Tangential flow filter frame

Abstract

The utility model discloses a tangential flow filter frame which comprises a bottom plate, a vertical guide rod, a transverse guide rod, a filter bracket and a pipeline pulley, the vertical guide rod is arranged on the bottom plate, the transverse guide rod is arranged on the vertical guide rod and can slide on the vertical guide rod, the filtering support is arranged on the vertical guide rod or the transverse guide rod, and the filtering support can slide on the vertical guide rod or the transverse guide rod. The filter support is arranged on the vertical guide rod or the transverse guide rod, the position of the filter support on the vertical guide rod or the transverse guide rod is changed according to the type of tangential flow filtration, the filter support is used for fixing the filter membrane, the centrifugal pump and the filter membrane are both arranged on the pipeline, and the pipeline pulley is arranged on the vertical guide rod or the transverse guide rod and used for guiding the pipeline. When different types of tangential flow filtering are needed, the corresponding tangential flow filtering system can be rapidly installed, three different tangential flow filtering systems do not need to be stored, and the production cost is saved.

Description

Technical Field

[0001] This utility model relates to the field of biopharmaceutical technology, and in particular to a tangential flow filter frame. Background Technology

[0002] In biopharmaceuticals, tangential flow filtration, also known as cross-flow filtration, is an advanced technique for separating and purifying biomolecules. This technique is particularly suitable for applications that require maintaining the integrity of biomolecules and high separation efficiency.

[0003] Tangential flow can effectively reduce the accumulation of particles and molecules on the membrane during filtration. However, prolonged unidirectional flow can still cause blockage at the membrane inlet, reducing the membrane's lifespan and increasing system operating costs. To eliminate this effect, the method of alternating the inlet and outlet of the membrane is often used to extend its service life. This method is called "alternating cross-flow filtration".

[0004] With the innovation of tangential flow filtration applications, a method has emerged that effectively increases the filtration area and improves filtration efficiency by establishing a constant pressure gradient across the filter membrane. This method is known as "high back pressure cross-flow filtration".

[0005] Conventional tangential flow filtration systems can often only meet a single mode and cannot effectively accommodate the above three applications. Therefore, it is necessary to reserve tangential flow filtration systems with three modes to meet different needs, which leads to an increase in product manufacturing costs. Summary of the Invention

[0006] According to an embodiment of the present utility model, a tangential flow filter frame is provided to enable the various components to meet the installation requirements of three types of tangential flow filtration, including: two tanks connected by a pipeline, including: a base plate, a vertical guide rod, a horizontal guide rod, a filter support, and a pipeline pulley;

[0007] The vertical guide rod is mounted on the base plate, and the horizontal guide rod is mounted on the vertical guide rod and can slide on the vertical guide rod. A centrifugal pump is mounted on the base plate or the horizontal guide rod. The filter support is mounted on the vertical guide rod or the horizontal guide rod and can slide on the vertical guide rod or the horizontal guide rod. The position of the filter support on the vertical guide rod or the horizontal guide rod changes according to the type of tangential flow filtration. The filter support is used to fix the filter membrane. The centrifugal pump and the filter membrane are both mounted on the pipeline. The pipeline pulley is mounted on the vertical guide rod or the horizontal guide rod and is used to guide the pipeline.

[0008] Furthermore, the base plate is rectangular, and each of the four corners of the base plate has an extension, and each of the four extensions has a fixing ring, with the vertical guide rod disposed on the fixing ring.

[0009] Furthermore, the filter support includes: an adjusting member, an adjusting horizontal bar, an adjusting vertical bar, a fixing member, and a snap-fit ​​block;

[0010] The adjusting component is connected to a vertical guide rod or a horizontal guide rod. The adjusting crossbar is provided on the adjusting component and can slide laterally on the adjusting component. One end of the adjusting crossbar is connected to the adjusting vertical rod. Both ends of the adjusting vertical rod are provided with fixing components. The fixing components are provided with snap-fit ​​blocks. The two snap-fit ​​blocks are used to fix the filter membrane.

[0011] Furthermore, a pressure gauge is provided at one end of the adjusting rod.

[0012] Furthermore, the filter membrane is a hollow fiber column.

[0013] Furthermore, the vertical or horizontal guide rod is provided with multiple pipe pulleys, and the type of tangential flow filtration of the pipe pulleys is changed in position on the vertical or horizontal guide rod.

[0014] Furthermore, a flow meter bracket is provided on the base plate, and a precision flow meter bracket is provided on the vertical guide rod or the horizontal guide rod.

[0015] Furthermore, it includes: quick-release rings;

[0016] The centrifugal pump, filter support, and pipe pulleys are all mounted on the vertical or horizontal guide rods via quick-release rings.

[0017] Furthermore, the quick-release ring includes: a sliding ring and a handle;

[0018] The sliding ring is sleeved on the vertical guide rod or the horizontal guide rod, and one end of the handle is connected to the sliding ring. The handle is used to fix the sliding ring on the vertical guide rod or the horizontal guide rod.

[0019] Furthermore, this includes control panels and electrical control boxes;

[0020] The control panel is used for closed-loop control of the centrifugal pump and monitoring of tangential flow filtration, while the electrical control box is used to supply power to the centrifugal pump.

[0021] According to an embodiment of the present invention, a tangential flow filter frame is provided. The two tanks are connected by pipelines. The connection path of the pipelines can be changed according to the type of tangential flow filtration required. By adjusting the positions of the filter support, pipeline pulleys and centrifugal pump on the vertical guide rod or guide rod, the installation requirements of three types of tangential flow filtration systems can be met. When different types of tangential flow filtration are required, the corresponding tangential flow filtration system can be quickly installed without the need to stock three different tangential flow filtration systems, thus saving production costs.

[0022] It should be understood that both the foregoing general description and the following detailed description are exemplary and intended to provide further illustration of the claimed technology. Attached Figure Description

[0023] Figure 1 This is a structural diagram of a tangential flow filter frame according to an embodiment of the present invention;

[0024] Figure 2 This is a partial structural diagram of a tangential flow filter frame according to an embodiment of the present invention;

[0025] Figure 3 This is a partial structural diagram of another tangential flow filter frame according to an embodiment of the present utility model;

[0026] Figure 4 This is a structural diagram of a quick-release ring for a tangential flow filter frame according to an embodiment of the present invention;

[0027] Figure 5 This is a structural diagram of an electrical control box for a tangential flow filter frame according to an embodiment of the present utility model.

[0028] The attached diagram is labeled as follows: 1 is the base plate, 11 is the extension, 12 is the fixing ring, 2 is the vertical guide rod, 3 is the horizontal guide rod, 31 is the centrifugal pump, 4 is the filter bracket, 41 is the adjusting component, 42 is the adjusting horizontal rod, 43 is the adjusting vertical rod, 44 is the fixing component, 45 is the snap-fit ​​block, 46 is the pressure gauge, 5 is the pipe pulley, 6 is the flow meter bracket, 7 is the precision flow meter bracket, 8 is the quick-release ring, 81 is the sliding ring, 82 is the handle, 9 is the control panel, and 10 is the electrical control box. Detailed Implementation

[0029] The preferred embodiments of the present invention will be described in detail below with reference to the accompanying drawings, further illustrating the present invention.

[0030] First, combine Figures 1-5 This invention describes a tangential flow filter frame according to an embodiment of the present invention, which is used to enable the components to meet the installation requirements of three types of tangential flow filtration.

[0031] like Figures 1-5 As shown, a tangential flow filter frame according to an embodiment of the present utility model is used to enable the various components to meet the installation requirements of three types of tangential flow filtration, including: two tanks connected by a pipeline, including: a base plate 1, a vertical guide rod 2, a horizontal guide rod 3, a filter bracket 4, and a pipe pulley 5;

[0032] The vertical guide rod 2 is mounted on the base plate 1, and the horizontal guide rod 3 is mounted on the vertical guide rod 2 and can slide on the vertical guide rod 2. A centrifugal pump 31 is mounted on the base plate 1 or the horizontal guide rod 3. The filter support 4 is mounted on the vertical guide rod 2 or the horizontal guide rod 3 and can slide on the vertical guide rod 2 or the horizontal guide rod 3. The position of the filter support 4 on the vertical guide rod 2 or the horizontal guide rod 3 changes according to the type of tangential flow filtration. The filter support 4 is used to fix the filter membrane. The centrifugal pump 31 and the filter membrane are both mounted on the pipeline. The pipeline pulley 5 is mounted on the vertical guide rod 2 or the horizontal guide rod 3 and is used to guide the pipeline.

[0033] The two tanks are connected by pipelines. The connection path of the pipeline can be changed according to the type of tangential flow filtration required. By adjusting the position of the filter bracket 4, pipeline pulley 5 and centrifugal pump 31 on the vertical guide rod 2 or guide rod, the installation requirements of three types of tangential flow filtration systems can be met. When different types of tangential flow filtration are required, the corresponding tangential flow filtration system can be installed quickly without the need to stock three different tangential flow filtration systems, thus saving production costs.

[0034] like Figures 1-3 As shown, the base plate 1 is rectangular, and each of the four corners of the base plate 1 is provided with an extension 11. Each of the four extensions 11 is provided with a fixing ring 12, and the vertical guide rod 2 is provided on the fixing ring 12.

[0035] In this embodiment, the base plate 1 is a regular polygon, and the four fixing rings 12 form a regular polygon, reducing the space occupied.

[0036] like Figure 2 As shown, the filter bracket 4 includes: an adjusting component 41, an adjusting horizontal bar 42, an adjusting vertical bar 43, a fixing component 44, and a snap-fit ​​block 45;

[0037] The adjusting member 41 is connected to the vertical guide rod 2 or the horizontal guide rod 3. The adjusting crossbar 42 is provided on the adjusting member 41 and can slide laterally on the adjusting member 41. One end of the adjusting crossbar 42 is connected to the adjusting vertical rod 43. Both ends of the adjusting vertical rod 43 are provided with fixing members 44. The fixing members 44 are provided with snap-fit ​​blocks 45. The two snap-fit ​​blocks are used to fix the filter membrane.

[0038] The position of the adjusting crossbar 42 on the vertical guide rod 2 or the horizontal guide rod 3 can be adjusted by adjusting the adjusting component 41. The horizontal position and angle of the adjusting vertical rod 43 can be adjusted by changing the connection position between the adjusting crossbar 42 and the adjusting component 41. The installation height of the filter membrane on the adjusting vertical rod 43 can be adjusted by changing the connection position between the adjusting vertical rod 43 and the adjusting crossbar 42. The filter membrane can be snapped into place by adjusting the snap-fit ​​blocks 45 at both ends of the adjusting vertical rod 43.

[0039] like Figure 2 As shown, a pressure gauge 46 is provided at one end of the adjusting rod 43. The filter membrane is a hollow fiber column. The pressure gauge 46 can detect the pressure inside the pipeline.

[0040] like Figures 1-3 As shown, the vertical guide rod 2 or the horizontal guide rod 3 is provided with multiple pipe pulleys 5, and the type of tangential flow filtration of the pipe pulleys 5 is changed by their positions on the vertical guide rod 2 or the horizontal guide rod 3.

[0041] The pipe pulley 5 can guide the pipe, enabling the pipe to meet the installation requirements of three tangential flow filtration systems.

[0042] like Figures 1-3 As shown, a flow meter bracket 6 is provided on the base plate 1, and a precision flow meter bracket 7 is provided on the vertical guide rod 2 or the horizontal guide rod 3.

[0043] A flow meter is installed on the flow meter bracket 6, and a precision flow meter is installed on the precision flow meter bracket 7. The flow meter and the precision flow meter can be used to detect the flow rate in the pipeline.

[0044] like Figures 1-4 As shown, it includes: quick-release ring 8;

[0045] The centrifugal pump 31, filter bracket 4, and pipe pulley 5 are all mounted on the vertical guide rod 2 or the horizontal guide rod 3 via quick-release rings 8.

[0046] The quick-release ring 8 includes: a sliding ring 81 and a handle 82;

[0047] The sliding ring 81 is sleeved on the vertical guide rod 2 or the horizontal guide rod 3. One end of the handle 82 is connected to the sliding ring 81. The handle 82 is used to fix the sliding ring 81 on the vertical guide rod 2 or the horizontal guide rod 3.

[0048] The sliding ring 81 is sleeved on the vertical guide rod 2 or the horizontal guide rod 3. The sliding ring 81 can slide on the vertical guide rod 2 or the horizontal guide rod 3. By rotating the handle 82, the sliding ring 81 can be fixed on the vertical guide rod 2 or the horizontal guide rod 3, so that the sliding ring 81 cannot slide on the vertical guide rod 2 or the horizontal guide rod 3.

[0049] like Figure 1 and Figure 5 As shown, it includes a control panel 9 and an electrical control box 10;

[0050] The control panel 9 is used to control the closed loop of the centrifugal pump 31 and monitor the tangential flow filtration, and the electrical control box 10 is used to supply power to the centrifugal pump 31.

[0051] The control panel 9 can monitor the flow meter and pressure gauge 46, and perform closed-loop control of the centrifugal pump 31. The electrical control box 10 can provide power to the control panel 9, the flow meter, the pressure gauge 46, and the centrifugal pump 31.

[0052] Above, refer to Figures 1-5 This invention describes a tangential flow filter frame according to an embodiment of the present invention. Two tanks are connected by pipelines. The connection path of the pipelines can be changed according to the type of tangential flow filtration required. By adjusting the positions of the filter support 4, pipeline pulley 5 and centrifugal pump 31 on the vertical guide rod 2 or the guide rod, the installation requirements of three tangential flow filtration systems can be met. When different types of tangential flow filtration are required, the corresponding tangential flow filtration system can be quickly installed without the need to stock three different tangential flow filtration systems, thus saving production costs.

[0053] It should be noted that, in this specification, the terms "comprising," "including," or any other variations thereof are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements includes not only those elements but also other elements not expressly listed, or elements inherent to such a process, method, article, or apparatus. Unless otherwise specified, an element defined by the phrase "comprising..." does not exclude the presence of additional identical elements in the process, method, article, or apparatus that includes said element.

[0054] Although the present invention has been described in detail through the above preferred embodiments, it should be understood that the above description should not be considered as a limitation of the present invention. Various modifications and substitutions to the present invention will be apparent to those skilled in the art after reading the above content. Therefore, the scope of protection of the present invention should be defined by the appended claims.

Claims

1. A tangential flow filter frame for enabling the components to meet the installation requirements of three types of tangential flow filtration, comprising: two tanks connected by a pipeline, characterized in that, include: Base plate, vertical guide rods, horizontal guide rods, filter brackets, and pipe pulleys; The vertical guide rod is mounted on the base plate, and the horizontal guide rod is mounted on the vertical guide rod and can slide on the vertical guide rod. A centrifugal pump is mounted on the base plate or the horizontal guide rod. The filter support is mounted on the vertical guide rod or the horizontal guide rod and can slide on the vertical guide rod or the horizontal guide rod. The position of the filter support on the vertical guide rod or the horizontal guide rod changes according to the type of tangential flow filtration. The filter support is used to fix the filter membrane. The centrifugal pump and the filter membrane are both mounted on the pipeline. The pipeline pulley is mounted on the vertical guide rod or the horizontal guide rod and is used to guide the pipeline.

2. The tangential flow filter frame as described in claim 1, characterized in that, The base plate is rectangular, and each of the four corners of the base plate has an extension. Each of the four extensions has a fixing ring, and the vertical guide rod is mounted on the fixing ring.

3. The tangential flow filter frame as described in claim 1, characterized in that, The filter support includes: an adjusting component, an adjusting horizontal bar, an adjusting vertical bar, a fixing component, and a snap-fit ​​block; The adjusting component is connected to a vertical guide rod or a horizontal guide rod. The adjusting crossbar is provided on the adjusting component and can slide laterally on the adjusting component. One end of the adjusting crossbar is connected to the adjusting vertical rod. Both ends of the adjusting vertical rod are provided with fixing components. The fixing components are provided with snap-fit ​​blocks. The two snap-fit ​​blocks are used to fix the filter membrane.

4. The tangential flow filter frame as described in claim 3, characterized in that, A pressure gauge is installed at one end of the adjusting rod.

5. The tangential flow filter frame as described in claim 1, characterized in that, The filter membrane is a hollow fiber column.

6. The tangential flow filter frame as described in claim 1, characterized in that, The vertical or horizontal guide rod is equipped with multiple pipe pulleys, and the type of tangential flow filtration of the pipe pulleys is changed by their position on the vertical or horizontal guide rod.

7. A tangential flow filter frame as described in claim 1, characterized in that, The base plate is equipped with a flow meter bracket, and the vertical guide rod or the horizontal guide rod is equipped with a precision flow meter bracket.

8. The tangential flow filter frame as described in claim 1, characterized in that, include: Quick-release ring; The centrifugal pump, filter support, and pipe pulleys are all mounted on the vertical or horizontal guide rods via quick-release rings.

9. A tangential flow filter frame as described in claim 8, characterized in that, The quick-release ring includes: a sliding ring and a handle; The sliding ring is sleeved on the vertical guide rod or the horizontal guide rod, and one end of the handle is connected to the sliding ring. The handle is used to fix the sliding ring on the vertical guide rod or the horizontal guide rod.

10. A tangential flow filter frame as described in claim 1, characterized in that, Including control panel and electrical control box; The control panel is used for closed-loop control of the centrifugal pump and monitoring of tangential flow filtration, while the electrical control box is used to supply power to the centrifugal pump.

Images