Coagulation function abnormality detection kit based on latex enhanced turbidimetry

Abstract

The utility model provides a coagulation function abnormality detection kit based on latex enhanced turbidimetry, which comprises an outer box, and an inner box is connected in an opening in a sliding manner; an openable side plate is arranged on one side wall of the outer box in the sliding direction of the inner box; a first stepped groove and a second stepped groove are respectively formed in the top edge and the bottom edge of the outer box; a cover body is detachably arranged in the second stepped groove in a covering manner; a supporting hole is formed in the cover body; a suction cup is fixedly installed at the bottom of the outer box, and the cover body can be taken down from the second stepped groove to expose the suction cup and covers the first stepped groove to be used for supporting. The cover body with the supporting hole is additionally arranged, the cover body is taken down from the bottom of the outer box and covers the top of the outer box, and the outer box is fixed on a specified plane by using the sucking disc, so that the test tube rack can be changed into a second type of test tube rack through the structure of the test tube rack; the support holes with different specifications are used for fixing various different sample containers, so that the stability and the safety in the detection process are improved.

Description

Technical Field

[0001] The utility model relates to the field of abnormal coagulation function detection, in particular to a blood coagulation function abnormality detection kit based on latex enhanced turbidimetry. Background Art

[0002] Abnormal coagulation function is a common pathological condition in clinical practice, usually manifested as bleeding tendency or thrombosis. Such abnormalities can be caused by a variety of factors, including genetic diseases (such as hemophilia A and hemophilia B), drug poisoning (such as vitamin K deficiency caused by accidental ingestion of rat poison), liver or kidney diseases, etc. Accurate and rapid detection of coagulation function is of great significance for clinical diagnosis and treatment;

[0003] Latex-enhanced turbidimetry is one of the most widely used turbidimetric methods, particularly suitable for measuring the content and activity of various coagulation factors in plasma. Its basic principle is that when the test antibody binds to the corresponding antigen, aggregation occurs to form immune complexes, which in turn produces turbidity. Latex-enhanced turbidimetry adsorbs the antibody onto microspheres with a diameter of 60-300 nm, significantly increasing the formation of antigen-antibody immune complexes and thus enhancing the turbidity signal. This signal change can be detected optically, and the antigen content in the test specimen can be calculated based on this signal.

[0004] In the prior art, although latex-enhanced turbidimetry performs well in coagulation function testing, existing test kits lack effective fixation of the sample container during sample processing. As a result, if the sample container is not stably fixed during the test process, it is easy to tilt or shake, causing sample splashing or contamination by external impurities, thereby affecting the accuracy of the test results. In addition, the lack of a fixed sample container increases the difficulty of operation and reduces the detection efficiency. The unstable sample container may also pose a safety hazard to the operator, especially when handling potentially dangerous samples, as splashed samples may increase the risk of infection. Utility Model Content

[0005] In order to solve the problem that the kit in the prior art lacks effective fixation of the sample container during sample processing, the utility model provides a coagulation function abnormality detection kit based on latex enhanced turbidimetry;

[0006] The utility model provides a latex-enhanced turbidimetry-based coagulation abnormality detection kit that adopts the following technical solutions:

[0007] A coagulation function abnormality detection kit based on latex enhanced turbidimetry, comprising an outer box, an opening of the outer box being arranged at the top, an inner box being slidably connected to the inside of the opening; a side wall of the outer box along the sliding direction of the inner box being arranged as an openable side panel; one end of the side panel being rotatably connected to the outer box, and the other end being movably connected to the outer box; a first stepped groove and a second stepped groove being respectively provided at the top and bottom edges of the outer box; a detachable cover in the second stepped groove being provided with a cover body; an exposed surface of the cover body being arranged as a bracket plate; a supporting hole being provided inside the bracket plate; a suction cup being fixedly mounted on the bottom of the outer box, the cover body being removable from the second stepped groove to expose the suction cup, and being covered on the first stepped groove for supporting a sample;

[0008] Furthermore, the outer side wall of the inner box is integrally formed with a slider; the inner side wall of the inner box is provided with a slide groove; the slider and the slide groove are slidably connected; the inner box can be slid out from the side of the outer box after the side panel is opened;

[0009] Furthermore, the side panel is integrally formed with a positioning block on the side wall relative to the inner side of the outer box; a positioning groove cooperating with the positioning block is provided on the adjacent side wall of the outer box close to the positioning block; the movable connection between the positioning groove and the positioning block is preferably a spherical protrusion provided on the positioning block and engaged with the positioning groove;

[0010] Furthermore, the number of the suction cups is N, where N≥2;

[0011] Furthermore, the number of groups of the support holes is W, W≥2; the number of the support holes in each group is S, S≥2; the apertures of the support holes in each group decrease in sequence;

[0012] Furthermore, the fixing method between the cover body and the first stepped groove and the second stepped groove is preferably to embed and fix the spherical protrusion and the spherical groove;

[0013] Furthermore, a protective pad is placed inside the inner box; a plurality of first placement slots are provided on the top of the protective pad, and R1 reagent, R2 reagent, calibrator, and quality control product are placed inside the first placement slots; a second placement slot is also provided on the top of the protective pad, and a plurality of test tubes for sample testing are placed inside the second placement slots;

[0014] Furthermore, the protective pad is made of sponge material;

[0015] Furthermore, the R1 reagent is a mixed solution of phosphate buffer, sodium chloride, and polyethylene glycol; and the R2 reagent is a mixed solution of sensitized latex particles of D-dimer-specific antibodies and a stabilizer.

[0016] In summary, the beneficial effects of the present invention are as follows:

[0017] The utility model adds a cover with a support hole, removes it from the bottom of the outer box and covers the top of the outer box, and uses a suction cup to fix the outer box on a specified plane. At this time, the utility model can be transformed into a second form "test tube rack" through its own structure. The support holes of different specifications are used to fix various sample containers, thereby improving the stability and safety of the detection process. BRIEF DESCRIPTION OF THE DRAWINGS

[0018] Figure 1 This is a schematic diagram of the overall structure of the utility model;

[0019] Figure 2 This is a schematic diagram of the overall structure of the inner box of the utility model;

[0020] Figure 3 This is a schematic diagram of the overall structure of the outer box of the utility model;

[0021] Figure 4 This is a schematic diagram of the internal structure of the inner box of the utility model;

[0022] Figure 5 This is a schematic diagram of the overall structure of the second form of the utility model;

[0023] Figure 6 This is a bottom view schematic diagram of the second form of the utility model;

[0024] Figure 7 This is a schematic diagram of the connection structure between the side panel and the outer box of the utility model.

[0025] As shown in the figure: 1-outer box, 11-first step groove, 12-second step groove, 13-side panel, 131-positioning block, 132-positioning groove, 2-suction cup, 3-cover, 31-support plate, 32-support hole, 4-inner box, 41-slider, 42-slide groove, 43-flip cover, 5-protective pad, 51-first placement groove, 52-second placement groove, 6-R1 reagent, 7-R2 reagent, 8-calibrator, 9-quality control product, 10-test tube. DETAILED DESCRIPTION

[0026] The following is combined with Figure 1-7 The utility model is further described in detail:

[0027] The present invention discloses a kit for detecting abnormal coagulation function based on latex enhanced turbidimetry. Figure 1-6As shown, a coagulation function abnormality detection kit based on latex enhanced turbidimetry includes an outer box 1, the opening of the outer box 1 is set at the top, and the inner box 4 is slidably connected to the inside of the opening; a side wall of the outer box 1 along the sliding direction of the inner box 4 is set as an openable side panel 13; one end of the side panel 13 is rotatably connected to the outer box 1, and the other end is movably connected to the outer box 1; the top and bottom edges of the outer box 1 are respectively provided with a first step groove 11 and a second step groove 12; a detachable cover in the second step groove 12 is provided with a cover body 3; the exposed surface of the cover body 3 is set as a bracket plate 31; a support hole 32 is provided inside the bracket plate 31; a suction cup 2 is fixedly installed on the bottom of the outer box 1, and the cover body 3 can be removed from the second step groove 12 to expose the suction cup 2, and is covered on the first step groove 11 for use Support sample; in this embodiment, the outer box 1 serves as the main container, and its opening is designed at the top; the inner box 4 is slidably connected to the outer box 1, so that the inner box 4 can be easily pulled out of the outer box 1 when needed; the side panel 13 is designed to be openable, which is convenient for the side of the inner box 4 to be pulled out; when in use, the user can remove the cover body 3 from the second stepped groove 12, then the suction cup 2 at the bottom is exposed, and the cover body 3 is re-placed on the first stepped groove 11, at this time, the inner box 4 is in the taken-out state, at this time, the utility model becomes the second form, and various sample tubes and reagents can be placed and fixed by using the support holes 32, which is convenient for operation during detection, and the design of multiple suction cups 2 improves the stability of the test kit on different surfaces; making the utility model more stable and firm when placed;

[0028] In addition, it is worth noting that when the cover 3 is not removed from the second stepped groove 12, the entire outer side of the utility model is heat-sealed with a layer of transparent outer packaging film, which is used to store the packaging box of the utility model to prevent dust from adhering;

[0029] like Figure 2 、 3 As shown, the outer wall of the inner box 4 is integrally formed with a slider 42; the inner wall of the inner box 4 is provided with a slide groove; the slider 42 is slidably connected to the slide groove; the inner box 4 can be slid and drawn out from the side of the outer box 1 after the side panel 13 is opened; in this embodiment, the inner box 4 is slidably connected to the outer box 1 by the sliding connection between the slider 42 and the slide groove, so that the inner box 4 can be easily drawn out from the outer box 1 when needed; the side panel 13 is designed to be openable, and the opening and closing of the side panel 13 is achieved by rotating connection and movable connection, which facilitates the side withdrawal of the inner box 4 and improves the convenience of operation;

[0030] like Figure 7As shown, a positioning block 131 is integrally formed on the side wall of the side panel 13 relative to the inner side of the outer box 1; a positioning groove 132 that cooperates with the positioning block 131 is provided on the adjacent side wall of the outer box 1 close to the positioning block 131; the movable connection between the positioning groove 132 and the positioning block 131 is preferably a spherical protrusion provided on the positioning block 131 and the positioning groove 132 that engages with each other; in this embodiment, the side panel 13 is connected to the outer box 1 by a rotating connection and a movable connection, wherein the design of the positioning block 131 and the positioning groove 132 ensures the stability of the side panel 13 when closed; the spherical protrusion on the positioning block 131 and the positioning groove 132 engage with each other, thereby enhancing the firmness of the connection; the snap-fit ​​design of the spherical protrusion and the positioning groove 132 makes the opening and closing operation of the side panel 13 smoother, reducing the difficulty of operation;

[0031] like Figure 6 As shown, the number of suction cups 2 is N, N ≥ 2; in this embodiment, the number of suction cups 2 can be determined according to the need for reproduction, and the setting position is preferably at the four top corners of the bottom of the outer box 1;

[0032] like Figure 5 As shown, the number of groups of support holes 32 is W, W ≥ 2; the number of support holes 32 in each group is S, S ≥ 2; the aperture of each group of support holes 32 decreases successively; in this embodiment, the support holes 32 provide a variety of aperture options to accommodate sample containers of different sizes; the aperture of the support holes 32 decreases successively to meet diverse support requirements; the design of multiple groups of support holes 32 enables the test kit to support sample containers of various specifications, thereby improving the flexibility of use;

[0033] The fixing method between the cover body 3 and the first stepped groove 11 and the second stepped groove 12 is preferably an embedded fixation of the spherical protrusion and the spherical groove; the embedded fixation method of the spherical protrusion and the spherical groove between the cover body 3 and the first stepped groove 11 and the second stepped groove 12 ensures the sealing and stability of the cover body 3 when closed; the design of the spherical protrusion and the groove enhances the stability of the cover body 3 when closed and prevents accidental falling off;

[0034] like Figure 4As shown, a protective pad 5 is placed inside the inner box 4; a plurality of first placement slots 51 are provided on the top of the protective pad 5, and R1 reagent 6, R2 reagent 7, calibration product 8, and quality control product 9 are placed inside the first placement slots 51; a second placement slot 52 is also provided on the top of the protective pad 5, and a plurality of test tubes 10 for sample detection are placed inside the second placement slots 52; the protective pad 5 is made of sponge material; in this embodiment, a protective pad 5 is placed inside the inner box 4 to protect reagents and samples from external impact; the first placement slots 51 provided on the protective pad 5 are used to place R1 reagent 6, R2 reagent 7, calibration product 8, quality control product 9, etc., and the second placement slots 52 are used to place sample detection test tubes 10; the protective pad 5 is made of sponge material and has good cushioning performance; the design of the protective pad 5 effectively protects the integrity of reagents and samples, and reduces damage caused by vibration during transportation or storage; the design of the first placement slots 51 and the second placement slots 52 enables reagents and samples to be stored in an orderly manner, which is convenient for access and management;

[0035] like Figure 4 As shown, R1 reagent 6 is a mixed solution of phosphate buffer, sodium chloride, and polyethylene glycol; R2 reagent 7 is a mixed solution of sensitized latex particles of D-dimer-specific antibodies and a stabilizer. In this embodiment, R1 reagent 6 is a mixed solution of phosphate buffer, sodium chloride, and polyethylene glycol, which is used to provide a stable reaction environment; R2 reagent 7 is a mixed solution of sensitized latex particles of D-dimer-specific antibodies and a stabilizer, which is used to specifically react with D-dimer in the sample to form a visible turbidity change;

[0036] It is worth noting that the calibrator 8 usually contains a known concentration of a coagulation function indicator antigen, which is used to calibrate the test results of the kit to ensure the accuracy and reproducibility of the test results of the kit;

[0037] Quality control products 9 are similar to calibrators 8, but are usually used for quality control in routine testing to ensure the stable performance of test kits and testing equipment; and to monitor the accuracy and reliability of the testing process;

[0038] The implementation principle of the embodiment of the present utility model is:

[0039] When using the present invention, it is first necessary to remove the outer packaging, then remove the cover 3 on the second stepped groove 12, then open the side panel 13, slide the inner box 4 out from the side of the outer box 1, then cover the side panel 13, then use the suction cup 2 to fix the outer box 1 on the plane, and re-cover the cover 3 on the first stepped groove 11. At this time, the present invention as a whole becomes a "test tube 10 rack", and different types of test tubes 10 and sample containers can be fixed using the support holes 32. Then, open the flip cover 43 of the inner box 4, and use the internal R1 reagent 6, R2 reagent 7, calibrator 8, quality control product 9, that is, the test tube 10, to perform coagulation function testing.

[0040] The above shows and describes the basic principles, main features and advantages of the present invention. The various components mentioned in the present invention are common technologies in the existing field. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and improvements fall within the scope of the present invention. The scope of protection claimed in this utility model is defined by the appended claims and their equivalents.

Claims

1. A kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry, comprising an outer box (1), characterized in that: The opening of the outer box (1) is arranged at the top, and the inner box (4) is slidably connected inside the opening; a side wall of the outer box (1) along the sliding direction of the inner box (4) is arranged as an openable side panel (13); one end of the side panel (13) is rotatably connected to the outer box (1), and the other end is movably connected to the outer box (1); a first step groove (11) and a second step groove (12) are respectively provided on the top and bottom edges of the outer box (1); a detachable cover is provided in the second step groove (12) with a cover body (3); the exposed surface of the cover body (3) is arranged as a bracket plate (31); a support hole (32) is provided inside the bracket plate (31); a suction cup (2) is fixedly installed on the bottom of the outer box (1), and the cover body (3) can be removed from the second step groove (12) to expose the suction cup (2), and is covered on the first step groove (11) for supporting the sample.

2. A kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that The outer side wall of the inner box (4) is integrally formed with a slider (42); the inner side wall of the inner box (4) is provided with a slide groove; the slider (42) and the slide groove are slidably connected; the inner box (4) can be slid and drawn out from the side of the outer box (1) after the side panel (13) is opened.

3. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that A positioning block (131) is integrally formed on the side wall of the side plate (13) relative to the inner side of the outer box (1); a positioning groove (132) is provided on the adjacent side wall of the outer box (1) close to the positioning block (131) and matched with the positioning block (131); the movable connection between the positioning groove (132) and the positioning block (131) is that a spherical protrusion is provided on the positioning block (131) and is engaged with the positioning groove (132) in a mutually clamping manner.

4. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that The number of the suction cups (2) is N, where N≥2.

5. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that The number of groups of the support holes (32) is W, where W is greater than or equal to 2; the number of the support holes (32) in each group is S, where S is greater than or equal to 2; and the aperture of the support holes (32) in each group decreases in sequence.

6. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that The fixing method between the cover body (3) and the first stepped groove (11) and the second stepped groove (12) is the embedding and fixing of the spherical protrusion and the spherical groove.

7. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 1, characterized in that A protective pad (5) is placed inside the inner box (4); a plurality of first placement slots (51) are provided on the top of the protective pad (5), and R1 reagent (6), R2 reagent (7), calibration product (8), and quality control product (9) are placed inside the first placement slots (51); a second placement slot (52) is also provided on the top of the protective pad (5), and a plurality of test tubes (10) for sample testing are placed inside the second placement slots (52).

8. The kit for detecting abnormal coagulation function based on latex-enhanced turbidimetry according to claim 7, characterized in that The protective pad (5) is made of sponge material.

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