purpose pipette tip box with multiple pipette tip specifications according to claim 7, characterized in that: A plurality of the second placement areas (8) are first through holes (14) distributed in a rectangular array, the first through holes (14) passing through the surface of the matrix board (6) from bottom to top, and the center of the first through hole (14) is located at the intersection of the diagonals of four adjacent first placement areas (7).

9. The multi-purpose pipette tip box with multiple pipette tip specifications according to claim 1, characterized in that: A plurality of the first placement areas (7) are second through holes (15) distributed in a rectangular array, the second through holes (15) penetrate the surface of the matrix plate (6) from top to bottom, and a plurality of the second placement areas (8) are second sample tubes (16) distributed in a rectangular array, the tube mouth surface of the second sample tube (16) is flush with the surface of the inner sink groove (10) of the edge.

10. The multi-purpose tip box with multiple tip specifications according to claim 9, characterized in that: A plurality of the second placement areas (8) are irregularly shaped holes (17) distributed in a rectangular array, the irregularly shaped holes (17) passing through the surface of the matrix plate (6) from bottom to top, and the centers of the irregularly shaped holes (17) are located at the intersection of the diagonals of the four adjacent first placement areas (7).

Images