Layered jaw model based on TPMS support
By designing a layered jawbone model and using the biomimetic layers of the TPMS scaffold to simulate the cortical and cancellous bone structures of the jawbone, the problem that existing scaffolds cannot meet the characteristics of the jawbone is solved, and a better jawbone regeneration effect is achieved.
Patent Information
- Application Number
- CN202422608736.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-10-28
- Publication Date
- 2025-11-11
- Estimated Expiration
- 2034-10-28
AI Technical Summary
Existing TPMS biomimetic scaffold structures cannot meet the anatomical characteristics and mechanical properties of the jawbone, and therefore cannot effectively promote jawbone regeneration.
A layered jawbone model based on a TPMS scaffold was designed, comprising a first biomimetic layer and a second biomimetic layer. The characteristic pore diameter of the first biomimetic layer is smaller than that of the second biomimetic layer. The two layers are integrally formed. By changing the pore size, the cortical bone and cancellous bone structure of the jawbone are simulated, forming a stable space that is conducive to bone regeneration and angiogenesis.
It achieves better simulation of the jawbone structure, enhances support and protection, promotes jawbone regeneration and vascularization, and conforms to the anatomical and mechanical characteristics of the jawbone.
Smart Images
Figure CN223539278U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of jawbone regeneration technology, and in particular to a layered jawbone model based on a TPMS scaffold. Background Technology
[0002] The jawbone is an important component of the human body. Congenital defects, trauma, degenerative diseases, tumors, and infectious necrosis (osteomyelitis) can all cause jawbone defects. Bone defects within a certain range can heal naturally, but if the defect exceeds a critical range, it cannot heal naturally and requires the implantation of a bone scaffold to promote healing and bone regeneration.
[0003] An ideal jawbone scaffold should have a structure similar to the jawbone, suitable compressive strength, and excellent bone regeneration promotion capabilities; however, achieving this with conventional scaffolds is exceptionally difficult. Triple periodic minimal surface (TPMS) structures are complex and highly cubically symmetric structures, mathematically described as surfaces with zero mean curvature that replicate infinitely in three directions, and can be repeatedly constructed through the periodicity of cubic translational unit cells.
[0004] However, when conventional TPMS structures are applied to jawbone regeneration, the resulting biomimetic scaffolds cannot meet the anatomical and mechanical characteristics of the jawbone and cannot effectively promote jawbone regeneration. Utility Model Content
[0005] To address the shortcomings of existing technologies, this invention provides a layered jawbone model based on a TPMS scaffold. This layered jawbone model can better simulate the jawbone structure and is more suitable for jawbone defect repair and regeneration.
[0006] To address the aforementioned technical problems, this utility model provides a layered jawbone model based on a TPMS scaffold, comprising:
[0007] A biomimetic scaffold has a first biomimetic layer and a second biomimetic layer. The first biomimetic layer has a plurality of first feature holes, and the second biomimetic layer has a plurality of second feature holes. The diameter of the first feature holes is smaller than the diameter of the second feature holes.
[0008] The first biomimetic layer and the second biomimetic layer are integrally formed Gyro id structures.
[0009] The diameter of the first feature hole is 100μm-300μm.
[0010] The diameter of the second feature hole is 300μm-900μm.
[0011] Wherein, at the connection between the first biomimetic layer and the second biomimetic layer, the diameters of the first feature hole and the second feature hole gradually increase along a predetermined direction, the predetermined direction being the direction from the first biomimetic layer to the second biomimetic layer.
[0012] In this process, a plurality of first feature holes are arranged in layers on the first biomimetic layer, and the number of first feature holes in each layer is equal; a plurality of second feature holes are arranged in layers on the second biomimetic layer, and the number of second feature holes in each layer is equal.
[0013] The height of the first biomimetic layer is 2mm-3mm, and the height of the second biomimetic layer is 6mm-7mm.
[0014] The bionic support has a circular cross-section with a diameter of 8mm-12mm.
[0015] The outer surface of the bionic scaffold has multiple concave surfaces.
[0016] The wall thickness between two adjacent concave surfaces is 200μm-500μm.
[0017] The present invention has the following beneficial effects:
[0018] According to the layered jawbone model based on the TPMS scaffold in this embodiment, in the two biomimetic layers of the biomimetic scaffold, since the pore size of the first characteristic hole in the first biomimetic layer is smaller than that of the second characteristic hole in the second biomimetic layer, the biomimetic scaffold achieves a biomimetic gradient change between the upper and lower layers. Furthermore, the first biomimetic layer has a higher density and greater mechanical strength, similar to the cortical bone of the jawbone, and can play a supporting and protective role; therefore, the first biomimetic layer can be used to simulate the cortical bone structure of the jawbone. The second biomimetic layer has a more porous structure, similar to the cancellous bone of the jawbone, providing good interconnectivity for metabolic activities and space for blood vessel and bone marrow penetration; therefore, the second biomimetic layer can be used to simulate the cancellous bone structure of the jawbone.
[0019] Furthermore, the layered jawbone model of this embodiment, by changing the aperture size, realizes the simulation of the cortical bone structure of the jawbone using the first biomimetic layer and the simulation of the cancellous bone structure of the jawbone using the second biomimetic layer. This allows the layered jawbone model to better simulate the jawbone structure and form a stable space that is conducive to bone regeneration and vascularization. Its structural features are consistent with the anatomical features and mechanical properties of the jawbone, making it more suitable for jawbone defect repair and regeneration. Attached Figure Description
[0020] Figure 1 This is an overall model diagram of the layered jawbone model in this utility model;
[0021] Figure 2This is a side view of the layered jawbone model in this utility model;
[0022] Figure 3 This is a top model view of the first biomimetic layer in this utility model;
[0023] Figure 4 This is a bottom model view of the second biomimetic layer in this utility model. Detailed Implementation
[0024] To make the objectives, technical solutions, and advantages of this utility model clearer, the following will describe this utility model in further detail with reference to the accompanying drawings. It is hereby declared that the terms "up," "down," "left," "right," "front," "back," "inner," and "outer," etc., appearing or about to appear in this document, are based solely on the accompanying drawings and are not intended to specifically limit this utility model.
[0025] It's important to note that the jawbone, as a complex natural structure, is composed of cortical bone and cancellous bone. Cancellous bone provides excellent interconnectivity for metabolic activities and space for blood vessels and bone marrow penetration. Cortical bone, with a higher density than cancellous bone, primarily provides support, protects the cancellous bone, and provides leverage for movement. An ideal jawbone framework should have a structure similar to the jawbone itself, suitable compressive strength, and excellent bone regeneration promotion capabilities; however, achieving this with conventional frameworks is exceptionally difficult.
[0026] The layered jawbone model based on TPMS scaffold of this invention can simulate the cortical bone structure of the jawbone using the first biomimetic layer 11 and the cancellous bone structure of the jawbone using the second biomimetic layer 12. This allows the layered jawbone model to better simulate the jawbone structure and form a stable space that is conducive to bone regeneration and vascularization. Its structural features are consistent with the anatomical features and mechanical properties of the jawbone, making it more suitable for jawbone defect repair and regeneration.
[0027] In one specific embodiment of this utility model, such as Figures 1 to 4 As shown, the layered jawbone model based on the TPMS scaffold includes a bionic scaffold 1. The bionic scaffold 1 has a first bionic layer 11 and a second bionic layer 12. The first bionic layer 11 has a plurality of first feature holes 13, and the second bionic layer 12 has a plurality of second feature holes 14. The diameter of the first feature holes 13 is smaller than the diameter of the second feature holes 14.
[0028] According to the layered jawbone model based on the TPMS scaffold in this embodiment, in the two biomimetic layers of the biomimetic scaffold 1, since the pore diameter of the first characteristic hole 13 in the first biomimetic layer 11 is smaller than the pore diameter of the second characteristic hole 14 in the second biomimetic layer 12, the biomimetic scaffold 1 achieves a biomimetic gradient change between the upper and lower layers. Furthermore, the first biomimetic layer 11 in the biomimetic scaffold 1 has a higher density and greater mechanical strength, similar to the cortical bone of the jawbone, and can play a supporting and protective role. Therefore, the first biomimetic layer 11 can be used to simulate the cortical bone structure of the jawbone. The second biomimetic layer 12 has a more porous structure, similar to the cancellous bone of the jawbone, providing good interconnectivity for metabolic activities and space for blood vessel and bone marrow penetration. Therefore, the second biomimetic layer 12 can be used to simulate the cancellous bone structure of the jawbone.
[0029] Furthermore, the layered jawbone model of this embodiment, by changing the aperture size, realizes the use of the first biomimetic layer 11 to simulate the cortical bone structure of the jawbone and the use of the second biomimetic layer 12 to simulate the cancellous bone structure of the jawbone. This allows the layered jawbone model to better simulate the jawbone structure and form a stable space that is conducive to bone regeneration and vascularization. Its structural features are consistent with the anatomical features and mechanical properties of the jawbone, making it more suitable for jawbone defect repair and regeneration.
[0030] It should be noted that the layered jawbone model can be modeled using Matlab or other conventional mathematical modeling software, and the parameters in the mathematical equations can be adjusted and controlled according to the corresponding aperture design parameters. After the modeling is completed, the 3D graphics can be exported to a 3D printer for model printing. The specific modeling and printing processes described above are conventional tools and processes, and will not be elaborated here.
[0031] Specifically, such as Figures 1 to 4 As shown, the first biomimetic layer 11 and the second biomimetic layer 12 are integrally formed Gyroid structures. Gyroid structures possess high permeability, low stress concentration, and a high surface area to volume ratio. Furthermore, their shape resembles bone trabeculae, further ensuring the biomimetic effect of the layered jawbone model. Since the first biomimetic layer 11 and the second biomimetic layer 12 are integral structures, a smooth transition between them is possible during modeling and printing. This further ensures that the formed layered jawbone model conforms to the anatomical characteristics of the jawbone, achieving performance that approximates the original jawbone to the greatest extent possible, thus guaranteeing the biomimetic effect of the layered jawbone model.
[0032] Furthermore, such as Figure 2As shown, at the connection between the first bionic layer 11 and the second bionic layer 12, the diameters of the first feature hole 13 and the second feature hole 14 gradually increase along a predetermined direction, which is from the first bionic layer 11 to the second bionic layer 12. This further ensures a smooth transition between the first bionic layer 11 and the second bionic layer 12, allowing the layered jawbone model to more closely resemble the structure and functional characteristics of the jawbone, thereby further ensuring the bionic effect of the layered jawbone model on the jawbone.
[0033] Specifically, such as Figure 3 As shown, to ensure the biomimetic effect of the first biomimetic layer 11, the diameter of the first feature hole 13 is 100μm-300μm. Preferably, the diameter of the first feature hole 13 is 300μm to ensure a high pore density in the first biomimetic layer 11, and further ensure that the first biomimetic layer 11 can simulate the cortical bone structure of the jawbone and achieve the functions of support and protection.
[0034] And such Figure 4 As shown, to ensure the biomimetic effect of the second biomimetic layer 12, the diameter of the second feature hole 14 is 300-900 μm, preferably 600 μm, so as to ensure that the pore size in the second biomimetic layer 12 is loose, further ensuring that the second biomimetic layer 12 can simulate the cancellous bone structure of the jawbone, ensuring good interconnectivity for metabolic activities, and providing space for blood vessels and bone marrow penetration.
[0035] It should be noted that the diameters of the first feature hole 13 and the second feature hole 14 can be effectively controlled by adjusting the parameters in the mathematical equation. The mathematical formula used to describe the TPMS structure is existing or can be derived based on mathematical principles, and will not be described in detail here.
[0036] Among them, such as Figures 1 to 3 As shown, multiple first characteristic pores 13 are arranged in layers on the first bionic layer 11, with each layer having an equal number of first characteristic pores 13. This ensures that the bionic scaffold maintains a relatively light weight while providing sufficient strength and deformability to protect the second bionic layer 12 and surrounding tissues from damage. Multiple second characteristic pores 14 are arranged in layers on the second bionic layer 12, with each layer having an equal number of second characteristic pores 14. This further ensures that the second bionic layer 12 provides good interconnectivity for metabolic activities and provides space for vascular and bone marrow penetration.
[0037] Among them, such as Figure 1 and Figure 2 As shown, the height of the first bionic layer 11 is less than the height of the second bionic layer 12. Specifically, the height of the first bionic layer 11 is 2mm-3mm, wherein the height of the first bionic layer 11 is preferably 2mm; the height of the second bionic layer 12 is 6mm-7mm, wherein the height of the second bionic layer 12 is preferably 6mm.
[0038] Among them, such as Figure 3 and Figure 4 As shown, the bionic scaffold 1 has a circular cross-section to simplify its molding process and ensure it can adapt to the structural requirements of the jawbone. The cross-sectional diameter of the bionic scaffold 1 is 8mm-12mm, preferably 8mm.
[0039] Among them, such as Figure 1 and Figure 2 As shown, the outer surface of the bionic scaffold 1 has multiple concave surfaces 15, which facilitate cell adhesion and growth, thereby rapidly promoting jawbone regeneration. Specifically, the wall thickness between two adjacent concave surfaces 15 is 200 μm-500 μm, preferably 200 μm.
[0040] The layered jawbone model provided by this utility model will be described in detail below.
[0041] like Figures 1 to 4 As shown, the bionic scaffold of the layered jawbone model adopts the Gyroid structure from the TPMS structure. The bionic scaffold is a cylindrical structure with a diameter of 10 mm and a height of 8 mm. Multiple concave surfaces 15 are formed on the outer surface of the bionic scaffold, with a wall thickness of 200 μm between any two adjacent concave surfaces 15. The upper layer of the bionic scaffold is the first bionic layer, and the lower layer is the second bionic layer. The first bionic layer is a Gyroid structure with a height of 2 mm and an internal characteristic pore diameter of 300 μm, exhibiting a high density that can simulate the cortical bone structure of the jawbone. The second bionic layer is a Gyroid structure with a height of 6 mm and an internal characteristic pore diameter of 600 μm, exhibiting a loose structure that can simulate the cancellous bone structure of the jawbone. Furthermore, the first and second bionic layers are integrally molded to form the bionic scaffold, with a smooth transition between them, ensuring that the bionic scaffold conforms to the anatomical characteristics of the jawbone. This makes the layered jawbone model more suitable for jawbone defect repair and regeneration.
[0042] The layered jawbone model provided by this utility model breaks through the limitations of bone powder lacking stable space, the limitations of ordinary cross-mesh structure shape, and the limitations of applying TPMS with a single pore size to jawbone regeneration. It conforms to both the anatomical characteristics and mechanical properties of the jawbone, thereby better promoting jawbone regeneration.
[0043] The above description is the preferred embodiment of this utility model. It should be noted that for those skilled in the art, several improvements and modifications can be made without departing from the principle of this invention, and these improvements and modifications are also considered to be within the protection scope of this utility model.
Claims
1. A layered jawbone model based on a TPMS scaffold, characterized in that, include: A biomimetic scaffold has a first biomimetic layer and a second biomimetic layer. The first biomimetic layer has a plurality of first feature holes, and the second biomimetic layer has a plurality of second feature holes. The diameter of the first feature holes is smaller than the diameter of the second feature holes.
2. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, The first biomimetic layer and the second biomimetic layer are integrally formed Gyroid structures.
3. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, The diameter of the first feature hole is 100μm-300μm.
4. The layered jawbone model based on a TPMS scaffold according to claim 3, characterized in that, The diameter of the second feature hole is 300μm-900μm.
5. The layered jawbone model based on a TPMS scaffold according to claim 2, characterized in that, At the connection between the first biomimetic layer and the second biomimetic layer, the diameters of the first feature hole and the second feature hole gradually increase along a predetermined direction, which is the direction from the first biomimetic layer to the second biomimetic layer.
6. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, Multiple first feature holes are arranged in layers on the first biomimetic layer, and the number of first feature holes in each layer is equal; multiple second feature holes are arranged in layers on the second biomimetic layer, and the number of second feature holes in each layer is equal.
7. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, The height of the first biomimetic layer is 2mm-3mm, and the height of the second biomimetic layer is 6mm-7mm.
8. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, The bionic scaffold has a circular cross-section with a diameter of 8mm-12mm.
9. The layered jawbone model based on a TPMS scaffold according to claim 1, characterized in that, The outer surface of the bionic scaffold has multiple concave surfaces.
10. The layered jawbone model based on a TPMS scaffold according to claim 9, characterized in that, The wall thickness between two adjacent concave surfaces is 200μm-500μm.