Liquid preparation system based on multifunctional pilot platform and liquid preparation chromatography system thereof

Abstract

The utility model provides a liquid preparation system based on a multifunctional pilot platform and a liquid preparation chromatography system thereof. The liquid preparation system comprises a first input main pipeline and a second input main pipeline which are respectively connected with a plurality of input pipelines, the outlet end of each input pipeline is connected with a liquid inlet port of the corresponding movable installation module, and each movable installation module is further provided with a plurality of liquid outlet ports. Each liquid outlet port is connected with a plurality of collecting pipelines through an output pipeline; the first input main pipeline is respectively connected with the two collecting pipelines through valves; the second input main pipeline is respectively connected with the plurality of collecting pipelines through valves; the second input main pipeline is connected with the first input main pipeline through a valve; the first input module is connected with an external pump module through a valve; a plurality of chromatographic columns are mounted in an inner shell of the movable mounting module; the device has the advantages that ternary liquid preparation and quaternary online dilution liquid preparation can be realized by a single pump and double pumps, and online liquid preparation chromatography is realized.

Description

Technical Field

[0001] The utility model relates to a liquid preparation system in the downstream of the pharmaceutical field, in particular to a liquid preparation system based on a multifunctional pilot platform and a liquid preparation chromatography system thereof. Background Art

[0002] An online buffer dispensing system is used to mix a diluent (water for injection) and several single-component concentrated solutions (acids, bases, salts, etc.) online in the required amounts according to the recipe to obtain the buffer required for final production. In the prior art, the above-mentioned solutions are usually prepared using a precision plunger pump and mixer, then collected and transported from a storage tank when needed. Alternatively, the dispensing system is directly connected to the chromatography column to provide the buffer required for chromatography. However, its disadvantages are: its single function cannot meet the requirements for dispensing or dispensing chromatography under different working conditions, its application range is relatively small, and multiple sets of equipment increase costs. Utility Model Content

[0003] In order to overcome the above-mentioned deficiencies of the prior art, the present invention provides a liquid preparation system and a liquid preparation chromatography system based on a multifunctional pilot platform. It can meet the needs of liquid preparation and liquid preparation chromatography, expand the functions of the system, and meet the production processes under different working conditions.

[0004] In order to achieve the above purpose, the technical solution adopted by the utility model is:

[0005] In response to the above technical problems, the first aspect of the disclosure of the utility model proposes a liquid distribution system based on a multifunctional automatic pilot platform, which platform system includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to multiple input pipelines and is controlled on and off by corresponding valves; the second input main pipeline is also connected to the above multiple input pipelines respectively and is controlled on and off by corresponding valves; the outlet end of each input pipeline is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each liquid outlet port is respectively connected to multiple collecting pipelines through an output pipeline; the first input main pipeline is respectively connected to the two collecting pipelines mentioned above through valves; the second input main pipeline is respectively connected to the multiple collecting pipelines mentioned above through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to the external pump module through a valve; a mixer is provided on the first input main pipeline; the connection ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer.

[0006] In some embodiments, two input pipes are provided, and the corresponding movable installation module is provided with two liquid inlet ports, two liquid outlet ports, and two output pipes respectively.

[0007] In some embodiments, the outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

[0008] In some embodiments, the second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

[0009] In some embodiments, the input pipeline and the output pipeline are connected one-to-one through pipelines, and valves are provided on the pipelines.

[0010] In some embodiments, there are two collecting pipes.

[0011] In some embodiments, the two output pipes are respectively connected to a second valve array group, and the second valve array group includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collection pipes.

[0012] In some embodiments, the external pump module includes a third input main pipeline, a plurality of input pumps are provided at the inlet end of the third input main pipeline, and the third input main pipeline is connected to the first input main pipeline respectively.

[0013] In some embodiments, one or two input pumps are provided at the inlet end of the third input main pipeline.

[0014] In some embodiments, the first input main pipeline and / or the second input main pipeline and / or the external pump module are respectively provided with a pressure sensor and / or a flow sensor.

[0015] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0016] The first aspect of the disclosure of the utility model proposes a liquid chromatography system based on a multifunctional automatic pilot platform, the platform system includes a first input main pipeline with a first input pump, and a second input main pipeline with a second input pump; the first input main pipeline is connected to multiple input pipelines and is controlled to be on and off by corresponding valves; the second input main pipeline is also respectively connected to the multiple input pipelines and is controlled to be on and off by corresponding valves; the outlet end of each of the input pipelines is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each of the liquid outlet ports is respectively connected to multiple collection pipelines through an output pipeline; the first input pipeline is connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each of the liquid outlet ports is connected to multiple collection pipelines through an output pipeline; the first input pipeline is connected to the liquid inlet port of the corresponding movable installation module, and the liquid inlet port is connected to the liquid inlet port of the corresponding movable installation module; the first input pipeline is connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is provided with multiple liquid outlet ports; the first input pipeline is connected to the liquid inlet port of the corresponding movable installation module, and the liquid inlet port is connected to the liquid inlet port of the corresponding movable installation module; the first input pipeline is connected to the liquid inlet port of the corresponding movable installation module, and the first input pipeline ... The input main pipeline is connected to the two collection pipelines mentioned above through valves; the second input main pipeline is connected to the multiple collection pipelines mentioned above through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input module is connected to the external pump module through a valve; a mixer and a bubble trap are provided on the first input main pipeline; the connection ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer; multiple chromatography columns are placed in the movable installation module, and the bottom inlet and outlet of each chromatography column are connected to the input pipeline through the corresponding liquid inlet port; the top inlet and outlet of the chromatography column are connected to the output pipeline through the corresponding liquid outlet port.

[0017] In some embodiments, two input pipes are provided, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively, and one or two chromatography columns are used.

[0018] In some embodiments, the outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

[0019] In some embodiments, the second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

[0020] In some embodiments, the input pipeline and the output pipeline are connected one-to-one through pipelines, and valves are provided on the pipelines.

[0021] In some embodiments, there are two collecting pipes.

[0022] In some embodiments, the two output pipes are respectively connected to a second valve array group, and the second valve array group includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet ends of the output pipes; the other group of opposite sides of the rectangular valve array corresponds to the inlets of the two collection pipes.

[0023] In some embodiments, the external pump module includes a third input main pipeline, a plurality of input pumps are provided at the inlet end of the third input main pipeline, and the third input main pipeline is connected to the first input main pipeline respectively.

[0024] In some embodiments, one or two input pumps are provided at the inlet end of the third input main pipeline.

[0025] In some embodiments, the first input main pipeline and / or the second input main pipeline and / or the external pump module are respectively provided with a pressure sensor and / or a flow sensor.

[0026] In some embodiments, the collection pipe is respectively provided with an ultraviolet sensor and / or a first conductivity sensor and / or a pH sensor.

[0027] Beneficial effects of the utility model:

[0028] The utility model adds an external pump module on the basis of the multifunctional automatic pilot platform, realizes the liquid dispensing function, expands the application range, and can realize ternary liquid dispensing and quaternary online dilution liquid dispensing by using a single pump or a double pump.

[0029] The utility model adds an external pump module and a chromatography column on the basis of a multifunctional automatic pilot platform, thereby realizing online liquid chromatography. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 It is a structural diagram of the liquid dispensing system of the utility model.

[0031] Figure 2 It is a structural schematic diagram of the liquid chromatography of the utility model. DETAILED DESCRIPTION

[0032] The present invention will be further described below with reference to the accompanying drawings.

[0033] The following describes the technical content of the present invention through specific embodiments. Those skilled in the art will readily understand the other advantages and functions of the present invention from the disclosure herein. The present invention may also be implemented or applied through various other specific embodiments. Those skilled in the art may make various modifications and alterations without departing from the spirit of the present invention.

[0034] Before introducing the specific embodiments of the present disclosure in detail, some terms used in the present disclosure are first explained.

[0035] Unless otherwise defined below, the meaning of all technical terms and scientific terms used herein is intended to be the same as that generally understood by those skilled in the art. Mention that the technology used in this article is intended to refer to the technology generally understood in the art, including those changes in technology that are obvious to those skilled in the art or the replacement of equivalent technology. Although it is believed that the following terms are well understood by those skilled in the art, the following definitions are still set forth to better explain the utility model. When a trade name appears in this article, it is intended to refer to its corresponding commodity. All patents, published patent applications and publications cited herein are incorporated herein by reference.

[0036] Unless otherwise indicated herein, plural references such as "a", "the" include plural references. The expression "one or more" or "at least one" may mean 1, 2, 3, 4, 5, 6, 7, 8, 9 or more.

[0037] As used herein, the terms “connect,” “connected,” “coupled,” or similar terms are not limited to direct connections but also include indirect connections.

[0038] As used herein, a "sample" is a biomolecule, including proteins, nucleic acids, lipids, carbohydrates, small nucleotides, amino acids, and their derivatives.

[0039] As used herein, the term "online monitoring" or "real-time monitoring" refers to the real-time detection of certain parameters or properties of a buffer, reaction fluid, or fluid flowing out of a flow reactor, such as pH, pressure, flow rate, conductivity, etc., during the use of a chromatography system. Unlike offline detection or analysis, online monitoring or real-time monitoring can provide real-time feedback of the detection results.

[0040] As mentioned in this article, the A2 liquid storage tank, A3 liquid storage tank, A4 liquid storage tank, A5 liquid storage tank, P1 liquid storage tank, P1-W liquid storage tank, P2 liquid storage tank, and P2-W liquid storage tank refer to tanks used to store different solutions, not tanks with specific limitations. Any container that can realize the storage function is sufficient.

[0041] For example, the positional relationship words "up", "down", "left", "right", "front", "back", etc. involved in this article are determined according to the layout direction of the drawings in the specification. They are only used to express relative positional relationships. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0042] The application scenarios of this patent are laboratory scale and pilot scale, and the maximum flow rate range of a single pump is 1000ml / min.

[0043] Reference Figure 1 As shown, the liquid dispensing system based on the multifunctional automatic pilot platform includes a first input main pipeline 5, the input end of which is connected to the A2 liquid storage tank through a first valve 1 and to the A1 liquid storage tank through a second valve 12. The first input main pipeline 5 is provided with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7, and an air trap 8, from left to right.

[0044] The input end of the second input main pipeline 19 is connected to the A3 liquid reservoir via the fourth valve 15, the A4 liquid reservoir via the fifth valve 14, and the A5 liquid reservoir via the sixth valve. From left to right, the second input main pipeline 19 is provided with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18. The second input main pipeline 19 is connected to the first input main pipeline 5 via the seventh valve 20, with the connection point positioned between the third valve 6 and the mixer 7. The A3 liquid reservoir is connected to the inlet end of the first input main pipeline 5 via the thirty-seventh valve 13.

[0045] The external pump module includes a third input main conduit 30. Its input end is connected to the A6 reservoir via the eighth valve 25 and to the A7 reservoir via the ninth valve 26. From left to right, the third input main conduit 30 is equipped with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29. The third input main conduit 30 is connected to the first input main conduit 5 via the tenth valve 22. The connection point is located between the third valve 6 and the mixer 7.

[0046] The output of the first input main pipeline 5 is connected to the first valve array 32. The first valve array 32 comprises four valves connected end-to-end to form a rectangular valve array: the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35, and the fourteenth valve 36. The output of the first input main pipeline 5 is connected between the eleventh valve 33 and the fourteenth valve 36. The inlet of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35. The outlet of the first connecting pipe 78 is connected to the inlet of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 via the fifteenth valve 65 and the sixteenth valve 64. The outlets of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 are connected to the outlet of the first collecting pipeline 53 and the outlet of the second collecting pipeline 54 via the nineteenth valve 60 and the twentieth valve 62, respectively. The second input main pipeline 19 is connected to the outlet of the first connecting pipe 78 via the second connecting pipe 23. The seventeenth valve 21 and the eighteenth valve 31 are respectively provided at each end of the second connecting pipe 23. The inlet of the first input pipeline 38 is connected between the eleventh and twelfth valves 33 and 34. The outlet of the first input pipeline 38 is connected to the first liquid inlet port 39 of the movable mounting module 40. The first input pipeline 38 is provided with a twenty-first valve 37. The inlet of the second input pipeline 42 is connected between the thirteenth and fourteenth valves 35 and 36. The outlet of the second input pipeline 42 is connected to the second liquid inlet port 41 of the movable mounting module 40. The second input pipeline 42 is provided with a twenty-second valve 79. The first liquid outlet port 50 of the movable mounting module 40 is connected to the liquid inlet of the first output pipeline 75. The second liquid outlet port 44 of the movable mounting module 40 is connected to the second output pipeline 43. The first output pipeline 75 is provided with a twenty-third and twenty-fourth valves 51 and 52, respectively. The second output pipeline 43 is provided with a twenty-fifth and twenty-sixth valves 80 and 49. The first input pipeline 38 and the first output pipeline 75 are connected via a third connecting pipeline 45. One end of the third connecting pipeline 45 is located between the 21st valve 37 and the first valve array 32, and the other end is located between the 23rd valve 51 and the 24th valve 52. A 27th valve 46 is provided on the third connecting pipeline 45. The second input pipeline 42 and the second output pipeline 43 are connected via a fourth connecting pipeline 47. One end of the fourth connecting pipeline 47 is located between the 22nd valve 79 and the first valve array 32, and the other end is located between the 25th valve 80 and the 26th valve 49. A 28th valve 48 is provided on the fourth connecting pipeline 47. The first output pipeline 75 and the second output pipeline 43 are respectively connected to the second valve array 70. The second valve array 70 comprises four valves connected end to end to form a rectangular valve array: the 29th valve 71, the 30th valve 72, the 31st valve 73, and the 32nd valve 74.The outlet of the second output pipeline 43 is connected between the 29th and 32nd valves 71 and 74, the outlet of the first output pipeline 75 is connected between the 30th and 31st valves 72 and 73, the inlet of the first collection pipeline 53 is connected between the 29th and 30th valves 71 and 72, and the inlet of the second collection pipeline 54 is connected between the 31st and 32nd valves 73 and 74. The first collection pipeline 53 is equipped with a first UV sensor 55, a first conductivity sensor 56, and a first pH sensor 57. The outlet of the first collection pipeline 53 is connected to the P1 and P1-W liquid storage tanks via the 33rd and 34th valves 58 and 59, respectively. The second collection pipeline 54 is equipped with a second conductivity sensor 68 and a second pH sensor 69. The outlet of the second collection pipeline 54 is connected to the P2 and P2-W liquid storage tanks via the 35th and 36th valves 61 and 63, respectively.

[0047] Reference Figure 2 As shown, the liquid preparation chromatography system based on the multifunctional automatic pilot platform includes a first input main pipeline 5,

[0048] The input end of the first input main pipeline 5 is connected to the A2 liquid storage tank through the first valve 1 and to the A1 liquid storage tank through the second valve 12. The first input main pipeline 5 is provided with a first input pump 2, a first pressure sensor 3, a first flow sensor 4, a third valve 6, a mixer 7, and an air trap 8 from left to right.

[0049] The input end of the second input main pipeline 19 is connected to the A3 liquid reservoir via the fourth valve 15, the A4 liquid reservoir via the fifth valve 14, and the A5 liquid reservoir via the sixth valve. From left to right, the second input main pipeline 19 is provided with a second input pump 16, a second pressure sensor 17, and a second flow sensor 18. The second input main pipeline 19 is connected to the first input main pipeline 5 via the seventh valve 20, with the connection point positioned between the third valve 6 and the mixer 7. The A3 liquid reservoir is connected to the inlet end of the first input main pipeline 5 via the thirty-seventh valve 13.

[0050] The external pump module includes a third input main conduit 30. Its input end is connected to the A6 reservoir via the eighth valve 25 and to the A7 reservoir via the ninth valve 26. From left to right, the third input main conduit 30 is equipped with a third input pump 27, a third pressure sensor 28, and a third flow sensor 29. The third input main conduit 30 is connected to the first input main conduit 5 via the tenth valve 22. The connection point is located between the third valve 6 and the mixer 7.

[0051] The output of the first input main pipeline 5 is connected to the first valve array 32. The first valve array 32 comprises four valves connected end-to-end to form a rectangular valve array: the eleventh valve 33, the twelfth valve 34, the thirteenth valve 35, and the fourteenth valve 36. The output of the first input main pipeline 5 is connected between the eleventh valve 33 and the fourteenth valve 36. The inlet of the first connecting pipe 78 is connected between the twelfth valve 34 and the thirteenth valve 35. The outlet of the first connecting pipe 78 is connected to the inlet of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 via the fifteenth valve 65 and the sixteenth valve 64. The outlets of the first intermediate pipeline connection 66 and the second intermediate pipeline 67 are connected to the outlet of the first collecting pipeline 53 and the outlet of the second collecting pipeline 54 via the nineteenth valve 60 and the twentieth valve 62, respectively. The second input main pipeline 19 is connected to the outlet of the first connecting pipe 78 via the second connecting pipe 23. The seventeenth valve 21 and the eighteenth valve 31 are respectively provided at each end of the second connecting pipe 23. The inlet of the first input pipeline 38 is connected between the eleventh and twelfth valves 33 and 34. The outlet of the first input pipeline 38 is connected to the first liquid inlet port 39 of the movable mounting module 40. A twenty-first valve 37 is provided on the first input pipeline 38. The inlet of the second input pipeline 42 is connected between the thirteenth and fourteenth valves 35 and 36. The outlet of the second input pipeline 42 is connected to the second liquid inlet port 41 of the movable mounting module 40. A twenty-second valve 79 is provided on the second input pipeline 42. The first liquid inlet port 39 is connected to the bottom inlet and outlet of the first chromatography column 76, and the second liquid inlet port 41 is connected to the bottom inlet and outlet of the second chromatography column 77. The top inlet and outlet of the first chromatography column 76 are connected to the first liquid outlet port 50 of the movable mounting module 40. The top inlet and outlet of the second chromatography column 77 are connected to the second liquid outlet port 44 of the movable mounting module 40. The first liquid outlet port 50 of the movable mounting module 40 is connected to the liquid inlet of the first output pipeline 75, and the second liquid outlet port 44 of the movable mounting module 40 is connected to the second output pipeline 43. The first output pipeline 75 is provided with a twenty-third valve 51 and a twenty-fourth valve 52, respectively. The second output pipeline 43 is provided with a twenty-fifth valve 80 and a twenty-sixth valve 49. The first input pipeline 38 and the first output pipeline 75 are connected via a third connecting pipeline 45. One end of the third connecting pipeline 45 is located between the twenty-first valve 37 and the first valve array 32, and the other end is located between the twenty-third valve 51 and the twenty-fourth valve 52. The third connecting pipeline 45 is provided with a twenty-seventh valve 46. The second input pipeline 42 and the second output pipeline 43 are connected via a fourth connecting pipeline 47. One end of the fourth connecting pipeline 47 is located between the twenty-second valve 79 and the first valve array 32, and the other end is located between the twenty-fifth valve 80 and the twenty-sixth valve 49. The fourth connecting pipeline 47 is provided with a twenty-eighth valve 48.The first output pipeline 75 and the second output pipeline 43 are respectively connected to the second valve array 70. The second valve array 70 comprises four valves connected end-to-end to form a rectangular valve array, including the 29th valve 71, the 30th valve 72, the 31st valve 73, and the 32nd valve 74. The outlet of the second output pipeline 43 is connected between the 29th valve 71 and the 32nd valve 74, the outlet of the first output pipeline 75 is connected between the 30th valve 72 and the 31st valve 73, the inlet of the first collection pipeline 53 is connected between the 29th valve 71 and the 30th valve 72, and the inlet of the second collection pipeline 54 is connected between the 31st valve 73 and the 32nd valve 74. The first collection pipeline 53 is equipped with a first UV sensor 55, a first conductivity sensor 56, and a first pH sensor 57. The outlet of the first collection pipeline 53 is connected to the P1 liquid storage tank and the P1-W liquid storage tank via the 33rd valve 58 and the 34th valve 59, respectively. The second collecting pipe 54 is provided with a second conductivity sensor 68 and a second pH sensor 69 respectively. The outlet end of the second collecting pipe 54 is connected to the P2 liquid storage tank and the P2-W liquid storage tank through the thirty-fifth valve 61 and the thirty-sixth valve 63.

Claims

1. The liquid preparation system based on the multifunctional pilot platform is characterized by: The pilot platform includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline is connected to multiple input pipelines and is controlled on and off by corresponding valves; the second input main pipeline is also respectively connected to the above-mentioned multiple input pipelines and is controlled on and off by corresponding valves; the outlet end of each input pipeline is respectively connected to the liquid inlet port of the corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each liquid outlet port is respectively connected to multiple collecting pipelines through an output pipeline; the first input main pipeline is respectively connected to the two collecting pipelines mentioned above through valves; the second input main pipeline is respectively connected to the multiple collecting pipelines mentioned above through valves; the second input main pipeline is connected to the first input main pipeline through a valve; the first input main pipeline is connected to the external pump module through a valve; a mixer is provided on the first input main pipeline; the connection ends of the second input main pipeline, the external pump module and the first input main pipeline are located on one side of the inlet end of the mixer.

2. The liquid dispensing system based on the multifunctional pilot platform according to claim 1, characterized in that: There are two input pipes, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively.

3. The liquid dispensing system based on the multifunctional pilot platform according to claim 2, characterized in that: The outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

4. The liquid dispensing system based on the multifunctional pilot platform according to claim 3, characterized in that: The second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

5. The liquid dispensing system based on the multifunctional pilot platform according to claim 3, characterized in that: The input pipeline and the output pipeline are connected to each other through pipelines, and valves are provided on the pipelines.

6. The liquid dispensing system based on the multifunctional pilot platform according to claim 3, characterized in that: There are two collecting pipes.

7. The liquid dispensing system based on the multifunctional pilot platform according to claim 3, characterized in that: The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet end of the output pipe; the other group of opposite sides of the rectangular valve array corresponds to the inlet end of the two collecting pipes.

8. The liquid dispensing system based on the multifunctional pilot platform according to claim 3, characterized in that: The external pump module includes a third input main pipeline. A plurality of input pumps are provided at the inlet end of the third input main pipeline. The third input main pipeline is connected to the first input main pipeline respectively.

9. The liquid dispensing system based on the multifunctional pilot platform according to claim 8, characterized in that: The inlet end of the third input main pipeline is provided with one or two input pumps.

10. A liquid chromatography system based on a multifunctional lead platform, characterized in that: The pilot platform includes a first input main pipeline with a first input pump and a second input main pipeline with a second input pump; the first input main pipeline connects to multiple input pipelines and is controlled on and off by corresponding valves; the second input main pipeline is also connected to the multiple input pipelines and is controlled on and off by corresponding valves; the outlet end of each input pipeline is connected to the liquid inlet port of its corresponding movable installation module, and the movable installation module is also provided with multiple liquid outlet ports; each liquid outlet port is connected to multiple collection pipelines via an output pipeline; the first input main pipeline is connected to the two collection pipelines via valves; the second input main pipeline is connected to the multiple collection pipelines via valves; the second input main pipeline is connected to the first input main pipeline via a valve; the first input main pipeline is connected to the external pump module via a valve; the first input main pipeline is provided with a mixer and a bubble trap; the connection end of the second input main pipeline, the external pump module and the first input main pipeline is located on one side of the mixer inlet; multiple chromatography columns are placed in the movable installation module, the bottom inlet and outlet of each chromatography column are connected to the input pipeline via the corresponding liquid inlet port, and the top inlet and outlet of the chromatography column are connected to the output pipeline via the corresponding liquid outlet port.

11. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 10, characterized in that: There are two input pipes, and the corresponding movable installation module has two liquid inlet ports, two liquid outlet ports, and two output pipes respectively. One or two chromatography columns are used.

12. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: The outlet end of the first input main pipeline is connected to the first valve array group, and the first valve array group includes four valves connected end to end to form a rectangular valve array; a group of opposite sides of the rectangular valve array are respectively connected to the outlet end of the first input main pipeline and the outlet of the connecting pipeline; the output end of the connecting pipeline is respectively connected to the multiple collecting pipelines through multiple intermediate pipelines; another group of opposite sides of the rectangular valve array are respectively connected to the inlets of the two input pipelines.

13. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: The second input main pipeline is connected to the output end of the connecting pipeline through a pipeline, and a valve is provided on the pipeline.

14. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: The input pipeline and the output pipeline are connected to each other through pipelines, and valves are provided on the pipelines.

15. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: There are two collecting pipes.

16. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: The two output pipes are respectively connected to the second valve array group, which includes four valves connected end to end to form a rectangular valve array; one group of opposite sides of the rectangular valve array corresponds to the outlet end of the output pipe; the other group of opposite sides of the rectangular valve array corresponds to the inlet end of the two collecting pipes.

17. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 11, characterized in that: The external pump module includes a third input main pipeline. A plurality of input pumps are provided at the inlet end of the third input main pipeline. The third input main pipeline is connected to the first input main pipeline respectively.

18. The liquid preparation chromatography system based on the multifunctional lead platform according to claim 17, characterized in that: The inlet end of the third input main pipeline is provided with one or two input pumps.

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