Inner and outer wall cleaning mechanism of pipetting needle and pipetting needle assembly

Abstract

The inner and outer wall cleaning mechanism is used for cleaning the pipetting needle and comprises an inner wall cleaning pipe, an outer wall cleaning pipe, an inner wall cleaning pipe, an outer wall cleaning pipe and a driving device, one end is communicated with the upper part of the pipetting needle, and the other end is communicated with the injection device; an outer wall cleaning pipe; one end is communicated with the liquid guide piece and the other end is communicated with the injection device; a liquid guide; liquid inlets are formed in the two sides of the liquid guiding piece respectively, a liquid outlet and an outer wall cleaning flow channel hole are formed in the liquid guiding piece, one end of the liquid inlet is communicated with the outer wall cleaning pipe, the other end of the liquid inlet is communicated with one end of the liquid outlet, and the other end of the liquid outlet is communicated with the outer wall cleaning flow channel hole. The pipetting needle cleaning device can comprehensively clean the inner wall and the outer wall of the pipetting needle, the outer wall of the pipetting needle can be cleaned from multiple angles, the cleaning effect is optimized, the flow speed and the pressure of cleaning liquid are improved, and the cleaning strength is enhanced. Dependence and requirements on manual operation are reduced, the cross contamination probability is reduced, the time interval of solution replacement is shortened, and the production efficiency is improved.

Description

TECHNICAL FIELD

[0001] The present application relates to the field of automatic laboratory sampling technology, in particular to a cleaning mechanism for the inner and outer walls of a pipetting needle and a pipetting needle assembly. BACKGROUND

[0002] In the field of pharmaceutical synthesis, when performing pipetting operations such as sampling, the pipetting needle will come into contact with different solutions, thereby causing cross-contamination of different solutions. In order to ensure that the experiment is not contaminated, the pipetting needle needs to be washed before changing the solution.

[0003] Common cleaning mechanisms for pipetting needles with inner and outer walls include gushing and waterfall types. The gushing type requires an external cleaning container to spray cleaning liquid from bottom to top for cleaning operation. This type of device has low integration level, large floor area, and is prone to cross-contamination. A large amount of cleaning liquid is required. The waterfall type sprays cleaning liquid from top to bottom. The pressure of the cleaning liquid is not enough, the needle cannot be effectively cleaned, and the pipetting needle cleaned by the above method is prone to liquid hanging, which can cause contamination when performing pipetting operations.

[0004] Therefore, there is an urgent need for a pipetting needle cleaning structure to ensure that the cleaning liquid has sufficient pressure, fully cleans the needle, avoids cross-contamination, and improves the integration level of the device. CONTENT OF THE INVENTION

[0005] The present application aims to solve the technical problems of high cross-contamination probability, low pipetting needle cleaning efficiency, and poor cleaning effect in the cleaning process of the inner and outer walls of the pipetting needle. To solve this technical problem, the present application provides a cleaning mechanism for the inner and outer walls of a pipetting needle and a pipetting needle assembly.

[0006] In one aspect, the present application provides a cleaning mechanism for the inner and outer walls of a pipetting needle, which is used to clean the pipetting needle, comprising:

[0007] an inner wall cleaning pipe, one end of which is in communication with the upper part of the pipetting needle, and the other end is in communication with an injection device;

[0008] an outer wall cleaning pipe, one end of which is in communication with a liquid guide, and the other end is in communication with the injection device;

[0009] a liquid guide, both sides of which are respectively provided with liquid inlets, and the liquid guide is provided with a liquid outlet and an outer wall cleaning flow channel hole, one end of the liquid inlet is in communication with the outer wall cleaning pipe, the other end of the liquid inlet is in communication with one end of the liquid outlet, and the other end of the liquid outlet is in communication with the outer wall cleaning flow channel hole.

[0010] In some possible embodiments, the diameter of the liquid outlet is smaller than the diameter of the liquid inlet.

[0011] In some possible embodiments, the outer wall cleaning tube is connected to the injection device through a pipe connector, the pipe connector comprising at least a liquid inlet pipe port and a cleaning pipe port, the liquid inlet pipe port being connected to the injection device, and the cleaning pipe port being connected to the outer wall cleaning tube.

[0012] In some possible embodiments, the outer wall cleaning tube comprises a first connecting port, a second connecting port and a third connecting port, the first connecting port being connected to the liquid inlet port on one side of the liquid guide, the second connecting port being connected to the liquid inlet port on the other side of the liquid guide, and the third connecting port being connected to the cleaning pipe port.

[0013] In some possible embodiments, the cleaning pipe port comprises a first pipe port and a second pipe port, and the outer wall cleaning tube comprises:

[0014] a first outer wall cleaning tube, one end of which being connected to the liquid inlet port on one side of the liquid guide;

[0015] a second outer wall cleaning tube, one end of which being connected to the liquid inlet port on the other side of the liquid guide;

[0016] the other end of the first outer wall cleaning tube being connected to the first pipe port, and the other end of the second outer wall cleaning tube being connected to the second pipe port.

[0017] In some possible embodiments, the outer wall cleaning tube further comprises a first pipe joint, a second pipe joint and a pipe joint connecting plate, one end of the first pipe joint being connected to one end of the inner wall cleaning tube, the first pipe joint and the second pipe joint being fixedly connected through the pipe joint connecting plate, a channel being formed between the first pipe joint and the second pipe joint, and one end of the second pipe joint being connected to the upper part of the pipette tip.

[0018] In some possible embodiments, the outer wall cleaning tube further comprises a third pipe joint, a fourth pipe joint, a fifth pipe joint and a sixth pipe joint, the third pipe joint connecting the first outer wall cleaning tube and the first pipe port, the fourth pipe joint connecting the second outer wall cleaning tube and the second pipe port, the fifth pipe joint connecting the first outer wall cleaning tube and the liquid inlet port on one side of the liquid guide, and the sixth pipe joint connecting the second outer wall cleaning tube and the liquid inlet port on the other side of the liquid guide.

[0019] In some possible embodiments, the outer wall cleaning tube further comprises a fixing member, the fixing member being sleeved on the outer wall of the pipette tip, and the fixing member being fixedly connected to the upper surface of the liquid guide, the upper surface being the surface of the liquid guide in contact with the fixing member.

[0020] In some possible implementation manners, a sealing member is further included and arranged on the groove surface of the liquid guide; wherein the groove surface is obtained by slotting the upper surface of the liquid guide, and the upper surface is the surface of the liquid guide close to the top of the pipette barrel.

[0021] In some possible implementation manners, the other end of the inner wall cleaning pipe and the other end of the outer wall cleaning pipe are respectively connected to the injection device, or the other end of the inner wall cleaning pipe and the other end of the outer wall cleaning pipe are respectively connected to different injection devices.

[0022] In another aspect, the application further provides a pipette assembly with an inner and outer wall cleaning mechanism of a pipette, the pipette assembly comprising a sliding structure, a moving module, a connecting structure and the inner and outer wall cleaning mechanism, the inner and outer wall cleaning mechanism being fixedly connected to the connecting structure, and the connecting structure being slidingly connected to the moving module through the sliding structure.

[0023] In some possible implementation manners, the moving module is provided with a first sensor and a second sensor, and the connecting structure is provided with a position measurement sensing sheet, the position measurement sensing sheet being slidingly arranged between the first sensor and the second sensor through the connecting structure.

[0024] With the above technical solutions, the inner and outer wall cleaning mechanism of a pipette and the pipette assembly provided by the application have the following beneficial effects:

[0025] (1) The inner and outer wall cleaning mechanism of a pipette provided by the application cleans the inner wall of the pipette through the inner wall cleaning pipe and cleans the outer wall of the pipette through the outer wall cleaning pipe, so as to realize comprehensive cleaning of the inner and outer walls of the pipette. By arranging the liquid inlet on both sides of the liquid guide, the outer wall of the pipette can be cleaned from multiple angles, and the cleaning effect of the pipette is optimized. By making the liquid outlet communicate with the middle part of the outer wall cleaning flow channel hole, the flow rate and pressure of the cleaning liquid are improved, and the cleaning strength of the outer wall is further enhanced. By cleaning the pipette through the inner and outer wall cleaning mechanism, the labor is saved, the dependence on manual operation and the precision requirement of manual operation are reduced, the probability of cross contamination of the pipette is reduced, the time interval of solution replacement of the pipette is shortened, and the production efficiency of the laboratory is improved.

[0026] (2) The pipette assembly provided by the application can conveniently clean the inner and outer walls of the pipette, realize dedicated cleaning of the pipette, save labor cost, shorten the interval time of putting the pipette into production and use, improve the cleaning efficiency, and by moving the pipette assembly up and down along with the moving module, the pipette can be moved to a specific position as needed to cooperate with other automated link experimental equipment, so as to improve the automation degree and production efficiency. BRIEF DESCRIPTION OF DRAWINGS

[0027] In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments will be briefly introduced. Obviously, the drawings in the following description only represent some of the embodiments of the present application, and for those skilled in the art, other drawings can be obtained without creative labor on the basis of these drawings.

[0028] Figure 1 is a structural schematic view of an inner and outer wall cleaning mechanism of a pipette needle provided by the embodiments of the present application;

[0029] Figure 2 is a structural schematic view of a liquid guide provided by the embodiments of the present application;

[0030] Figure 3 is a connection relationship schematic view of an outer wall cleaning pipe provided by the embodiments of the present application;

[0031] Figure 4 is a structural schematic view of a pipette needle assembly provided by the embodiments of the present application.

[0032] The following is a supplementary description of the drawings:

[0033] 1-inner wall cleaning pipe; 21-first outer wall cleaning pipe; 22-second outer wall cleaning pipe; 3-liquid guide; 31-liquid inlet; 32-liquid outlet; 33-outer wall cleaning flow channel hole; 4-pipette needle; 50-pipe joint connecting plate; 51-first pipe joint; 52-second pipe joint; 53-third pipe joint; 54-fourth pipe joint; 55-fifth pipe joint; 56-sixth pipe joint; 57-clamping piece; 6-sealing piece; 61-groove surface; 7-fixing piece; 8-pipe connecting piece; 81-first pipe opening; 82-second pipe opening; 83-liquid inlet pipe opening; 9-sliding structure; 10-moving module; 11-connection structure; 12-inner and outer wall cleaning mechanism; 13-first sensor; 14-second sensor; 15-positioning sensing sheet. DETAILED DESCRIPTION

[0034] The technical solutions in the embodiments of the present application will be described clearly and completely in combination with the drawings in the embodiments of the present application. Obviously, the described embodiments only represent some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative labor fall within the scope of protection of the present application.

[0035] References to "one embodiment" or "embodiment" herein refer to specific features, structures, or characteristics that may be included in at least one implementation of the present application. Throughout the description of this application, it should be understood that the terms "upper," "lower," "top," and "bottom," etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings and are intended solely for ease of description and simplification. They do not indicate or imply that the devices or components referred to must have a specific orientation, be constructed, or operate in a specific orientation, and are therefore not to be construed as limiting the present application. Furthermore, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly specifying the number of the technical features referred to. Thus, a feature designated "first" or "second" may explicitly or implicitly include one or more of the features. Furthermore, the terms "first," "second," etc. are used to distinguish similar objects and are not necessarily used to describe a specific order or sequential sequence. It should be understood that the terms used in this manner are interchangeable where appropriate, such that the embodiments of the present application described herein can be implemented in an order other than that illustrated or described herein.

[0036] See Figure 1 , Figure 1 This is a schematic diagram of the structure of the inner and outer wall cleaning mechanism of a pipette needle provided by an embodiment of the present invention. Figure 1 As shown, the utility model provides an inner and outer wall cleaning mechanism for a pipette needle, and the inner and outer wall cleaning mechanism is used to clean the pipette needle 4, comprising:

[0037] Inner wall cleaning tube 1; one end of the inner wall cleaning tube 1 is connected to the upper part of the pipette needle 4, and the other end is connected to the injection device;

[0038] The present application does not limit the communication method between the inner wall cleaning tube and the pipette needle, and can be flexibly set according to actual needs. Optionally, one end of the inner wall cleaning tube 1 can directly extend to the upper part of the pipette needle 4, or it can be connected through a pipe joint to form a flow channel, and then connected to the upper part of the pipette needle 4 through the pipe joint.

[0039] Outer wall cleaning pipe; one end of the outer wall cleaning pipe is connected to the liquid guide 3, and the other end is connected to the injection device;

[0040] The present application does not limit the connection method between the outer wall cleaning pipe and the injection device, and can be set according to actual needs. For example, the outer wall cleaning pipe and the injection device can be connected through connecting components such as pipe connectors and pipe joints.

[0041] Liquid guide 3;The two sides of the liquid guide 3 are respectively provided with liquid inlet 31, the liquid guide 3 is provided with liquid outlet 32 and outer wall cleaning flow channel hole 33, one end of the liquid inlet 31 is communicated with the outer wall cleaning pipe, the other end of the liquid inlet 31 is communicated with one end of the liquid outlet 32, the other end of the liquid outlet 32 is communicated with the outer wall cleaning flow channel hole 33.

[0042] Wherein, the liquid guide 3 is used for guiding the flow direction of the cleaning liquid, so that the cleaning liquid enters the outer wall cleaning flow channel hole 33 along the pre-set liquid inlet 31-liquid outlet 32, thereby cleaning the outer wall of the pipette needle 4.The outer wall cleaning pipe is used for introducing the cleaning liquid into the liquid inlet 31, thereby cleaning the outer wall of the pipette needle 4. Optionally, the liquid outlet 32 can be communicated with any position on the outer wall cleaning flow channel hole 33, or can be communicated with the top of the outer wall cleaning flow channel hole 33, since the top of the outer wall cleaning flow channel hole 33 is close to the top of the needle cylinder of the pipette needle 4, in order to prevent the cleaning liquid from overflowing into the inside of the needle cylinder of the pipette needle 4, causing secondary pollution, the two sides of the groove surface 61 are sealed, the liquid outlet 32 can also be communicated with the bottom of the outer wall cleaning flow channel hole 33, preferably, the liquid outlet 32 can be communicated with the middle part of the outer wall cleaning flow channel hole 33, so as to ensure that the cleaning liquid for cleaning the outer wall has higher flow rate and pressure.

[0043] The present application does not limit the number of outer wall cleaning pipes and liquid inlets 31 in the liquid guide 3, which can be determined according to actual application, the number of outer wall cleaning pipes is related to the number of liquid inlets 31, for example, the liquid guide 3 includes two liquid inlets 31, then the number of outer wall cleaning pipes can be two, the liquid guide 3 includes three liquid inlets, then the number of outer wall cleaning pipes can be three.

[0044] The inner and outer wall cleaning mechanism of the pipette needle provided by the present application cleans the inner wall of the pipette needle through the inner wall cleaning pipe, and cleans the outer wall of the pipette needle through the outer wall cleaning pipe, so as to realize comprehensive cleaning of the inner and outer walls of the pipette needle, by arranging liquid inlets on the two sides of the liquid guide, the pipette needle can be cleaned from multiple angles, the cleaning effect of the pipette needle is optimized, by communicating the liquid outlet with the middle part of the outer wall cleaning flow channel hole, the flow rate and pressure of the cleaning liquid are improved, and the cleaning strength of the outer wall is further enhanced. By cleaning the pipette needle through the inner and outer wall cleaning mechanism, manpower is saved, the dependence on manual operation and the precision requirement of manual operation are reduced, the probability of cross contamination of the pipette needle is reduced, the time interval of replacing the solution of the pipette needle is shortened, and the production efficiency of the laboratory is improved.

[0045] Please refer to Figure 2 , Figure 2 is a structure diagram of a liquid guide provided by the embodiment of the present application, like Figure 2As shown, in some possible embodiments, the diameter of the liquid outlet 32 is smaller than the diameter of the liquid inlet 31.

[0046] When liquid flows into the narrow channel at a certain flow rate, the liquid flow rate is increased, which has the effect of slit acceleration.

[0047] Alternatively, the diameter of the liquid outlet 32 can also be equal to or greater than the diameter of the liquid inlet 31, and the liquid outlet 32 and the liquid inlet 31 together guide the flow direction of the cleaning liquid.

[0048] The embodiment of the utility model discloses through setting the diameter of liquid outlet is less than the diameter of liquid inlet, make the cleaning liquid when via liquid inlet and flow through the liquid outlet from the outer wall cleaning flow channel hole and flow out after acceleration, improve the flow rate of cleaning liquid, make two cleaning liquid in the outer wall of pipette needle form high -speed spiral flow, improve the cleaning strength to the outer wall, simultaneously, make the cleaning liquid of high -speed flow can take away the solution droplet of pipette needle needle tip, further improve the effect of cleaning to pipette needle.

[0049] Please refer to Figure 1 In some possible embodiments, the outer wall cleaning pipe is connected with the injection device through a pipeline connecting piece, and the pipeline connecting piece at least includes a liquid inlet pipeline port 83 and a cleaning pipeline port, the liquid inlet pipeline port 83 is connected with the injection device, and the cleaning pipeline port is connected with the outer wall cleaning pipe.

[0050] Alternatively, the liquid inlet pipeline port 83 is used to introduce the cleaning liquid in the injection device into the pipeline connecting piece, and the cleaning pipeline port is used to deliver the cleaning liquid in the pipeline connecting piece to the outer wall cleaning pipe, so as to clean the outer wall of the pipette needle 4.

[0051] Alternatively, the number of cleaning pipeline ports is at least one, and the number of pipeline ports of the outer wall cleaning pipe can be set according to requirements and is at least three.

[0052] Please refer to Figure 3 , Figure 3 is a connection relationship diagram of an outer wall cleaning pipe provided by the embodiment of the utility model, as Figure 3 As shown, in some possible embodiments, the outer wall cleaning pipe includes a first connecting port, a second connecting port and a third connecting port, the first connecting port is connected with the liquid inlet port 31 on one side of the liquid guide piece 3, the second connecting port is connected with the liquid inlet port 31 on the other side of the liquid guide piece 3, and the third connecting port is connected with the cleaning pipeline port.

[0053] Further, the outer wall cleaning pipe can be an integrally formed pipe with three pipe openings, or a pipe assembly obtained by connecting multiple double-hole pipes through a tee connector. The double-hole pipe is a pipe with two pipe openings. For example, one end of a double-hole pipe can be connected to the cleaning pipe opening, and the other end can be connected to two other double-hole pipes through a tee connector to obtain the outer wall cleaning pipe in the form of a pipe assembly, and the two double-hole pipes clean the outer wall of the pipette from both sides.

[0054] The embodiment of the utility model adopts the pipe with three pipe openings or the pipe assembly obtained by connecting multiple double-hole pipes, and divides the cleaning liquid flowing into the outer wall cleaning pipe from the cleaning pipe opening into two branches, which flow to the two side liquid inlets of the liquid guide, and washes the outer wall of the pipette from two different angles, thereby enhancing the coverage area of washing and cleaning strength.

[0055] Please continue to see Figure 1 、 Figure 2 In some possible embodiments, the cleaning pipe opening includes a first pipe opening 81 and a second pipe opening 82, and the outer wall cleaning pipe includes:

[0056] A first outer wall cleaning pipe 21 is in communication with one side of the liquid inlet 31 of the liquid guide 3;

[0057] A second outer wall cleaning pipe 22 is in communication with the other side of the liquid inlet 31 of the liquid guide 3;

[0058] The other end of the first outer wall cleaning pipe 21 is in communication with the first pipe opening 81, and the other end of the second outer wall cleaning pipe 22 is in communication with the second pipe opening 82.

[0059] Optionally, if the first outer wall cleaning pipe 21 and the second outer wall cleaning pipe 22 are both hoses, the number of outer wall cleaning pipes corresponds to the number of liquid inlets 31 in the liquid guide 3, and the number of liquid inlets 31 can be increased for multi-directional cleaning of the outer wall of the pipette. For example, when the number of liquid inlets 31 is 2, the number of outer wall cleaning pipes is also 2.

[0060] Further, one end of the outer wall cleaning pipe is connected to the injection device for injecting cleaning liquid. When the outer wall cleaning pipe includes the first outer wall cleaning pipe 21 and the second outer wall cleaning pipe 22, the same injection device or different injection devices can be connected, and the outer wall cleaning pipes in multiple directions can be controlled to clean the outer wall of the pipette 4 simultaneously or sequentially.

[0061] The injection device refers to a device for injecting liquid or gas, and examples of the injection device include an injection pump capable of controlling the injection speed and flow rate. The injection device is not limited in the present application, and the injection pump can be a multi-channel injection pump, a micro-injection pump, a programmable injection pump, or the like.

[0062] Further, when the outer wall cleaning tubes are connected to the same injection device, the tubes need to be connected through the pipe connector 8. The pipe connector 8 is a component for changing the flow direction of the liquid. As shown in FIG. 8, the pipe connector 8 is a three-way connector, which includes a first pipe port 81, a second pipe port 82, and a liquid inlet pipe port 83. When the cleaning liquid flows into the pipe connector 8 from the liquid inlet pipe port 83, the cleaning liquid is divided into two paths and flows to the first pipe port 81 and the second pipe port 82, respectively, and then flows to the first outer wall cleaning tube 21 and the second outer wall cleaning tube 22, respectively. Figure 1

[0063] The outer wall cleaning tubes are arranged to clean the outer wall of the pipette tip, thereby improving the cleaning efficiency of the outer wall of the pipette tip and enhancing the cleaning effect of the outer wall. The first outer wall cleaning tube and the second outer wall cleaning tube are connected to different injection devices, respectively, so that the two sides of the pipette tip can be cleaned at different flow rates and different intensities, and the cleaning sequence can be controlled, thereby enriching the diversity and flexibility of the pipette tip cleaning scheme.

[0064] Please continue to refer to Figure 1 、 Figure 3 As shown in FIG. 8, in some possible embodiments, the inner and outer wall cleaning mechanism further includes a first pipe joint 51, a second pipe joint 52, and a pipe joint connecting plate 50. One end of the first pipe joint 51 is in communication with one end of the inner wall cleaning tube 1. The first pipe joint 51 and the second pipe joint 52 are fixedly connected through the pipe joint connecting plate 50. A passage is formed between the first pipe joint 51 and the second pipe joint 52. One end of the second pipe joint 52 is in communication with the upper part of the pipette tip 4.

[0065] Optionally, the fixed connection between the first pipe joint 51 and the second pipe joint 52 through the pipe joint connecting plate 50 can be clamping, plug-in, threaded connection, or the like. As an example, the pipe joint connecting plate 50 includes a clamping piece 57. The first pipe joint 51 and the second pipe joint 52 are inserted into the clamping piece 57, respectively. The clamping piece 57 is fastened with a nut or the like, so as to be connected and fixed with the pipe joint connecting plate 50.

[0066] ​Optionally, for the inner wall cleaning pipe 1 or the outer wall cleaning pipe, two ends of each cleaning pipe are connected through pipe joints, wherein the upper part of the first pipe joint 51 can be connected with an injection device, the cleaning liquid is introduced from the first pipe joint 51, flows into the channel of the second pipe joint 52 through the inner wall cleaning pipe 1, and then flows into the inner part of the pipette through the upper part of the pipette needle 4, so that the inner part of the pipette is cleaned.

[0067] Further, in order to ensure that the inner part of the pipette 4 is cleaned more thoroughly, a channelled flow guide groove can be arranged on the upper part of the pipette 4, one end of the channel extends to the inner wall of the pipette 4, and the cleaning liquid can flow down along the inner wall of the pipette 4 after flowing into the pipette 4.

[0068] The embodiment of the utility model discloses through setting first pipe joint and second pipe joint and fixing the inner wall cleaning pipe, make the cleaning liquid can flow into the pipette through the channel formed between the inner wall cleaning pipe and pipe joint, thereby the inner wall is cleaned deeply, improve the inner wall cleaning efficiency and cleaning effect, reduce the possibility of the residual liquid of the inner wall, improve the non-pollution of experiment.

[0069] In some possible embodiments, the inner and outer wall cleaning mechanism further comprises a third pipe joint 53, a fourth pipe joint 54, a fifth pipe joint 55 and a sixth pipe joint 56, the third pipe joint 53 is communicated with the first outer wall cleaning pipe 21 and the first pipe port 81, the fourth pipe joint 54 is communicated with the second outer wall cleaning pipe 22 and the second pipe port 82, the fifth pipe joint 55 is communicated with the first outer wall cleaning pipe 21 and the liquid inlet 31 on one side of the liquid guide 3, and the sixth pipe joint 56 is communicated with the second outer wall cleaning pipe 22 and the liquid inlet 31 on the other side of the liquid guide 3.

[0070] Further, in order to meet the needs of different cleaning liquid flow, pipe joints with different inner diameters can also be used. By replacing pipe joints with different inner diameters, the cleaning speed and intensity can be controlled. In addition, in order to adapt to different experimental environments and the chemical properties of different solutions, pipe joints made of different materials can be selected. For example, the material of the pipe joint can be PFA material, and the like, which will not be described here.

[0071] The embodiment of the utility model discloses through setting pipe joint between pipe, make the dismounting of pipe more convenient, improved the convenience of inner and outer wall cleaning device maintenance thereby prolong the service life of device, simultaneously strengthened the sealing property of cleaning liquid in pipe, reduced the risk of cross contamination, guaranteed the cleanliness of pipette.

[0072] Please continue to see Figure 3In some possible embodiments, the inner and outer wall cleaning mechanism further comprises a fixing member 7, which is sleeved on the outer wall of the pipette tip 4, and is fixedly connected with the upper surface of the liquid guide 3, which is the surface of the liquid guide 3 in contact with the fixing member 7.

[0073] The fixing member 7 is used to fix the pipette tip 4, as shown in the figure, the upper part of the pipette tip 4 passes through the fixing member 7, and the lower part of the pipette tip 4 passes through the outer wall cleaning flow channel hole 33 of the liquid guide 3, and the fixing member 7 fixes the pipette tip 4 and the liquid guide 3 together.

[0074] The pipette tip and the liquid guide are fixed in the embodiments of the utility model, the stability of the pipette tip in the mechanism is enhanced, the inner wall cleaning pipe can guide the cleaning liquid into the needle cylinder inside the pipette tip, the cleaning liquid is prevented from flowing into other parts, the accuracy of position control of pipette tip cleaning is enhanced, and the efficiency and cleaning effect of pipette tip cleaning are improved.

[0075] Please continue to refer to Figure 2 、 Figure 3 In some possible embodiments, the inner and outer wall cleaning mechanism further comprises a sealing member 6, which is arranged on the groove surface 61 of the liquid guide 3; wherein the groove surface 61 is obtained by slotting the upper surface of the liquid guide 3, and the upper surface is the surface of the liquid guide 3 close to the top of the needle cylinder of the pipette tip 4.

[0076] It should be noted that the cleaning liquid flows in from the liquid inlets 31 on both sides of the liquid guide 3, flows out from the liquid outlets 32 to the outer wall cleaning flow channel hole 33, and thus cleans the outer wall of the pipette tip 4. At this time, the cleaning liquid has a large flow rate and strong impact, and may produce strong impact on the outer wall of the pipette tip 4, causing the cleaning liquid in the outer wall cleaning flow channel hole 33 to splash around. Since the top of the needle cylinder of the pipette tip 4 is close to the outer wall cleaning flow channel hole 33, the cleaning liquid may splash to the top of the needle cylinder of the pipette tip 4. In order to avoid the cleaning liquid from the outer wall cleaning flow channel hole 33 flowing into the top of the needle cylinder of the pipette tip 4 and causing secondary pollution to the inside of the pipette tip 4, the hole close to the top of the needle cylinder of the pipette tip 4 in the outer wall cleaning flow channel hole 33 is sealed.

[0077] Further, as shown in the figure, the groove surface 61 is arranged on the upper surface of the liquid guide 3, and the sealing member 6 is arranged in the groove surface 61, so as to limit the cleaning liquid in the outer wall cleaning flow channel hole 33 below the sealing member 6. Optionally, the slotting processing refers to machining the upper surface of the liquid guide 3 to obtain the groove surface 61, and the sealing member can be an O-ring or the like.

[0078] The utility model embodiment sets sealing piece in the upper portion of the pipette needle, separates the needle cylinder top of the pipette needle and the cleaning solution for cleaning the outer wall of the pipette needle, avoids the cleaning solution splashing to the inside of the needle cylinder of the pipette needle when cleaning the outer wall of the pipette needle, causes secondary pollution to the inner wall of the needle cylinder, improves the safety and effectiveness of the cleaning of the pipette needle, strengthens the anti -pollution function of the cleaning of the inner and outer wall of the pipette needle, improves the independence of the cleaning of the inner and outer wall of the pipette needle.

[0079] In some possible embodiments, the other end of the inner wall cleaning pipe 1 and the other end of the outer wall cleaning pipe are respectively connected to the injection device, or the other end of the inner wall cleaning pipe 1 and the other end of the outer wall cleaning pipe are respectively connected to different injection devices.

[0080] Further, the inner and outer wall cleaning mechanism 12 can clean the inner and outer walls simultaneously, and the cleaning solution flows out from the inner wall cleaning pipe 1 and the outer wall cleaning pipe respectively through the control of two injection pumps, or the inner wall or the outer wall can be cleaned separately, that is, the inner wall cleaning pipe 1 and the outer wall cleaning pipe are connected to the same injection pump, and only the electromagnetic valve of the single injection pump needs to be switched, in addition, the cleaning solution flowing out from the inner wall cleaning pipe 1 and the outer wall cleaning pipe can be the same cleaning solution or different cleaning solutions.

[0081] The utility model embodiment sets the connection mode between the inner wall cleaning pipe and the outer wall cleaning pipe and the injection device in multiple ways, realizes the independent control of the inner and outer wall cleaning, improves the flexibility of the pipette needle inner and outer wall cleaning control, and improves the efficiency and cleaning effect of the pipette needle inner and outer wall cleaning.

[0082] Please refer to Figure 4 , Figure 4 is a structure schematic view of a pipette needle assembly provided by the utility model embodiment, as Figure 4 shown, according to another aspect of the utility model, a pipette needle assembly with an inner and outer wall cleaning mechanism of pipette needle is also provided, the pipette needle assembly includes sliding structure 9, mobile module 10, connecting structure 11 and inner and outer wall cleaning mechanism, the inner and outer wall cleaning mechanism is fixedly connected with the connecting structure 11, and the connecting structure 11 is slidably connected with the mobile module 10 through the sliding structure 9.

[0083] It should be noted that the inner and outer wall cleaning mechanism 12 is fixedly connected with the first surface of the connecting mechanism 11, the inner and outer wall cleaning structure 12 is fixedly connected with the sliding structure 9 via the second surface of the connecting structure 11, the sliding structure 9 is slidably arranged on the track of the mobile module 10, the sliding structure 9 drives the inner and outer wall cleaning mechanism 12 to slide on the track of the mobile module 10, and the sliding structure 9 can be a sliding block exemplarily.

[0084] Optionally, the first surface of the connecting structure 11 is parallel to and away from the surface of the mobile module 10, and the second surface is parallel to and close to the surface of the mobile module 10.

[0085] Optionally, the transmission mode of the mobile module 10 can be a slide rail screw transmission, a synchronous belt transmission, a gear and rack transmission, etc. Figure 4 As shown in the figure, the mobile module 10 uses a screw to cooperate with a linear slide rail to drive the sliding structure 9 to slide up and down, and further, a waste liquid collecting device is arranged below the pipette assembly for collecting the cleaning liquid flowing down after cleaning the inner and outer walls of the pipette 4.

[0086] Further, for the cleaning of the inner and outer walls, the injection amount and injection speed of the cleaning liquid of the injection device can be set by the upper computer to control the cleaning time each time.

[0087] The pipette assembly is combined with the inner and outer wall cleaning mechanism to realize the cleaning of the inner and outer walls of the pipette, realize the cleaning of the pipette, save the labor cost, shorten the interval time of the pipette into production and use, improve the cleaning efficiency, and realize the cooperation of the pipette assembly with other automatic link experimental equipment by moving the pipette assembly up and down with the mobile module, improve the automation degree and production efficiency.

[0088] In some possible embodiments, the mobile module 10 is provided with a first sensor 13 and a second sensor 14, and the connecting structure 11 is provided with a position measuring sensing sheet 15, which is slidably arranged between the first sensor 13 and the second sensor 14 through the connecting structure 11.

[0089] Optionally, the first sensor 13 and the second sensor 14 can be microwave sensors for detecting the position of the position measuring sensing sheet 15, and the position change of the position measuring sensing sheet 15 is consistent with the position change of the inner and outer wall cleaning mechanism.

[0090] The embodiment of the utility model discloses two sensors on the mobile module, and the position of the position measuring sensing sheet on the inner and outer wall cleaning mechanism is detected in real time, so that the inner and outer wall cleaning mechanism is controlled to slide to the specified position through the sliding block structure, the accuracy of the inner and outer wall cleaning mechanism control is improved, the environmental cleanliness is improved, and the inner and outer wall cleaning mechanism can be closely matched with other automatic equipment.

[0091] The technical scheme of the utility model is implemented, and at least the following beneficial effects can be obtained:

[0092] 1. The inner and outer wall cleaning mechanism of the pipette provided by the application cleans the inner wall of the pipette through the inner wall cleaning pipe and cleans the outer wall of the pipette through the outer wall cleaning pipe, so as to realize comprehensive cleaning of the inner and outer walls of the pipette, the liquid inlet is arranged on the two sides of the liquid guide piece, the outer wall of the pipette can be cleaned from multiple angles, the cleaning effect of the pipette is optimized, the liquid outlet is communicated with the middle part of the outer wall cleaning flow channel hole, the flow rate and pressure of the cleaning liquid are improved, and the cleaning strength of the outer wall is further enhanced. The pipette is cleaned by the inner and outer wall cleaning mechanism, manpower is saved, the dependence on manual operation and the accuracy requirement of manual operation are reduced, the probability of cross contamination of the pipette is reduced, the time interval of solution replacement of the pipette is shortened, and the production efficiency of the laboratory is improved.

[0093] 2. The diameter of the liquid outlet is smaller than that of the liquid inlet, so that the cleaning liquid is accelerated when flowing out of the outer wall cleaning flow channel hole through the liquid inlet and the liquid outlet, the flow rate of the cleaning liquid is improved, two streams of cleaning liquid form high-speed spiral flow on the outer wall of the pipette, the cleaning strength of the outer wall is improved, and at the same time, the cleaning liquid flowing at high speed can carry away solution droplets on the tip of the pipette, and the cleaning effect of the pipette is further improved.

[0094] 3. The pipeline assembly obtained by adopting the pipeline with three pipeline openings or a plurality of double-hole pipes is combined, the cleaning liquid flowing into the outer wall cleaning pipe from the cleaning pipeline opening is divided into two branches, flows to the liquid inlet on the two sides of the liquid guide piece respectively, and washes the outer wall of the pipette from two different angles, so that the coverage area of washing is increased and the cleaning strength is enhanced.

[0095] 4. The outer wall cleaning pipe is arranged, the outer wall of the pipette is fully cleaned, the cleaning efficiency of the outer wall of the pipette is improved, the cleaning effect of the outer wall is enhanced, the first outer wall cleaning pipe and the second outer wall cleaning pipe are connected to different injection devices respectively, the two sides of the pipette can be cleaned at different flow rates and different intensities, the cleaning sequence can be controlled, and the diversity and flexibility of the pipette cleaning scheme are enriched.

[0096] 5. The first pipe joint and the second pipe joint are arranged to fix the inner wall cleaning pipe, so that the cleaning liquid can flow into the pipette through the channel formed between the inner wall cleaning pipe and the pipe joint, thereby deeply cleaning the inner wall, improving the cleaning efficiency and cleaning effect of the inner wall, reducing the possibility of residual liquid in the inner wall, and improving the non-pollution of the experiment.

[0097] 6. The utility model discloses a pipe joint is provided between the pipeline, make the pipeline of dismounting more convenient, improve the convenience of the maintenance of inner and outer wall cleaning device to prolong the service life of the device, and simultaneously strengthen the sealing property of cleaning fluid in the pipeline, reduce the risk of cross contamination, guarantee the cleanliness of pipette tip.

[0098] 7. The utility model discloses a pipette tip and liquid guide are fixed, strengthen the stability of pipette tip in the mechanism, make the inner wall cleaning pipe can guide the cleaning fluid into the needle cylinder inside pipette tip, avoid the cleaning fluid to flow into other parts, strengthen the accuracy of position control of pipette tip cleaning, improve the efficiency and cleaning effect of pipette tip.

[0099] 8. The utility model discloses a sealing element is arranged at the upper portion of pipette tip, separates the needle cylinder top of pipette tip and the cleaning fluid for cleaning the outer wall of pipette tip, avoid the cleaning fluid when cleaning the outer wall of pipette tip to splash into the needle cylinder inside pipette tip, cause secondary pollution to the inner wall of needle cylinder, improve the safety and effectiveness of pipette tip cleaning, strengthen the anti -pollution function of inner and outer wall cleaning of pipette tip, improve the independence of inner and outer wall cleaning of pipette tip.

[0100] 9. The utility model discloses a connecting mode between inner wall cleaning pipe and outer wall cleaning pipe and injection device is set up in multiple, realizes the independent control of inner and outer wall cleaning, improves the flexibility of pipette tip inner and outer wall cleaning control, improves the efficiency and cleaning effect of pipette tip inner and outer wall cleaning.

[0101] 10. The utility model discloses a pipette tip and inner and outer wall cleaning mechanism are combined to constitute pipette tip assembly, can conveniently carry out inner and outer wall cleaning to pipette tip, realize special needle special wash, save the manual cost, thereby shorten the interval time of pipette tip putting into production and use, improve the cleaning efficiency, through with the movement module up and down movement of pipette tip assembly, make pipette tip can move to the specific position as needed and realize cooperation with other automation link experimental equipment, improve the degree of automation and production efficiency.

[0102] 11. The utility model discloses two sensors are set up on the movement module, and the position of the position sensing sheet on the inner and outer wall cleaning mechanism is detected in real time, thereby controling the inner and outer wall cleaning mechanism to slide to the specified position through the slider structure, improve the accuracy of the control of the inner and outer wall cleaning mechanism, thereby improve the environmental cleanliness, can cooperate with other automation equipment closely.

[0103] The above-mentioned is only optional embodiment of the application, and does not use to limit the application, and any modification, equivalent replacement, improvement etc. that is made within the spirit and principle of the application should be included in the protection scope of the application.

Claims

1. An inner and outer wall cleaning mechanism for cleaning a pipetting needle (4), characterized in that The application relates to a liquid injection device, which comprises the following parts: an inner wall cleaning pipe (1) which is in communication with the upper part of a pipette (4) at one end and with an injection device at the other end; an outer wall cleaning pipe which is in communication with a liquid guide (3) at one end and with the injection device at the other end; the liquid guide (3) is provided with liquid inlets (31) at both sides, and is provided with a liquid outlet (32) and an outer wall cleaning flow channel hole (33), one end of the liquid inlet (31) is in communication with the outer wall cleaning pipe, the other end of the liquid inlet (31) is in communication with one end of the liquid outlet (32), and the other end of the liquid outlet (32) is in communication with the outer wall cleaning flow channel hole (33).

2. The inner and outer wall cleaning mechanism according to claim 1, characterized by, The diameter of the liquid outlet (32) is smaller than that of the liquid inlet (31).

3. The inner and outer wall cleaning mechanism according to claim 1, characterized by, The outer wall cleaning pipe is in communication with the injection device through a pipe connecting piece, the pipe connecting piece comprises at least a liquid inlet pipe port (83) and a cleaning pipe port, the liquid inlet pipe port (83) is in communication with the injection device, and the cleaning pipe port is in communication with the outer wall cleaning pipe.

4. The inner and outer wall cleaning mechanism according to claim 3, characterized by The outer wall cleaning pipe comprises a first connecting port, a second connecting port and a third connecting port, the first connecting port is in communication with the liquid inlet (31) at one side of the liquid guide (3), the second connecting port is in communication with the liquid inlet (31) at the other side of the liquid guide (3), and the third connecting port is in communication with the cleaning pipe port.

5. The inner and outer wall cleaning mechanism according to claim 3, characterized by, The cleaning pipe port comprises a first pipe port (81) and a second pipe port (82), and the outer wall cleaning pipe comprises: a first outer wall cleaning pipe (21) which is in communication with the liquid inlet (31) at one side of the liquid guide (3) at one end; a second outer wall cleaning pipe (22) which is in communication with the liquid inlet (31) at the other side of the liquid guide (3) at one end; the other end of the first outer wall cleaning pipe (21) is in communication with the first pipe port (81), and the other end of the second outer wall cleaning pipe (22) is in communication with the second pipe port (82).

6. The inner and outer wall cleaning mechanism according to claim 1, characterized by The application further comprises a first pipe joint (51), a second pipe joint (52) and a pipe joint connecting plate (50), one end of the first pipe joint (51) is in communication with one end of the inner wall cleaning pipe (1), the first pipe joint (51) and the second pipe joint (52) are fixedly connected through the pipe joint connecting plate (50), a channel is formed between the first pipe joint (51) and the second pipe joint (52), and one end of the second pipe joint (52) is in communication with the upper part of the pipette (4).

7. The inner and outer wall cleaning mechanism according to claim 5, wherein The third pipe joint (53) is in communication with the first outer wall cleaning pipe (21) and the first pipe opening (81), the fourth pipe joint (54) is in communication with the second outer wall cleaning pipe (22) and the second pipe opening (82), the fifth pipe joint (55) is in communication with the first outer wall cleaning pipe (21) and the liquid inlet (31) on one side of the liquid guide (3), and the sixth pipe joint (56) is in communication with the second outer wall cleaning pipe (22) and the liquid inlet (31) on the other side of the liquid guide (3).

8. The inner and outer wall cleaning mechanism according to claim 4, wherein The fixing member (7) is sleeved on the outer wall of the pipette needle (4), and the fixing member (7) is fixedly connected with the upper surface of the liquid guide (3), wherein the upper surface is the surface of the liquid guide (3) in contact with the fixing member (7).

9. The inside and outside wall cleaning mechanism according to claim 1, wherein The sealing member (6) is arranged on the groove surface (61) of the liquid guide (3), wherein the groove surface (61) is obtained by slotting the upper surface of the liquid guide (3), and the upper surface is the surface of the liquid guide (3) close to the top of the needle cylinder of the pipette needle (4).

10. The inside and outside wall cleaning mechanism according to claim 1, characterized by, The other end of the inner wall cleaning pipe (1) and the other end of the outer wall cleaning pipe are respectively connected to the injection device, or the other end of the inner wall cleaning pipe (1) and the other end of the outer wall cleaning pipe are respectively connected to different injection devices.

11. A pipette tip assembly having an internal and external wall cleaning mechanism with a pipetting needle, characterized in that The pipette needle assembly comprises a sliding structure (9), a moving module (10), a connecting structure (11) and the inner and outer wall cleaning mechanism according to any one of claims 1-10, the inner and outer wall cleaning mechanism is fixedly connected with the connecting structure (11), and the connecting structure (11) is slidably connected with the moving module (10) through the sliding structure (9).

12. The pipette tip assembly of claim 11, wherein, The moving module (10) is provided with a first sensor (13) and a second sensor (14), and the connecting structure (11) is provided with a position measuring induction sheet (15), the position measuring induction sheet (15) is slidably arranged between the first sensor (13) and the second sensor (14) through the connecting structure (11).

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