Sample transfer box for drug clinical test

Abstract

The utility model provides a sample transfer box for clinical drug tests, which comprises a box body, a box cover covers the top of the box body, and a partition plate is arranged in the box body; a compressor is arranged between the partition plate and the bottom of the box body; a constant-temperature pipeline is arranged on the upper side of the partition plate and connected with the compressor. A supporting plate is further arranged on the upper side of the partition plate. The supporting plate is movably mounted on the inner side wall of the box body; a plurality of mounting holes distributed in a rectangular array are formed in the supporting plate, and fixing assemblies for fixing samples are arranged in the mounting holes; the constant-temperature pipeline can act on the fixing assembly to keep the temperature around the sample constant; according to the utility model, the temperature around the sample is uniformly controlled, and the precision and the stability of temperature control are improved; more reliable, efficient and convenient sample transfer efficiency is provided for drug clinical tests, and progress and development of the drug research and development field are further promoted.

Description

TECHNICAL FIELD

[0001] The utility model relates to the field of clinical test especially relates to a sample transfer case for drug clinical test. BACKGROUND

[0002] In the drug research and development process, clinical test is the key link of evaluating drug safety, effectiveness and pharmacokinetics characteristics, these tests often need strict condition control, especially for temperature sensitive samples such as blood samples of subject's secret collection, vaccine, specific chemical medicine etc., must keep constant temperature range in the process of transfer and storage to ensure its activity and stability are not affected,

[0003] Traditionally, the transfer and storage of clinical test samples usually adopt ice box, incubator etc. simple equipment, however, these equipment has many limitations, is difficult to meet the strict requirement of modern drug clinical test to temperature control, first, the temperature control range of ice box etc. equipment is limited, and is difficult to maintain constant temperature for a long time, is easy to lead to sample temperature fluctuation, influences the accuracy of test result, second, the heat preservation effect of these equipment is greatly influenced by external environment, such as temperature change, vibration etc. factors in the transportation process can have adverse effects on samples, in addition, traditional equipment also has many inconveniences in sample fixation, observation and management, increases the complexity and risk of test,

[0004] In order to solve the above problems, more advanced and professional drug clinical test sample transfer case gradually appears in the market, these transfer cases usually are equipped with refrigeration or heating system and accurate temperature control device, can realize accurate control and long time maintenance of sample temperature, however, even so, the existing transfer case still has deficiencies in temperature uniformity, sample fixation and observation etc., for example, part of the transfer case does not fully consider the temperature distribution problem around the sample in the design, leads to large local temperature difference, influences the reliability of test result, UTILITARY MODEL CONTENTS

[0005] In order to solve the problem of uneven temperature distribution around the sample in the prior art, leading to large local temperature difference, the utility model provides a sample transfer case for drug clinical test,

[0006] The utility model provides a sample transfer case for drug clinical test adopts the following technical scheme:

[0007] The utility model provides a sample transport case for drug clinical test, including the box, the top cover of box is equipped with the box cover, the inside of box is equipped with the baffle, the baffle with the bottom of box is equipped with the compressor, the upside of baffle is equipped with constant temperature pipeline and is connected with the compressor, the upside of baffle still is equipped with the support plate, the support plate is installed in the inside wall of box, the inside of support plate is equipped with a plurality of rectangular array distribution's mounting hole, and the inside of mounting hole is equipped with the fixed component for fixing sample, constant temperature pipeline can act to fixed component and realize keeping the temperature constant around sample,

[0008] Further, the constant temperature pipeline includes a spiral pipe, a first branch pipe, a second branch pipe, an output pipe and an input pipe. The same number of spiral pipes are arranged on the upper side of the baffle corresponding to the fixed components. One end of the spiral pipes in the same row is connected to the first branch pipe and communicates with each other. The input pipe is connected to one end of the first branch pipe, and the other end of the input pipe is connected to the input end of the compressor. The other end of the spiral pipes in the same row is connected to the second branch pipe and communicates with each other. The output pipe is connected to one end of the second branch pipe, and the other end of the output pipe is connected to the output end of the compressor. The inner ring of the spiral pipe is wrapped outside the fixed component.

[0009] Further, the baffle and the support plate are filled with thermal insulation cotton, which avoids filling the space in the ring of the spiral pipe.

[0010] Further, the fixed component includes a constant temperature cylinder, a fixed block, a fixed hole and a cushion block. The constant temperature cylinder is made of stainless steel. The constant temperature cylinder is arranged in the mounting hole in the support plate, and the top of the constant temperature cylinder is provided with a flange clamped outside the mounting hole. The inner bottom of the constant temperature cylinder is provided with a cushion block. The inner side wall of the constant temperature cylinder is fixedly connected with a fixed block. The fixed block is provided with a fixed hole.

[0011] Further, the fixed block and the cushion block are made of sponge material.

[0012] Further, a sealing ring made of rubber is arranged between the box cover and the opening of the box.

[0013] Further, handles are arranged at both ends of the box by bolts for overall carrying.

[0014] Further, an observation window is arranged on the outer side wall of the box, and a transparent acrylic plate is inlaid in the observation window for observing the state of the sample.

[0015] Further, a handle is integrally formed on the top of the support plate for taking out the support plate from the box as a whole.

[0016] Further, the outer side wall of the box is provided with a detection hole, and an electronic thermometer for displaying the real-time temperature in the box is arranged in the detection hole.

[0017] In summary, the beneficial effects of the present application are:

[0018] The temperature control system combining the partition plate and the compressor, the spiral pipe distributed constant temperature pipeline, the movably installed supporting plate and the fixed assembly are adopted, so that the uniform control on the temperature around the sample is realized, and the precision and stability of temperature control are improved; meanwhile, the sample fixing mode is optimized, the observation window and the electronic thermometer and other auxiliary equipment are additionally arranged, so that the practicality and convenience of the sample transfer box are further improved; the sample transfer efficiency is more reliable, efficient and convenient for the drug clinical test sample, and the progress and development of the drug research field are further promoted. BRIEF DESCRIPTION OF DRAWINGS

[0019] Figure 1 It is a whole structure schematic view of the present application;

[0020] Figure 2 It is a whole structure schematic view of the present application after opening the box cover;

[0021] Figure 3 It is a whole structure schematic view of the present application after opening the box cover;

[0022] Figure 4 It is a whole structure schematic view of the present application after opening the box cover;

[0023] Figure 5 It is a whole structure schematic view of the present application after opening the box cover;

[0024] Figure 6 It is a whole structure schematic view of the present application after opening the box cover.

[0025] As shown in the figure: 1-box, 11-observation window, 12-box cover, 2-handle, 3-partition plate, 4-compressor, 41-spiral pipe, 42-first branch pipe, 43-second branch pipe, 44-output pipe, 45-input pipe, 5-supporting plate, 51-handle, 6-fixed assembly, 61-constant temperature cylinder, 62-fixed block, 63-fixed hole, 64-pad block, 7-electronic thermometer. DETAILED DESCRIPTION

[0026] The following will be combined with the Figures 1-6 The present application will be further described in detail:

[0027] The present application discloses a sample transfer box for drug clinical test, like Figure 1 、 2As shown in Figure 3, it includes a box body 1, the top cover of the box body 1 is provided with a box cover 12, and a partition 3 is provided inside the box body 1; a compressor 4 is provided between the partition 3 and the bottom of the box body 1; a constant temperature pipeline is provided on the upper side of the partition 3, which is connected to the compressor 4; a support plate 5 is also provided on the upper side of the partition 3; the support plate 5 is movably mounted on the inner wall of the box body 1; a plurality of mounting holes distributed in a rectangular array are provided inside the support plate 5, and a fixing component 6 for fixing the sample is provided inside the mounting hole; the constant temperature pipeline can act on the fixing component 6 to keep the temperature around the sample constant; in this embodiment, the compressor 4 serves as the core of the refrigeration or heating system, and realizes energy transfer by compressing and expanding the refrigerant; when it is necessary to reduce the temperature, the compressor 4 can be used as a cooling or heating system. At low temperatures, the compressor 4 compresses the refrigerant to turn it into a high-temperature, high-pressure gas, which then dissipates heat through the condenser and turns into a high-pressure liquid. The throttle valve then reduces the pressure to turn it into a low-temperature, low-pressure liquid. Finally, it absorbs heat in the evaporator and turns into a low-temperature, low-pressure gas before returning to the compressor 4, completing a refrigeration cycle. When the temperature needs to be raised, the working process is reversed. The constant temperature pipeline is connected to a channel that allows the refrigerant to flow evenly. The cooling capacity or heat is transferred to the fixed component 6 through heat transfer. This ensures that the temperature around each fixed component 6 is uniform and consistent, eliminating local temperature differences, thereby ensuring to the greatest extent that all samples are transported in the same ideal temperature environment, thereby improving the accuracy and reliability of the final test results.

[0028] like Figure 3 、 4 As shown, the thermostatic pipeline includes a spiral tube 41, a first branch tube 42, a second branch tube 43, an output tube 44, and an input tube 45; the upper side of the partition 3 is provided with the same number of spiral tubes 41 corresponding to the fixed component 6; one end of the spiral tubes 41 in the same row is connected to the first branch tube 42 and is interconnected; the first branch tube 42 is connected to one end of the input tube 45, and the other end of the input tube 45 is connected to the input end of the compressor 4; the other end of the spiral tubes 41 in the same row is connected to the second branch tube 43 and is interconnected; the second branch tube 43 is connected to one end of the output tube 44, and the other end of the output tube 44 is connected to the output end of the compressor 4; The inner ring of the spiral tube 41 is wrapped around the outside of the fixed component 6. In this embodiment, the spiral tube 41, the first branch tube 42, the second branch tube 43, the output tube 44, and the input tube 45 in the constant temperature pipeline form a connected channel, allowing the refrigerant to flow evenly through each spiral tube 41. The spiral tube 41 tightly surrounds the outside of the fixed component 6 and transfers cooling or heat to the fixed component 6 through heat transfer. The efficient operation of the compressor 4 can quickly and accurately adjust the temperature inside the chamber to meet the strict temperature requirements of different samples. The design of the constant temperature pipeline ensures that the temperature around each fixed component 6 is uniform and consistent, eliminating local temperature differences.

[0029] In addition, it is worth noting that the box 1 should also be set up to match the power and compressor 4 mobile power supply for the compressor 4 to implement the power supply;

[0030] The partition plate 3 and the support plate 5 are filled with thermal insulation cotton (not shown in the figure), which avoids filling the annular space of the spiral pipe 41; in this embodiment, the thermal insulation cotton is composed of a fiber material with a low thermal conductivity, which is filled between the partition plate 3 and the support plate 5; there are a large number of micro pores between the fibers, which are filled with still air, and the air has poor thermal conductivity, thereby effectively preventing heat transfer; when filling, special attention is paid to avoid filling the annular space of the spiral pipe 41 and the normal installation of the fixing assembly 6; the filling of the thermal insulation cotton significantly reduces the upward transmission of heat below the partition plate 3, reduces the influence of the heat generated by the compressor 4 during operation on the sample area, improves the accuracy and stability of temperature control, guarantees the refrigeration or heating effect, and further optimizes the temperature uniformity in the box;

[0031] As shown in Figure 5 , 6 , the fixing assembly 6 includes a thermostat cylinder 61, a fixing block 62, a fixing hole 63, and a cushion block 64; the thermostat cylinder 61 is made of stainless steel; the thermostat cylinder 61 is arranged in the mounting hole formed in the inside of the support plate 5, and the top of the thermostat cylinder 61 is provided with a flange clamped outside the mounting hole; the inside bottom of the thermostat cylinder 61 is provided with the cushion block 64; the inside wall of the thermostat cylinder 61 is fixedly connected with the fixing block 62; the inside of the fixing block 62 is provided with the fixing hole 63; the fixing block 62 and the cushion block 64 are both made of sponge material; in this embodiment, the support plate 5 is movably installed on the inside wall of the box 1; for example, the support frame, buckle and other installation methods ensure that the fixing assembly 6 can be stably installed therein; the thermostat cylinder 61 is made of stainless steel, which has good thermal conductivity and strength; the fixing block 62 and the cushion block 64 are made of sponge material, which has a certain elasticity and softness, can adapt to samples of different shapes and sizes, and can fix the samples in the inside of the thermostat cylinder 61 through friction and elastic force; in this embodiment, the structure of the fixing assembly 6 can stably fix the samples, prevent shaking and displacement during transportation, and protect the integrity of the samples; the sponge material of the fixing block 62 and the cushion block 64 not only provides good fixing effect, but also absorbs a certain amount of vibration and impact due to the porous structure of the sponge, reducing damage to the samples.

[0032] A sealing ring made of rubber is arranged between the box cover 12 and the opening of the box 1; in this embodiment, the rubber has elasticity and sealing performance, which can tightly fit the contact surface of the box cover 12 and the box 1, effectively prevent the intrusion of external air and moisture, and maintain the dry and stable environmental conditions in the box;

[0033] As shown in Figure 1 , 2As shown, handles 2 are installed at both ends of the box body 1 through bolts for carrying the entire box; a handle 51 is integrally formed on the top of the support plate 5 for removing the support plate 5 from the box body 1 as a whole; in this embodiment, the handles 2 are installed at both ends of the box body 1 through bolts, and their positions and shapes conform to ergonomic principles, making it convenient for users to carry the transfer box in a comfortable posture; the handles 51 are integrally formed with the support plate 5, ensuring stability and reliability during operation;

[0034] like Figure 1 As shown, an observation window 11 is provided on the outer wall of the box body 1, and a transparent acrylic plate is embedded inside; it is used to observe the state of the sample; in this embodiment, the observation window 11 adopts a highly transparent acrylic plate, which can clearly observe the state of the sample in the box without affecting the temperature and environment in the box;

[0035] like Figure 1 As shown, a detection hole is opened on the outer wall of the box body 1, and an electronic thermometer 7 for displaying the real-time temperature inside the box is installed inside the detection hole; in this embodiment, the electronic thermometer 7 monitors the temperature inside the box in real time through a high-precision sensor and displays the data accurately, so that the user can understand the temperature changes in time and take corresponding measures.

[0036] The above shows and describes the basic principles, main features and advantages of the present invention. The various components mentioned in the present invention are common technologies in the existing field. Those skilled in the art should understand that the present invention is not limited to the above embodiments. The above embodiments and descriptions are merely illustrative of the principles of the present invention. Various changes and improvements may be made to the present invention without departing from the spirit and scope of the present invention. Such changes and improvements fall within the scope of the present invention. The scope of protection claimed in this utility model is defined by the appended claims and their equivalents.

Claims

1. A sample transport box for drug clinical trials, comprising a box body (1), a box cover (12) is arranged on the top of the box body (1), characterized in that: The inside of the box (1) is provided with a partition (3); the partition (3) and the bottom of the box (1) are provided with a compressor (4); the upper side of the partition (3) is provided with a constant temperature pipeline connected with the compressor (4); the upper side of the partition (3) is further provided with a support plate (5); the support plate (5) is movably installed on the inner side wall of the box (1); a plurality of mounting holes in rectangular array are formed in the inside of the support plate (5), and the mounting holes are all provided with fixing assemblies (6) for fixing samples; the constant temperature pipeline can act on the fixing assemblies (6) to keep the temperature around the samples constant.

2. The sample transport case for clinical trials of a drug according to claim 1, characterized by The constant temperature pipeline comprises spiral pipes (41), first branch pipes (42), second branch pipes (43), output pipes (44) and input pipes (45); the same number of spiral pipes (41) are arranged on the upper side of the partition (3) corresponding to the fixing assemblies (6); one end of the spiral pipes (41) in the same row is connected to the first branch pipes (42), and the first branch pipes (42) are in communication with each other; one end of the first branch pipes (42) is connected to the input pipes (45), and the other end of the input pipes (45) is connected to the input end of the compressor (4); the other end of the spiral pipes (41) in the same row is connected to the second branch pipes (43), and the second branch pipes (43) are in communication with each other; one end of the second branch pipes (43) is connected to the output pipes (44), and the other end of the output pipes (44) is connected to the output end of the compressor (4); the inner ring of the spiral pipe (41) is wrapped outside the fixing assembly (6).

3. The sample transport case for clinical trials of a drug according to claim 2, characterized by The partition (3) and the support plate (5) are filled with thermal insulation cotton, which avoids filling the space in the ring of the spiral pipe (41).

4. The sample transport case for clinical trials of a drug according to claim 2, characterized by The fixing assembly (6) comprises a constant temperature cylinder (61), a fixing block (62), a fixing hole (63) and a cushion block (64); the constant temperature cylinder (61) is made of stainless steel; the constant temperature cylinder (61) is arranged in the mounting hole formed in the inside of the support plate (5), and the top of the constant temperature cylinder (61) is provided with a flange clamped outside the mounting hole; the inside bottom of the constant temperature cylinder (61) is provided with the cushion block (64); the inner side wall of the constant temperature cylinder (61) is fixedly connected with the fixing block (62); the inside of the fixing block (62) is provided with the fixing hole (63).

5. The sample transport case for clinical trials of a drug according to claim 4, characterized by The fixing block (62) and the cushion block (64) are both made of sponge material.

6. The sample transport case for clinical trials of a drug according to claim 1, characterized by A sealing ring made of rubber is arranged between the box cover (12) and the opening of the box (1).

7. The sample transport case for clinical trials of a drug according to claim 1, characterized by Bolts are arranged at both ends of the box (1) to install handles (2) for overall carrying.

8. The sample transport case for clinical trials of a drug according to claim 1, characterized by An observation window (11) is formed in the outer side wall of the box (1), and a transparent acrylic plate is inlaid in the inside of the observation window (11); the observation window (11) is used for observing the state of the samples.

9. The sample transport case for clinical trials of a drug according to claim 1, characterized by A handle (51) is integrally formed on the top of the support plate (5) for taking out the support plate (5) from the box (1) as a whole.

10. The sample transport case for clinical trials of a drug according to claim 1, characterized by An detection hole is formed in the outer side wall of the box (1), and an electronic thermometer (7) for displaying the real-time temperature in the box is arranged in the detection hole.

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