Chromosome slide preparation and dropping device

Abstract

The utility model relates to the field of chromosome slide preparation, and discloses a chromosome slide preparation dropping device, which comprises a placing table, a slide dropping device and a slide dropping device, the dropping plate is arranged above the placing table and is used for placing droppers; the placing table is arranged to be close to or far away from the dropping plate and is used for adjusting the distance between the slide and the dropping plate; and the bottom plate is arranged at the bottom of the placing table, and the placing table is arranged between the bottom plate and the dropping plate. According to the utility model, by adopting the design that the screw rod is matched with the nut, the lifting of the placing table can be accurately controlled, the consistency of the distance between the slide and the slide dropping plate is ensured, the consistency of the liquid dropping height and the uniformity of the liquid drop size are ensured, the liquid dropping precision is improved, and the experiment error caused by the change of the liquid dropping height is reduced; by accurately controlling the liquid dropping process, the random error in the experiment is reduced, and the repeatability and comparability of the experiment are enhanced.

Description

Technical Field

[0001] The utility model relates to the field of chromosome preparation, in particular to a device for chromosome preparation and dropping. Background Art

[0002] Chromosome slide preparation is a critical step in karyotyping, and its quality directly impacts the accuracy and reliability of subsequent analysis. During the slide preparation process, factors such as the number of mitotic phases, the degree of dispersion, the height of the droplet, and the size of the droplet are crucial. The height of the droplet has a certain impact on the ductility and dispersion of the chromosomes. Generally speaking, the droplet height should be maintained uniform to ensure that the chromosomes on each slide are evenly distributed and well dispersed.

[0003] Most laboratories still use a handheld dropper to drip liquid. Although this method is simple and intuitive, it is difficult to ensure the high consistency of the droplets and the uniformity of the droplet size. The change in the droplet height directly affects the kinetic energy of the droplet when it hits the slide, which in turn affects the diffusion area of ​​the droplet and the distribution of chromosomes. Utility Model Content

[0004] In order to solve the above-mentioned problems, the present invention is implemented through the following technical solutions:

[0005] A device for preparing chromosome slides comprises: a placement table for placing glass slides; a dropper plate arranged above the placement table for placing a dropper; the placement table is arranged to move closer to or away from the dropper plate for adjusting the distance between the glass slide and the dropper plate; a base plate arranged at the bottom of the placement table, the placement table being arranged between the base plate and the dropper plate; a plurality of support rods installed between the base plate and the dropper plate, the support rods being used to support and fix the dropper plate, the placement table being arranged to move on the support rods, and the support rods being provided with scales.

[0006] The placing table comprises: a plurality of placing grooves, which are arranged on the placing table; a plurality of through holes, which are arranged on the placing table, and the support rods pass through the through holes.

[0007] The utility model also includes: a screw rod, one end of which is connected to the bottom plate, and the other end of which passes through the placement table and the drop plate at the same time; and a knob, which is installed on the top end of the screw rod.

[0008] The placement platform also includes: a nut, which is installed on the placement platform, and the screw rod is connected to the nut.

[0009] The drop plate includes: a plurality of adjustment holes, which are opened on the drop plate; a plurality of moving blocks, which are respectively connected to the adjustment holes; and a plurality of sample addition holes, which are respectively opened on the moving blocks and are used to place droppers.

[0010] The adjusting hole includes: a guide rail installed on the side wall of the adjusting hole, the moving block is connected to the guide rail, and the guide rail is used to guide the moving block to move in the adjusting hole.

[0011] The present invention provides a device for preparing chromosome slides. Compared with the prior art, it has the following advantages:

[0012] 1. The design of screw and nut can accurately control the lifting and lowering of the placement table, ensure the consistent distance between the glass slide and the drop plate, ensure the consistency of the drop height and the uniformity of the drop size, improve the drop accuracy, and reduce the experimental error caused by the change of the drop height.

[0013] 2. By precisely controlling the dripping process, random errors in the experiment are reduced, and the repeatability and comparability of the experiment are enhanced. Due to the precise control of the dripping height, the kinetic energy of the droplet when it hits the slide can be kept stable, making the droplet diffusion area and the distribution of chromosomes more uniform.

[0014] 3. The multiple placement slots on the placement table can process multiple slides at the same time, improving work efficiency and experimental parallelism. The adjustment holes and movable blocks on the drop plate allow users to quickly adjust the position of the sample wells according to experimental needs, further saving experimental time. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 This is a schematic diagram of the three-dimensional structure proposed by the utility model.

[0016] Figure 2 This is a schematic diagram of the three-dimensional structure from another perspective proposed by the utility model.

[0017] Figure 3 This is a schematic diagram of the placement table structure proposed by the utility model.

[0018] Figure 4 This is a schematic diagram of the drip plate structure proposed by the utility model.

[0019] The reference numerals in the figures are:

[0020] 1. Bottom plate;

[0021] 2. Placement table; 201. Placement slot; 202. Nut; 203. Through hole;

[0022] 3. Drip plate; 301. Adjustment hole; 302. Moving block; 303. Sample addition hole; 304. Guide rail;

[0023] 4. Support rod; 401. Scale;

[0024] 5. Screw;

[0025] 6. Knob. DETAILED DESCRIPTION

[0026] The present invention will be further described below with reference to specific embodiments. It should be understood that these embodiments are only used to illustrate the present invention and are not used to limit the scope of protection of the present invention.

[0027] The following describes the embodiments of the present invention through specific examples. Those skilled in the art will readily understand the other advantages and benefits of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments, and the details in this specification may be modified or altered based on different perspectives and applications without departing from the spirit of the present invention.

[0028] Reference Figures 1-4 , a device for chromosome film preparation and droplet preparation, comprising: a placement table 2 for placing a glass slide; a droplet plate 3, arranged above the placement table 2, for placing a dropper; the placement table 2 is arranged to move closer to or away from the droplet plate 3, for adjusting the distance between the glass slide and the droplet plate 3; a base plate 1, arranged at the bottom of the placement table 2, the placement table 2 is arranged between the base plate 1 and the droplet plate 3, the base plate 1 serves as the foundation of the entire device, provides a stable support platform, ensures the stability and safety of all components above, its design takes into account load-bearing and balance, so that the overall stability of the device can be maintained even under high load; a number of support rods 4, installed between the base plate 1 and the droplet plate 3, the support rods 4 are used to support and fix the droplet plate 3, the placement table 2 is arranged to move on the support rods 4, the support rods 4 are provided with scales 401, the support rods 4 not only serve to connect the base plate 1 and the droplet plate 3, but also serve as a track for the movement of the placement table 2, its sturdy structural design ensures that the entire device will not be deformed or loosened due to external forces during operation, thereby ensuring the continuity of the experiment and the reliability of the results.

[0029] The placement table 2 includes: a number of placement slots 201, which are opened on the placement table 2. The number of placement slots 201 can process multiple glass slides at the same time, which improves work efficiency and experimental parallelism and is convenient for batch chromosome preparation operations; a number of through holes 203, which are opened on the placement table 2, and the support rod 4 passes through the through holes 203; a screw rod 5, one end of which is connected to the base plate 1, and the other end passes through the placement table 2 and the drop plate 3 at the same time; a knob 6, which is installed at the top of the screw rod 5; a nut 202, which is installed on the placement table 2, and the screw rod 5 is connected to the nut 202. One end of the screw rod 5 is fixed to the base plate 1, and the other end passes through the placement table 2 and the drop plate 3. In combination with the use of the nut 202, the lifting and lowering of the placement table 2 can be precisely controlled by rotating the knob 6, thereby achieving fine-tuning of the slide position and enhancing the accuracy of the operation.

[0030] The dropper plate 3 includes: a plurality of adjustment holes 301, which are opened on the dropper plate 3; a plurality of movable blocks 302, which are respectively connected to the plurality of adjustment holes 301; a plurality of sample addition holes 303, which are respectively opened on the plurality of movable blocks 302, and the sample addition holes 303 are used to place droppers; the adjustment hole 301 includes: a guide rail 304, which is installed on the side wall of the adjustment hole 301, and the movable block 302 is connected to the guide rail 304, and the guide rail 304 is used to guide the movable block 302 to move in the adjustment hole 301. The adjustment hole 301 designed on the dropper plate 3 and the movable block 302 inside it allow the user to adjust the position of the sample addition hole 303 according to experimental requirements, thereby increasing the flexibility and adaptability of the experiment, especially for glass slides of different specifications or special requirements, the reagent can be better dropped in the right position. The guide rail 304 installed on the side wall of the adjustment hole 301 ensures the stability and linearity of the movable block 302 during the adjustment process, avoids the problem of inaccurate dropping due to position offset, and improves the accuracy and repeatability of the experiment.

[0031] During use, the glass slide to be processed is placed in the placement groove 201 on the placement table 2. Each placement groove 201 can accommodate one glass slide. According to the experimental requirements, multiple glass slides can be processed at the same time to improve work efficiency. By rotating the knob 6, the screw rod 5 rotates in the nut 202 to accurately control the lifting and lowering of the placement table 2. Observe the scale 401 on the support rod 4 to ensure that the distance between the glass slide and the drop plate 3 reaches the height required for the experiment. According to the specific requirements of the glass slide and the experiment, adjust the position of the moving block 302 on the drop plate 3, move the moving block 302 along the guide rail 304, align the sample well 303 with the target position on the glass slide, and ensure that the moving block 302 is aligned with the target position on the glass slide. The moving block 302 moves smoothly and linearly during the adjustment process to avoid position deviation. Insert the dropper into the sample addition hole 303 and prepare to add the reagent. Keep the dropper plate 3 stable and gently squeeze the dropper to make the reagent drip evenly on the target position on the glass slide. Pay attention to controlling the height and size of the droplet to ensure the dispersion and ductility of the chromosomes. Wait for the reagent to fully diffuse and react on the glass slide, observe the distribution status of the chromosomes, and ensure that the quality of the chromosome preparation meets the requirements of subsequent analysis. When the reagent is completely reacted and dried, gently remove the glass slide and place it in a dry, dust-free environment for storage in preparation for subsequent chromosome karyotype analysis.

[0032] In summary, compared with the existing technology, it has the following beneficial effects:

[0033] By adopting the design of the screw rod 5 and the nut 202, the lifting and lowering of the placement table 2 can be accurately controlled to ensure the consistency of the distance between the glass slide and the drop plate 3, the consistency of the drop height and the uniformity of the drop size are guaranteed, the accuracy of the drop is improved, and the experimental error caused by the change of the drop height is reduced.

[0034] By precisely controlling the dripping process, random errors in the experiment are reduced and the repeatability and comparability of the experiment are enhanced. Due to the precise control of the dripping height, the kinetic energy of the droplet when it hits the slide can be kept stable, making the diffusion area of ​​the droplet and the distribution of chromosomes more uniform.

[0035] The multiple placement slots 201 on the placement table 2 can process multiple glass slides at the same time, improving work efficiency and experimental parallelism. The adjustment holes 301 and moving blocks 302 on the dropper plate 3 allow users to quickly adjust the position of the sample addition holes 303 according to experimental requirements, further saving experimental time.

[0036] Thus, although the present invention has been described herein with reference to specific embodiments thereof, freedom of modification, various changes and substitutions are within the foregoing disclosure, and it should be understood that in some cases, some features of the present invention will be employed without the corresponding use of other features without departing from the scope and spirit of the proposed invention. Thus, many modifications may be made to adapt particular circumstances or materials to the true scope and spirit of the present invention. The present invention is not intended to be limited to the specific terminology used in the claims below and / or to the specific embodiments disclosed as the best mode contemplated for carrying out the invention, but the present invention will include any and all embodiments and equivalents falling within the scope of the appended claims. Therefore, the scope of the present invention will be determined solely by the appended claims.

Claims

1. A device for preparing chromosome slices, characterized in that: include: a placement table (2) for placing a slide; A dropper plate (3) is arranged above the placement table (2) and is used for placing a dropper; The placement platform (2) is configured to move closer to or farther from the drop plate (3) so as to adjust the distance between the glass slide and the drop plate (3).

2. The device for preparing chromosome slices according to claim 1, characterized in that: Also includes: The bottom plate (1) is arranged at the bottom of the placement table (2), and the placement table (2) is arranged between the bottom plate (1) and the drip plate (3).

3. The device for preparing chromosome slices according to claim 2, characterized in that: Also includes: A plurality of support rods (4) are installed between the base plate (1) and the drop plate (3), the support rods (4) being used to support and fix the drop plate (3), the placement platform (2) being configured to move on the support rods (4), and the support rods (4) being provided with scales (401).

4. The device for preparing chromosome slides according to claim 3, characterized in that: The placement platform (2) comprises: A plurality of placement slots (201) are provided on the placement platform (2); A plurality of through holes (203) are provided on the placement platform (2), and the support rods (4) pass through the through holes (203).

5. The device for preparing chromosome slides according to claim 2, characterized in that: Also includes: A screw rod (5), one end of which is connected to the bottom plate (1), and the other end of which passes through both the placement table (2) and the drip plate (3); The knob (6) is mounted on the top end of the screw rod (5).

6. The device for preparing chromosome slides according to claim 5, characterized in that: The placement platform (2) further comprises: The nut (202) is mounted on the placement platform (2), and the screw rod (5) is connected to the nut (202).

7. The device for preparing chromosome slides according to claim 1, characterized in that: The drop plate (3) comprises: A plurality of adjustment holes (301) are provided on the drip plate (3); A plurality of moving blocks (302) are respectively connected to the plurality of adjusting holes (301); A plurality of sample addition holes (303) are respectively provided on a plurality of movable blocks (302), and the sample addition holes (303) are used for placing droppers.

8. The device for preparing chromosome slides according to claim 7, characterized in that: The regulating hole (301) comprises: The guide rail (304) is installed on the side wall of the adjustment hole (301), the moving block (302) is connected to the guide rail (304), and the guide rail (304) is used to guide the moving block (302) to move in the adjustment hole (301).

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