Preassembled radial chromatographic column

Abstract

The utility model discloses a preassembled radial chromatographic column, which relates to the technical field of chromatographic columns and comprises a barrel, a dispersion disc is arranged on the barrel, a screw is arranged in the middle of the barrel, a first nut is mounted on the screw in a threaded manner, a pressing block is arranged below the first nut, an upper adapter block is connected onto the barrel, and a lower adapter block is connected onto the barrel. An inner filter element is arranged on the outer side of the screw rod, an outer filter element is arranged on the dispersion disc, a bolt is arranged between the upper adapter block and the cylinder body, a second nut is connected to the bolt, a left PEEK plug and a right PEEK plug are connected to the pressing block, an upper PEEK plug is arranged at the upper end of the screw rod, and a lower PEEK plug is arranged at the bottom of the dispersion disc. According to the preassembled radial chromatographic column, the packing in the column can be compressed by the pressing block, so that the packing in the column flows to fill the dead volume, and no dead volume residue exists in the column.

Description

Technical Field

[0001] The utility model relates to the technical field of chromatographic columns, in particular to a pre-installed radial chromatographic column. Background Art

[0002] Prepacked chromatographic columns are core components in chromatographic analysis, offering efficient and precise separation capabilities. They typically consist of a column tube, a cap, and a ferrule, and are filled with a high-quality separating agent or adsorbent. The advantage of prepacked columns lies in their pre-assembled design, allowing for quick installation and use, reducing experimental preparation time. Furthermore, they offer stable and reliable separations, can withstand high pressures and temperatures, and are suitable for analyzing a wide range of complex samples. In fields such as biomedicine, environmental protection, and food safety, prepacked chromatographic columns play an irreplaceable role, providing strong support for scientific research and production.

[0003] The dead volume of a chromatographic column refers to the void space within the column that is not occupied by the stationary phase. Existing prepacked radial chromatographic columns contain some dead volume. Excessive dead volume can lead to peak broadening and reduced resolution, thus compromising the accuracy and sensitivity of chromatographic analysis, resulting in long column packing cycles and unstable quality. Therefore, a prepacked radial chromatographic column was proposed. Utility Model Content

[0004] The purpose of the utility model is to provide a pre-packed radial chromatographic column to solve the problem of some dead volumes in the pre-packed radial chromatographic column in the prior art.

[0005] To achieve the above-mentioned objectives, the present invention provides the following technical solutions: a pre-installed radial chromatographic column, comprising a barrel, a dispersion disk provided on the barrel, a screw provided in the middle position of the barrel, a first nut threadedly mounted on the screw, a pressure block provided below the first nut, an upper adapter block connected to the barrel, an inner filter element provided on the outer side of the screw, an outer filter element provided on the dispersion disk, a bolt provided between the upper adapter block and the barrel, a second nut connected to the bolt, a left PEEK plug and a right PEEK plug connected to the pressure block, an upper PEEK plug provided at the upper end of the screw, a lower PEEK plug provided at the bottom of the dispersion disk, an upper PEEK tube fixedly mounted on the upper PEEK plug, a lower PEEK tube fixedly mounted on the lower PEEK plug, and the PEEK plug blocks the opening.

[0006] Preferably, the left PEEK plug and the right PEEK plug are both connected to a feed pipe, and the feed pipe is made of PEEK plastic.

[0007] Preferably, a first sealing ring is provided between the screw and the pressing block, and a fourth sealing ring is provided between the dispersion disk and the barrel. The first sealing ring and the fourth sealing ring can play a sealing role.

[0008] Preferably, a connecting hole is provided on the pressing block, and the left PEEK plug and the right PEEK plug are connected to the pressing block through the connecting hole.

[0009] Preferably, a second sealing ring and a third sealing ring are provided at the connection between the upper adapter block and the cylinder, and the second sealing ring and the third sealing ring can play a sealing role.

[0010] Preferably, the screw is hollow inside, and an upper docking port is provided at the upper end of the screw, the upper PEEK plug is connected to the screw through the upper docking port, and a lower docking port is provided at the bottom of the dispersion disk, and the lower PEEK plug is connected to the bottom of the dispersion disk through the lower docking port.

[0011] Preferably, the upper adapter block is fixed to the cylinder by bolts, and the pressing block is restricted in the cylinder by a first nut.

[0012] Compared with the prior art, the beneficial effects of the present invention are:

[0013] 1. In this application, the second sealing ring can be inserted into the groove of the upper adapter block so that it is located between the pressure block and the barrel to limit the height of the pressure block after filling. Then, the pressure block and the barrel are connected together using bolts and the second nut. Then, the first nut is screwed onto the screw. The first nut is used to tighten and squeeze the pressure block downward after the initial filling. The pressure block then compresses the filler inside the column, so that the filler inside the column flows to fill the dead volume, making it easier to load the column.

[0014] 2. The user can turn the first nut to screw it onto the screw. Tighten the first nut downward to squeeze the compression block, which in turn compresses the filler inside the column, causing the filler inside the column to flow and fill the dead volume. Water is discharged from the inner filter element and then flows out through the screw, completing the filling. There is no dead volume remaining inside the column, thereby improving the quality of the chromatographic column. BRIEF DESCRIPTION OF THE DRAWINGS

[0015] Figure 1 It is a schematic diagram of the overall structure of the utility model;

[0016] Figure 2 It is a schematic diagram of the local structure of the utility model;

[0017] Figure 3 For this utility model Figure 1 Enlarged view of point A in the middle;

[0018] Figure 4 For this utility model Figure 2 Enlarged view of point A in the middle.

[0019] Numbers in the figure: 1. Screw; 2. First nut; 3. Press block; 4. Upper adapter block; 5. Cylinder; 6. Dispersion disc; 7. Inner filter element; 8. Outer filter element; 9. First sealing ring; 10. Second sealing ring; 11. Third sealing ring; 12. Fourth sealing ring; 13. Bolt; 14. Second nut; 15. Left PEEK plug; 16. Upper PEEK plug; 17. Lower PEEK plug; 18. Upper PEEK tube; 19. Lower PEEK tube; 21. Right PEEK plug; 22. Feed pipe. DETAILED DESCRIPTION

[0020] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts are within the scope of protection of the present invention.

[0021] like Figure 1 and Figure 2 As shown, the utility model provides a technical solution for a pre-loaded radial chromatographic column, comprising a barrel 5, a dispersion disk 6 is provided on the barrel 5, a screw 1 is provided in the middle position of the barrel 5, a first nut 2 is threadedly installed on the screw 1, a pressing block 3 is provided below the first nut 2, an upper adapter block 4 is connected to the barrel 5, an inner filter element 7 is provided on the outer side of the screw 1, an outer filter element 8 is provided on the dispersion disk 6, a bolt 13 is provided between the upper adapter block 4 and the barrel 5, a second nut 14 is connected to the bolt 13, a left PEEK plug 15 and a right PEEK plug 21 are connected to the pressing block 3, an upper PEEK plug 16 is provided at the upper end of the screw 1, a lower PEEK plug 17 is provided at the bottom of the dispersion disk 6, an upper PEEK tube 18 is fixedly installed on the upper PEEK plug 16, and a lower PEEK tube 19 is fixedly installed on the lower PEEK plug 17. The pressing block 3 can compress the internal filler of the column so that the internal filler of the column flows to fill the dead volume, and there is no dead volume remaining inside the column.

[0022] like Figure 1 and Figure 3 As shown, a dispersion disc 6 is provided on the cylinder 5, a screw 1 is provided in the middle position of the cylinder 5, a first nut 2 is threadedly installed on the screw 1, a pressure block 3 is provided under the first nut 2, an upper adapter block 4 is connected to the cylinder 5, an inner filter element 7 is provided on the outside of the screw 1, an outer filter element 8 is provided on the dispersion disc 6, a bolt 13 is provided between the upper adapter block 4 and the cylinder 5, a second nut 14 is connected to the bolt 13, a first sealing ring 9 is provided between the screw 1 and the pressure block 3, and a fourth sealing ring 12 is provided between the dispersion disc 6 and the cylinder 5.

[0023] Specifically, the user can rotate the first nut 2 to screw it onto the screw 1. The first nut 2 is tightened to squeeze the pressing block 3 downward, and the pressing block 3 then compresses the internal filler, causing the internal filler to flow and fill the dead volume. The water is discharged from the inner filter element 7 and then flows out through the screw 1, completing the filling and leaving no dead volume inside the column.

[0024] like Figure 2 and Figure 4 As shown, the pressing block 3 is connected to a left PEEK plug 15 and a right PEEK plug 21, an upper PEEK plug 16 is provided at the upper end of the screw 1, and a lower PEEK plug 17 is provided at the bottom of the dispersion disk 6. An upper PEEK tube 18 is fixedly installed on the upper PEEK plug 16, and a lower PEEK tube 19 is fixedly installed on the lower PEEK plug 17. A feed pipe 22 is connected to both the left PEEK plug 15 and the right PEEK plug 21, and the feed pipe 22 is made of PEEK plastic. A second sealing ring 10 and a third sealing ring 11 are provided at the connection between the upper adapter block 4 and the barrel 5.

[0025] Specifically, the second sealing ring 10 can be inserted into the groove of the upper adapter block 4 so that it is located between the pressing block 3 and the barrel 5 to limit the height of the pressing block 3 after filling. Then, the bolt 13 and the second nut 14 are used to connect the pressing block 3 and the barrel 5 together. Then, the first nut 2 is screwed onto the screw 1. The first nut 2 is used to tighten and squeeze the pressing block 3 downward after the initial filling. The pressing block 3 then compresses the filler inside the column, so that the filler inside the column flows to fill the dead volume.

[0026] Working principle: First, insert the inner filter element 7 into the screw 1, and then tighten it through the threaded hole in the middle of the dispersion disc 6 to fix the inner filter element 7 in the middle position of the dispersion disc 6. There is a circle of grooves on the dispersion disc 6, which is used to locate the position of the inner filter element 7. The through hole on the screw 1 is connected to the outlet channel for liquid discharge; then position the outer filter element 8 on the outside of the dispersion disc 6; then insert the fourth sealing ring 12 into the groove on the dispersion disc 6, and then insert the cylinder 5 into the dispersion disc 6, and connect and tighten it with the second nut 14 and bolt 13, and then insert the first sealing ring 9 into the groove on the screw 1, and the third sealing ring 11 into the 3 pressure blocks. Then connect it between the inside of the outer filter element 8 and the screw 1; secondly, insert the second sealing ring 10 into the groove of the upper adapter block 4 so that it is located between the pressure block 3 and the barrel 5 to limit the height of the pressure block 3 after filling. Then use the bolt 13 and the second nut 14 to connect the pressure block 3 and the barrel 5 together, and then screw the first nut 2 onto the screw 1. The first nut 2 is used to tighten and squeeze the pressure block 3 downward after the initial filling. The pressure block 3 then compresses the filler inside the column so that the filler inside the column flows to fill the dead volume; when filling, switch the upper PEEK plug 16 and the upper PEEK tube 18 to plug the outlet, and the left PEEK plug 15 and the right PEEK plug 21 are replaced with a pipeline as the feed channel, and the prepared slurry is injected into the packing space through the pipeline by a pump. Due to the presence of the inner filter element 7 and the outer filter element 8, the agar balls will remain in the packing space, and the water will pass through the outer filter element 8 from the dispersion disk 6 pipeline and then be discharged through the PEEK tube. When the volume of the packing increases, the pump shows that the pressure increases. When a certain pressure is reached, the packing is almost full. At this time, switch to another feed port to continue filling. At this time, the increase in the volume and pressure of the packing space will push the pressing block 3 upward until it reaches the upper adapter block 4. At this time, the feed pipe 22 and the upper PEEK tube 18 are switched to PEEK plugs. , and there is no dead angle in the outer circle of the lower packing space, and there will be dead volume at the top edge of the upper packing space; then the PEEK tube is switched to the upper PEEK plug 16 and the upper PEEK tube 18, and the lower PEEK plug 17 and the lower PEEK tube 19 are switched to the PEEK plug to block the outlet, and the liquid is discharged from the upper outlet; then the first nut 2 is rotated to screw it onto the screw 1, and the first nut 2 is tightened to squeeze the pressing block 3 downward, and the pressing block 3 then compresses the filling material inside the column, so that the filling material inside the column flows to fill the dead volume, and the water is discharged from the inner filter element 7 and then flows out through the screw 1, completing the filling, so that there is no dead volume remaining inside the column.

[0027] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above and that the present invention can be implemented in other specific forms without departing from the spirit or essential characteristics of the present invention. Therefore, the embodiments should be considered in all respects as illustrative and non-restrictive, and the scope of the present invention is defined by the appended claims, not the foregoing description, and all variations within the meaning and range of equivalents of the claims are intended to be encompassed within the present invention. Any reference sign in a claim should not be construed as limiting the claim to which it relates.

Claims

1. A prepacked radial chromatographic column, characterized in that: The invention comprises a cylinder (5), a dispersion disk (6) is provided on the cylinder (5), a screw (1) is provided in the middle of the cylinder (5), a first nut (2) is threadedly mounted on the screw (1), a pressure block (3) is provided below the first nut (2), an upper adapter block (4) is connected to the cylinder (5), an inner filter element (7) is provided on the outer side of the screw (1), an outer filter element (8) is provided on the dispersion disk (6), and a bolt (13) is provided between the upper adapter block (4) and the cylinder (5). The bolt (13) is connected to a second nut (14), the pressing block (3) is connected to a left PEEK plug (15) and a right PEEK plug (21), an upper PEEK plug (16) is provided at the upper end of the screw rod (1), a lower PEEK plug (17) is provided at the bottom of the dispersion disk (6), an upper PEEK tube (18) is fixedly mounted on the upper PEEK plug (16), and a lower PEEK tube (19) is fixedly mounted on the lower PEEK plug (17).

2. A prepacked radial chromatographic column according to claim 1, characterized in that: The left PEEK plug (15) and the right PEEK plug (21) are both connected to a feed pipe (22), and the feed pipe (22) is made of PEEK plastic.

3. A prepacked radial chromatographic column according to claim 2, characterized in that: A first sealing ring (9) is provided between the screw (1) and the pressing block (3), and a fourth sealing ring (12) is provided between the dispersion disk (6) and the barrel (5).

4. A prepacked radial chromatographic column according to claim 3, characterized in that: A connecting hole is provided on the pressing block (3), and the left PEEK plug (15) and the right PEEK plug (21) are connected to the pressing block (3) through the connecting hole.

5. A prepacked radial chromatographic column according to claim 4, characterized in that: A second sealing ring (10) and a third sealing ring (11) are provided at the connection between the upper adapter block (4) and the cylinder (5).

6. A prepacked radial chromatography column according to claim 5, characterized in that: The screw (1) is hollow inside, and an upper docking port is provided at the upper end of the screw (1); the upper PEEK plug (16) is connected to the screw (1) via the upper docking port; a lower docking port is provided at the bottom of the dispersion disk (6); and the lower PEEK plug (17) is connected to the bottom of the dispersion disk (6) via the lower docking port.

7. A prepacked radial chromatography column according to claim 6, characterized in that: The upper transfer block (4) is fixed to the cylinder (5) by means of bolts (13), and the pressing block (3) is restricted in the cylinder (5) by means of a first nut (2).

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