Constant-temperature extraction device for cell capsule preparation

Abstract

The utility model discloses a constant-temperature extraction device for cell capsule preparation, and effectively solves the problems that a centrifugal tube is easy to fall off and cannot keep constant temperature during cell capsule extraction. Comprising a containing shell and a placement block located in the containing shell and in the vertical axial direction, a plurality of placement grooves evenly distributed in the circumferential direction of the placement block are formed in the placement block, a plurality of limiting grooves which correspond to the placement grooves one to one and communicate with the placement grooves are formed in the placement block, and limiting columns capable of being inserted into the placement grooves are slidably connected into the limiting grooves; a containing groove which is located between the multiple limiting grooves and communicates with the limiting grooves is coaxially formed in the placing block, multiple swing rods which correspond to the limiting columns one to one and can swing are arranged in the containing groove, and the inner ends of the limiting columns are inserted into the containing groove and make contact with the lower ends of the swing rods. A plurality of heat dissipation fan blades which are uniformly distributed in the circumferential direction of the rotating column are arranged on the rotating column; the device is simple in structure, novel in conception, convenient to use and high in practicability.

Description

Technical Field

[0001] This utility model relates to the field of cell capsule extraction technology, and in particular to a constant temperature extraction device for cell capsule preparation. Background Technology

[0002] Cellular vesicles are cellular structures formed when the cell membrane deforms or expands outward due to uneven stress on its surface, encapsulating other cellular contents. They are commonly used in biological experiments and drug development. Purification is often required during extraction, and ultracentrifugation is one of the most common extraction methods. Different centrifugation speeds can separate vesicles of different densities.

[0003] However, existing high-speed centrifugal extraction devices have the following drawbacks when in use: 1. Existing centrifugal extraction devices generally lack a centrifuge tube fixing and protection structure. When the loading is unbalanced, vibration is likely to occur during centrifugation, which may cause the end cap to break due to tube detachment, thereby causing injury to the experimental personnel. 2. During high-speed centrifugation, the motor of existing centrifugal extraction devices is prone to heat generation, resulting in a high overall temperature inside the centrifuge. It is impossible to maintain a constant temperature during centrifugation, which may cause the material to denature due to heat. Utility Model Content

[0004] In view of the above situation and in order to make up for the shortcomings of the existing technology, the purpose of this utility model is to provide a constant temperature extraction device for cell capsule preparation, which effectively solves the problems of centrifuge tubes easily falling off and the inability to maintain a constant temperature during cell capsule extraction.

[0005] The technical solution is as follows: This utility model includes a receiving shell and a placement block located inside the receiving shell and axially extending vertically. The placement block has multiple placement grooves evenly distributed along its circumference. The placement block has multiple limiting grooves that correspond one-to-one with and communicate with the placement grooves. A limiting post that can be inserted into the placement groove is slidably connected in the limiting groove. A receiving groove located between and communicating with the limiting groove is coaxially opened in the placement block. The receiving groove has multiple swing rods that correspond one-to-one with the limiting posts and can swing. The inner end of the limiting post is inserted into the receiving groove and contacts the lower end of the swing rod. A rotating post is coaxially provided at the lower end of the placement block. The rotating post has multiple heat dissipation fan blades evenly distributed along its circumference.

[0006] Compared with the prior art, the beneficial effects of this utility model are: 1. It can realize centrifugation operation to prepare extracted cell capsules, and at the same time, it can clamp and fix the centrifuge tube to prevent the centrifuge tube from falling off due to loosening and vibration during centrifugation. 2. At the same time, it can dissipate the heat generated during centrifugation, maintain a constant temperature, and prevent the material from denaturing. Attached Figure Description

[0007] Figure 1This is the main view axonometric drawing of this utility model.

[0008] Figure 2 This is a full-section main view axonometric drawing of this utility model.

[0009] Figure 3 This is a full-section top-view axonometric drawing of this utility model.

[0010] Figure 4 This is a utility model Figure 2 A magnified view of A in the middle.

[0011] Figure label:

[0012] 1. Housing; 2. Placement block; 3. Placement slot; 4. Limiting slot; 5. Limiting post; 6. Housing slot; 7. Swing rod; 8. Rotating post; 9. Cooling fan blade; 10. Fixing block; 11. Stud; 12. Knob; 13. Reset plate; 14. Spring; 15. Motor; 16. Heat dissipation hole. Detailed Implementation

[0013] To make the above-mentioned objectives, features, and advantages of this utility model more apparent and understandable, the specific embodiments of this utility model are described in detail below with reference to the accompanying drawings. Many specific details are set forth in the following description to provide a full understanding of this utility model. However, this utility model can be implemented in many other ways different from those described herein, and those skilled in the art can make similar modifications without departing from the spirit of this utility model. Therefore, this utility model is not limited to the implementations of the base model disclosed below.

[0014] Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The term "and / or" as used herein includes any and all combinations of one or more of the associated listed items.

[0015] The specific embodiments of this utility model will be further described in detail below with reference to the accompanying drawings.

[0016] Depend on Figures 1 to 4The device includes a housing 1 and a placement block 2 located inside the housing 1 and axially aligned vertically. The placement block 2 has multiple placement grooves 3 evenly distributed along its circumference. The placement block 2 has multiple limiting grooves 4 that correspond one-to-one with and communicate with the placement grooves 3. A limiting post 5 that can be inserted into the placement groove 3 is slidably connected in the limiting groove 4. The placement block 2 has a housing groove 6 coaxially located between and communicating with the multiple limiting grooves 4. The housing groove 6 has multiple swing rods 7 that correspond one-to-one with the limiting posts 5 and can swing. The inner end of the limiting post 5 is inserted into the housing groove 6 and contacts the lower end of the swing rod 7. The lower end of the placement block 2 has a rotating post 8 coaxially located, and the rotating post 8 has multiple heat dissipation fan blades 9 evenly distributed along its circumference.

[0017] To facilitate the fixing of the swing arm 7, a plurality of fixing blocks 10 are fixedly connected in the receiving groove 6, each corresponding to and hinged to the swing arm 7.

[0018] In order to make the swing arm 7 swing, the placement block 2 is threaded with a stud 11 located above the swing arm 7 and able to contact the upper end of the swing arm 7.

[0019] To facilitate the rotation of the stud 11, a knob 12 is coaxially fixed to the upper end of the stud 11.

[0020] To facilitate the reset of the limiting post 5, the limiting post 5 is provided with a reset plate 13 in the receiving groove 6, and the reset plate 13 is connected to the placement block 2 via a spring 14.

[0021] To facilitate the rotation of the rotating column 8, a motor 15 located below the rotating column 8 is fixed inside the housing 1, and the output shaft of the motor 15 is coaxially and fixedly connected to the rotating column 8.

[0022] To facilitate heat dissipation, the housing 1 is provided with multiple heat dissipation holes 16.

[0023] In use, the centrifuge tubes containing the purified material are first inserted into the placement groove 3 in sequence. After insertion, the knob 12 is rotated in the forward direction. The knob 12 drives the stud 11 to rotate, which in turn causes the stud 11 to move downward. The lower end of the stud 11 contacts the upper end of the multiple swing rods 7 and presses the multiple swing rods 7 downward, which causes the lower end of the swing rods 7 to swing upward. The lower end of the swing rods 7 swings upward and presses the corresponding limiting post 5 to move. After the outer end of the limiting post 5 moves a certain distance, it is inserted into the placement groove 3 and contacts the outer surface of the centrifuge tube inside, thus achieving the clamping and fixing of the centrifuge tube. When the multiple limiting posts 5 move, they also compress the corresponding spring 14.

[0024] Once the centrifugation is complete, the motor 15 is turned on, which drives the rotating column 8 to rotate. The rotating column 8 then drives the placement block 2 to rotate, thus centrifuging the material inside the centrifuge tube to obtain cell capsules. While the rotating column 8 drives the placement block 2 to rotate, it also drives multiple cooling fan blades 9 to rotate, dissipating the heat emitted by the motor 15 through the heat dissipation holes 16 to prevent the temperature from rising. After the centrifugation operation is completed, the motor 15 is turned off, and the knob 12 is turned in the opposite direction. The knob 12 drives the stud 11 to rotate in the opposite direction, which in turn moves the stud 11 upward, releasing the pressure on the swing arm 7. At the same time, due to the restoring force of the spring 14, the limiting column 5 moves in the opposite direction and moves back into the limiting groove 4 to disengage from the centrifuge tube, thus releasing the pressure and fixation on the centrifuge tube. At this time, the centrifuge tube can be removed, and the supernatant can be collected to extract the cell capsules.

[0025] Compared with the prior art, the beneficial effects of this utility model are: the placement block, placement groove, limiting column, etc., can realize centrifugation operation to prepare extracted cell capsules, and at the same time can clamp and fix the centrifuge tube to prevent the centrifuge tube from falling off due to loosening and vibration during centrifugation. It can also dissipate the heat generated during centrifugation, maintain a constant temperature, and prevent material denaturation. This structure is simple, novel in concept, convenient to use, and highly practical.

[0026] It should be noted that, depending on the implementation needs, the various components described in the embodiments of this utility model can be split into more components, or two or more components or parts of components can be combined into new components to achieve the purpose of the embodiments of this utility model.

[0027] The above embodiments only illustrate several implementation methods of this utility model, and their descriptions are relatively specific and detailed, but they should not be construed as limiting the scope of this utility model patent. It should be noted that those skilled in the art can make various modifications and improvements without departing from the concept of this utility model, and these all fall within the protection scope of this utility model. Therefore, the protection scope of this utility model patent should be determined by the appended claims.

Claims

1. A constant-temperature extraction device for preparing cell capsules, comprising a receiving shell (1) and a placement block (2) located within the receiving shell (1) and axially aligned vertically, characterized in that, The placement block (2) has multiple placement slots (3) evenly distributed along its circumference. The placement block (2) has multiple limiting slots (4) that correspond one-to-one with the placement slots (3) and are connected to the placement slots (3). The limiting slots (4) are slidably connected to the limiting pins (5) that can be inserted into the placement slots (3). The placement block (2) has a receiving slot (6) coaxially located between the multiple limiting slots (4) and connected to the limiting slots (4). The receiving slots (6) have multiple swing rods (7) that correspond one-to-one with the limiting pins (5) and can swing. The inner end of the limiting pin (5) is inserted into the receiving slot (6) and contacts the lower end of the swing rod (7). The lower end of the placement block (2) is coaxially provided with a rotating column (8). The rotating column (8) has multiple heat dissipation fan blades (9) evenly distributed along its circumference.

2. The isothermal extraction device for cell vesicle preparation according to claim 1, characterized in that, The receiving groove (6) is fixedly connected with a plurality of fixed blocks (10) that correspond one-to-one with the swing rod (7) and are hinged to the swing rod (7).

3. The isothermal extraction device for cell vesicle preparation according to claim 1, characterized in that, The placement block (2) is threaded with a stud (11) located above the swing arm (7) and in contact with the upper end of the swing arm (7).

4. The isothermal extraction device for cell vesicle preparation according to claim 3, characterized in that, A knob (12) is coaxially fixed at the upper end of the stud (11).

5. The isothermal extraction device for cell vesicle preparation according to claim 1, characterized in that, The limiting post (5) is provided with a reset plate (13) in the receiving groove (6), and the reset plate (13) is connected to the placement block (2) via a spring (14).

6. The isothermal extraction device for cell vesicle preparation according to claim 1, characterized in that, The housing (1) contains a motor (15) located below the rotating column (8), and the output shaft of the motor (15) is coaxially and fixedly connected to the rotating column (8).

7. The isothermal extraction device for cell vesicle preparation according to claim 1, characterized in that, The housing (1) is provided with multiple heat dissipation holes (16).

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