Fixing structure of double-96-well plate in automatic sampler tray

Abstract

The utility model relates to the technical field of high performance liquid chromatography, in particular to a fixing structure of a double-96-well plate in an automatic sampler tray. Comprising two fixing assemblies and a second check block, and each fixing assembly corresponds to one 96-well plate; each fixing assembly comprises a pressing piece and a first check block, the pressing piece is arranged at one end of the 96-well plate, the first check block and the second check block are arranged at the other end of the 96-well plate, and the pressing piece, the first check block and the second check block are all detachably and fixedly connected to the tray. The two 96-well plates are clamped on the tray through the two pressing pieces, the two first check blocks and the second check block; the double-96-well plate is stably and reliably fixed, and the accuracy and repeatability of an experimental result are ensured.

Description

TECHNICAL FIELD

[0001] The utility model relates to high performance liquid chromatography technical field especially relates to a kind of fixing structure of double 96-hole plate in autosampler tray. BACKGROUND

[0002] With the rapid development of biopharmaceutical industry, liquid chromatography technology as a key analysis tool, the application demand in medical field is increasing day by day.The technology has become the core technology in the separation and purification process of biopharmaceutical, and has an indispensable role for producing high-purity, high-activity biological products.Its main application fields include biochemical analysis, impurity analysis and separation and purification of chemical drugs and natural drugs.

[0003] In the field of biopharmaceuticals, most experiments need to be carried out in 96-well plates, because 96-well plates can significantly improve the efficiency and convenience of sample processing. As a substitute for traditional sample containers (such as centrifuge tubes), 96-well plates can hold 96 samples, greatly improving the throughput of sample processing. In addition, 96-well plates can be combined with gas discharge guns, high-performance automatic liquid manipulators and software systems to achieve high-efficiency biological sample processing operations such as protein precipitation and liquid-liquid extraction, thereby significantly improving the efficiency of sample processing. After using 96-well plates to process samples, direct injection can be performed, avoiding the cumbersome steps of sample suction, placement, capping, insertion processing and cleaning in traditional operations, simplifying the operation process. This design not only doubles the sample capacity of the injection chamber, but also allows direct injection into the chamber, further improving the convenience and efficiency of the experiment. In summary, 96-well plates in liquid chromatography technology can improve the efficiency and convenience of sample processing, providing a high-efficiency, convenient tool for laboratory researchers, especially when handling a large number of samples, its advantages are more pronounced.

[0004] However, although 96-well plates have many advantages, in the use process of high-performance liquid chromatography autosampler, when sampling is completed and the sampling needle is lifted, there is a risk that the 96-well plate will be taken off the tray by the sampling needle due to the special material of the 96-well plate.

[0005] Therefore, it is urgent to provide a fixing structure of double 96-well plates in autosampler tray, which can stably and reliably fix the double 96-well plates to ensure the accuracy and repeatability of experimental results compared with the prior art. UTILITY MODEL CONTENT

[0006] The utility model solves the technical problems existing in the prior art, and provides a fixing structure of double 96-well plates in autosampler tray.

[0007] To achieve the above purpose, the utility model adopts the following technical scheme:

[0008] The utility model provides a kind of fixing structure of double 96-hole plate in autosampler tray, including two fixed components and second stopper, each described fixed component corresponds one 96-hole plate setting;Each described fixed component includes pressing part and first stopper, the pressing part is arranged at one end of 96-hole plate, the first stopper and the second stopper are arranged at the other end of 96-hole plate, the pressing part, the first stopper, the second stopper are detachably fixedly connected on tray, two 96-hole plates are clamped on the tray by two described pressing parts, two described first stoppers and the second stopper.

[0009] Further, the pressing part includes a pressure rod sleeve, a pressure column and a spring, the pressure rod sleeve is connected with the tray, the pressure column is slidingly connected inside the pressure rod sleeve, the spring is arranged inside the pressure rod sleeve, one end of the spring is connected with the inside of the pressure rod sleeve, the other end of the spring is fixedly connected with the pressure column, the end of the pressure column away from the spring extends out of the pressure rod sleeve.

[0010] Further, the end of the pressure rod sleeve away from the tray is connected with a clamping screw, and the spring is fixedly connected with the clamping screw.

[0011] Further, the clamping screw is threadedly connected with the pressure rod sleeve.

[0012] Further, the two ends of the 96-hole plate away from the pressing part are provided with clamping grooves, the first stopper is clamped with one of the clamping grooves, and the second stopper is clamped with the other clamping groove.

[0013] Further, the second stopper is provided with one, and the second stopper is located between the two 96-hole plates.

[0014] Further, one end of the second stopper is clamped with one clamping groove provided on one of the 96-hole plates, and the other end of the second stopper is clamped with one clamping groove provided on the other 96-hole plate.

[0015] Further, the pressing part, the first stopper and the second stopper are threadedly fixedly connected with the tray.

[0016] Compared with the prior art, the utility model has the beneficial effects that:

[0017] The utility model discloses a kind of fixing structure of double 96-hole plate in autosampler tray, including two fixed components and second stopper, each described fixed component corresponds one 96-hole plate setting;Each described fixed component includes pressing part and first stopper, the pressing part is arranged at one end of 96-hole plate, the first stopper and the second stopper are arranged at the other end of 96-hole plate, the pressing part, the first stopper, the second stopper are detachably fixedly connected on tray, two 96-hole plates are clamped on the tray by two described pressing parts, two described first stoppers and the second stopper. BRIEF DESCRIPTION OF DRAWINGS

[0018] Figure 1 It is the whole structure schematic diagram of the utility model.

[0019] Figure 2 It is the schematic diagram of the connection relation on the display tray of the utility model.

[0020] Figure 3 It is Figure 1 the sectional view of A-A direction.

[0021] Mark explanation:

[0022] 1, sets the screw;2, the pressure bar sleeve;3, the pressure column;4, the tray;5, 96 hole plate;6, the first stopper;7, the spring;8, the second stopper. Specific implementation

[0023] The technical scheme of the utility model will be described clearly in combination with the drawings, obviously, the described embodiment is not all the embodiments of the utility model, all other embodiments obtained by the person skilled in the art without making the creative labor belong to the protection scope of the utility model. It needs to be explained that the orientation or position relation indicated by the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal" is based on the orientation or position relation shown in the drawings, only for the convenience of describing the utility model and simplifying the description, and is not indicative or implied that the indicated device or element must have a particular orientation, a particular orientation and operation, therefore, it cannot be understood as the limitation of the utility model.

[0024] As Figure 1 , Figure 2 indicated, the utility model provides a kind of fixing structure of double 96 hole plate in automatic sampler tray, including two fixed components and second stopper 8, two 96 hole plates 5 are provided on each tray 4, each 96 hole plate 5 is fixed on tray 4 by one fixed component, second stopper 8, two 96 hole plates 5 are fixed by one second stopper 8, fixed component, second stopper 8 has clamping action to 96 hole plate 5.

[0025] Each fixed component comprises a pressing part and a first stopper 6, the pressing part, the first stopper 6 and a second stopper 8 are detachably connected to the tray 4, preferably by bolt connection, the pressing part is located at one side of the 96-hole plate 5, the first stopper 6 and the second stopper 8 are located at the other side of the 96-hole plate 5, the second stopper 8 is located between the two 96-hole plates 5, the first stopper 6 is located at the end of the side of the 96-hole plate 5 away from the second stopper 8, the two ends of the side of the 96-hole plate 5 away from the pressing part are provided with clamping grooves, the first stopper 6 is clamped with one of the clamping grooves, and the second stopper 8 is clamped with the other clamping groove; one end of the second stopper 8 is clamped with the clamping groove arranged on one of the 96-hole plates 5, and the other end of the second stopper 8 is clamped with the clamping groove arranged on the other 96-hole plate 5.

[0026] As shown in Figure 3 The pressing part comprises a tightening screw 1, a pressing rod sleeve 2, a pressing column 3 and a spring 7, the pressing rod sleeve 2 is connected to the tray 4 by bolt connection, the pressing rod sleeve 2 is provided as a hollow structure, the pressing column 3 is located inside the sleeve, one end of the pressing column 3 extends out of the pressing rod sleeve 2, the pressing column 3 can only partially extend out of the pressing rod sleeve 2, the spring 7 is arranged inside the pressing column 3, the end of the pressing column 3 away from the tray 4 is detachably fixedly connected to the tightening screw 1, the tightening screw 1 is detachably fixedly connected to the pressing column 3 by thread connection, one end of the spring 7 is fixedly connected to the tightening screw 1, the other end of the spring 7 is fixedly connected to the pressing column 3, the end of the pressing column 3 extending out of the pressing rod sleeve 2 is in contact with the 96-hole plate 5, and the pressing column 3 is arranged in extrusion with the 96-hole plate 5 under the action of the spring 7; the tightening screw 1 is an internal hexagonal flat-end tightening screw.

[0027] The fixing structure of the double 96-hole plates in the automatic sampler tray provided by the utility model, by arranging the pressing part, the first stopper 6 and the second stopper 8, and by arranging the spring 7 and the pressing column 3 in the pressing part, the two 96-hole plates 5 on the tray 4 are pressed between the pressing part, the first stopper 6 and the second stopper 8, so that when sampling is finished and the sampling needle is lifted, the 96-hole plate 5 cannot be taken away from the tray 4 by the sampling needle, the double 96-hole plates 5 are stably and reliably fixed, and the accuracy and repeatability of experimental results can be ensured.

[0028] Finally, it should be noted that the above content is only used to explain the technical scheme of the utility model, and is not a limitation on the protection scope of the utility model. Simple modifications or equivalent replacements of the technical scheme of the utility model made by ordinary technical personnel in the art do not deviate from the essence and scope of the technical scheme of the utility model.

Claims

1. A fixture for dual 96-well plates in an autosampler tray, comprising: The application relates to a 96-well plate fixing device, which comprises two fixing assemblies and a second stopper, each of the fixing assemblies is arranged at one end of a 96-well plate; each of the fixing assemblies comprises a pressing part and a first stopper, the pressing part is arranged at one end of the 96-well plate, the first stopper and the second stopper are arranged at the other end of the 96-well plate, the pressing part, the first stopper and the second stopper are detachably fixedly connected to a tray, and two 96-well plates are clamped on the tray through the two pressing parts, the two first stoppers and the second stopper.

2. The dual 96-well plate holding structure in an autosampler tray according to claim 1, wherein, The pressing part comprises a pressing rod sleeve, a pressing column and a spring, the pressing rod sleeve is connected to the tray, the pressing column is slidably connected in the pressing rod sleeve, the spring is arranged in the pressing rod sleeve, one end of the spring is connected to the inside of the pressing rod sleeve, the other end of the spring is fixedly connected to the pressing column, and the end, away from the spring, of the pressing column extends out of the pressing rod sleeve.

3. The dual 96-well plate holding structure in an autosampler tray of claim 2, wherein, The end, away from the tray, of the pressing rod sleeve is connected to a clamping screw, and the spring is fixedly connected to the clamping screw.

4. The dual 96-well plate holding structure in an autosampler tray of claim 3, wherein, The clamping screw is threadedly connected to the pressing rod sleeve.

5. The dual 96-well plate holding structure in an autosampler tray of claim 1, wherein, The two ends of the 96-well plate, away from the pressing part, are provided with clamping grooves, the first stopper is clamped with one of the clamping grooves, and the second stopper is clamped with the other clamping groove.

6. The dual 96-well plate holding structure in an autosampler tray of claim 5, wherein, The second stopper is arranged at one, and the second stopper is arranged between the two 96-well plates.

7. The dual 96-well plate holding structure in an autosampler tray of claim 6, wherein, One end of the second stopper is clamped with one clamping groove arranged on one of the 96-well plates, and the other end of the second stopper is clamped with one clamping groove arranged on the other 96-well plate.

8. The dual 96-well plate holding structure in an autosampler tray of claim 1, wherein, The pressing part, the first stopper and the second stopper are threadedly fixedly connected to the tray.

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