Analyzer

Abstract

The utility model relates to the technical field of sample analysis, and particularly discloses an analyzer which is characterized in that a first valve body is at least provided with eight interfaces and at least has a sample loading state and an analysis state; two ends of the quantitative ring are respectively communicated with one interface; the two ends of the analytical column are respectively communicated with one interface, and the injector, the sampling needle, the detector and the pump are respectively communicated with one interface; when the first valve body is in a sample loading state, the sampling needle, the quantitative ring and the injector are communicated in sequence; the pump, the analytical column and the detector are communicated in sequence; when the first valve body is in an analysis state, the pump, the quantitative loop, the analytical column and the detector are sequentially communicated; the injector is communicated with the sampling needle; when the first valve body is in the sample loading state and the analysis state, the flow directions of liquid flowing through the analysis column are opposite. The arrangement does not need to replace the analytical column and does not need to arrange a filter, so that the production and use cost is greatly saved.

Description

Technical Field

[0001] This utility model relates to the field of sample analysis technology, and in particular to an analyzer. Background Technology

[0002] A glycated hemoglobin (HbA1c) analyzer is an instrument that best reflects the degree to which hemoglobin binds to glucose. HbA1c is a good indicator of the degree of disease control in diabetic patients and can reflect blood glucose levels at different stages. HbA1c analyzers are widely used in clinical practice.

[0003] The main cost of using a glycated hemoglobin analyzer is the analytical column. Therefore, modern glycated hemoglobin analyzers add a pre-filter to the front end of the analytical column to protect the column, extend the chromatography life, and reduce the cost of consumables.

[0004] However, after a certain amount of sample analysis is completed, the filter needs to be replaced to ensure analytical efficiency. Frequent filter replacements increase operating costs. In addition, since the filter can only filter large impurities, small impurities can pass through the filter and accumulate at the front end of the analytical column, which has a packing particle size of micrometers. During sample loading and analysis, the liquid flow direction through the analytical column is consistent, causing impurities in the sample to continuously accumulate at the front end of the analytical column. Over time, this leads to a continuous increase in column pressure, reduced column efficiency, severe peak tailing, and the end of the analytical column's lifespan, thus requiring column replacement and increasing operating costs.

[0005] Therefore, there is an urgent need to develop an analyzer to solve the above problems. Utility Model Content

[0006] The purpose of this invention is to provide an analyzer that solves the problem of high operating costs caused by the frequent replacement of filters and analytical columns in the prior art.

[0007] To achieve the above objectives, the present invention adopts the following technical solution:

[0008] The analyzer includes a first valve body, a syringe, a quantitative loop, a sampling needle, an analytical column, a detector, and a pump, wherein the first valve body has at least eight interfaces and at least a sample loading state and an analytical state;

[0009] Each end of the quantitative loop is connected to an interface; each end of the analytical column is connected to an interface; and the syringe, sampling needle, detector, and pump are each connected to an interface.

[0010] When the first valve body is in the sample loading state, the sampling needle, quantitative loop, and syringe are connected in sequence; and the pump, analytical column, and detector are connected in sequence.

[0011] When the first valve body is in the analysis state, the pump, metering loop, analytical column, and detector are connected in sequence; and the syringe and sampling needle are connected.

[0012] When the first valve body is in the sample loading state and the analysis state, the liquid flowing through the analytical column flows in opposite directions.

[0013] As an optional technical solution for the analyzer, the first valve body is a two-position eight-way valve, which has a first port, a second port, a third port, a fourth port, a fifth port, a sixth port, a seventh port, and an eighth port arranged sequentially; one end of the quantitative loop is connected to the second port, and the other end is connected to the seventh port; the syringe is connected to the eighth port; the sampling needle is connected to the first port; one end of the analytical column is connected to the third port, and the other end is connected to the fifth port; the detection inlet of the detector is connected to the fourth port; and the outlet of the pump is connected to the sixth port.

[0014] When the two-position eight-way valve is in the sample loading state, the first and second ports are internally connected, the third and fourth ports are internally connected, the fifth and sixth ports are internally connected, and the seventh and eighth ports are internally connected.

[0015] When the two-position eight-way valve is in the analysis state, the second and third ports are internally connected, the fourth and fifth ports are internally connected, the sixth and seventh ports are internally connected, and the eighth port is internally connected to the first port.

[0016] As an optional technical solution for the analyzer, the analyzer further includes a second valve body and a first container. The first container is used to contain rinsing fluid. The syringe and the first container are each connected to one interface of the second valve body. The third interface of the second valve body is connected to the first valve body, so that the syringe can draw up the rinsing fluid and inject the rinsing fluid into the first valve body and the sampling needle.

[0017] As an optional technical solution for the analyzer, the second valve body is a two-position three-way valve. When the second valve body is in the suction state, the syringe and the first container are connected. When the second valve body is in the injection state, the syringe and the first valve body are connected.

[0018] As an optional technical solution for the analyzer, the rinsing solution is a hemolytic agent.

[0019] As an optional technical solution for the analyzer, the analyzer further includes a third valve body and a second container, the second container being used to contain the first reagent, and the third valve body being connected in series between the pump inlet and the second container.

[0020] As an optional technical solution for the analyzer, the analyzer further includes a third container for containing a second reagent, and the third container and the second container are selectively connected to the pump via the third valve body.

[0021] As an optional technical solution for the analyzer, the third valve body is a two-position three-way valve. When the third valve body is in the first state, the second container and the inlet of the pump are connected. When the third valve body is in the second state, the third container and the inlet of the pump are connected.

[0022] As an optional technical solution for the analyzer, the analyzer also includes a waste liquid collection container, which is used to collect waste liquid and is connected to the waste liquid outlet of the detector.

[0023] As an optional technical solution for the analyzer, the pump is an electric constant flow pump; and / or,

[0024] The syringe is an electric syringe.

[0025] The beneficial effects of this utility model are as follows:

[0026] This invention provides an analyzer comprising a first valve body, a syringe, a quantitative loop, a sampling needle, an analytical column, a detector, and a pump. The first valve body has at least eight ports and can be configured for at least two states: a sample loading state and an analytical state. When the first valve body is in the sample loading state, the sampling needle, quantitative loop, and syringe are sequentially connected, as are the pump, analytical column, and detector. When the first valve body is in the analytical state, the pump, quantitative loop, analytical column, and detector are sequentially connected, as are the syringe and sampling needle. In the sample loading and analytical states, the liquid flowing through the analytical column flows in opposite directions. This allows the analyzer to backflush the analytical column during the sample loading process, removing impurities accumulated at the front end of the analytical column from the previous analysis. This ensures that the front end of the analytical column remains clean, guaranteeing the smooth flow of liquid through the analytical column and the reliability of the test results in subsequent analyses. Furthermore, it eliminates the need to replace the analytical column or install filters, significantly reducing production and operating costs. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the analyzer in an embodiment of the present invention, showing the first valve body in the sample loading state;

[0028] Figure 2 This is a schematic diagram of the analyzer in an embodiment of the present invention, with the first valve body in the analysis state;

[0029] Figure 3 This is a schematic diagram of the structure of the first valve body in an embodiment of this utility model.

[0030] In the picture:

[0031] 100, First valve body; 110, First port; 120, Second port; 130, Third port; 140, Fourth port; 150, Fifth port; 160, Sixth port; 170, Seventh port; 180, Eighth port;

[0032] 200. Syringe; 210. Second valve body; 220. First container; 300. Metering loop; 400. Sampling needle; 500. Analytical column; 600. Detector; 610. Waste collection container; 700. Pump; 710. Third valve body; 720. Second container; 730. Third container. Detailed Implementation

[0033] The technical solution of this utility model will now be clearly and completely described with reference to the accompanying drawings. Obviously, the described embodiments are only some, not all, of the embodiments of this utility model. Based on the embodiments of this utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of this utility model.

[0034] In the description of this utility model, it should be noted that the terms "center," "upper," "lower," "left," "right," "vertical," "horizontal," "inner," and "outer," etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. They are used only for the convenience of describing this utility model and for simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation. Therefore, they should not be construed as limitations on this utility model. Furthermore, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance. The terms "first position" and "second position" refer to two different positions. Moreover, "above," "on top of," and "over" the first feature in relation to the second feature includes the first feature directly above and diagonally above the second feature, or simply indicates that the first feature is at a higher horizontal level than the second feature. "Below," "under," and "below" the first feature in relation to the second feature includes the first feature directly below and diagonally below the second feature, or simply indicates that the first feature is at a lower horizontal level than the second feature.

[0035] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model based on the specific circumstances.

[0036] The embodiments of this utility model are described in detail below. Examples of these embodiments are shown in the accompanying drawings, wherein the same or similar reference numerals denote the same or similar elements or elements having the same or similar functions throughout. The embodiments described below with reference to the accompanying drawings are exemplary and are only used to explain this utility model, and should not be construed as limiting this utility model.

[0037] like Figures 1 to 3 As shown, this embodiment provides an analyzer for sample analysis, saving on the production and usage costs of the analyzer. The sample can be glycated hemoglobin or other substances that can be analyzed by the analyzer.

[0038] The analyzer includes a first valve body 100, a syringe 200, a quantitative loop 300, a sampling needle 400, an analytical column 500, a detector 600, and a pump 700. The first valve body 100 has at least eight interfaces and at least two states: a sample loading state and an analytical state. Each end of the quantitative loop 300 is connected to one interface. Each end of the analytical column 500 is connected to one interface. The syringe 200, sampling needle 400, detector 600, and pump 700 are each connected to one interface. When the valve body 100 is in the sample loading state, the sampling needle 400, the quantitative loop 300, and the syringe 200 are connected in sequence; and the pump 700, the analytical column 500, and the detector 600 are connected in sequence. When the first valve body 100 is in the analytical state, the pump 700, the quantitative loop 300, the analytical column 500, and the detector 600 are connected in sequence; and the syringe 200 and the sampling needle 400 are connected. When the first valve body 100 is in the sample loading state and the analytical state, the liquid flowing through the analytical column 500 flows in opposite directions.

[0039] The analyzer operates in two phases: sample loading and analysis. During sample loading, the first valve body 100 is in the loading state, and the sampling needle 400, quantitative loop 300, and syringe 200 are sequentially connected; the pump 700, analytical column 500, and detector 600 are also sequentially connected. In other words, the sample passes sequentially through the sampling needle 400, quantitative loop 300, and syringe 200; simultaneously, the reagent, drawn by the pump 700, passes sequentially through the analytical column 500 and detector 600, flowing from the rear end to the front end of the analytical column 500.

[0040] During the analysis phase, the first valve body 100 is in the analytical state, and the pump 700, quantitative loop 300, analytical column 500, and detector 600 are sequentially connected; and the syringe 200 and sampling needle 400 are connected. In other words, under the action of the pump 700, the sample in the quantitative loop 300 passes sequentially through the analytical column 500 and the detector 600, flowing from the front end to the rear end of the analytical column 500; simultaneously, the rinsing solution, under the action of the syringe 200, can enter the sampling needle 400 after the first valve body 100.

[0041] With the above setup, the analyzer backflushes the analytical column 500 with reagents from pump 700 during each sample loading process. This removes impurities that accumulated at the tip of the analytical column 500 during the previous analysis, keeping the tip of the analytical column 500 clean at all times. This ensures the smooth flow of liquid through the analytical column 500 and the reliability of test results in subsequent analyses. It also eliminates the need to replace the analytical column 500 or install filters, greatly saving production and operating costs.

[0042] Of course, in some embodiments, a program can be set to backflush the analytical column 500 at any time to remove impurities at the tip of the analytical column 500.

[0043] The first valve body 100 is a two-position eight-way valve, which has a first port 110, a second port 120, a third port 130, a fourth port 140, a fifth port 150, a sixth port 160, a seventh port 170, and an eighth port 180 arranged sequentially. One end of the metering loop 300 is connected to the second port 120, and the other end is connected to the seventh port 170. The syringe 200 is connected to the eighth port 180. The sampling needle 400 is connected to the first port 110. One end of the analytical column 500 is connected to the third port 130, and the other end is connected to the fifth port 150. The detection inlet of the detector 600 is connected to the fourth port 110. 40; The outlet of pump 700 is connected to the sixth port 160; When the two-position eight-way valve is in the sample loading state, the first port 110 and the second port 120 are internally connected, the third port 130 and the fourth port 140 are internally connected, the fifth port 150 and the sixth port 160 are internally connected, and the seventh port 170 and the eighth port 180 are internally connected; When the two-position eight-way valve is in the analysis state, the second port 120 and the third port 130 are internally connected, the fourth port 140 and the fifth port 150 are internally connected, the sixth port 160 and the seventh port 170 are internally connected, and the eighth port 180 and the first port 110 are internally connected.

[0044] Specifically, during the sample loading stage, the first valve body 100 is in the sample loading state, and the sampling needle 400, the first interface 110, the second interface 120, the quantitative loop 300, the seventh interface 170, the eighth interface 180, and the syringe 200 are connected in sequence; the sample can pass through the sampling needle 400, the first interface 110, and the second interface 120 in sequence before entering the quantitative loop 300; at the same time, the pump 700, the sixth interface 160, the fifth interface 150, the analytical column 500, the third interface 130, the fourth interface 140, and the detector 600 are connected, and the reagent, under the extraction action of the pump 700, can pass through the pump 700, the sixth interface 160, the fifth interface 150, the analytical column 500, the third interface 130, the fourth interface 140, and the detector 600 in sequence, wherein the reagent flows from the rear end to the front end of the analytical column 500.

[0045] During the analysis phase, the first valve body 100 is in the analytical state, and the pump 700, the sixth port 160, the seventh port 170, the quantitative loop 300, the second port 120, the third port 130, the analytical column 500, the fifth port 150, the fourth port 140, and the detector 600 are connected in sequence. Under the action of the pump 700, the sample in the quantitative loop 300 passes through the second port 120, the third port 130, the analytical column 500, the fifth port 150, the fourth port 140, and the detector 600 in sequence, with the reagent flowing from the front end to the rear end of the analytical column 500. At the same time, the syringe 200, the eighth port 180, the first port 110, and the sampling needle 400 are connected, and under the action of the syringe 200, the rinsing solution can pass from the syringe 200 through the eighth port 180, the first port 110, and the sampling needle 400 in sequence.

[0046] To facilitate switching between the syringe 200's extraction and injection functions, the analyzer also includes a second valve body 210 and a first container 220. The first container 220 is used to hold the rinsing fluid. The syringe 200 and the first container 220 are each connected to one port of the second valve body 210. The third port of the second valve body 210 is connected to the first valve body 100, so that the syringe 200 can draw up the rinsing fluid and inject it into the first valve body 100 and the sampling needle 400. That is, the third port of the second valve body 210 is connected to the eighth port 180.

[0047] The second valve body 210 is a two-position three-way valve. When the second valve body 210 is in the aspiration state, the syringe 200 and the first container 220 are connected, allowing the rinsing fluid to be drawn into the syringe 200. When the second valve body 210 is in the injection state, the syringe 200 and the first valve body 100 are connected, allowing the rinsing fluid in the syringe 200 to be pushed out and sequentially pass through the two-position three-way valve, the eighth port 180, the first port 110, and the sampling needle 400. The second valve body 210 is an electrically operated valve, which improves the switching efficiency of the sample loading and analysis process.

[0048] In some embodiments, the rinsing solution is a hemolytic agent, which can thoroughly clean the inner walls of the quantitative loop 300 and the sampling needle 400, preventing residual sample in the quantitative loop 300 from affecting subsequent samples, i.e., avoiding cross-contamination.

[0049] To improve testing efficiency, in some embodiments, the analyzer further includes a third valve body 710 and a second container 720. The second container 720 is used to hold the first reagent, and the third valve body 710 is connected in series between the inlet of the pump 700 and the second container 720. The analyzer also includes a third container 730, which is used to hold the second reagent. The third container 730 and the second container 720 are selectively connected to the pump 700 through the third valve body 710. The two containers each hold two different reagents, allowing for the selective use of different reagents to correspond to different stages; alternatively, different reagents can be used in the same stage to complete a stepped cleaning of each part. The first reagent (reagent A in the figure) and the second reagent (reagent B in the figure) have different cleaning intensities, forming a gradient for better cleaning. Of course, in other embodiments, the first and second reagents can be the same, so that the second reagent is used only after the first reagent is depleted.

[0050] The third valve body 710 is a two-position three-way valve. When the third valve body 710 is in the first state, the inlet of the second container 720 and the pump 700 are connected. When the third valve body 710 is in the second state, the inlet of the third container 730 and the pump 700 are connected. The third valve body 710 is an electrically operated valve, which improves the switching efficiency of the sample loading and analysis processes.

[0051] To facilitate waste liquid collection, in some embodiments, the analyzer further includes a waste liquid collection container 610, which is used to collect waste liquid and is connected to the waste liquid outlet of the detector 600. This arrangement allows the first and / or second reagents used to clean the entire pathway to be collected during the sample loading stage, and the sample after analysis to be collected during the analysis stage.

[0052] In some embodiments, pump 700 is an electric constant flow pump. Syringe 200 is an electric syringe, specifically an electric high-pressure constant flow pump 700. The above configuration improves the automation of sample loading and analysis, thereby increasing experimental efficiency.

[0053] Obviously, the above embodiments of this utility model are merely examples for clearly illustrating the present utility model, and are not intended to limit the implementation of the present utility model. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of this utility model should be included within the protection scope of the claims of this utility model.

Claims

1. An analyzer, characterized in that, It includes a first valve body (100), a syringe (200), a quantitative loop (300), a sampling needle (400), an analytical column (500), a detector (600), and a pump (700), wherein the first valve body (100) has at least eight interfaces and at least has a sample loading state and an analytical state; The quantitative loop (300) is connected to an interface at both ends; the analytical column (500) is connected to an interface at both ends; and the syringe (200), sampling needle (400), detector (600) and pump (700) are each connected to an interface. When the first valve body (100) is in the sample loading state, the sampling needle (400), the quantitative loop (300) and the syringe (200) are connected in sequence; and the pump (700), the analytical column (500) and the detector (600) are connected in sequence. When the first valve body (100) is in the analysis state, the pump (700), quantitative loop (300), analytical column (500) and detector (600) are connected in sequence; and the syringe (200) and sampling needle (400) are connected. When the first valve body (100) is in the sample loading state and the analysis state, the liquid flowing through the analysis column (500) flows in opposite directions.

2. The analyzer according to claim 1, characterized in that, The first valve body (100) is a two-position eight-way valve, which has a first port (110), a second port (120), a third port (130), a fourth port (140), a fifth port (150), a sixth port (160), a seventh port (170), and an eighth port (180) arranged sequentially. One end of the quantitative loop (300) is connected to the second port (120), and the other end is connected to the seventh port (170). The syringe (200) is connected to the eighth port (180). The sampling needle (400) is connected to the first port (110). One end of the analytical column (500) is connected to the third port (130), and the other end is connected to the fifth port (150). The detection inlet of the detector (600) is connected to the fourth port (140). The outlet of the pump (700) is connected to the sixth port (160). When the two-position eight-way valve is in the sample loading state, the first port (110) and the second port (120) are internally connected, the third port (130) and the fourth port (140) are internally connected, the fifth port (150) and the sixth port (160) are internally connected, and the seventh port (170) and the eighth port (180) are internally connected. When the two-position eight-way valve is in the analysis state, the second port (120) and the third port (130) are internally connected, the fourth port (140) and the fifth port (150) are internally connected, the sixth port (160) and the seventh port (170) are internally connected, and the eighth port (180) and the first port (110) are internally connected.

3. The analyzer according to claim 1, characterized in that, The analyzer also includes a second valve body (210) and a first container (220), the first container (220) being used to contain rinsing fluid, the syringe (200) and the first container (220) being connected to one interface of the second valve body (210), and the third interface of the second valve body (210) being connected to the first valve body (100), so that the syringe (200) can draw up the rinsing fluid and inject the rinsing fluid into the first valve body (100) and the sampling needle (400).

4. The analyzer according to claim 3, characterized in that, The second valve body (210) is a two-position three-way valve. When the second valve body (210) is in the suction state, the syringe (200) and the first container (220) are connected. When the second valve body (210) is in the injection state, the syringe (200) and the first valve body (100) are connected.

5. The analyzer according to claim 3, characterized in that, The flushing solution is a hemolytic agent.

6. The analyzer according to claim 1, characterized in that, The analyzer also includes a third valve body (710) and a second container (720), the second container (720) being used to contain the first reagent, and the third valve body (710) being connected in series between the inlet of the pump (700) and the second container (720).

7. The analyzer according to claim 6, characterized in that, The analyzer also includes a third container (730) for containing a second reagent, and the third container (730) and the second container (720) are selectively connected to the pump (700) via the third valve body (710).

8. The analyzer according to claim 7, characterized in that, The third valve body (710) is a two-position three-way valve. When the third valve body (710) is in the first state, the second container (720) and the inlet of the pump (700) are connected. When the third valve body (710) is in the second state, the third container (730) and the inlet of the pump (700) are connected.

9. The analyzer according to any one of claims 1 to 8, characterized in that, The analyzer also includes a waste liquid collection container (610) for collecting waste liquid and connected to the waste liquid outlet of the detector (600).

10. The analyzer according to any one of claims 1 to 8, characterized in that, The pump (700) is an electric constant flow pump; and / or, The syringe (200) is an electric syringe.

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