Cell therapy drug delivery device stable in drug delivery

Abstract

The utility model discloses a cell therapy drug delivery device stable in drug delivery, which relates to the technical field of drug delivery devices and comprises a drug storage tube with a drug storage space and a drug delivery head detachably connected to the front end of the drug storage tube; the piston rod is of a hollow structure and can slide in the axial direction of the medicine storage pipe, and the end, extending into the medicine storage pipe, of the piston rod is connected with a piston head. The threaded rod is rotationally arranged in the piston rod, and the outer wall of the threaded rod is in threaded connection with a threaded sleeve capable of sliding in the axial direction of the piston rod; the movable plate is connected to the interior of the medicine storage pipe in a sliding mode, a plurality of through holes are formed in the movable plate, and the front end of the threaded sleeve penetrates through the piston head and is fixedly connected with the center of the movable plate. According to the utility model, the medicine can be stirred and disturbed before being used, so that the uniform distribution of cell exosomes in a target area in the treatment process is ensured, the adverse reaction or invalid treatment condition caused by over-high or over-low local concentration is avoided, and the stability and the accuracy of therapeutic administration are remarkably improved.

Description

TECHNICAL FIELD

[0001] The utility model relates to a dosing device technical field, concretely is a cell treatment dosing device of dosing stability. BACKGROUND

[0002] In the biomedical field, cell therapy and exosome application are more and more concerned. Cell therapy as a new treatment method has great potential and can be used for treating various diseases such as cancer, cardiovascular disease, nervous system disease, etc. Exosome as a microvesicle secreted by cell also has various biological functions such as participating in intercellular communication, regulating immune response, promoting tissue repair, etc.

[0003] However, in the storage and transportation process of cell exosome, there are many challenges. At present, cell exosome is usually suspended in liquid, but in this state, it is easy to appear due to sinking or aggregation phenomenon, resulting in uneven suspension dispersion. This unevenness will have a serious impact on treatment and preservation.

[0004] On the one hand, in the treatment and administration process, uneven distribution of cell exosome may lead to inaccurate administration dose and affect treatment effect. For example, the concentration of cell exosome in some parts is too high, which may cause adverse reactions; while the concentration in some parts is too low, which may not achieve the treatment effect.

[0005] On the other hand, in the storage process, the sinking or aggregation of cell exosome may lead to its activity decrease or even inactivation. This is because cell exosome may be affected by extrusion, hypoxia and other adverse environmental factors in the aggregation process, thereby affecting its biological function.

[0006] Therefore, the present application is proposed. UTILITY MODEL CONTENT

[0007] The utility model aims at providing a cell treatment dosing device of dosing stability to solve the problems in the above background.

[0008] To solve the above technical problem, the utility model provides a cell treatment dosing device of dosing stability, which comprises,

[0009] The medicine storage pipe has a medicine storage space, and the front end is detachably connected with the dosing head;

[0010] The piston rod is in a hollow structure and can slide axially along the medicine storage pipe, and one end extending into the medicine storage pipe is connected with the piston head;

[0011] The threaded rod is rotationally arranged in the interior of the piston rod, and the outer wall is threadedly connected with the threaded sleeve capable of sliding axially along the piston rod;

[0012] The movable plate is slidably connected in the inside of the medicine storage pipe, and a plurality of through holes are formed in the movable plate; the front end of the threaded sleeve penetrates the piston head and is fixedly connected with the center of the movable plate.

[0013] Further, the piston rod is fixedly connected with a push plate at the end away from the piston head, the push plate has a cavity in the inside, a micro motor is installed in the inside of the cavity, and the driving end of the micro motor is fixedly connected with one end of the threaded rod.

[0014] Further, a guide groove is arranged on the outer wall of the piston rod, the guide groove is arranged along the length direction of the piston rod, and a guide block is slidably installed in the guide groove, and the end of the guide block extending into the inside of the piston rod is fixedly connected with the outer wall of the threaded sleeve.

[0015] Further, the piston head is in a rubber cylindrical structure, the piston head is slidably arranged in the inside of the medicine storage pipe, and the outer peripheral wall of the piston head is attached to the inner wall of the medicine storage pipe.

[0016] Further, a threaded ring is fixedly connected with the end of the medicine storage pipe away from the medicine administration head, a sleeve shell is threadedly connected with the outer wall of the threaded ring, and the sleeve shell is sleeved on the outside of the piston rod.

[0017] Further, anti-skid lines are arranged on the outer walls of the medicine storage pipe and the sleeve shell, and the anti-skid lines are arranged along the peripheries of the medicine storage pipe and the sleeve shell.

[0018] Further, a protective cover is sleeved on the outside of the medicine administration head, and the protective cover covers the outside of the needle head.

[0019] Further, turbulence vanes are arranged on the outer wall of the piston rod, and the turbulence vanes are located between the movable plate and the piston head.

[0020] Compared with the prior art, the utility model has the advantages that:

[0021] 1、the utility model discloses, through rotating threaded rod, can push threaded sleeve to the inside of medicine storage pipe sliding, the medicine liquid stored in the inside of medicine storage pipe can pass through the through -hole and enter between movable plate and piston head, then discharges through the through -hole, and before using, the medicine can be disturbed to flow, ensure that the uniform distribution of exosome in the target area during the treatment process, avoid the adverse reaction or the invalid condition of treatment caused by local concentration being too high or too low, thereby significantly improve the stability and accuracy of treatment administration.

[0022] 2、The utility model discloses, in the process that the screw sleeve promotes the reciprocating motion of movable plate in the inside of the medicine storage pipe, the medicine liquid stored in the inside of the medicine storage pipe can enter between movable plate and piston head through the through -hole, then is discharged by the through -hole, and the medicine liquid can drive the spoiler blade to rotate on the outer wall of the screw sleeve in the flowing process, can disturb the medicine liquid in the inside of the medicine storage pipe in the process that the spoiler blade rotates, realizes the effect of agitating the medicine liquid and avoids the adverse reaction or the invalid treatment condition that the local concentration is too high or too low causes. BRIEF DESCRIPTION OF DRAWINGS

[0023] Figure 1 It is the front view structure schematic diagram of the utility model;

[0024] Figure 2 It is the section structure schematic diagram of the utility model;

[0025] Figure 3 It is the connecting structure schematic diagram of piston rod and piston head in the utility model;

[0026] Figure 4 It is the connecting structure schematic diagram of screw sleeve and movable plate in the utility model.

[0027] In the drawing: 1, medicine storage pipe, 2, dosing head, 3, needle, 4, protective cover, 5, shell, 6, piston rod, 7, piston head, 8, push plate, 9, micro motor, 10, threaded rod, 11, screw sleeve, 12, movable plate, 13, through -hole, 14, screw ring, 15, non -slip line, 16, guide slot, 17, guide block, 18, spoiler blade. DETAILED DESCRIPTION

[0028] The technical scheme in the embodiments of the utility model will be described clearly and completely in combination with the drawings in the embodiments of the utility model, and obviously, the described embodiments are only part of the embodiments of the utility model, not all the embodiments. Based on the embodiments in the utility model, all other embodiments obtained by the person skilled in the art without making creative labor belong to the range of protection of the utility model.

[0029] Please refer to Figures 1-4 The utility model provides a kind of technical scheme: a cell treatment dosing device of dosing stability, comprising,

[0030] Medicine storage pipe 1 has storage space, and its front end is detachably connected with dosing head 2;

[0031] Piston rod 6 is hollow structure, and can slide along the axis of medicine storage pipe 1, and its one end connected with piston head 7 in the inside of medicine storage pipe 1 is extended;

[0032] A threaded rod 10 is rotationally arranged inside the piston rod 6, and a threaded sleeve 11 capable of sliding along the piston rod 6 in the axial direction is threadedly connected to the outer wall of the threaded rod 10.

[0033] A movable plate 12 is slidingly connected inside the medicine storage tube 1, and a plurality of through holes 13 are formed in the movable plate 12, and the front end of the threaded sleeve 11 penetrates the piston head 7 and is fixedly connected to the center of the movable plate 12.

[0034] Specifically, by rotating the threaded rod 10, the threaded sleeve 11 can be pushed to slide into the interior of the medicine storage tube 1, and the threaded sleeve 11 can push the movable plate 12 to move inside the medicine storage tube 1, and during the reciprocating movement of the threaded sleeve 11 pushing the movable plate 12 inside the medicine storage tube 1, the medicine liquid stored inside the medicine storage tube 1 will pass through the through holes 13 into the space between the movable plate 12 and the piston head 7, and then be discharged through the through holes 13, which can disturb the flow of the medicine before use, ensure the uniform distribution of the exosome in the target area during treatment, and avoid adverse reactions or ineffective treatment caused by excessive or insufficient local concentration, thereby significantly improving the stability and accuracy of the treatment and drug delivery.

[0035] Referring to Figure 2 , the end of the piston rod 6 away from the piston head 7 is fixedly connected with a push plate 8, the inside of the push plate 8 has a cavity, and a micro motor 9 is installed inside the cavity, and the driving end of the micro motor 9 is fixedly connected with one end of the threaded rod 10.

[0036] Specifically, the micro motor 9 can drive the threaded rod 10 to rotate, thereby achieving the effect of automatically agitating and disturbing the flow of the medicine liquid inside the medicine storage tube 1.

[0037] Referring to Figures 3-4 , a guide groove 16 is arranged on the outer wall of the piston rod 6, the guide groove 16 is arranged along the length direction of the piston rod 6, a guide block 17 is slidingly installed inside the guide groove 16, and the end of the guide block 17 extending into the interior of the piston rod 6 is fixedly connected with the outer wall of the threaded sleeve 11.

[0038] Specifically, the guide groove 16 and the guide block 17 are arranged to guide the threaded sleeve 11, avoiding the threaded sleeve 11 from rotating with the threaded rod 10.

[0039] Referring to Figure 2 , the piston head 7 is in the structure of a rubber cylinder, the piston head 7 is slidingly arranged inside the medicine storage tube 1, and the outer peripheral wall of the piston head 7 is attached to the inner wall of the medicine storage tube 1.

[0040] Specifically, the rubber material has a certain elastic deformation effect, which can ensure that it is attached to the inner wall of the medicine storage tube 1.

[0041] Referring to Figure 1 and Figure 2The threaded ring 14 is fixedly connected to the end of the medicine storage tube 1 away from the medicine administration head 2, and the outer wall of the threaded ring 14 is threadedly connected with the sleeve 5, and the sleeve 5 is sleeved on the outer portion of the piston rod 6.

[0042] Specifically, the sleeve 5 is connected with the medicine storage tube 1 through the threaded ring 14, and the piston rod 6 is protected through the sleeve 5, so that the piston rod 6 is prevented from being accidentally pushed during transportation and storage.

[0043] Referring to Figure 1 The medicine storage tube 1 and the outer wall of the sleeve 5 are both provided with anti-skid lines 15, and the anti-skid lines 15 are arranged along the outer periphery of the medicine storage tube 1 and the sleeve 5.

[0044] Specifically, the anti-skid lines 15 have an anti-skid effect.

[0045] Referring to Figures 1-2 The medicine administration head 2 is sleeved with a protective cover 4, and the protective cover 4 covers the outer portion of the needle 3.

[0046] Specifically, the protective cover 4 has an effect of protecting the needle 3, and improves the safety of use.

[0047] Referring to Figures 2-4 The outer wall of the piston rod 6 is provided with a turbulence vane 18, and the turbulence vane 18 is located between the movable plate 12 and the piston head 7.

[0048] Specifically, during the reciprocating movement of the movable plate 12 in the medicine storage tube 1 driven by the threaded sleeve 11, the medicine liquid stored in the medicine storage tube 1 enters between the movable plate 12 and the piston head 7 through the through hole 13, and then is discharged through the through hole 13. The medicine liquid can drive the turbulence vane 18 to rotate on the outer wall of the threaded sleeve 11 during the flowing process, and the turbulence vane 18 can disturb the medicine liquid in the medicine storage tube 1 during the rotating process, so as to realize the effect of agitating and disturbing the medicine liquid, and avoid adverse reactions or ineffective treatment caused by excessively high or low local concentration.

Claims

1. A cell therapy drug delivery device with stable drug delivery, characterized in that: The utility model relates to a medicine storage tube, which comprises a medicine storage tube (1) with a medicine storage space, a medicine delivery head (2) detachably connected to the front end of the medicine storage tube (1), a piston rod (6) in a hollow structure, which is axially slidable along the medicine storage tube (1) and has a piston head (7) connected to the end extending into the medicine storage tube (1), a threaded rod (10) rotatably arranged inside the piston rod (6), a threaded sleeve (11) threadedly connected to the outer wall of the threaded rod (10) and axially slidable along the piston rod (6), a movable plate (12) slidably connected to the inside of the medicine storage tube (1) and having a plurality of through holes (13) formed therein, and the threaded sleeve (11) penetrates the piston head (7) at the front end and is fixedly connected to the center of the movable plate (12). The end of the piston rod (6) away from the piston head (7) is fixedly connected with a push plate (8), the inside of the push plate (8) has a cavity, a micro motor (9) is installed in the cavity, and the driving end of the micro motor (9) is fixedly connected with one end of the threaded rod (10). The outer wall of the piston rod (6) is provided with a guide groove (16) arranged along the length direction of the piston rod (6), the guide groove (16) is slidably installed with a guide block (17), and the end of the guide block (17) extending into the piston rod (6) is fixedly connected with the outer wall of the threaded sleeve (11). The piston head (7) is in a rubber cylindrical structure, the piston head (7) is slidably arranged in the inside of the medicine storage tube (1), and the outer peripheral wall of the piston head (7) is attached to the inner wall of the medicine storage tube (1). The end of the medicine storage tube (1) away from the medicine delivery head (2) is fixedly connected with a threaded ring (14), the outer wall of the threaded ring (14) is threadedly connected with a sleeve shell (5), and the sleeve shell (5) is sleeved on the outside of the piston rod (6).

2. A device for administering a stable cell therapy according to claim 1, wherein: The outer walls of the medicine storage tube (1) and the sleeve shell (5) are both provided with anti-skid lines (15) arranged along the outer periphery of the medicine storage tube (1) and the sleeve shell (5).

3. The device of claim 1, wherein the device is a cell therapy delivery device. The outside of the medicine delivery head (2) is sleeved with a protective cover (4), and the protective cover (4) covers the outside of the needle (3).

4. The device of claim 1, wherein the device is a cell therapy delivery device. The outer wall of the piston rod (6) is provided with a spoiler blade (18) located between the movable plate (12) and the piston head (7).

5. The device of claim 1, wherein the device is a cell therapy delivery device. ​ 6. A device for administering a stable cell therapy according to claim 5, wherein: ​ 7. The device of claim 1, wherein the device is a cell therapy delivery device. ​ 8. The device of claim 1, wherein the device is a cell therapy delivery device. ​

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