Ophthalmic disease animal model experiment device

Abstract

The utility model provides an ophthalmic disease animal model experiment device. The ophthalmic disease animal model experiment device comprises a cabin body, a cabin door and a sliding bottom plate, the cabin body comprises a cabin body frame and an operation cavity, the cabin door is arranged between the cabin body frame and the operation cavity, a bottom plate opening is formed in the side face of the cabin body, and the sliding bottom plate is arranged at the bottom of the inner side of the operation cavity and extends out of the operation cavity from the bottom plate opening. An operation hole is further formed in the cabin body, the eye position of the animal model can be adjusted by pulling the sliding bottom plate at the bottom of the cabin body during use, and the eye of the animal model is subjected to medicine supply treatment by using an eye speculum through the operation hole.

Description

Technical Field

[0001] This utility model relates to the technical field of medical animal experimental devices, and more particularly to an experimental device for an animal model of ophthalmic diseases. Background Art

[0002] Ophthalmic disease models mainly include humanized mouse models and gene-edited mouse models. These models simulate the occurrence and development of human ophthalmic diseases, providing important support for research on the pathogenesis of ophthalmic diseases, drug target research, and evaluation of treatment effects. Experimental animals are selected according to experimental needs and divided into multiple experimental groups and a control group. Based on ocular data obtained from regular eye examinations of the experimental groups, the animal experimental model is determined, and the eyeballs of the animal experimental model are analyzed to obtain experimental results. In current experiments, mice are mainly handled by the experimenter to administer drugs to the eyes or observe symptoms. Different mice exhibit different stress responses when resisting handling, causing varying degrees of stimulation, interfering with the disease progression, or causing harm, thus affecting the comparability or accuracy of experimental results. Therefore, there is an urgent need for a device to solve the above problems in ophthalmic animal model experiments. Summary of the Invention

[0003] In view of the above-mentioned deficiencies of the prior art, the purpose of this utility model is to provide an experimental device for an animal model of ophthalmic diseases, so as to reduce the impact of the aforementioned problems on the experimental results.

[0004] The experimental device for animal models of ophthalmic diseases of this utility model includes a chamber, a door, and a sliding base plate;

[0005] The cabin includes a cabin frame and an operating cavity, and the cabin door is disposed between the cabin frame and the operating cavity; the cabin includes a bottom plate opening, and the sliding bottom plate is disposed at the bottom of the inner side of the operating cavity and extends from the bottom plate opening to the outside of the operating cavity; the cabin also includes at least one operating hole.

[0006] As an optional solution for an animal model experimental device for ophthalmic diseases, a groove is provided at the connection between the cabin frame and the operating cavity, and the bottom of the groove is lower than the inner bottom surface of the operating cavity.

[0007] As an optional design for an animal model experimental device for ophthalmic diseases, the operating cavity is provided with a slide rail groove at the end of the side wall opposite to the hatch, and a slide rail strip is provided at the position corresponding to the slide rail groove of the hatch, with the slide rail strip matching the slide rail groove.

[0008] As an optional design for an animal model experimental device for ophthalmic diseases, the slide rail can be single or multiple. When there are multiple slide rails, they are parallel to each other.

[0009] As an optional embodiment of the experimental device for animal models of ophthalmic diseases, the hatch also includes a hatch protrusion, which is located on the upper side of the hatch.

[0010] As an optional experimental device for animal models of ophthalmic diseases, the operating hole is located on the opposite wall of the chamber and the sliding base plate.

[0011] As an optional design for an animal model experimental device for ophthalmic diseases, the operating hole is located on the inner or outer wall of the chamber, and at least one side of the hole edge is chamfered.

[0012] As an optional embodiment of the experimental device for animal models of ophthalmic diseases, the experimental device for animal models of ophthalmic diseases also includes an anesthesia plug, which can be inserted into the operating port.

[0013] As an optional solution for an animal model experimental device for ophthalmic diseases, the chamber also includes a bottom plate limiting component, which is disposed on two opposite sides of the bottom of the chamber and matches the sliding bottom plate.

[0014] As an optional design for an animal model experimental device for ophthalmic diseases, the base plate limiting member and the opposite surface of the sliding base plate are provided with rollers or balls.

[0015] As an optional experimental device for animal models of ophthalmic diseases, the sliding base plate includes a base plate body and a base plate protrusion, wherein the base plate protrusion is located at one end of the base plate body that protrudes outside the opening of the base plate.

[0016] As an optional experimental device for animal models of ophthalmic diseases, the chamber is also equipped with partitions.

[0017] As an optional experimental device for animal models of ophthalmic diseases, the chamber is also equipped with an image acquisition device.

[0018] This utility model adopts the above technical solution, resulting in the following technical effects:

[0019] It can effectively solve the problem of adjusting the position of the animal model's eyes during animal model experiments for ophthalmic diseases by pulling the sliding bottom plate of the chamber. Users can use the eyelid opener through the operating hole to administer drugs and treat the animal model's eyes, or use other instruments for other treatments.

[0020] This invention relates to an experimental device for animal models of ophthalmic diseases. By further improving the operability of the sliding base plate or the degree of freedom of the eyelid opener in the operating hole, the combination of the two achieves controllability and consistency of the movements, avoiding harm to the experimental animals and reducing the impact of differences in experimental techniques on the experimental results.

[0021] This invention relates to an animal model experimental device for ophthalmic diseases. By improving the operability of the sliding base plate and combining it with an image acquisition device, it enables non-irritating observation of mouse symptoms and can upload the acquired image data to the system, facilitating the collection and comparison of experimental data. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of an experimental apparatus for an animal model of an ophthalmic disease according to an embodiment of the present invention;

[0023] Figure 2 This is a front view of an embodiment of the present invention; the operability of the plate, combined with the image acquisition device, enables non-stimulating observation of mouse symptoms, and can upload the acquired image data to the system, facilitating the collection and comparison of experimental data.

[0024] Figure 3 yes Figure 2 Schematic diagram along section AA in the main view;

[0025] Figure 4 yes Figure 2 A schematic diagram along the BB section of the main view.

[0026] Explanation of reference numerals in the attached figures:

[0027] 10-Canister body; 101-Canister frame; 102-Operating cavity; 103-Transfer groove; 104-Slide rail groove; 105-Operating hole; 106-Anesthetic plug; 107-Base plate limiting component; 108-Base plate opening; 20-Canister door; 201-Canister door protrusion; 202-Slide rail; 30-Sliding base plate; 301-Base plate main body; 302-Base plate protrusion; 40-Eyelid opener; 401-Operating handle; 402-Drip tube; 403-Eyelid opener finger. DETAILED DESCRIPTION

[0028] To make the purpose, technical solutions, and advantages of the embodiments of the present invention more clear, the technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the accompanying drawings of the embodiments of the present invention. Obviously, the described embodiments are only some embodiments of the present invention, not all embodiments. Generally, the components of the embodiments of the present invention described and shown in the drawings herein can be arranged and designed in various different configurations.

[0029] Therefore, the following detailed description of the embodiments of the present invention provided in the accompanying drawings is not intended to limit the scope of the claimed invention, but rather merely represents selected embodiments of the present invention. All other embodiments derived by persons of ordinary skill in the art based on the embodiments of the present invention without creative effort are also within the scope of protection of the present invention.

[0030] It should be noted that similar reference numerals and letters denote similar items in the following drawings, and therefore, once an item is defined in one drawing, it does not need to be further defined or explained in subsequent drawings.

[0031] In the description of this utility model, it should be noted that the terms "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, or the orientation or positional relationship commonly used when the product of this utility model is in use. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first," "second," and "third," etc., are used only to distinguish descriptions and should not be construed as indicating or implying relative importance. In the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0032] In this invention, unless otherwise explicitly specified and limited, "above" or "below" the second feature can include direct contact between the first and second features, or contact between the first and second features through another feature between them. Furthermore, "above," "over," and "on top" of the second feature includes the first feature directly above or diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "below," and "under" the second feature includes the first feature directly below or diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0033] In the description of this utility model, it should also be noted that, unless otherwise explicitly specified and limited, the terms "set" and "connection" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0034] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0035] This embodiment provides an experimental apparatus for an animal model of an ophthalmic disease, which is described below in conjunction with... Figures 1 to 4The specific content of this embodiment is described in detail below. In this embodiment, the purpose of this utility model is to provide an experimental device for an animal model of ophthalmic diseases, including a chamber 10, a door 20, and a sliding base plate 30; the chamber 10 includes a chamber frame 101 and an operating cavity 102, with the door 20 disposed between the chamber frame 101 and the operating cavity 102; the chamber 10 includes a base plate opening 108, and the sliding base plate 30 is disposed at the bottom inner side of the operating cavity 102 and extends from the base plate opening 108 to the outside of the operating cavity 102; the chamber 10 also includes at least one operating hole 105.

[0036] When using the device, the mouse can be anesthetized by dripping anesthetic into the operating port 105. After the mouse is anesthetized, the animal model's eyes can be adjusted to a suitable position by pulling the sliding base plate 30 at the bottom of the chamber, and the eyelid opener can be used to administer medication to the animal model's eyes through the operating port.

[0037] Specifically, the operating cavity 102 is made of transparent material or has an observation window to facilitate observation and execution of operating actions.

[0038] The eyelid opener 40 includes an operating handle 401, a drip tube 402, and an eyelid opening finger 403. In use, the operator inserts the eyelid opener 40 into the operating cavity 102 through the operating hole 105, adjusts the animal model's eye to a suitable position by pulling the sliding base plate 30 at the bottom of the chamber, controls the eyelid opening finger 403 to open the mouse's eyelid through the operating handle 401, and drips the medication into the mouse's eye through the drip tube 402.

[0039] In another optional embodiment, a pass groove 103 is provided at the connection between the cabin frame 101 and the operating cavity 102, and the bottom of the pass groove 103 is lower than the inner bottom surface of the operating cavity 102.

[0040] The placement of the slot 103 can prevent the mouse from lifting the hatch 20, thus preventing the mouse from escaping.

[0041] In another optional embodiment, a slide rail groove 104 is provided on the side wall end of the operating cavity 102 opposite to the hatch 20, and a slide rail 202 is provided on the hatch 20 at the position corresponding to the slide rail groove 104. The slide rail 202 on the hatch 20 matches the slide rail groove 104 on the side wall end of the operating cavity 102 and can slide relative to each other.

[0042] There can be one or more slide rails 202. When there are multiple slide rails 202, the slide rails are parallel to each other.

[0043] The slide rail 202 on the hatch 20 matches the slide rail groove 104 at the end of the side wall of the operating cavity 102. On the one hand, it can prevent the hatch 20 from sliding laterally, and on the other hand, it can reduce the friction between the slide rail 202 and the slide rail groove 104, thus better controlling the opening size of the hatch.

[0044] In another alternative embodiment, the hatch 20 further includes a hatch protrusion 201 disposed on the upper side of the hatch 20. The hatch protrusion 201 can provide a user with a grip to facilitate the operation and adjustment of the opening or closing of the hatch 20.

[0045] In another alternative embodiment, the operating hole 105 is located on the opposite wall of the chamber 10 and the sliding base plate 30. The operating hole 105 can be used to instill anesthetic or insert an eyelid speculum, facilitating procedures such as eye drops on mice.

[0046] In another optional embodiment, the operating hole 105 has a chamfer on at least one side of the hole edge on the inner or outer wall of the chamber. Specifically, the inner or outer wall refers to the inner or outer side wall of the chamber wall, i.e., the hole edge forms an inner or outer chamfer. The chamfer provides a larger angle adjustment space for the use of the eyelid opener. The user can use the operating hole as the apex to rotate and adjust the eyelid opener in a cone shape. With the adjustment of the sliding base plate 30, the position of the mouse's eye inside the chamber can be fully covered.

[0047] In another optional embodiment, the ophthalmic animal model experimental device further includes an anesthesia plug 106, which can be inserted into the operating port 105. The anesthesia plug 106 can temporarily block the operating port after the anesthetic is instilled, reducing gas convection or anesthetic spillage within the chamber, thereby achieving a better anesthetic effect.

[0048] In another optional embodiment, the cabin 10 further includes a bottom plate limiting member 107, which is disposed on two opposite sides of the bottom of the cabin 10 and matches the sliding bottom plate 30. The bottom plate limiting member 107 can ensure that the sliding bottom plate 30 maintains linear movement during sliding, avoiding deviation during sliding and thus preventing a jerky feeling during sliding.

[0049] In another optional embodiment, the base plate limiting member 107 is provided with rollers or balls on the opposite side of the sliding base plate 30. The rollers or balls can further reduce the resistance of the sliding base plate 30 during sliding, improving the feel and precision of operation.

[0050] In another optional embodiment, the sliding base plate 30 includes a base plate body 301 and a base plate protrusion 302, the base plate protrusion 302 being disposed at the end of the base plate body 301 that protrudes outside the base plate opening 108. The base plate protrusion 302 allows the user to easily adjust the position of the sliding base plate 30.

[0051] In another optional embodiment, the cabin 10 is further provided with a partition (not shown). The partition inside the cabin allows multiple mice to be managed simultaneously and to be numbered for management.

[0052] In another optional embodiment, an image acquisition device (not shown) is installed inside the chamber 10. This image acquisition device, combined with a sliding base plate, enables non-stimulating observation of mouse symptoms and can upload the acquired image data to the system, facilitating the collection and comparison of experimental data. Furthermore, the system can aggregate real-time video information of mice in multiple experimental chambers through a backend system.

[0053] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating the present utility model, and are not intended to limit the implementation of the present utility model. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. Any modifications—equivalent substitutions and improvements—made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.

Claims

1. An experimental apparatus for an animal model of an ophthalmic disease, characterized in that, Includes a cabin (10), a hatch (20), and a sliding floor (30); The cabin (10) includes a cabin frame (101) and an operating cavity (102), and the cabin door (20) is disposed between the cabin frame (101) and the operating cavity (102); the cabin (10) includes a bottom plate opening (108), and the sliding bottom plate (30) is disposed at the bottom inside the operating cavity (102) and extends from the bottom plate opening (108) to the outside of the operating cavity (102); the cabin (10) also includes at least one operating hole (105).

2. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The connection between the cabin frame (101) and the operating cavity (102) is provided with a pass groove (103), the bottom of which is lower than the inner bottom surface of the operating cavity (102).

3. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The operating cavity (102) is provided with a slide rail groove (104) at the side wall end opposite to the hatch (20), and a slide rail strip (202) is provided at the position corresponding to the slide rail groove (104) of the hatch (20), and the slide rail strip (202) matches the slide rail groove (104).

4. The experimental apparatus for animal models of ophthalmic diseases according to claim 3, characterized in that, The hatch (20) also includes a hatch protrusion (201), which is disposed on the upper side of the hatch (20).

5. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The operating hole (105) is located on the bulkhead of the cabin (10) opposite to the sliding base plate (30).

6. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The operating hole (105) is located on the inner or outer wall of the cabin (10), and at least one side of the hole edge is chamfered.

7. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The ophthalmic animal model experimental device also includes an anesthesia plug (106), which can be inserted into the operation hole (105).

8. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The cabin (10) also includes a bottom plate limiting member (107), which is disposed on two opposite sides of the bottom of the cabin (10) and matches the sliding bottom plate (30).

9. The experimental apparatus for animal models of ophthalmic diseases according to claim 8, characterized in that, The bottom plate limiting member (107) and the sliding bottom plate (30) are provided with rollers or balls on their opposite sides.

10. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The sliding base plate (30) includes a base plate body (301) and a base plate protrusion (302), wherein the base plate protrusion (302) is disposed at one end of the base plate body (301) that protrudes outside the base plate opening (108).

11. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, The cabin (10) is also equipped with a partition.

12. The experimental apparatus for animal models of ophthalmic diseases according to claim 1, characterized in that, An image acquisition device is installed inside the cabin (10).

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