Continuous production device for chlorantraniliprole active compound

Abstract

The utility model relates to the technical field of pesticide production equipment, in particular to a chlorantraniliprole raw pesticide continuous production device which comprises a metering pump set, a static mixer, a dynamic mixer, a material transfer pump, a tubular reactor, a disperser and a solid-liquid separator which are sequentially connected. And the tubular reactor is also connected with a metering pump for introducing a condensing agent. The whole device is designed into a high-efficiency, energy-saving, closed and continuous production device, so that continuous production is realized, and the production efficiency is improved. The tubular reactor is adopted for reaction, so that the mass transfer efficiency and the heat transfer efficiency of a reaction system are enhanced, the energy loss is reduced, and the production period is shortened. According to the utility model, the disperser is used for dispersing and separating out reacted materials, so that the technical problems that particles are not uniform and impurities are easy to wrap when products are separated out due to slow stirring speed of anchor frame type separation in the prior art are solved, and the quality of raw drugs and preparation forms of the products is effectively ensured.

Description

Technical Field

[0001] The utility model relates to the technical field of pesticide production equipment, in particular to a continuous production device for chlorantraniliprole technical. Background Art

[0002] Chlorantraniliprole belongs to the o-anisamide class of insecticides, exhibiting systemic, penetrating, and contact properties. It primarily targets the insect's nervous system, inhibiting the activity of a key enzyme and disrupting normal nerve conduction, causing paralysis and ultimately death. This unique insecticidal mechanism makes chlorantraniliprole effective against a wide range of pests, while maintaining low toxicity to mammals and beneficial arthropods such as birds, fish, and bees, allowing it to meet permitted residue limits.

[0003] Currently, most companies use the technical route disclosed in patent WO2003015519A1 to produce chlorantraniliprole technical. This involves reacting 3-bromo-1-(3-chloropyridin-2-pyridyl)-1H-pyrazolecarboxylic acid (K acid) with 2-amino-5-chloro-N,3-dimethylbenzamide (K amine) using a condensing agent in the presence of an acid binder and a solvent. After the reaction, chlorantraniliprole technical is obtained through water precipitation and solid-liquid separation.

[0004] The above traditional production method adopts a batch process with kettle type, which has many disadvantages, mainly including the following three points:

[0005] First, the batch process is carried out in a kettle, which takes a long time from feeding, reaction to post-processing, greatly affecting production efficiency;

[0006] Secondly, the reaction liquid is in a slurry state during the reaction, which has an adverse effect on the reaction mass transfer and heat transfer, thereby affecting the yield;

[0007] Third, the product precipitation kettle often adopts the anchor frame type, and the slow stirring rate causes the particles of the product to be uneven during precipitation and easily contain impurities, which has an adverse effect on the product formulation and quality. Utility Model Content

[0008] In view of the technical problems in the existing technology of chlorantraniliprole technical production, such as low intermittent production efficiency, low mass and heat transfer efficiency, and poor dosage form quality, the utility model provides a continuous production device for chlorantraniliprole technical, which can realize continuous production, improve production efficiency, enhance the mass and heat transfer efficiency of the reaction system, improve product yield, and effectively ensure the product qualification rate.

[0009] In order to solve the above technical problems, the technical solution adopted by the present invention is:

[0010] A continuous production device for chlorantraniliprole technical, comprising:

[0011] A metering pump group, the metering pump group includes a first metering pump and a second metering pump arranged in parallel;

[0012] A static mixer, wherein a first feed port of the static mixer is connected to a discharge port of a first metering pump via a pipeline, and a second feed port of the static mixer is connected to a discharge end of a second metering pump via a pipeline;

[0013] A dynamic mixer, wherein a first feed port of the dynamic mixer is connected to a discharge port of the static mixer via a pipeline;

[0014] The quantitative feeder group includes a first quantitative feeder and a second quantitative feeder arranged in parallel, and the discharge ports of the first quantitative feeder and the second quantitative feeder are combined and connected to the second feed port of the dynamic mixer through a pipeline;

[0015] A material transfer pump, the feed port of the material transfer pump is connected to the discharge port of the dynamic mixer through a pipeline;

[0016] A tubular reactor, wherein a first feed port of the tubular reactor is connected to a discharge port of a transfer pump via a pipeline;

[0017] a third metering pump, wherein the discharge port of the third metering pump is connected to the second feed port of the tubular reactor through a pipeline;

[0018] A disperser, wherein the feed port of the disperser is connected to the discharge port of the tubular reactor through a pipeline;

[0019] A solid-liquid separator, wherein the feed port of the solid-liquid separator is connected to the discharge port of the disperser through a pipeline, and the discharge port of the solid-liquid separator is connected to the finished product storage device.

[0020] Furthermore, the static mixer is a paddle type, spiral vane type, pipe grid type, nozzle type, orifice plate type, or rib plate type. The static mixer mixes two liquid materials (acid binding agent and solvent) by using a mixing unit fixed in the tube to change the flow state of the fluid in the tube to achieve good dispersion and thorough mixing between the different fluids.

[0021] Furthermore, the dynamic mixer is a reciprocating, spiral, or vibrating pipeline dynamic mixer. The pipeline dynamic mixer mixes two solid materials (main raw materials, mono-K acid and main raw material, di-K amine) with one liquid material (the mixed liquid output from the static mixer). Active stirring is achieved by a motor-driven stirring mechanism installed outside the pipeline T-tube, ensuring more thorough mixing of the mixed fluids.

[0022] Further, the first quantitative feeder is a screw type or a vibration type quantitative feeder, and the second quantitative feeder is a screw type or a vibration type quantitative feeder.

[0023] Further, the tubular reactor is one of a vertical tubular type, a coil type, a U type or a multi-tube parallel type.

[0024] Further, the disperser is one of a centrifugal type, a stirring type or a high shear type.

[0025] Further, the solid-liquid separator is one of a sedimentation separator, a filtration separator or a centrifugal separator.

[0026] The static mixer, the dynamic mixer, the feeder, the tubular reactor, the disperser and the solid-liquid separator can be made of acid and alkali resistant stainless steel, glass lining, polytetrafluoroethylene or the like, and the metering pump and the material transfer pump can be made of polytetrafluoroethylene, ceramic or acid resistant alloy, so that corrosion resistance is improved.

[0027] The static mixer, the dynamic mixer, the feeder, the tubular reactor, the disperser and the solid-liquid separator can be made of acid and alkali resistant stainless steel, glass lining, polytetrafluoroethylene or the like, and the metering pump and the material transfer pump can be made of polytetrafluoroethylene, ceramic or acid resistant alloy, so that corrosion resistance is improved.

[0028] (1) The whole production device of the utility model is from feeding, reaction to post-treatment process, respectively adopts efficient and safe equipment, designs the whole production device into an efficient, energy-saving, closed and continuous production device, realizes continuous production and improves production efficiency.

[0029] (2) The utility model adopts a tubular reactor to react raw materials, and the tubular reactor is suitable for large-scale and continuous chemical production.

[0030] (3) The utility model uses a disperser to disperse and precipitate the reacted materials, solves the technical problems of slow stirring rate of an anchor frame type in the prior art, uneven particle size of precipitated products and easy wrapping of impurities, effectively guarantees the quality of product raw materials and preparation forms, and effectively guarantees the qualified rate of products. BRIEF DESCRIPTION OF DRAWINGS

[0031] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the following briefly introduces the drawings required for use in the embodiments or the description of the prior art. Obviously, for ordinary technicians in this field, other drawings can be obtained based on these drawings without any creative work.

[0032] Figure 1 This is a structural diagram of Example 1 of the specific implementation method of the present utility model.

[0033] In the figure, 1-1, the first metering pump, 1-2, the second metering pump, 2, the static mixer, 3, the dynamic mixer, 4-1, the first quantitative feeder, 4-2, the second quantitative feeder, 5, the material transfer pump, 6, the tubular reactor, 7, the third metering pump, 8, the disperser, and 9, the solid-liquid separator. DETAILED DESCRIPTION

[0034] In order to enable those skilled in the art to better understand the technical solutions of the present invention, the following will be combined with the drawings of the embodiments of the present invention to clearly and completely describe the technical solutions of the embodiments of the present invention. Obviously, the embodiments described are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts should fall within the scope of protection of the present invention.

[0035] Example 1

[0036] Combine Figure 1 The utility model provides a continuous production device for chlorantraniliprole technical, comprising:

[0037] The metering pump group includes two first metering pumps 1-1 and a second metering pump 1-2 arranged in parallel;

[0038] Static mixer 2, the first feed port of static mixer 2 is connected to the discharge port of the first metering pump 1-1 through a pipeline, the second feed port of static mixer 2 is connected to the discharge end of the second metering pump 1-2 through a pipeline, and static mixer 2 is a paddle type static mixer;

[0039] Dynamic mixer 3, the first feed port of dynamic mixer 3 is connected to the discharge port of static mixer 2 through a pipeline, and dynamic mixer 3 is a spiral dynamic mixer;

[0040] The quantitative feeder group includes two parallel arranged first quantitative feeders 4-1 and second quantitative feeders 4-2. The discharge ports of the first quantitative feeder 4-1 and the second quantitative feeder 4-2 are combined and connected to the second feed port of the dynamic mixer 3 through a pipeline. The first quantitative feeder 4-1 and the second quantitative feeder 4-2 are both spiral quantitative feeders.

[0041] A material transfer pump 5, the feed port of the material transfer pump 5 is connected to the discharge port of the dynamic mixer 3 through a pipeline;

[0042] A tubular reactor 6, wherein a first feed port of the tubular reactor 6 is connected to a discharge port of a transfer pump 5 via a pipeline, and the tubular reactor 6 is a coil reactor;

[0043] a third metering pump 7, wherein the discharge port of the third metering pump 7 is connected to the second feed port of the tubular reactor 6 through a pipeline;

[0044] Disperser 8, the feed port of disperser 8 is connected to the discharge port of tubular reactor 6 through a pipeline, and disperser 8 is a stirring disperser;

[0045] The solid-liquid separator 9 has a feed port connected to the discharge port of the disperser 8 through a pipeline, and the discharge port of the solid-liquid separator 9 is connected to the finished product storage device. The solid-liquid separator 9 is a centrifugal solid-liquid separator.

[0046] The operation process of this utility model is:

[0047] (1) The acid-binding agent 3-methylpyridine and the solvent acetonitrile are quantitatively added to the static mixer 2 through the first metering pump 1-1 and the second metering pump 1-2 respectively. After being fully mixed in the static mixer 2, the mixed liquid enters the dynamic mixer 3.

[0048] (2) The dynamic mixer 3 is turned on. The main raw material K-acid and the main raw material di-K-amine enter the dynamic mixer 3 through the first quantitative feeder 4-1 and the second quantitative feeder 4-2 respectively. In the dynamic mixer 3, they are further mixed and dissolved with the mixed solution of the above-mentioned acid binding agent and solvent.

[0049] (3) The inlet and outlet valves of the jacket circulating liquid of the tubular reactor 6 are opened, and the temperature is controlled to be maintained at 25°C. The mixed liquid after remixing in the dynamic mixer 3 enters the tubular reactor 6 through the material transfer pump 5. At the same time, the condensing agent methylsulfonyl chloride enters the tubular reactor 6 through the third metering pump 7. During this period, the reaction temperature is controlled at 25~30°C. After the reaction is completed, the reaction liquid enters the disperser 8.

[0050] (4) Open the inlet and outlet valves of the stirring and jacket circulating liquid of the disperser 8, control the temperature to maintain at 25°C, and the reaction liquid enters the disperser 8 from the tubular reactor 6. Open the valve to allow water to enter at the same time, and enter the solid-liquid separator 9 after the product precipitates.

[0051] (5) The precipitation liquid enters the solid-liquid separator 9 from the disperser 8 to realize solid-liquid separation, and the obtained solid is the chlorantraniliprole finished product.

[0052] Although the utility model has been described in detail by referring to the drawings and in combination with the preferred embodiments, the utility model is not limited thereto. Without departing from the spirit and essence of the utility model, those skilled in the art can make various equivalent modifications or replacements to the embodiments of the utility model, and these modifications or replacements should be within the scope of the utility model. Any person skilled in the art can easily think of changes or replacements within the technical range disclosed by the utility model, and these changes or replacements should be within the protection scope of the utility model.

Claims

1. A continuous production device for chlorantraniliprole technical, characterized in that: include: A metering pump group, the metering pump group includes a first metering pump and a second metering pump arranged in parallel; A static mixer, wherein a first feed port of the static mixer is connected to a discharge port of a first metering pump via a pipeline, and a second feed port of the static mixer is connected to a discharge end of a second metering pump via a pipeline; A dynamic mixer, wherein a first feed port of the dynamic mixer is connected to a discharge port of the static mixer via a pipeline; The quantitative feeder group includes a first quantitative feeder and a second quantitative feeder arranged in parallel, and the discharge ports of the first quantitative feeder and the second quantitative feeder are combined and connected to the second feed port of the dynamic mixer through a pipeline; A material transfer pump, the feed port of the material transfer pump is connected to the discharge port of the dynamic mixer through a pipeline; A tubular reactor, wherein a first feed port of the tubular reactor is connected to a discharge port of a transfer pump via a pipeline; a third metering pump, wherein the discharge port of the third metering pump is connected to the second feed port of the tubular reactor through a pipeline; A disperser, wherein the feed port of the disperser is connected to the discharge port of the tubular reactor through a pipeline; A solid-liquid separator, wherein the feed port of the solid-liquid separator is connected to the discharge port of the disperser through a pipeline, and the discharge port of the solid-liquid separator is connected to the finished product storage device.

2. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The static mixer is one of a paddle plate type, a spiral blade type, a pipe mesh type, a nozzle type, a perforated plate type or a rib plate type static mixer.

3. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The dynamic mixer is a reciprocating, spiral or vibrating pipeline dynamic mixer.

4. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The first quantitative feeder is a screw type or vibrating quantitative feeder, and the second quantitative feeder is a screw type or vibrating quantitative feeder.

5. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The tubular reactor is a vertical tube type, a coil type, a U-type or a multi-tube parallel type tubular reactor.

6. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The disperser is a centrifugal, stirring, or high shear disperser.

7. A chlorantraniliprole technical continuous production device as claimed in claim 1, characterized in that, The solid-liquid separator is a sedimentation separator, a filter separator or a centrifugal separator.

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