Wireless optical genetic system of charging version

Abstract

The utility model provides a wireless photogenetic system of a charging version, which solves the problems that the activity range of an animal is limited and the experimental design is influenced in the existing photogenetic experiment through an animal head connection mode, and the main scheme is that the wireless photogenetic system comprises a control host and a plurality of implantable photoelectric probes, the plurality of implantable photoelectric probes are independently packaged and can be independently controlled through the control host, the plurality of implantable photoelectric probes can be charged through the charging box at the same time, each implantable photoelectric probe comprises an RF chip, an antenna, a battery, a flexible probe substrate and a miniature LED, and the front and back surfaces of the flexible probe substrate are provided with a plurality of groups of joints. The micro LEDs are electrically connected with the connectors in a one-to-one correspondence mode, the battery is electrically connected with the RF chip and the micro LEDs, the RF chip is electrically connected with the micro LEDs and transmits external signals through the antenna, and the control host adjusts output of the micro LEDs through the driving circuit.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of optical genetic technology, especially to a wireless optical genetic system of charging version. BACKGROUND

[0002] Optical genetic stimulation system, as an advanced tool for regulating nerve cells, has been widely adopted and applied in the field of neuroscience research. However, this commonly used optical genetic stimulation method has a significant problem: it requires a fiber optic to be drawn out of the animal's head, which limits the experiment to some extent. The natural activity of animals often leads to the entanglement and knotting of the fiber optic, which not only may interrupt the experiment, but also may damage the critical connection. In addition, when the animal is dragged or entangled by the fiber optic, its behavior will be affected, which may lead to the distortion of the behavioral detection results.

[0003] Furthermore, due to the wire bundle on the animal's head, the behavioral software may misjudge or miscount when analyzing the animal's behavior, because the wire bundle may interfere with the accurate identification of the animal's behavior by the software. It is especially noteworthy that in long-term unattended experiments, such as sleep experiments, the wire bundle is often bitten by small animals, which may lead to data loss or experimental failure. In some special experimental designs, such as the need for animals to interact or drill holes in a closed space, the connection of the head is a serious obstacle, because it may limit the range of animal activity, and even lead to the failure of the experiment. Therefore, solving this problem is crucial to improve the accuracy and efficiency of the experiment.

[0004] Therefore, we propose a wireless optical genetic system of charging version to solve the above problems. CONTENT OF THE UTILITY MODEL

[0005] The utility model solves the technical problem of overcoming the defects of the prior art, and proposes a wireless optical genetic system of charging version.

[0006] The utility model discloses a technical scheme that a wireless optical genetic system of charging version is adopted to solve the above -mentioned technical problem, including: control host computer and implantable photoelectric probe, the implantable photoelectric probe includes multiple, and its independent encapsulation can be through control host computer and carry out independent control, and multiple implantable photoelectric probe carries out simultaneous charging through charging box, and each implantable photoelectric probe includes RF chip, antenna, battery, flexible probe base and micro -led, the positive and negative two sides of flexible probe base are provided with multiple groups of joints, the micro -led includes multiple and with the joint one -to -one electric connection, the battery electric connection RF chip and micro -led, RF chip and micro -led electric connection and through antenna and external signal transmission, the control host computer passes through the drive circuit and adjusts the output of micro -led.

[0007] Further, the control host computer is built-in serial communication module, data transceiver module and main control chip, the serial communication module and data transceiver module all with control host computer corresponding pin electric connection, the serial communication module is used to carry out serial communication with control host computer to realize the control to micro -led, and the data transceiver module is used to receive and issue the control signal of control host computer.

[0008] Further, the drive circuit includes a driving chip, the driving chip includes LED pin, power pin and signal input pin, the LED pin corresponds to each micro -led and electric connection respectively, the power pin is connected to the power supply for power supply, and the signal input pin is used for signal transmission with the control host computer.

[0009] Further, the charging box is provided with a plurality of charging ports, and the charging port corresponds to each implantable photoelectric probe.

[0010] Further, the implantable photoelectric probe is coated with a waterproof encapsulation layer.

[0011] Compared with the prior art, the utility model has the beneficial effects that:

[0012] 1. The implantable photoelectric probe is used to realize the precise control and real-time monitoring of the animal nervous system, and avoid the limitations of traditional optical fiber bundle fixation animals;

[0013] 2. By optimizing the circuit design and communication technology, independent and synchronous control of multiple animals is realized, which provides the possibility for studying animal group behavior;

[0014] 3. The LED output power is adjustable and stable, and the battery life is enough to support long-time experiment, and by adjusting the frequency, current and other parameters, the optical genetic experiment of different nuclear groups is realized;

[0015] 4. The flexible probe base and metal-organic hybrid structure improve the mechanical matching of the probe and soft brain tissue, reduce tissue inflammatory response, and improve biocompatibility. BRIEF DESCRIPTION OF DRAWINGS

[0016] The disclosure of the present application will be described with reference to the accompanying drawings. It should be understood that the drawings are only for the purpose of illustration and are not intended to limit the scope of protection of the present application. In the drawings, the same reference signs are used to refer to the same parts. Among them:

[0017] Figure 1 And Figure 2 The schematic diagram of the implantable photoelectric probe according to one embodiment of the present application is shown schematically.

[0018] Figure 3 The schematic diagram of the charging box structure according to one embodiment of the present application is shown schematically.

[0019] Figure 4 The schematic diagram of the driving circuit according to one embodiment of the present application is shown schematically.

[0020] Figure 5 The schematic diagram of the internal circuit of the control host according to one embodiment of the present application is shown schematically.

[0021] Reference signs in the drawings: 1, implantable photoelectric probe; 2, charging box; 3, RF chip; 4, antenna; 5, flexible probe base; 6, micro LED; 7, LED pin; 8, power pin; 9, signal input pin; 10, charging port; 11, serial communication module; 12, data transceiver module; 13, main control chip; 14, interface. DETAILED DESCRIPTION

[0022] It is easy to understand that according to the technical scheme of the present application, a person skilled in the art can propose a plurality of structure modes and implementation modes which can be replaced with each other without changing the essential spirit of the present application. Therefore, the following specific embodiments and drawings are only exemplary descriptions of the technical scheme of the present application, and should not be regarded as the whole or regarded as the limitation or restriction of the technical scheme of the present application.

[0023] According to one embodiment of the present application in combination Figures 1-5 It is shown.

[0024] As Figure 1 , Figure 2 and Figure 3As shown, in the present embodiment, a wireless optical genetic system of a charging version, comprising: a control host and an implantable photoelectric probe 1, the implantable photoelectric probe 1 comprises a plurality, which are independently packaged and can be independently controlled by the control host, the plurality of implantable photoelectric probes 1 are simultaneously charged by a charging box 2, each implantable photoelectric probe 1 comprises an RF chip 3, an antenna 4, a battery, a flexible probe substrate 5 and a micro LED 6, the flexible probe substrate is provided with a plurality of groups of connectors on the front and back surfaces, the micro LED 6 comprises a plurality and is electrically connected with the connectors one by one, the battery is electrically connected with the RF chip 3 and the micro LED 6, the RF chip 3 is electrically connected with the micro LED 6 and transmits signals with the outside through the antenna 4, and the implantable photoelectric probe 1 is externally coated with a waterproof packaging layer in the present embodiment.

[0025] Further, a plurality of charging ports 10 are arranged in the charging box 2, and the charging port 10 corresponds to each implantable photoelectric probe 1.

[0026] For the control host, the control host adjusts the output of the micro LED 6 through a driving circuit. Figure 5 As shown, the control host is built-in with a serial communication module, a data transceiver module and a main control chip 13, the serial communication module and the data transceiver module are electrically connected with the corresponding pins of the main control chip 13, the serial communication module is used for serial communication with the control host to realize control of the micro LED 6, and the data transceiver module is used to receive and issue control signals of the control host.

[0027] For the driving process of the LED, the circuit driving process is as shown in 4, the driving circuit comprises a driving chip, the driving chip comprises an LED pin 7, a power pin 8 and a signal input pin 9, the LED pin 7 corresponds to each micro LED 6 and is electrically connected, the power pin 8 is externally connected with a power supply for power supply, and the signal input pin 9 is used for signal transmission with the control host.

[0028] Based on the above system setting, the control host can adjust the output of the micro LED 6 on the implantable photoelectric probe 1, and realize remote control switching through 2.4GHz wireless radio frequency communication, and the control distance can reach 50 meters at the farthest; the implantable photoelectric probe 1 comprises an RF chip 3, an antenna 4, a battery, a flexible probe substrate 5 and a micro LED 6, can receive signals of the control host to control the switching and light output intensity of the micro LED 6; the serial communication module 11 built-in in the control host is used for serial communication with the external control software to realize control of the implanted micro LED 6.

[0029] Similarly, in some embodiments, the control host can achieve independent and synchronous control of multiple implantable optoelectronic probes 1, thereby achieving independent operation of multiple animals in optogenetic research; at the same time, the control host is configured with a charging box 2, which can achieve simultaneous charging of multiple implantable optoelectronic probes 1, and this process can uniformly package multiple implantable optoelectronic probes 1 through the charging box 2 equipped with a charging port 10.

[0030] In some embodiments, the implantable optoelectronic probe 1 is further designed with a waterproof packaging layer (not shown in the figure) to ensure stability in a physiological environment; the antenna 4 chip can receive signals at almost all angles of arrival, achieving effective transmission of signals over long distances.

[0031] The technical scope of the utility model is not only limited to the contents in the above description, and the skilled in the art can make various deformations and modifications to the above embodiments without departing from the technical thought of the utility model, and these deformations and modifications should all belong to the protection scope of the utility model.

Claims

1. A rechargeable wireless optogenetics system, characterized in that: include: A control host and an implantable photoelectric probe, wherein the implantable photoelectric probe includes a plurality of independently packaged probes and can be independently controlled by the control host, and the plurality of implantable photoelectric probes are charged simultaneously through a charging box, and each of the implantable photoelectric probes includes an RF chip, an antenna, a battery, a flexible probe base and a micro-LED. A plurality of connectors are provided on the front and back sides of the flexible probe base, and the micro-LED includes a plurality of connectors and is electrically connected to the connectors one by one. The battery is electrically connected to the RF chip and the micro-LED, and the RF chip is electrically connected to the micro-LED and transmits external signals through the antenna. The control host adjusts the output of the micro-LED through the driving circuit.

2. The rechargeable wireless optogenetics system according to claim 1, characterized in that: The control host has a built-in serial communication module, a data transceiver module and a main control chip. The serial communication module and the data transceiver module are electrically connected to the corresponding pins of the main control chip. The serial communication module is used to perform serial communication with the control host to realize the control of the micro LED, and the data transceiver module is used to receive and send control signals from the control host.

3. The rechargeable wireless optogenetics system according to claim 1, characterized in that: The driving circuit includes a driving chip, which includes LED pins, power pins and signal input pins. The LED pins correspond to each micro LED and are electrically connected. The power pins are connected to an external power source for power supply. The signal input pins are used to transmit signals with the control host.

4. The rechargeable wireless optogenetics system according to claim 1, characterized in that: The charging box is provided with a plurality of charging ports, each of which corresponds one to one with each of the implantable photoelectric probes.

5. The rechargeable wireless optogenetics system according to claim 1, characterized in that: The implantable photoelectric probe is externally coated with a waterproof packaging layer.

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