Immunological sterile cell culture device

Abstract

The utility model relates to the technical field of cell culture, and discloses an immunological sterile cell culture device which comprises a base and a mounting ring arranged above the base, a first loading block is arranged in the mounting ring, a plurality of loading holes are formed in the first loading block, cell culture tubes are arranged in the loading holes in a sliding and penetrating mode, a mounting frame is arranged below the mounting ring, and the cell culture tubes are arranged in the mounting frame. A second loading block is arranged in the mounting frame, a plurality of loading grooves corresponding to the cell culture tubes are formed in the side, close to the first loading block, of the second loading block, and the bottoms of the cell culture tubes are inserted into the adjacent loading grooves in a sliding mode. The device is reasonable in structure, convenient to use and wide in application range, the opening of the cell culture tube can be integrally closed and opened, researchers can conveniently take the cell culture tube, and the device can be adaptively regulated and controlled.

Description

Technical Field

[0001] This utility model relates to the field of cell culture technology, and in particular to an immunological sterile cell culture device. Background Technology

[0002] Cell culture is a technique that mimics the in vivo environment, allowing cells to grow and multiply in an artificially controlled setting. By culturing specific cells, researchers can study disease mechanisms and screen for drugs.

[0003] Cell culture requires the use of appropriate cell culture tubes. While existing cell culture tubes can culture cells, researchers need to open and close the openings of each tube individually, which is time-consuming, labor-intensive, cumbersome, and inconvenient. To address this, we propose an immunological sterile cell culture device. Utility Model Content

[0004] To address the technical problem that existing cell culture tubes are inconvenient to use, this invention provides an immunological sterile cell culture device.

[0005] This utility model is achieved using the following technical solution: an immunological sterile cell culture device, comprising a base and a mounting ring disposed above the base. The mounting ring contains a loading block I with multiple loading holes. Cell culture tubes are slidably inserted through the loading holes. A mounting frame is located below the mounting ring, and a loading block II is located inside the mounting frame. The loading block II has multiple loading slots corresponding to the cell culture tubes on its side near the loading block I. The bottom of the cell culture tubes is slidably inserted into adjacent loading slots. A mounting hole is located in the middle of the loading block II. The internal sliding part is equipped with a drive column. One end of the drive column is fixed to the bottom of loading block one, and the other end of the drive column is rotatably connected to the top side of the base. The base is equipped with a shielding component. When the cell culture tube is inserted into the loading hole, after the bottom of the cell culture tube enters the corresponding loading slot, the opening of the cell culture tube between loading block one and loading block two can be completely sealed by the operation of the shielding component. The rotation of the drive column drives loading block one to rotate, which in turn drives the cell culture tube and loading block two to rotate, thereby making it convenient for researchers to take the cell culture tube between loading block one and loading block two.

[0006] As a further improvement to the above solution, a drive sleeve is embedded at one end of the mounting frame, and a screw is threaded through the internal thread of the drive sleeve. One end of the screw is rotatably connected to the bottom side of the mounting ring, and a handle is fixed at the other end of the screw. Rotating the handle drives the screw to rotate. Through the threaded engagement between the screw and the drive sleeve, the drive sleeve and the mounting frame are displaced, causing the second loading block to move vertically. The distance between the second loading block and the first loading block can be adjusted.

[0007] As a further improvement to the above solution, support blocks are fixed at both ends of the bottom side of the mounting ring. The end of the support block away from the mounting ring is fixed to the top side of the base. Both loading block one and loading block two are circular blocks. An annular groove one is formed on the inner wall of the mounting ring. Multiple sliders one that slide inside the annular groove one are fixed on the outer wall of loading block one. An annular groove two is formed on the inner wall of the mounting frame. Multiple sliders two that slide inside the annular groove two are fixed on the outer wall of loading block two. The circular loading block one can rotate inside the mounting ring. The circular loading block two can rotate inside the mounting frame. The sliding cooperation between slider one and annular groove one can confine loading block one inside the mounting ring. The sliding cooperation between slider two and annular groove two can confine loading block two inside the mounting frame.

[0008] As a further improvement to the above solution, the shielding assembly includes a support column rotatably mounted on one end of the top side of the base. A shielding block for shielding the opening of the cell culture tube is provided above the mounting ring. A sliding hole is provided at the end of the shielding block near the support column, and the support column slidably passes through the sliding hole. A support sleeve is fixedly fitted onto the outer wall of the support column on the bottom side of the shielding block. Multiple positioning holes are provided on the shielding block, arranged circumferentially around the sliding hole. A positioning column fixed to the top side of the support sleeve slides through the interior of one of the positioning holes. The positioning column has a receiving groove, and the receiving groove slides inside. A sliding block is connected to the groove of the receiving slot, and a limiting block fixed on the sliding block slides through the groove. The limiting block located outside the receiving slot contacts the top side of the shielding block. A gear one is fixedly sleeved on the outer wall of the bottom of the drive column. A rack plate that meshes with the gear one is provided on one side of the gear one. A linkage block is fixed at one end of the rack plate. A hydraulic cylinder fixed to the top side of the base is provided on the side of the linkage block away from the rack plate. The piston end of the hydraulic cylinder is fixed on the linkage block. A gear two that meshes with the rack plate is fixedly sleeved on the outer wall of the bottom of the support column. Through the operation of the above components, researchers can easily disassemble the shielding block.

[0009] As a further improvement to the above solution, the diameter of the support sleeve is larger than the diameter of the sliding hole, and a rubber pad is provided on the top side of the support sleeve. The blocking block can be supported by the support sleeve with a diameter larger than the diameter of the sliding hole.

[0010] As a further improvement to the above solution, a plurality of push springs are fixed on the side of the sliding block away from the limiting block. The end of the push spring away from the sliding block is fixed on the inner wall of the receiving groove. The depth of the receiving groove is greater than the length of the limiting block. The limiting block can be stored in the receiving groove with a depth greater than the length of the limiting block.

[0011] As a further improvement to the above solution, a through hole is provided on the support block near the rack plate, and the rack plate slides inside the through hole. The through hole can prevent the support block from interfering with the displacement of the rack plate.

[0012] As a further improvement to the above solution, a guide hole is provided at the end of the mounting frame away from the screw, and a guide rod slides through the guide hole. One end of the guide rod is fixed to the bottom side of the mounting ring, and the other end of the guide rod is fixed to the top side of the base. Through the sliding cooperation of the guide hole and the guide rod, the displacement of the mounting frame can be limited, thereby improving the stability of the mounting frame.

[0013] Compared with the prior art, the beneficial effects of the present invention are:

[0014] This utility model, through the coordinated operation of a base, mounting ring, loading block one, mounting frame, loading block two, drive column, support block, drive sleeve, screw, guide rod, gear one, rack plate, linkage block, hydraulic cylinder, shielding block, support column, gear two, support sleeve, positioning column, positioning hole, receiving groove, push spring, and limiting block, can completely close and open the opening of cell culture tubes used by researchers. This avoids researchers having to open and close the opening of each cell culture tube individually, saving manpower and making it convenient for researchers to access cell culture tubes. It is easy to use and can be adaptively adjusted according to the length of the cell culture tubes, with a wide range of applications. The closing components can be easily and conveniently disassembled, allowing researchers to easily clean and disinfect the closing components.

[0015] In summary, this utility model has a reasonable structure, which can completely close and open the opening of the cell culture tube, making it convenient for researchers to access the cell culture tube. It also allows for adaptive adjustment of the device, making it easy to use and with a wide range of applications. Attached Figure Description

[0016] Figure 1 This is a schematic diagram of an immunological sterile cell culture device;

[0017] Figure 2 A cross-sectional view of an immunological sterile cell culture device;

[0018] Figure 3 A cross-sectional view of a ring installed in an immunological sterile cell culture device;

[0019] Figure 4for Figure 2 A schematic diagram of the structure enlarged in the middle;

[0020] Figure 5 This is a schematic diagram of a shielding block sealing a cell culture tube in an immunological sterile cell culture device;

[0021] Figure 6 for Figure 5 Enlarged structural diagram at point B.

[0022] Explanation of key symbols:

[0023] 1. Base; 2. Mounting ring; 3. Loading block one; 4. Cell culture tube; 5. Mounting frame; 6. Loading block two; 7. Drive column; 8. Support block; 9. Drive sleeve; 10. Screw; 11. Guide rod; 12. Gear one; 13. Rack plate; 14. Linkage block; 15. Hydraulic cylinder; 16. Blocking block; 17. Support column; 18. Gear two; 19. Support sleeve; 20. Positioning column; 21. Positioning hole; 22. Receiving groove; 23. Push spring; 24. Limiting block. Detailed Implementation

[0024] The present invention will be further described below with reference to the accompanying drawings and specific embodiments. It should be noted that, without conflict, the various embodiments or technical features described below can be arbitrarily combined to form new embodiments.

[0025] Example 1:

[0026] Combination Figure 1 and Figure 2 An immunological sterile cell culture device according to this embodiment includes a base 1 and a mounting ring 2 disposed above the base 1. The mounting ring 2 has a loading block 3 inside, which rotates within the mounting ring 2. The loading block 3 has multiple loading holes, through which cell culture tubes 4 slide. A mounting frame 5 is disposed below the mounting ring 2, and a loading block 6 is disposed inside the mounting frame 5. The loading block 6 rotates within the mounting frame 5. Multiple loading slots corresponding to the cell culture tubes 4 are formed on the side of the loading block 6 near the loading block 3. The bottom of the cell culture tubes 4 slides into adjacent loading slots. A mounting hole is formed in the middle of the loading block 6, through which a drive column 7 slides. One end of the drive column 7 is fixed to the bottom of the loading block 3, and the other end of the drive column 7 is rotatably connected to the top side of the base 1. A shielding assembly is provided on the base 1.

[0027] The implementation principle of an immunological sterile cell culture device in this embodiment is as follows: When it is necessary to close the opening of the cell culture tube 4, the cell culture tube 4 can be inserted into the loading hole. After the bottom of the cell culture tube 4 enters the corresponding loading slot, the opening of the cell culture tube 4 between loading block 1 3 and loading block 2 6 can be completely closed by the operation of the shielding component, avoiding researchers from closing the opening of the cell culture tube 4 one by one. By rotating the drive column 7, loading block 1 3 can be rotated, which in turn drives the cell culture tube 4 and loading block 2 6 to rotate, thereby facilitating researchers to take the cell culture tube 4 between loading block 1 3 and loading block 2 6.

[0028] Example 2:

[0029] Combination Figure 3 Based on Embodiment 1, this embodiment is further improved in that: a drive sleeve 9 is embedded at one end of the mounting frame 5, and a screw 10 is threaded through the internal thread of the drive sleeve 9. One end of the screw 10 is rotatably connected to the bottom side of the mounting ring 2, and a handle is fixed at the other end of the screw 10. By rotating the handle, the screw 10 is driven to rotate. Through the threaded engagement between the screw 10 and the drive sleeve 9, the drive sleeve 9 and the mounting frame 5 can be displaced, and the second loading block 6 can be vertically displaced. At this time, the distance between the second loading block 6 and the first loading block 3 can be adjusted.

[0030] Support blocks 8 are fixed at both ends of the bottom side of the mounting ring 2. The end of the support block 8 away from the mounting ring 2 is fixed to the top side of the base 1. Loading block 1 3 and loading block 2 6 are both circular blocks. The inner wall of the mounting ring 2 has an annular groove 1. The outer wall of loading block 1 3 has multiple sliders 1 that slide inside the annular groove 1. The inner wall of the mounting frame 5 has an annular groove 2. The outer wall of loading block 2 6 has multiple sliders 2 that slide inside the annular groove 2. The mounting ring 2 can be fixed above the base 1 by the support blocks 8. The circular loading block 1 3 can rotate inside the mounting ring 2. The circular loading block 2 6 can rotate inside the mounting frame 5. The sliding cooperation between slider 1 and annular groove 1 can limit loading block 1 3 inside the mounting ring 2. The sliding cooperation between slider 2 and annular groove 2 can limit loading block 2 6 inside the mounting frame 5.

[0031] Example 3:

[0032] Combination Figure 4 , Figure 5 and Figure 6This embodiment, based on Embodiment 1, further improves upon the following: the shielding assembly includes a support column 17 rotatably mounted on one end of the top side of the base 1; a shielding block 16 for shielding the opening of the cell culture tube 4 is provided above the mounting ring 2; a sliding hole is provided at one end of the shielding block 16 near the support column 17; the support column 17 slides through the sliding hole; a support sleeve 19 is fixedly fitted onto the outer wall of the support column 17 on the bottom side of the shielding block 16; a plurality of positioning holes 21 are provided on the shielding block 16 circumferentially arranged with the sliding hole as the center; a positioning column 20 fixed to the top side of the support sleeve 19 slides through the interior of one of the positioning holes 21; and the positioning column 20 has a receiving groove. 22. A sliding block is slidably connected inside the receiving groove 22. A limiting block 24 fixed on the sliding block slides through the groove of the receiving groove 22. The limiting block 24 located outside the receiving groove 22 contacts the top side of the blocking block 16. A gear 12 is fixedly sleeved on the outer wall of the bottom of the drive column 7. A rack plate 13 meshing with the gear 12 is provided on one side of the gear 12. A connecting block 14 is fixed to one end of the rack plate 13. A hydraulic cylinder 15 fixed to the top side of the base 1 is provided on the side of the connecting block 14 away from the rack plate 13. The piston end of the hydraulic cylinder 15 is fixed to the connecting block 14. A gear 2 18 meshing with the rack plate 13 is fixedly sleeved on the outer wall of the bottom of the support column 17. The operation of hydraulic cylinder 15 causes the connecting block 14 to move, which in turn causes the rack plate 13 to move towards gear 12. When the rack plate 13 meshes with gear 12, the displaced rack plate 13 can drive gear 12 and drive column 7 to rotate. The operation of hydraulic cylinder 15 also causes the connecting block 14 to move, which in turn causes the rack plate 13 to move towards gear 18. When the rack plate 13 meshes with gear 18, the displaced rack plate 13 can drive gear 18 and support column 17 to rotate, which in turn drives support sleeve 19 to rotate, and drives positioning column 20 on support sleeve 19 to rotate. The engagement of the hole 21 allows the shielding block 16 to rotate, thus sealing the opening of the cell culture tube 4. When the shielding block 16 needs to be disassembled for cleaning, the limiting block 24 can be pressed to move it. After the limiting block 24 enters the receiving groove 22 and separates from the shielding block 16, the shielding block 16 can be pulled. Through the sliding hole on the shielding block 16 and the sliding engagement of the support column 17, the shielding block 16 can be moved vertically. After the shielding block 16 separates from the support column 17, it is removed from the device, and researchers can then clean and disinfect it.

[0033] The diameter of the support sleeve 19 is larger than the diameter of the sliding hole. A rubber pad is provided on the top side of the support sleeve 19. The shielding block 16 can be supported by the support sleeve 19, which has a diameter larger than the diameter of the sliding hole.

[0034] Multiple push springs 23 are fixed on the side of the sliding block away from the limiting block 24. The end of the push spring 23 away from the sliding block is fixed on the inner wall of the receiving groove 22. The depth of the receiving groove 22 is greater than the length of the limiting block 24. The limiting block 24 can be stored through the receiving groove 22, which is deeper than the length of the limiting block 24.

[0035] The support block 8 near the rack plate 13 has a through hole, and the rack plate 13 slides inside the through hole. The through hole can prevent the support block 8 from interfering with the displacement of the rack plate 13.

[0036] A guide hole is provided at the end of the mounting frame 5 away from the screw 10. A guide rod 11 slides through the guide hole. One end of the guide rod 11 is fixed to the bottom side of the mounting ring 2, and the other end of the guide rod 11 is fixed to the top side of the base 1. Through the sliding cooperation of the guide hole and the guide rod 11, the displacement of the mounting frame 5 can be limited, thereby improving the stability of the mounting frame 5.

[0037] Working principle: When it is necessary to close the opening of the cell culture tube 4, the cell culture tube 4 can be inserted into the loading hole. After the bottom of the cell culture tube 4 enters the corresponding loading groove, the operation of the hydraulic cylinder 15 drives the connecting block 14 to move, which in turn drives the rack plate 13 to move towards the gear 18. When the rack plate 13 meshes with the gear 18, the displaced rack plate 13 can drive the gear 18 and the support column 17 to rotate, thereby driving the support sleeve 19 to rotate and causing the support sleeve 19 to move upwards. The positioning post 20 rotates, and through the cooperation of the positioning post 20 and the positioning hole 21, the blocking block 16 can be rotated. The rotating blocking block 16 can completely seal the opening of the cell culture tube 4 on the mounting ring 2, avoiding researchers from sealing the opening of the cell culture tube 4 one by one. Through the operation of the hydraulic cylinder 15, the connecting block 14 is moved, which in turn moves the rack plate 13 toward the gear 12. When the rack plate 13 meshes with the gear 12, the displaced rack plate 13 can drive the gear 12. Wheel 12 and drive column 7 rotate, which in turn rotates loading block 3, loading block 6, and cell culture tube 4, facilitating researchers' access to the cell culture tube 4 between loading block 3 and loading block 6. Turning the handle rotates screw 10, which, through the threaded engagement between screw 10 and drive sleeve 9, displaces drive sleeve 9 and mounting frame 5, causing loading block 6 to move vertically. This allows for adjustment of the distance between loading block 6 and loading block 3. When the shielding block 16 needs to be disassembled and cleaned, the limiting block 24 can be pressed to move the limiting block 24. After the limiting block 24 enters the receiving groove 22, the limiting block 24 separates from the shielding block 16. The shielding block 16 can then be pulled. Through the sliding hole on the shielding block 16 and the sliding cooperation of the support column 17, the shielding block 16 can be moved vertically. After the shielding block 16 separates from the support column 17, the shielding block 16 is removed from the device. At this time, the researchers can clean and disinfect the shielding block 16.

[0038] The above-mentioned embodiments are only preferred embodiments of the present invention and cannot be used to limit the scope of protection of the present invention. Any non-substantial changes and replacements made by technicians in this field on the basis of the present invention fall within the scope of protection required by the present invention.

Claims

1. An immunological sterile cell culture device, comprising a base and a mounting ring disposed above the base, characterized in that, The mounting ring has a loading block one inside, which has multiple loading holes. Cell culture tubes slide through the loading holes. The mounting ring has a mounting frame below it, and the mounting frame has a loading block two inside it. The loading block two has multiple loading slots corresponding to the cell culture tubes on the side near the loading block one. The bottom of the cell culture tubes slides into the adjacent loading slots. The loading block two has a mounting hole in the middle, and a drive column slides through the mounting hole. One end of the drive column is fixed to the bottom of the loading block one, and the other end of the drive column is rotatably connected to the top side of the base. The base has a shielding component.

2. The immunological sterile cell culture device as described in claim 1, characterized in that, A drive sleeve is fitted at one end of the mounting frame, and a screw rod is threaded through the internal threads of the drive sleeve. One end of the screw rod is rotatably connected to the bottom side of the mounting ring, and a handle is fixed at the other end of the screw rod.

3. The immunological sterile cell culture device as described in claim 1, characterized in that, Support blocks are fixed at both ends of the bottom side of the mounting ring. The end of the support block away from the mounting ring is fixed to the top side of the base. Loading block one and loading block two are both circular blocks. An annular groove one is opened on the inner wall of the mounting ring. Multiple sliders one that slide inside the annular groove one are fixed on the outer wall of loading block one. An annular groove two is opened on the inner wall of the mounting frame. Multiple sliders two that slide inside the annular groove two are fixed on the outer wall of loading block two.

4. The immunological sterile cell culture device as described in claim 1, characterized in that, The shielding assembly includes a support column rotatably mounted on one end of the top side of the base. Above the mounting ring is a shielding block for shielding the opening of the cell culture tube. A sliding hole is formed at the end of the shielding block near the support column, and the support column slidably passes through the sliding hole. A support sleeve is fixedly fitted onto the outer wall of the support column on the bottom side of the shielding block. Multiple positioning holes are formed on the shielding block, arranged circumferentially around the sliding hole. A positioning column, fixed to the top side of the support sleeve, slidably passes through the interior of one of the positioning holes. The positioning column has a receiving groove. The groove has a sliding block inside, and a limiting block fixed on the sliding block slides through the groove opening. The limiting block located outside the groove contacts the top side of the blocking block. A gear one is fixedly sleeved on the outer wall of the bottom of the drive column. A rack plate meshing with the gear one is provided on one side of the gear one. A linkage block is fixed on one end of the rack plate. A hydraulic cylinder fixed on the top side of the base is provided on the side of the linkage block away from the rack plate. The piston end of the hydraulic cylinder is fixed on the linkage block. A gear two meshing with the rack plate is fixedly sleeved on the outer wall of the bottom of the support column.

5. The immunological sterile cell culture device as described in claim 4, characterized in that, The diameter of the support sleeve is larger than the diameter of the sliding hole, and a rubber pad is provided on the top side of the support sleeve.

6. The immunological sterile cell culture device as described in claim 4, characterized in that, Multiple push springs are fixed to the side of the sliding block away from the limiting block. The end of the push spring away from the sliding block is fixed to the inner wall of the receiving groove. The depth of the receiving groove is greater than the length of the limiting block.

7. An immunological sterile cell culture device as described in claim 4, characterized in that, A through hole is provided in the support block near the rack plate, and the rack plate slides inside the through hole.

8. An immunological sterile cell culture device as described in claim 2, characterized in that, The mounting frame has a guide hole at one end away from the screw, and a guide rod slides through the guide hole. One end of the guide rod is fixed to the bottom side of the mounting ring, and the other end of the guide rod is fixed to the top side of the base.

Images