Coaxial adjusting mechanism and sleeve type micro-fluidic chip

Abstract

The utility model discloses a coaxial adjusting mechanism and a sleeve type micro-fluidic chip, and relates to the technical field of micro-fluidic chips, the coaxial adjusting mechanism comprises a mechanism main body, an adjusting disc and at least one adjusting block; a first center hole penetrating through the mechanism main body is formed in the axial center of the mechanism main body; the adjusting disc is rotationally installed on one side face of the mechanism body and provided with a second center hole penetrating through the adjusting disc and coaxially communicated with the first center hole. The adjusting block is installed on the mechanism body in a sliding mode in the radial direction of the first center hole, and one end of the adjusting block can stretch into the first center hole or can stretch into an axis extension area of the first center hole. A limiting bulge is arranged on the adjusting block; the adjusting disc is provided with a track groove which allows the limiting protrusion to be clamped in and is in sliding connection with the limiting protrusion. The track groove is configured in the rotating process of the adjusting disc and moves relative to the limiting protrusion so as to drive the adjusting block to slide. The structure is simple, operation is convenient, and coaxial adjustment efficiency and success rate are improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of microfluidic chip, and particularly to a coaxial adjusting mechanism and a sleeve type microfluidic chip. BACKGROUND

[0002] The microfluidic chip is a technology platform for manipulating fluid in a micron scale space, and has wide application prospects and important scientific value.

[0003] The sleeve type microfluidic chip is a kind of microfluidic chip, which generally uses a needle as a fixed support and a liquid storage cavity. A hole needs to be punched on the needle to insert a capillary tube. When the capillary tubes are coupled, a coaxial alignment operation needs to be performed under a microscope, which is difficult to operate and has a low success rate. CONTENT OF THE UTILITY MODEL

[0004] Therefore, the present application aims to provide a coaxial adjusting mechanism and a sleeve type microfluidic chip to solve the technical problems of difficult coaxial alignment operation and low success rate of the existing sleeve type microfluidic chip.

[0005] To achieve the above technical purposes, the present application provides a coaxial adjusting mechanism, which comprises a mechanism main body, an adjusting disc and at least one adjusting block.

[0006] The mechanism main body is provided with a first center hole penetrating through the center of the mechanism main body in the axial direction of the mechanism main body.

[0007] The adjusting disc is rotatably installed on one side surface of the mechanism main body, and is provided with a second center hole penetrating through the adjusting disc and coaxially communicating with the first center hole.

[0008] The adjusting block is slidably installed on the mechanism main body along a radial direction of the first center hole, and one end of the adjusting block can extend into the first center hole or an axial extension area of the first center hole.

[0009] The adjusting block is provided with a limiting protrusion.

[0010] The adjusting disc is provided with a track groove for clamping and slidingly connecting the limiting protrusion.

[0011] The track groove is configured to be relatively displaced with the limiting protrusion during rotation of the adjusting disc to drive the adjusting block to slide.

[0012] Further, the first center hole is provided with an extension pipe portion extending outwardly from one side surface of the mechanism main body in the axial direction of the first center hole.

[0013] The adjusting disc is rotatably installed on one side surface of the mechanism main body, and is provided with a second center hole penetrating through the adjusting disc and coaxially communicating with the first center hole.

[0014] The application further discloses a sleeve type micro-fluidic chip which comprises a single emulsion micro-fluidic component and the coaxial adjusting mechanism.

[0015] The single emulsion micro-fluidic component comprises a first carrier, a second carrier, an inner phase pipe, an outer phase pipe and a receiving pipe.

[0016] The coaxial adjusting mechanism is installed on one side of the first carrier in the axial direction.

[0017] The outer phase pipe is installed between the coaxial adjusting mechanism and the second carrier.

[0018] The first carrier is provided with an inner phase channel in the axial direction of the first carrier.

[0019] The inner phase pipe is installed in the inner phase channel and one end of the inner phase pipe extends into the outer phase pipe through the coaxial adjusting mechanism to form an inner phase droplet in the outer phase pipe.

[0020] The second carrier is provided with a receiving channel in the axial direction of the second carrier.

[0021] The receiving pipe is installed in the receiving channel and one end of the receiving pipe extends into the outer phase pipe to receive the inner phase droplet.

[0022] Further, the other end of the inner phase pipe extends out of the first carrier to form an inner phase inlet, or the first carrier is provided with an inner phase inlet channel which is connected to the other end of the inner phase pipe.

[0023] Further, the outer phase pipe is provided with an outer phase inlet.

[0024] Or the second carrier is further provided with an outer phase channel which is connected to the outer phase pipe in the axial direction of the second carrier, and the second carrier is further provided with an outer phase inlet channel which is connected to the outer phase channel.

[0025] Further, the first carrier, the second carrier and the coaxial adjusting mechanism are all prepared by 3D printing.

[0026] The application further discloses another sleeve type micro-fluidic chip which comprises a double emulsion micro-fluidic component and the coaxial adjusting mechanism.

[0027] The double emulsion micro-fluidic component comprises a first carrier, a second carrier, an inner phase pipe, an intermediate phase pipe, an outer phase pipe and a receiving pipe.

[0028] The coaxial adjusting mechanism is installed on one side of the first carrier in the axial direction.

[0029] The outer phase pipe is installed between the coaxial adjusting mechanism and the second carrier.

[0030] The first carrier is provided with an inner phase channel and an intermediate phase channel in the axial direction of the first carrier.

[0031] The inner phase tube is installed in the inner phase channel and one end thereof extends into the middle phase channel for forming inner phase droplets in the middle phase tube;

[0032] The middle phase tube is installed in the middle phase channel and one end thereof extends into the outer phase tube through the coaxial adjusting mechanism for forming middle phase droplets containing inner phase droplets in the outer phase tube;

[0033] The second carrier is provided with a receiving channel along the axial direction thereof;

[0034] The receiving tube is installed in the receiving channel and one end thereof extends into the outer phase tube for receiving middle phase droplets.

[0035] Further, the other end of the inner phase tube extends out of the first carrier to form an inner phase liquid inlet, or the first carrier is provided with an inner phase liquid inlet channel communicating with the other end of the inner phase tube;

[0036] The first carrier is provided with a middle phase liquid inlet channel communicating with the middle phase tube, or the mechanism body of the coaxial adjusting mechanism is provided with a middle phase liquid inlet channel communicating with the middle phase tube.

[0037] Further, the outer phase tube is provided with an outer phase liquid inlet;

[0038] Or the second carrier is further provided with an outer phase channel along the axial direction thereof and connected to the outer phase tube in a conductive manner, and the second carrier is further provided with an outer phase liquid inlet channel communicating with the outer phase channel.

[0039] Further, the first carrier, the second carrier and the coaxial adjusting mechanism are all prepared by 3D printing.

[0040] From the above technical solutions, it can be seen that the coaxial adjusting mechanism designed in the application can be rotated in the clockwise or counterclockwise direction to drive the track groove on the adjusting disc to rotate synchronously, and the relative displacement cooperation between the track groove and the limiting protrusion and the sliding setting of the adjusting block along the radial direction of the first center hole are utilized to synchronously drive the adjusting block to slide, so as to push the tube passing through the first center hole to a certain displacement along the radial direction of the first center hole, and the coaxial adjustment is completed. The coaxial adjusting mechanism designed in the application has simple structure and convenient operation, and improves the efficiency and success rate of coaxial adjustment.

[0041] From the above technical scheme can be seen, the application designed with single milk microfluidic components of the sleeve type microfluidic chip, it adopts modular design, the first carrier and the second carrier can be prepared according to the size of inner phase pipe, outer phase pipe and receiving pipe, cooperate more closely and reliably, get rid of the shackles of traditional glass slide, the overall volume is smaller, the appearance is more free;At the same time, the application has coaxial adjusting mechanism, which can make radial fine adjustment to the inner phase pipe, so as to realize coaxial adjustment quickly.

[0042] From the above technical scheme can be seen, the application designed with single milk microfluidic components of the sleeve type microfluidic chip, it adopts modular design, the first carrier and the second carrier can be prepared according to the size of inner phase pipe, outer phase pipe and receiving pipe, cooperate more closely and reliably, get rid of the shackles of traditional glass slide, the overall volume is smaller, the appearance is more free;At the same time, the application has coaxial adjusting mechanism, which can make radial fine adjustment to the inner phase pipe, so as to realize coaxial adjustment quickly. BRIEF DESCRIPTION OF DRAWINGS

[0043] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the drawings needed to be used in the embodiments or prior art description will be briefly introduced below. Obviously, the drawings in the following description are only some embodiments of the present application, and those skilled in the art can also obtain other drawings according to these drawings without creating labor.

[0044] Figure 1 It is an explosion schematic diagram of the coaxial adjusting mechanism provided in the present application.

[0045] Figure 2 It is a perspective view of the coaxial adjusting mechanism provided in the present application.

[0046] Figure 3 It is a sectional view of the sleeve type microfluidic chip with single milk provided in the present application.

[0047] Figure 4 It is a sectional view of the sleeve type microfluidic chip with double milk provided in the present application.

[0048] In the figure: 1, mechanism main body;11, first center hole;12, sliding groove;13, extension pipe part;2, adjusting disc;21, second center hole;22, track groove;23, knob part;3, adjusting block;31, limiting protrusion;4, first carrier;41, inner phase channel;42, groove;43, intermediate phase channel;44, intermediate phase liquid inlet channel;5, second carrier;51, receiving channel;52, outer phase channel;53, outer phase liquid inlet channel;61, outer phase pipe;62, inner phase pipe;63, receiving pipe;64, intermediate phase pipe. DETAILED DESCRIPTION

[0049] The technical solutions of the embodiments of the present application will be clearly and completely described below with reference to the drawings. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by those of ordinary skill in the art without creative work fall within the scope of the present application.

[0050] In the description of the embodiments of the present application, it should be noted that the terms "center", "upper", "lower", "left", "right", "vertical", "horizontal", "inner", "outer", and the like indicate the orientation or positional relationship shown in the drawings, and are only used to facilitate the description of the embodiments of the present application and simplify the description, and do not indicate or imply that the device or element referred to must have a particular orientation, be constructed and operated in a particular orientation, and therefore cannot be understood as a limitation on the embodiments of the present application. In addition, the terms "first", "second", "third" are only for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0051] In the description of the embodiments of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms "mounting", "connecting", "connecting" should be understood in a broad sense, for example, it can be fixedly connected, or it can be replaceably connected, or it can be integrally connected, it can be mechanically connected, or it can be electrically connected, it can be directly connected, or it can be indirectly connected through an intermediate medium, it can be the communication inside two elements. For those of ordinary skill in the art, the specific meaning of the above terms in the embodiments of the present application can be understood according to the specific circumstances.

[0052] The embodiments of the present application disclose a coaxial adjustment mechanism.

[0053] Please refer to Figure 1 One embodiment of the coaxial adjustment mechanism provided in the embodiments of the present application includes:

[0054] The mechanism body 1, the adjustment disc 2, and at least one adjustment block 3.

[0055] The mechanism body 1 is provided with a first center hole penetrating through itself at the center of the axial direction of itself; the adjustment disc 2 is rotationally installed on one side surface of the mechanism body 1, and is provided with a second center hole 21 penetrating through itself and coaxially communicated with the first center hole.

[0056] The mechanism body 1 plays a role of bearing and fixing, and its specific structure can be a columnar shape, which is not limited.

[0057] The adjustment block 3 is slidingly installed on the mechanism body 1 along a radial direction of the first center hole, and one end can extend into the first center hole or can extend into an axial extension area of the first center hole; specifically, it can be as follows Figure 1As shown, a sliding groove 12 is arranged on one side surface of the mechanism body 1, one end of the sliding groove 12 penetrates the outer circumferential surface of the mechanism body 1, and the other end communicates with the first central hole.

[0058] The adjusting block 3 is provided with a limiting protrusion 31, which can be integrally formed with the adjusting block 3 to reduce the assembly process; the shape of the limiting protrusion 31 can be a square block, a cylindrical state, etc., without limitation.

[0059] The adjusting disc 2 is provided with a track groove 22 for clamping the limiting protrusion 31 and slidingly connecting with the limiting protrusion 31, the track groove 22 is arranged in the rotating process of the adjusting disc 2, and the limiting protrusion 31 is relatively displaced to drive the adjusting block 3 to slide.

[0060] The length shape of the track groove 22 is related to the adjusting range and accuracy of the final adjusting block 3, such as Figure 1 and Figure 2 As shown, the track groove 22 of the present application is spiral, and the difference between the distances of the two ends of the track groove 22 from the center of the first central hole is the adjustable range of the adjusting block 3.

[0061] The number of limiting protrusions 31 can be multiple, and the corresponding track grooves 22 are multiple, the limiting protrusions 31 of the present application are two, and the corresponding track grooves 22 are two, and the two track grooves 22 can be connected to form a continuous track groove. Those skilled in the art can make changes and designs according to actual needs, without limitation.

[0062] The above is the first embodiment of the coaxial adjusting mechanism provided by the embodiment of the present application, and the second embodiment of the coaxial adjusting mechanism provided by the embodiment of the present application is as follows, please refer to Figures 1 to 2 .

[0063] Based on the scheme of the above embodiment one:

[0064] Further, the first central hole is provided with an extension pipe portion 13 extending outwardly along the axial direction of the first central hole to one side surface of the mechanism body 1. The adjusting disc 2 is rotatably arranged on the extension pipe portion 13.

[0065] By arranging the extension pipe portion 13, the convenience of rotating installation of the adjusting disc 2 is provided, and the rotating installation of the rotating disc is facilitated.

[0066] In the present application, in order to facilitate the rotation of the adjusting disc 2, as shown in Figure 1 and Figure 2 A knob portion 23 (the knob portion 23 is a protruding block structure, without limitation) is designed on the outer circumferential surface of the adjusting disc 2, and personnel can hold the knob portion 23 to drive the adjusting disc 2 to rotate.

[0067] When the pipe to be adjusted can rotate, the adjusting block 3 can be provided only one, and the pipe is rotated to find the position to be coaxially adjusted, for example, when the pipe to be adjusted is offset in a radial direction relative to the pipe to be connected (offset in a direction opposite to the adjusting block 3), the pipe can be first rotated to offset in a direction opposite to the adjusting block 3, and then the adjusting disc 2 is rotated to control the adjusting block 3 to drive the pipe to be adjusted to move in a direction away from the adjusting block 3, so as to correct the offset and realize coaxial adjustment.

[0068] Of course, if the pipe to be adjusted cannot rotate, the adjusting block 3 can be provided with multiple adjusting blocks 3, and the corresponding adjusting disc 2 is also provided with multiple adjusting discs 2, but the adjusting disc 2 can be a non-complete disc, but a sector disc structure, so that the thickness in the axial direction is not increased too much, and the structure is kept compact.

[0069] As shown in Figure 3 The application discloses a single-milk sleeve type microfluidic chip, which comprises a single-milk microfluidic assembly and a coaxial adjusting mechanism.

[0070] The single-milk microfluidic assembly comprises a first carrier 4, a second carrier 5, an inner phase pipe 62, an outer phase pipe 61 and a receiving pipe 63.

[0071] The coaxial adjusting mechanism is installed on one side of the first carrier 4 in the axial direction.

[0072] The outer phase pipe 61 is installed between the coaxial adjusting mechanism and the second carrier 5.

[0073] The first carrier 4 is provided with an inner phase channel 41 in the axial direction of the first carrier 4; the inner phase pipe 62 is installed in the inner phase channel 41 and one end of the inner phase pipe 62 extends into the outer phase pipe 61 through the coaxial adjusting mechanism, so as to form an inner phase droplet in the outer phase pipe 61.

[0074] The coaxial adjusting mechanism can coaxially adjust the inner phase pipe 62 passing through.

[0075] The second carrier 5 is provided with a receiving channel 51 in the axial direction of the second carrier 5; the receiving pipe 63 is installed in the receiving channel 51 and one end of the receiving pipe 63 extends into the outer phase pipe 61, so as to receive the inner phase droplet.

[0076] In order to improve the installation and maintenance convenience, the first carrier 4 is detachably connected with the coaxial adjusting mechanism. Specifically, the first carrier 4 is provided with a groove 42 on the side facing the coaxial adjusting mechanism, and the extension pipe part 13 of the mechanism body 1 of the coaxial adjusting mechanism is clamped into the groove 42. The extension pipe part 13 is in interference fit with the groove 42. A sealing ring can be arranged between the end of the extension pipe part 13 and the bottom of the groove 42 to improve the sealing performance. The inner hole of the sealing ring is in sealing contact with the inner phase pipe 62, thereby sealing the outer phase pipe 61. Of course, the side of the mechanism body 1 facing the outer phase pipe 61 can also be provided with a clamping groove (not shown in the figure) for clamping the outer phase pipe 61. One end of the outer phase pipe 61 is clamped into the clamping groove and is in interference fit with the clamping groove. A sealing ring can also be arranged between the end of the outer phase pipe 61 and the clamping groove to improve the sealing performance. The inner hole of the sealing ring is in sealing contact with the inner phase pipe 62, thereby sealing the outer phase pipe 61. The detachable connection between the outer phase pipe 61 and the second carrier 5 can refer to the above design, and details are not repeated here.

[0077] The sealing connection is realized by the sealing ring and the interference fit. Compared with the glue sealing method, the assembly is simple, and the damaged parts can be disassembled and maintained at any time.

[0078] Of course, the outer phase pipe 61 can also be integrally formed with the mechanism body 1 and the second carrier 5. In this way, a sealing ring for sealing one end of the outer phase pipe 61 and allowing the inner phase pipe 62 to pass through can be arranged in the first carrier 4, and a sealing ring for sealing the other end of the outer phase pipe 61 and allowing the receiving pipe 63 to pass through can be arranged in the second carrier 5, thereby realizing the sealing arrangement of the outer phase pipe 61.

[0079] The outer phase pipe 61 is made of transparent material or has a viewing window, so that the droplet formation in the outer phase pipe 61 can be observed.

[0080] Further, as shown in Figure 3 the other end of the inner phase pipe 62 extends out of the first carrier 4 to form an inner phase liquid inlet.

[0081] Or the first carrier 4 is provided with an inner phase liquid passage (at this time, the first carrier 4 is a three-way structure design) communicating with the other end of the inner phase pipe 62. Those skilled in the art can make changes according to actual needs, and details are not limited.

[0082] Further, the outer phase pipe 61 is provided with an outer phase liquid inlet.

[0083] Or as Figure 3As shown, the second carrier 5 is also provided with an outer phase passage 52 connected and communicated with the outer phase tube 61 along the axial direction of the second carrier 5 (at this time, the second carrier 5 is designed as a three-way structure), and the second carrier 5 is also provided with an outer phase inlet passage 53 communicated with the outer phase passage 52, which can be designed and changed according to actual needs by those skilled in the art, and the specific design is not limited.

[0084] Further, the first carrier 4, the second carrier 5 and the coaxial adjusting mechanism are all prepared by 3D printing. The design of 3D printing preparation greatly reduces the manufacturing difficulty and improves the success rate. Moreover, the size can be freely controlled to better fit the inner phase tube 62, the outer phase tube 61 and the receiving tube 63.

[0085] As can be seen from the above technical solutions, the sleeve type microfluidic chip with a single-lactation microfluidic assembly designed by the present application adopts a modular design. The first carrier 4 and the second carrier 5 can be prepared according to the size of the inner phase tube 62, the outer phase tube 61 and the receiving tube 63, which are more closely and reliably matched, free from the constraints of traditional glass slides, have a smaller overall volume and a more free shape. At the same time, the coaxial adjusting mechanism is applied to make radial fine adjustment of the inner phase tube 62 to quickly realize coaxial adjustment.

[0086] As shown in Figure 4 The present application also discloses a double-lactation sleeve type microfluidic chip, which comprises a double-lactation microfluidic assembly and a coaxial adjusting mechanism.

[0087] The double-lactation microfluidic assembly comprises a first carrier 4, a second carrier 5, an inner phase tube 62, an intermediate phase tube 64, an outer phase tube 61 and a receiving tube 63.

[0088] The coaxial adjusting mechanism is installed on one side of the first carrier 4 in the axial direction.

[0089] The outer phase tube 61 is installed between the coaxial adjusting mechanism and the second carrier 5.

[0090] The first carrier 4 is provided with an inner phase passage 41 and an intermediate phase passage 43 in the axial direction of the first carrier 4;

[0091] The inner phase tube 62 is installed in the inner phase passage 41 and has one end extending into the intermediate phase passage 43 to form an inner phase droplet in the intermediate phase tube 64.

[0092] The intermediate phase tube 64 is installed in the intermediate phase passage 43 and has one end extending into the outer phase tube 61 through the coaxial adjusting mechanism to form an intermediate phase droplet containing the inner phase droplet in the outer phase tube 61.

[0093] The coaxial adjusting mechanism can coaxially adjust the intermediate phase tube 64 passing through.

[0094] The second carrier 5 is provided with a receiving channel 51 along the axial direction of the second carrier 5; the receiving tube 63 is installed in the receiving channel 51 and has one end extending into the outer phase tube 61 for receiving the intermediate phase liquid droplets.

[0095] In order to improve the installation and maintenance convenience, the first carrier 4 and the coaxial adjusting mechanism are designed in a detachable manner. Specifically, one side of the first carrier 4 facing the coaxial adjusting mechanism is provided with a groove 42 for clamping the extension pipe part 13 of the mechanism body 1 of the coaxial adjusting mechanism. The extension pipe part 13 is in interference fit with the groove 42. A sealing ring can be further arranged between the end of the extension pipe part 13 and the bottom of the groove 42 to improve the sealing performance of the fit. The inner hole of the sealing ring is arranged to movably pass through the intermediate phase tube 64 and is in sealing contact with the intermediate phase tube 64, thereby sealing the outer phase tube 61. Of course, the side of the mechanism body 1 facing the outer phase tube 61 can also be provided with a clamping groove (not shown in the figure) for clamping the outer phase tube 61. One end of the outer phase tube 61 is clamped into the clamping groove and is in interference fit with the clamping groove. Then, a sealing ring can be arranged between the one end of the outer phase tube 61 and the clamping groove to improve the sealing performance of the fit. The inner hole of the sealing ring is arranged to movably pass through the intermediate phase tube 64 and is in sealing contact with the intermediate phase tube 64, thereby sealing the outer phase tube 61. The detachable connection and fit between the outer phase tube 61 and the second carrier 5 can refer to the above design, and details are not described herein.

[0096] The sealing connection is realized in the form of a sealing ring and interference fit. Compared with the glue sealing method, the assembly is simple, and the damaged parts can be disassembled and maintained at any time.

[0097] Of course, the outer phase tube 61 can also be designed in an integral manner with the mechanism body 1 and the second carrier 5. In this way, a sealing ring for sealing one end of the outer phase tube 61 and for movably passing through the intermediate phase tube 64 can be arranged in the first carrier 4, and a sealing ring for sealing the other end of the outer phase tube 61 and for movably passing through the receiving tube 63 can be arranged in the second carrier 5, thereby realizing the sealing arrangement of the outer phase tube 61.

[0098] The outer phase tube 61 is made of transparent material or has a viewing window, so as to facilitate the observation of the liquid droplet formation in the outer phase tube 61.

[0099] Further, as shown in Figure 4 the other end of the inner phase tube 62 extends out of the first carrier 4 to form an inner phase liquid inlet.

[0100] Or the first carrier 4 is provided with an inner phase liquid inlet channel communicating with the other end of the inner phase tube 62.

[0101] Further, as shown in Figure 4 the first carrier 4 is provided with an intermediate phase liquid inlet channel 44 (the first carrier 4 at this time is designed in a three-way structure) communicating with the intermediate phase tube 64.

[0102] Or the mechanism body 1 of the coaxial adjustment mechanism is provided with an intermediate phase liquid inlet channel 44 connected with the intermediate phase tube 64.

[0103] Further, the outer phase tube 61 is provided with an outer phase liquid inlet;

[0104] Or as Figure 4 shown, the second carrier 5 is further provided with an outer phase channel 52 connected with the outer phase tube 61 along the self axis, and the second carrier 5 is further provided with an outer phase liquid inlet channel 53 connected with the outer phase channel 52.

[0105] Further, the first carrier 4, the second carrier 5 and the coaxial adjustment mechanism are all prepared by 3D printing. The 3D printing preparation design greatly reduces the manufacturing difficulty and improves the success rate. Moreover, the size can be freely controlled to better fit the inner phase tube 62, the outer phase tube 61, the intermediate phase tube 64 and the receiving tube 63.

[0106] From the above technical solutions, it can be seen that the sleeve type microfluidic chip with the double-milk microfluidic assembly designed by the present application adopts modular design. The first carrier 4 and the second carrier 5 can be prepared according to the size of the inner phase tube 62, the intermediate phase tube 64, the outer phase tube 61 and the receiving tube 63, which is more closely and reliably cooperated, breaks away from the shackles of traditional glass slides, has smaller overall volume and more free shape. At the same time, the coaxial adjustment mechanism is applied, which can make radial fine adjustment to the intermediate phase tube 64 to quickly realize coaxial adjustment.

[0107] The coaxial adjustment mechanism and the sleeve type microfluidic chip provided by the present application are described in detail above. For those skilled in the art, according to the idea of the embodiments of the present application, the specific implementation and application range will be changed. In view of the above, the content of the specification should not be understood as a limitation of the present application.

Claims

1. A coaxial adjustment mechanism, characterized by, The coaxial adjusting mechanism comprises a mechanism body (1), an adjusting disc (2) and at least one adjusting block (3); The mechanism body (1) is provided with a first center hole penetrating through the mechanism body (1) in the center of the mechanism body (1) in the axial direction of the mechanism body (1); The adjusting disc (2) is rotatably installed on one side of the mechanism body (1), and is provided with a second center hole (21) penetrating through the adjusting disc (2) and coaxially communicated with the first center hole; The adjusting block (3) is slidably installed on the mechanism body (1) along a radial direction of the first center hole, and one end of the adjusting block (3) can extend into the first center hole or an axial extension area of the first center hole; The adjusting block (3) is provided with a limiting protrusion (31); The adjusting disc (2) is provided with a track groove (22) for the limiting protrusion (31) to be clamped into and in sliding connection with the limiting protrusion (31); The track groove (22) is configured to be relatively displaced with the limiting protrusion (31) during rotation of the adjusting disc (2) to drive the adjusting block (3) to slide.

2. The coaxial adjustment mechanism of claim 1, wherein, The first center hole is provided with an extension pipe portion (13) extending outwardly from one side of the mechanism body (1) in the axial direction of the first center hole; The adjusting disc (2) is rotatably sleeved on the extension pipe portion (13).

3. A microfluidic chip of the casing type, characterized in that, The coaxial adjusting mechanism comprises a mechanism body (1), an adjusting disc (2) and at least one adjusting block (3); The single emulsion microfluidic assembly comprises a first carrier (4), a second carrier (5), an inner phase tube (62), an outer phase tube (61) and a receiving tube (63); The coaxial adjusting mechanism is installed on one side of the first carrier (4) in the axial direction; The outer phase tube (61) is installed between the coaxial adjusting mechanism and the second carrier (5); The first carrier (4) is provided with an inner phase channel (41) in the axial direction of the first carrier (4); The inner phase tube (62) is installed in the inner phase channel (41), and one end of the inner phase tube (62) extends into the outer phase tube (61) through the coaxial adjusting mechanism to form an inner phase droplet in the outer phase tube (61); The second carrier (5) is provided with a receiving channel (51) in the axial direction of the second carrier (5); The receiving tube (63) is installed in the receiving channel (51), and one end of the receiving tube (63) extends into the outer phase tube (61) to receive the inner phase droplet.

4. The capillary microfluidic chip according to claim 3, wherein, The other end of the inner phase tube (62) extends out of the first carrier (4) to form an inner phase inlet, or the first carrier (4) is provided with an inner phase inlet channel communicating with the other end of the inner phase tube (62).

5. The capillary microfluidic chip according to claim 3, wherein, The outer phase tube (61) is provided with an outer phase inlet; Or the second carrier (5) is further provided with an outer phase channel (52) in the axial direction of the second carrier (5) and in communication with the outer phase tube (61), and the second carrier (5) is further provided with an outer phase inlet channel (53) in communication with the outer phase channel (52).

6. The capillary microfluidic chip according to claim 3, wherein, The first carrier (4), the second carrier (5) and the coaxial adjusting mechanism are all prepared by 3D printing.

7. A microfluidic chip of the casing type, characterized in that, The coaxial adjusting mechanism comprises a mechanism body (1), an adjusting disc (2) and at least one adjusting block (3); The double emulsion microfluidic assembly comprises a first carrier (4), a second carrier (5), an inner phase tube (62), an intermediate phase tube (64), an outer phase tube (61) and a receiving tube (63); The coaxial adjusting mechanism is mounted on one side of the first carrier (4) in the axial direction; The outer phase tube (61) is mounted between the coaxial adjusting mechanism and the second carrier (5); The first carrier (4) is provided with an inner phase channel (41) and an intermediate phase channel (43) in the axial direction of the first carrier (4); The inner phase tube (62) is mounted in the inner phase channel (41) and extends into the intermediate phase channel (43) at one end to form inner phase droplets in the intermediate phase tube (64); The intermediate phase tube (64) is mounted in the intermediate phase channel (43) and extends into the outer phase tube (61) at one end through the coaxial adjusting mechanism to form intermediate phase droplets containing inner phase droplets in the outer phase tube (61); The second carrier (5) is provided with a receiving channel (51) in the axial direction of the second carrier (5); The receiving tube (63) is mounted in the receiving channel (51) and extends into the outer phase tube (61) at one end to receive intermediate phase droplets.

8. The capillary microfluidic chip according to claim 7, wherein, The other end of the inner phase tube (62) extends out of the first carrier (4) to form an inner phase inlet, or the first carrier (4) is provided with an inner phase inlet channel (44) connected to the other end of the inner phase tube (62); The first carrier (4) is provided with an intermediate phase inlet channel (44) connected to the intermediate phase tube (64), or the mechanism body (1) of the coaxial adjusting mechanism is provided with an intermediate phase inlet channel (44) connected to the intermediate phase tube (64).

9. The capillary microfluidic chip according to claim 7, wherein, The outer phase tube (61) is provided with an outer phase inlet; Or the second carrier (5) is further provided with an outer phase channel (52) connected to the outer phase tube (61) in the axial direction of the second carrier (5), and the second carrier (5) is further provided with an outer phase inlet channel (53) connected to the outer phase channel (52).

10. The capillary microfluidic chip of claim 7, wherein, The first carrier (4), the second carrier (5), and the coaxial adjusting mechanism are all prepared by 3D printing.

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