Recycling device for urokinase eluent

Abstract

The utility model discloses a urokinase eluent recovery device which comprises a base, a mounting rack is arranged above the base, an elution tank is fixedly arranged on the base, four groups of symmetrically distributed liquid collecting tanks are arranged on the mounting rack, the liquid collecting tanks and the elution tank are correspondingly distributed, a mounting ring is arranged above the elution tank, and the mounting ring is arranged on the mounting rack. A mounting ring is arranged below the elution tank, a scraping rod is fixedly mounted on the mounting ring, the scraping rod is attached to the inner wall of the elution tank, a cleaning block is arranged on the scraping rod, the cleaning block is in sliding connection with the scraping rod, a rotating ring is arranged below the elution tank, a plurality of groups of annularly distributed bottom plates are arranged below the elution tank, and the plurality of groups of bottom plates are rotationally connected with the elution tank through mounting shafts; the multiple sets of annularly-distributed bottom plates are matched with the scraping rods and the cleaning blocks, so that complete cleaning of kieselguhr on the inner wall of the elution tank is achieved, and the situation that the next use of the eluent recovery device is affected due to the fact that residual kieselguhr cannot be completely cleaned is avoided.

Description

TECHNICAL FIELD

[0001] The utility model relates to urokinase preparation technical field, concretely is a kind of urokinase eluent recovery device. BACKGROUND

[0002] Urokinase is an enzyme protein isolated from healthy human urine or obtained from human kidney tissue culture, mainly used as thrombolytic drug, directly acting on endogenous fibrinolysis system, can catalyze the cleavage of plasminogen into fibrinolysin, in the extraction process of urokinase, fresh urine is collected and filtered, impurities are removed, urine is treated by sedimentation, then diatomite is used for adsorption, before adsorption, according to the certain proportion of acidified urine volume, neutral diatomite is added, and preliminary washing is carried out, under the condition of 5 DEG C, diatomite is allowed to adsorb urine for 1 hour, diatomite adsorbent is washed once using cold water under the condition of 5 DEG C, then using 0.02% ammonia water is washed, until washing liquid becomes clear from turbidity, then, 0.02% ammonia water and 0.1mL sodium chloride solution are used for washing again, when the water flowing out of diatomite column changes from clear to turbid, urokinase is collected.

[0003] The eluent recovery device used in the prior art does not have good cleaning measures for diatomite column, after eluent recovery is completed, part of diatomite cannot be completely cleaned, thereby affecting the next use of eluent recovery device, and various different stage liquids are generated during diatomite elution, the currently used recovery device does not have the function of corresponding classified recovery, so that different stage liquids are mixed together, the purity of eluent recovery and the preparation effect of urokinase are affected. TECHNICAL SOLUTION

[0004] The utility model aims at providing a kind of urokinase eluent recovery device to solve the problems raised in the above background.

[0005] To achieve the above object, the utility model provides the following technical scheme: a kind of urokinase eluent recovery device, including base, the base top is equipped with mounting bracket, the base is fixedly installed with elution tank, the mounting bracket is equipped with four groups of symmetrical distribution's liquid collecting tank, the liquid collecting tank is distributed with elution tank, the elution tank top is equipped with mounting ring, the mounting ring is fixedly installed with scraper rod, the scraper rod is attached to the inner wall of elution tank, the scraper rod is equipped with cleaning block, the cleaning block is slidably connected with scraper rod, the elution tank lower is equipped with swivel, the elution tank lower is equipped with multiple groups of annular distribution's bottom plate, multiple groups The bottom plate is rotatably connected with elution tank by mounting shaft.

[0006] As a further preferred of the technical scheme, the mounting ring is rotatably connected with the elution tank by bearing, a first gear ring is sleeved on the mounting ring, and a first driving wheel is arranged in the elution tank.

[0007] As a further preferred embodiment of the present application, the first driving wheel is rotatably connected to the elution tank through a rotating shaft, and the first driving wheel is meshingly connected to the first gear ring.

[0008] As a further preferred embodiment of the present application, the scraper rod is internally provided with a threaded rod, both ends of the threaded rod are respectively penetrated through the scraper rod and rotatably connected to the scraper rod, and the threaded rod is penetrated through the cleaning block and threadedly connected to the cleaning block.

[0009] As a further preferred embodiment of the present application, the rotating ring is rotatably connected to the elution tank through a bearing, a second gear ring is sleeved on the rotating ring, a second driving wheel is arranged below the elution tank, the second driving wheel is rotatably connected to the elution tank through a rotating shaft, and the second driving wheel is meshingly connected to the second gear ring.

[0010] As a further preferred embodiment of the present application, a plurality of second gear rings are sleeved on the mounting shafts, and the plurality of second gear rings are meshingly connected to the second gear ring.

[0011] As a further preferred embodiment of the present application, the mounting frame is rotatably connected to the base through a mounting rod, a first gear ring is sleeved on the mounting rod, a rack is arranged on the base, a lead screw is arranged in the base, the rack is slidably connected to the base, the rack is meshingly connected to the first gear ring, both ends of the lead screw are respectively penetrated through the base and rotatably connected to the base, and the lead screw is penetrated through the rack and threadedly connected to the rack.

[0012] The present application provides a kind of urokinase eluent recovery device, with the following beneficial effects:

[0013] (1) the present application is completely cleaned for diatomite in the inner wall of elution tank by the multiple groups of bottom plates arranged in annular distribution cooperating with scraper rod and cleaning block, avoids that residual diatomite cannot be completely cleaned to affect the next use of eluent recovery device;Multiple bottom plates are used to partially close or completely open the bottom of elution tank, and cooperate with scraper rod and cleaning block to discharge the diatomite contained in elution tank and completely clean the diatomite attached to the inner wall.

[0014] (2) the present application is converted for multiple groups of liquid collecting tanks by the mounting frame arranged, different washing liquids are used in the process of eluting diatomite column in elution tank, the rotation of lead screw is driven by motor, the position of rack is driven, then cooperate with first gear to realize the rotation of mounting frame, then convert different liquid collecting tanks, push different liquid collecting tanks to the position corresponding to elution tank, and collect different liquids. BRIEF DESCRIPTION OF DRAWINGS

[0015] Figure 1 It is the overall structure schematic view of the present application.

[0016] Figure 2 The utility model discloses a structure schematic view of the liquid collecting tank of the utility model;

[0017] Figure 3 The utility model discloses a structure schematic view of the elution tank of the utility model; Figure 2 The structure enlarged view of A place;

[0018] Figure 4 The utility model discloses a structure schematic view of the elution tank of the utility model;

[0019] Figure 5 The utility model discloses a structure schematic view of the utility model Figure 4 The structure enlarged view of B place;

[0020] Figure 6 The utility model discloses a structure schematic view of the utility model's scraping rod;

[0021] In the drawing: 1, base; 2, mounting frame; 3, elution tank; 4, liquid collecting tank; 5, mounting rod; 6, first gear; 7, rack; 8, screw rod; 9, mounting ring; 10, first tooth ring; 11, first drive wheel; 12, scraping rod; 13, cleaning block; 14, threaded rod; 15, bottom plate; 16, swivel ring; 17, second tooth ring; 18, mounting shaft; 19, second gear; 20, second drive wheel. DETAILED DESCRIPTION

[0022] The technical scheme in the embodiments of the utility model will be described clearly and completely in connection with the drawings in the embodiments of the utility model.

[0023] The utility model provides technical scheme: as Figures 1-6 As shown in the drawing, in the embodiment, a urokinase eluent recovery device includes a base 1, the base 1 top is equipped with the mounting frame 2, the base 1 is fixedly installed with elution tank 3, the mounting frame 2 is equipped with four groups of symmetrical distribution's liquid collecting tank 4, and the liquid collecting tank 4 is distributed with elution tank 3 corresponding, and the elution tank 3 top is equipped with the mounting ring 9, and the mounting ring 9 is fixedly installed with scraping rod 12, and the scraping rod 12 is attached to the inner wall of elution tank 3, and the scraping rod 12 is equipped with cleaning block 13, and the cleaning block 13 is slidably connected with scraping rod 12, and the elution tank 3 below is equipped with swivel ring 16, and the elution tank 3 below is equipped with multiple groups of annular distribution's bottom plate 15, and multiple bottom plates 15 are all rotatably connected with elution tank 3 through mounting shaft 18, and through the multiple groups of annular distribution's bottom plate 15 cooperation scraping rod 12 and cleaning block 13 realize for the complete cleaning of diatomite in the inner wall of elution tank 3, avoid the residual diatomite to be completely cleaned and lead to the influence eluent recovery device's next use; through multiple bottom plate 15 realize for the partial closure or complete opening of elution tank 3 bottom, cooperate scraping rod 12 and cleaning block 13 for the diatomite in the elution tank 3 and the complete cleaning of the diatomite attached to the inner wall.

[0024] AsFigure 4 , Figure 5 and Figure 6 As shown, the mounting ring 9 is rotatably connected to the eluent tank 3 via a bearing. A first toothed ring 10 is fitted onto the mounting ring 9. A first drive wheel 11 is provided inside the eluent tank 3, and the first drive wheel 11 is rotatably connected to the eluent tank 3 via a rotating shaft. The first drive wheel 11 is meshed with the first toothed ring 10. The first drive wheel 11 is driven to rotate by a motor, which in turn, in conjunction with the meshing first toothed ring 10, causes the mounting ring 9 to rotate inside the eluent tank 3. The scraper 12 inside the eluent tank 3 rotates synchronously with the mounting ring 9 to clean the diatomaceous earth residue adhering to the inner wall of the eluent tank 3. The scraper 12 is provided with a threaded rod 14, the two ends of which pass through the scraper 12 and are rotatably connected to it. The threaded rod 14 passes through the cleaning block 13 and is threadedly connected to it. When the motor inside the scraper 12 is started, it drives the threaded rod 14 to rotate. Under the limiting action of the scraper 12, the cleaning block 13 slides on the scraper 12, removing the diatomaceous earth adhering to the scraper 12. The cleaning process ensures complete removal of residual diatomaceous earth from the eluent tank 3. A rotating ring 16 is rotatably connected to the eluent tank 3 via a bearing. A second gear ring 17 is fitted onto the rotating ring 16. A second drive wheel 20 is located below the eluent tank 3, rotatably connected to the eluent tank 3 via a rotating shaft. The second drive wheel 20 meshes with the second gear ring 17. Multiple sets of mounting shafts 18 are fitted with second gears 19, which mesh with the second gear ring 17. Starting the motor below the eluent tank 3 drives the second drive wheel 20 to rotate, which, in conjunction with the second gear ring 17, causes the rotating ring 16 to rotate within the eluent tank 3. During the rotation of the second gear ring 17, the multiple sets of second gears 19 meshing with it drive the corresponding mounting shafts 18 to rotate. The base plates 15 fixedly mounted on the multiple sets of mounting shafts 18 rotate synchronously, completely opening the bottom of the eluent tank 3, thus facilitating the complete discharge of the diatomaceous earth removed by the scraper 12 and cleaning block 13.

[0025] like Figure 2 and Figure 3 As shown, the mounting frame 2 is rotatably connected to the base 1 via the mounting rod 5. A first gear 6 is sleeved on the mounting rod 5. A rack 7 is provided on the base 1, and a lead screw 8 is provided inside the base 1. The rack 7 is slidably connected to the base 1 and meshes with the first gear 6. The two ends of the lead screw 8 pass through the base 1 and are rotatably connected to the base 1. The lead screw 8 passes through the rack 7 and is threadedly connected to the rack 7. During the elution process in the elution tank 3, different liquids need to be added to the elution tank 3, resulting in different washing liquids in the elution tank 3. At different stages, the motor inside the base 1 is activated to drive the lead screw 8 to rotate. Under the limiting action of the base 1, the rack 7 is moved inside the base 1. In conjunction with the gear, the mounting rod 5 drives the mounting frame 2 to rotate on the base 1, completing the conversion between multiple sets of collection tanks 4, so that different collection tanks 4 are located at the bottom of the elution tank 3 to complete the collection of liquid at different stages.

[0026] The utility model provides a kind of urokinase eluent recovery device, specific working principle as follows: the rotation of first drive wheel 11 is driven by motor, and then cooperation and the first tooth ring 10 meshing connection make that mounting ring 9 rotates in elution tank 3, the scraper bar 12 in elution tank 3 rotates synchronously with mounting ring 9, and the diatomite residue adhered on the inner wall of elution tank 3 is cleaned, the motor in scraper bar 12 is driven to rotate screw rod 14, under the limiting action of scraper bar 12, make that clean block 13 slides on scraper bar 12, diatomite adhered on scraper bar 12 is cleaned, and then realize the complete cleaning of residual diatomite in elution tank 3, the rotation of second drive wheel 20 is driven by motor under elution tank 3, cooperation second tooth ring 17 makes that rotating ring 16 rotates in elution tank 3, the second gear 19 meshing connection with it in the rotation process of second tooth ring 17 respectively drives corresponding mounting shaft 18 to rotate, and the bottom plate 15 fixedly installed on multiple mounting shafts 18 is synchronously deflected, elution tank 3 bottom is completely opened, and then the complete discharge of diatomite cleaned by scraper bar 12 and clean block 13 is facilitated, different liquid needs to be added in elution tank 3 during the process of elution in elution tank 3, and then different washing liquid will be produced in elution tank 3, the rotation of screw rod 8 is driven by motor in base 1 in different stages, under the limiting action of base 1, make that rack 7 is in base 1, cooperation gear makes that mounting rod 5 drives mounting frame 2 to rotate on base 1, complete the conversion between multiple liquid collecting tanks 4, so that different liquid collecting tanks 4 are located at the bottom of elution tank 3 to complete different stages of liquid collection.

[0027] Although the embodiments of the utility model have been shown and described, it can be understood by those of ordinary skill in the art that various changes, modifications, replacements and variations can be made to these embodiments without departing from the principles and spirits of the utility model, and the scope of the utility model is defined by the appended claims and their equivalents.

Claims

1. A urokinase eluate recovery device comprising a base (1) characterised in that: The mounting frame (2) is arranged above the base (1), the elution tank (3) is fixedly installed on the base (1), four groups of symmetrical liquid collecting tanks (4) are arranged on the mounting frame (2), the liquid collecting tanks (4) are correspondingly arranged with the elution tank (3), the mounting ring (9) is arranged above the elution tank (3), the scraping rod (12) is fixedly installed on the mounting ring (9), the scraping rod (12) is attached to the inner wall of the elution tank (3), the cleaning block (13) is arranged on the scraping rod (12), the cleaning block (13) is slidably connected with the scraping rod (12), the rotating ring (16) is arranged below the elution tank (3), and a plurality of groups of annular bottom plates (15) are arranged below the elution tank (3), and the plurality of groups of bottom plates (15) are rotatably connected with the elution tank (3) through the mounting shaft (18).

2. The urokinase eluate recovery device of claim 1, wherein: The mounting ring (9) is rotatably connected with the elution tank (3) through a bearing, the first gear ring (10) is sleeved on the mounting ring (9), and the first driving wheel (11) is arranged in the elution tank (3).

3. A urokinase eluate recovery device according to claim 2, wherein: The first driving wheel (11) is rotatably connected with the elution tank (3) through a rotating shaft, and the first driving wheel (11) is in meshing connection with the first gear ring (10).

4. The urokinase eluate recovery device of claim 1, wherein: The scraping rod (12) is internally provided with a threaded rod (14), both ends of the threaded rod (14) penetrate through the scraping rod (12) and are rotatably connected with the scraping rod (12), and the threaded rod (14) penetrates through the cleaning block (13) and is threadedly connected with the cleaning block (13).

5. The urokinase eluate recovery device of claim 1, wherein: The rotating ring (16) is rotatably connected with the elution tank (3) through a bearing, the second gear ring (17) is sleeved on the rotating ring (16), the second driving wheel (20) is arranged below the elution tank (3), the second driving wheel (20) is rotatably connected with the elution tank (3) through a rotating shaft, and the second driving wheel (20) is in meshing connection with the second gear ring (17).

6. The urokinase eluate recovery device of claim 1, wherein: A plurality of groups of second gear wheels (19) are sleeved on the mounting shaft (18), and the plurality of groups of second gear wheels (19) are in meshing connection with the second gear ring (17).

7. The urokinase eluate recovery device of claim 1, wherein: The mounting frame (2) is rotatably connected with the base (1) through the mounting rod (5), the first gear wheel (6) is sleeved on the mounting rod (5), the rack (7) is arranged on the base (1), the lead screw (8) is arranged in the base (1), the rack (7) is slidably connected with the base (1), the rack (7) is in meshing connection with the first gear wheel (6), both ends of the lead screw (8) penetrate through the base (1) and are rotatably connected with the base (1), the lead screw (8) penetrates through the rack (7) and is threadedly connected with the rack (7).

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