Special mouse cage for behavioral research

By designing a special mouse cage for behavioral research with partitions, multi-functional isolation panels, and a detachable cage cover, the problem of existing cages being unable to isolate the mouse's senses has been solved, enabling convenient observation and manipulation of mouse behavior in a variety of ways.

CN223541127UActive Publication Date: 2025-11-14RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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Patent Information

Application Number
CN202422660236.X
Authority / Receiving Office
CN · China
Patent Type
Utility models(China)
Current Assignee / Owner
Priority Date
2024-10-09
Filing Date
2024-10-31
Publication Date
2025-11-14
Estimated Expiration
2034-10-31

AI Technical Summary

Technical Problem

Existing research cages are insufficient to simulate partial sensory isolation in mice under different conditions, failing to meet the sensory isolation requirements of behavioral research and affecting the observation and study of mouse cognitive behavior.

Method used

A mouse cage specifically designed for behavioral research is presented. The cage cavity is divided into two activity areas for mice by an internal partition. The partition has interactive holes, and the cage is equipped with a multi-functional isolation plate and a drinking mechanism. The top is a removable cage cover, and the bottom has partition rails and multi-functional isolation plate rails to achieve sensory isolation and convenient operation.

Benefits of technology

It achieves isolation of the mouse's vision, hearing, and touch, simplifies operation, reduces stress behavior in mice, improves research safety, and supports the observation of multiple behavioral patterns.

✦ Generated by Eureka AI based on patent content.

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Abstract

The utility model discloses a cage box special for a behavioral mouse, and relates to the technical field of mouse behavioral research. The mouse cage box special for behavioral research comprises a cage box body with the top capable of being opened and closed, and a partition plate which is detachably connected with the cage box body and divides the inner cavity of the cage box body into two mouse activity areas is arranged in the inner cavity of the cage box body. One or more interaction holes for interaction of mice are formed in the partition plate, and a multifunctional isolation plate detachably connected with the partition plate is arranged in the partition plate; a feeding trough matched with the mouse activity area is further arranged in the inner cavity of the cage box, and a water drinking mechanism matched with the mouse activity area is further arranged at one end of the cage box; the top of the cage box is further provided with an air supply nozzle and an exhaust nozzle which are communicated with an inner cavity of the cage box. The partition plate is arranged in the inner cavity of the cage box to divide the inner cavity of the cage box into the two mouse activity areas, meanwhile, the interaction hole for mouse interaction is formed in the partition plate, and the multifunctional partition plate can seal the interaction hole so as to isolate visual sense and / or auditory sense and / or tactile sense of the mouse. Therefore, the behavioristics of the mouse after partial sense organs are isolated can be observed.
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Description

Technical Field

[0001] This utility model relates to the field of mouse behavior, and in particular to a mouse cage specifically designed for behavioral research. Background Technology

[0002] Mice, as a widely used model organism, play a crucial role in exploring and studying social behavior. Through behavioral studies, scientists can gain a deeper understanding of mouse behavioral patterns and cognitive functions. The social characteristics these small animals exhibit in nature, such as their group living, territoriality, and complex social interaction patterns, provide scientists with a unique window into observing and studying animal social structures and behavioral mechanisms. For example, mice communicate within groups using multiple senses, including smell, hearing, and touch, methods essential for their survival and reproduction. The cognitive behaviors exhibited by mice during social interactions show striking similarities to human social behavior. This similarity makes mice an ideal model organism for studying human social behavioral disorders, such as autism spectrum disorder (ASD). Furthermore, the hierarchy and cooperative behavior within mouse groups provide valuable biological perspectives for understanding human social structures. In-depth research into mouse social behavior not only enhances our understanding of animal behavior but also provides profound insights into the biological basis of human social behavior, thus achieving significant progress in scientific research.

[0003] Hearing and vision are crucial senses for animals to perceive their environment, playing a vital role in their behavior and survival. Studying the effects of partial sensory isolation on mouse behavior can not only help us understand the specific roles of these senses in behavioral regulation but also provide potential scientific evidence for the treatment of related human diseases. Mice, as social laboratory animals, are typically housed in pairs or groups to promote social interaction. They are usually housed in individually ventilated cages such as IVC or EVC cages to avoid cross-contamination, with a typical stocking density of 5 mice per cage. However, in behavioral and even cognitive behavioral studies, such as those on depression or mental illness, it is often necessary to simulate different conditions of solitary housing for mice: for example, solitary mice that cannot see their companions but can hear and smell them; or mice that can see their companions but cannot touch them. The lack of suitable cages for such studies hinders this research. Therefore, developing a new type of cage to meet this specific research need is particularly urgent. The development of such a new cage will provide an effective tool for in-depth research on the behavioral performance of mice in special solitary situations, and is expected to propel cognitive behavioral research to new heights. In summary, there is an urgent need for a specialized mouse cage that can isolate some of the mouse's senses and observe the mouse's cognitive behavior after sensory isolation in behavioral research. Utility Model Content

[0004] To address the aforementioned problems, the purpose of this invention is to provide a mouse cage specifically designed for behavioral research, capable of observing the cognitive behavior of mice after some of their senses have been isolated.

[0005] This utility model provides a mouse cage for behavioral research, comprising a cage with an openable and closable top, a partition detachably connected to the cage and dividing the cage cavity into two mouse activity areas; one or more interaction holes for mouse interaction are provided on the partition, and a multifunctional isolation plate detachably connected to the partition is provided in the partition; a feeding trough matching the mouse activity areas is also provided in the cage cavity, and a drinking mechanism matching the mouse activity areas is also provided at one end of the cage; an air inlet and an exhaust outlet communicating with the cage cavity are also provided on the top of the cage.

[0006] In one embodiment, the top of the cage box is further provided with a cage cover that is detachably connected to the cage box; the cage cover includes two detachably connected sub-covers, and each sub-cover can be detachably connected to the top of the cage box individually.

[0007] In one embodiment, the bottom of the inner cavity of the cage is provided with a partition slide rail, and the partition is slidably connected to the partition slide rail; the end of the cage opposite to the drinking mechanism is provided with a partition inlet / outlet that communicates with the partition slide rail.

[0008] In one embodiment, the partition has a multi-functional partition plate slot with openings at both ends and the bottom, and the bottom of the partition slide rail is provided with a multi-functional partition plate slide rail; the multi-functional partition plate is slidably connected to both the multi-functional partition plate slot and the multi-functional partition plate slide rail.

[0009] In one embodiment, the partition includes a partition working part located in the inner cavity of the cage and a partition fixing part passing through the partition inlet and located outside the cage; at least one side of the partition fixing part is provided with a fixing block, and one end of the partition with the partition inlet and outlet is also provided with a clamping member located on the same side of the partition as the fixing block; the clamping member includes a clamping slide rail and a clamping slider slidably connected to the clamping slide rail, and the clamping slider is detachably connected to the fixing block.

[0010] In one embodiment, fixing blocks are provided on both sides of the partition fixing part, and two clamping members are provided on one end of the partition with the partition inlet and outlet, which are respectively matched with the fixing blocks on different sides of the partition fixing part; the clamping sliders of the two clamping members are respectively provided with buckles and slots, and the buckles and slots are detachably connected.

[0011] In one embodiment, the drinking mechanism includes a water bottle holder located at one end of the cage, a water bottle located in the water bottle holder, and a drinking pipe; one end of the drinking pipe is connected to the water outlet of the water bottle, and the other end passes through the cage and is located in the inner cavity of the cage.

[0012] In some possible implementations, the interactive holes are arranged sequentially from one end of the partition to the other end, with a center distance of 1 to 3 cm between adjacent interactive holes; and / or, the interactive holes are rectangular in shape, with a length of 10 to 20 cm and a width of 2 to 5 cm.

[0013] In some possible implementations, the center distance between adjacent interactive holes gradually decreases from one end of the partition to the other end; and / or, the width of the interactive hole gradually decreases from one end of the partition to the other end.

[0014] In some possible implementations, the number of interactive holes is 5 to 10; and / or, the shape of the interactive holes is any one of rectangle, circle, ellipse, triangle or trapezoid.

[0015] The mouse cage for behavioral research provided by this utility model has the following beneficial effects:

[0016] 1) This utility model divides the inner cavity of the cage into two mouse activity areas by setting a partition in the inner cavity of the cage. At the same time, the partition is provided with an interaction hole for mouse interaction. The multi-functional partition can close the interaction hole to isolate the mouse's vision and / or hearing and / or touch, thereby enabling observation of the mouse's behavior after some senses are isolated.

[0017] 2) This utility model provides a cage cover that is detachably connected to the top of the cage box. The cage cover includes two detachably connected sub-covers, and each sub-cover can be detachably connected to the top of the cage box independently. In this way, the sub-covers can be opened and closed independently, allowing for operations on one side of the mouse, such as gavage or blood collection, without affecting the mouse on the other side.

[0018] 3) By setting a partition slide rail that can be slidably connected to the partition in the inner cavity of the cage, the operator can replace the partition without opening the cage, which can prevent stress behavior of mice when the cage is opened, and improve the safety of the present invention while simplifying the operation.

[0019] 4) This utility model provides a multi-functional isolation plate slide rail at the bottom of the partition slide rail and a multi-functional isolation plate slot in the partition, so that the operator can isolate the mouse's vision by pushing in the multi-functional isolation plate without removing the partition, which makes it convenient for the operator to observe the mouse's behavior pattern after the vision is isolated. Attached Figure Description

[0020] Figure 1 This is a schematic diagram of the overall structure of this utility model.

[0021] Figure 2 This is a top view of the present invention.

[0022] Figure 3 This is a cross-sectional view of the present invention.

[0023] Figure 4 This is a schematic diagram of the partition slide rail, the multi-functional partition slide rail, and the partition entrance / exit of this utility model.

[0024] Figure 5 This is a schematic diagram of the cage box in this utility model.

[0025] Figure 6 This is a schematic diagram of the cage, partition, multi-functional isolation plate, and clamping component in this utility model.

[0026] Figure 7 This is an enlarged view of the clamping component in this utility model.

[0027] Figure 8 This is a side view of the partition plate of this utility model.

[0028] Figure 9 This is a front view of a partition in this utility model.

[0029] Figure 10 This is a front view of a partition in this utility model.

[0030] Figure 11 This is a front view of a partition in this utility model.

[0031] Figure Labels

[0032] Cage Box 1

[0033] Mouse activity area 11

[0034] Feed trough 12

[0035] 13 cages

[0036] 13.1

[0037] partition slide rail 14

[0038] Partition entrance 15

[0039] Multifunctional isolation panel slide rail 16

[0040] Air nozzle 17

[0041] 18 exhaust nozzles

[0042] Partition 2

[0043] Interactive Hole 21

[0044] Multifunctional isolation panel with groove 22

[0045] Partition Working Section 23

[0046] Partition fixing part 24

[0047] Fixed block 25

[0048] Multifunctional isolation panel 3

[0049] Drinking water facility 4

[0050] Water bottle holder 41

[0051] Aquarius 42

[0052] Water pipe 43

[0053] Clamping component 5

[0054] Clamping slide rail 51

[0055] Clamping slider 52

[0056] Buckle 53

[0057] Card slot 54 Detailed Implementation

[0058] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present utility model. In the description of the present utility model, it should be noted that the terms "left side", "right side", "upper side", "lower side", "above", "below", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing the present utility model and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation of the present utility model. In addition, the terms "first" and "second" are used for descriptive purposes only and should not be construed as indicating or implying relative importance.

[0059] In the description of this utility model, it should be noted that, unless otherwise explicitly specified and limited, the terms "installation," "connection," and "joining" should be interpreted broadly. For example, they can refer to a fixed connection, a detachable connection, or an integral connection; they can refer to a mechanical connection or an electrical connection; they can refer to a direct connection or an indirect connection through an intermediate medium; and they can refer to the internal connection of two components. Those skilled in the art can understand the specific meaning of the above terms in this utility model according to the specific circumstances.

[0060] Furthermore, in the description of this utility model, unless otherwise stated, "a plurality of" means two or more.

[0061] This utility model provides a mouse cage specifically for behavioral research, see reference. Figure 1 and Figure 2 The cage includes a top-openable and closable cage box 1. Inside the cage box 1, there is a partition 2 detachably connected to the cage box 1 and dividing the interior into two mouse activity areas 11. The partition 2 has one or more interaction holes 21 for mouse interaction. A multi-functional isolation plate 3 detachably connected to the partition 2 can close the interaction holes 21 in the partition 2. The cage box 1 also has a feeding trough 12 corresponding to the mouse activity areas 11 inside its interior. One end of the cage box 1 also has a drinking mechanism 4 corresponding to the mouse activity areas 11. The top of the cage box 1 has an air supply nozzle 17 and an exhaust nozzle 18 communicating with the interior of the cage box 1. Both the air supply nozzle 17 and the exhaust nozzle 18 can be connected to an external air purifier. Typically, the air supply nozzle 17 and the exhaust nozzle 18 use standard connectors to adapt to standard IVC cage frames. The bottom of the cage box 1 also typically has a slide rail matching the IVC cage frame to adapt to the standard IVC cage frame.

[0062] For illustration, the two mouse activity areas 11 are usually independent of each other. When the partition 2 is placed inside the cage 1, the length of the partition 2 should be sufficient to completely separate the two mouse activity areas 11. A mouse in one mouse activity area 11 can only interact with a mouse in the other mouse activity area 11 through the interaction hole 21 on the partition 2. The size of the interaction hole 21 should ensure that the mouse can interact but cannot enter the other mouse activity area 11 through the interaction hole 21. In mouse behavioral observation, it is usually necessary to observe the behavioral patterns of mice when they perceive their own kind after their vision and / or hearing and / or touch are isolated. Therefore, the multifunctional partition 3 can be used to close the interaction hole 21 in the partition 2 to shield the mouse's vision and / or hearing and / or touch. In use, this invention can be configured according to the desired mouse behavior pattern: 1) When observing mouse behavior patterns after visual and tactile isolation, an opaque multifunctional isolation plate 3 is placed in the partition 2; 2) When observing mouse behavior patterns after tactile isolation, a transparent multifunctional isolation plate 3 can be placed in the partition 2; 3) When observing mouse behavior patterns after auditory and tactile isolation, a sound-insulating transparent multifunctional isolation plate 3 can be placed in the partition 2. Through the above configuration, this invention achieves the isolation of mice to prevent mutual aggression and allows for the observation of mouse behavior after partial sensory isolation.

[0063] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 1 and Figure 2 The cage box 1 is also provided with a cage cover 13 detachably connected to the top of the cage box 1. The cage cover 13 includes two detachably connected sub-covers 13.1, and each sub-cover 13.1 can be detachably connected to the top of the cage box 1 individually. One sub-cover 13.1 is provided with an air supply nozzle 17, and the other sub-cover 13.1 is provided with an exhaust nozzle 18. For illustration, the air supply nozzle 17 matches the air supply nozzle on the IVC cage frame, and the exhaust nozzle 18 matches the exhaust nozzle on the IVC cage frame. When the cage box 1 is inserted into the IVC standard cage frame, the air supply nozzle 17 and the exhaust nozzle 18 are respectively connected to the air supply nozzle and exhaust nozzle on the IVC cage frame to achieve air circulation in the inner cavity of the cage box 1. Through the above settings, this utility model can realize the individual opening and closing of the sub-covers 13.1, realizing the operation of unilateral mice such as gavage, blood collection, etc. without affecting the mice on the other side.

[0064] For illustration, the cage cover 13 can be connected to the cage box 1 via a snap fastener, and the two separate covers 13.1 can be connected via a mortise and tenon structure. The size of each separate cover 13.1 is typically large enough to cover the activity area 11 of a mouse, allowing the operator to manage the individual mouse activity area 11. Additionally, each separate cover 13.1 is equipped with an air inlet vent 17 and an exhaust vent 18, forming an independent air circulation system. Furthermore, the materials of both the cage box 1 and the cage cover 13 are independently selected from either transparent plastic or transparent glass, preferably transparent plastic.

[0065] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 4 and Figure 5 The bottom of the inner cavity of the cage 1 is provided with a partition slide rail 14, and the partition 2 is slidably connected to the partition slide rail 14. The end of the cage 1 opposite to the drinking mechanism 4 is provided with a partition inlet / outlet 15 that communicates with the partition slide rail 14. (See reference...) Figure 5 The partition slide rail 14 and the partition inlet / outlet 15 are L-shaped. In use, the partition 2 is aligned with the partition inlet / outlet 15 and pushed along the partition slide rail 14 to place the partition 2 in the cage box 1.

[0066] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 8 The partition 2 has a multi-functional partition plate slot 22 with openings at both ends and the bottom, see reference. Figure 5The bottom of the partition slide rail 14 is provided with a multi-functional partition slide rail 16. The multi-functional partition 3 can be slidably connected to both the multi-functional partition slot 22 and the multi-functional partition slide rail 16. In use, first select a suitable partition 2 and push the partition 2 into the cage box 1 along the partition slide rail 14. At this time, mice in the two mouse activity areas 11 can interact through the interaction hole 21 on the partition 2. Taking the isolation of the mouse's vision and touch as an example, if you want to observe the behavior of the mouse after its vision and touch are isolated, align the multi-functional partition 3 with the multi-functional partition slot 22 in the partition 2 and push it into the partition 2 along the multi-functional partition slide rail 16. After pushing it in, the multi-functional partition 3 will close the interaction hole 21 on the partition 2. At this time, the mouse cannot interact with the mouse in the other mouse activity area 11 through the interaction hole 21, but it can hear the sound of the mouse in the other mouse activity area 11 through the interaction hole 21. Additionally, if it is desired to modify partition 2 to expand the behavioral sample when observing mouse behavior, the multifunctional partition 3 can be first pushed into partition 2 in the manner described above. Then, partition 2 is pulled outward along partition slide rail 14 while maintaining multifunctional partition 3 within the cage cavity 1. A suitable partition 2 is then selected and aligned with partition inlet / outlet 15, while the multifunctional partition slot 22 is aligned with multifunctional partition 3 and pushed in along partition slide rail 14. This method of inserting and replacing partition 2 and multifunctional partition 3 allows for replacement of partition 2 and multifunctional partition 3 without opening cage 1, preventing stress behaviors in mice when cage 1 is opened. This simplifies operation and improves the safety of the invention. Furthermore, the invention also retains the option of removing partition 2 and multifunctional partition 3 from the top of cage 1; see reference [link to relevant documentation]. Figure 5 and Figure 6 The partition inlet / outlet 15 has a top opening structure, and the operator can still remove and replace the partition 2 located in the partition slide rail 14 by opening the cage cover 13.

[0067] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 7 , Figure 9 and Figure 10The partition 2 includes a partition working part 23 located inside the cage 1 and a partition fixing part 24 passing through the partition inlet / outlet 15 and located outside the cage 1. Generally, the interaction holes 21 are all located on the partition working part 23. At least one side of the partition fixing part 24 is provided with a fixing block 25, and one end of the partition 2 with the partition inlet / outlet 15 is also provided with a clamping member 5 located on the same side of the partition 2 as the fixing block 25. The clamping member 5 includes a clamping slide rail 51 and a clamping slider 52 slidably connected to the clamping slide rail 51. The clamping slider 52 is detachably connected to the fixing block 25. For illustration, the extending direction of the clamping slide rail 51 is generally perpendicular to the side of the partition fixing part 24 with the fixing block 25, and a relatively simple mortise and tenon structure can be used to complete the connection between the clamping slider 52 and the fixing block 25. In use, the clamping slider 52 is slid along the clamping slide rail 51 toward the fixing block 25, and the clamping slider 52 and the fixing block 25 are connected by a tenon and mortise structure. After the connection is completed, the position of the partition 2 is fixed by the clamping slider 52.

[0068] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 7 , Figure 9 and Figure 10 The partition fixing part 24 has fixing blocks 25 on both sides. The partition 2 with the partition inlet / outlet 15 has two clamping members 5 at one end, each matching the fixing blocks 25 on a different side of the partition fixing part 24. The clamping sliders 52 of the two clamping members 5 are respectively provided with buckles 53 and slots 54, which are detachably connected. For illustration, when the clamping members 5 on both sides of the partition 2 are connected to their corresponding fixing blocks 25, the buckles 53 and slots 54 on the clamping sliders 52 are also simultaneously connected. The connection of the buckles 53 and slots 54 effectively fixes the multi-functional partition 3, preventing it from detaching from the partition 2.

[0069] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 1 and Figure 3 The drinking mechanism 4 includes a water bottle holder 41 located at one end of the cage 1, a water bottle 42 disposed within the water bottle holder 41, and a drinking pipe 43. One end of the drinking pipe 43 is connected to the outlet of the water bottle 42, and the other end passes through the cage 1 and is disposed within the inner cavity of the cage 1. For illustration, the water bottle holder 41 can be a C-shaped holder 5, and the holding portion of the water bottle holder 41 typically has a certain degree of elasticity to accommodate various sizes of water bottles 42.

[0070] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 9 and Figure 10 The number of interactive holes 21 is 5 to 10, preferably 7.

[0071] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 9 and Figure 10 The interactive hole 21 can be any one of a rectangle, a circle, an ellipse, a triangle, or a trapezoid, preferably a rectangle.

[0072] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 9 and Figure 10 The interactive holes 21 are arranged sequentially from one end of the partition 2 to the other end of the partition 2, and the center distance between adjacent interactive holes 21 is 1 to 3 cm, preferably 2 cm.

[0073] The mouse cage for behavioral research provided by this utility model is described in reference to... Figure 9 and Figure 10 The interactive hole 21 is rectangular in shape, and its length is 0.5 to 1 cm, preferably 0.5 cm; the width of the interactive hole 21 is 0.5 to 1 cm, preferably 0.5 cm.

[0074] In the mouse cage for behavioral research provided by this utility model, the center distance between adjacent interaction holes 21 gradually decreases from one end of the partition 2 to the other end of the partition 2; and / or, the width of the interaction hole 21 gradually decreases from one end of the partition 2 to the other end of the partition 2.

[0075] Example 1

[0076] In the mouse cage specifically designed for behavioral research provided in this embodiment, see... Figure 9 The partition 2 includes an interactive hole 21. There are 7 interactive holes 21. The interactive holes 21 are rectangular in shape, with a length of 15cm, a width of 0.5cm, and a center distance of 2cm between adjacent interactive holes 21.

[0077] Example 2

[0078] In the mouse cage specifically designed for behavioral research provided in this embodiment, see... Figure 10 The partition 2 includes two types of interactive holes 21. There are 7 interactive holes 21 located above the partition 2 and arranged in sequence. They are rectangular in shape, 15cm long, 0.5cm wide, and 6cm apart. There is 1 interactive hole 21 located below the partition 2. It is rectangular in shape, 0.5cm long, and 90cm wide.

[0079] Example 3

[0080] In the mouse cage specifically designed for behavioral research provided in this embodiment, see... Figure 9The partition 2 includes 27 interactive holes 21. The interactive holes 21 are circular in shape, with a diameter of 0.5 cm and a center distance of 2 cm between adjacent interactive holes 21.

[0081] The above description is only a preferred embodiment of the present utility model. It should be noted that for those skilled in the art, several improvements and substitutions can be made without departing from the technical principles of the present utility model, and these improvements and substitutions should also be considered within the protection scope of the present utility model.

Claims

1. A mouse cage specifically designed for behavioral research, characterized in that: Includes a cage (1) with an openable and closable top, wherein the inner cavity of the cage (1) is provided with a partition (2) that is detachably connected to the cage (1) and divides the inner cavity of the cage (1) into two mouse activity areas (11); the partition (2) is provided with one or more interaction holes (21) for mouse interaction, and the partition (2) is provided with a multifunctional isolation plate (3) that is detachably connected to the partition (2); The cage (1) is also provided with a feeding trough (12) in the inner cavity of the cage (1) to match the mouse activity area (11), and a drinking mechanism (4) in the same way is provided at one end of the cage (1) to match the mouse activity area (11); the top of the cage (1) is also provided with an air supply nozzle (17) and an exhaust nozzle (18) that are connected to the inner cavity of the cage (1).

2. The mouse cage for behavioral research according to claim 1, characterized in that: The top of the cage box (1) is also provided with a cage cover (13) that is detachably connected to the cage box (1); the cage cover (13) includes two detachably connected sub-covers (13.1) and each of the two sub-covers (13.1) can be detachably connected to the top of the cage box (1) individually; wherein the air supply nozzle (17) is provided on one sub-cover (13.1) and the exhaust nozzle (18) is provided on the other sub-cover (13.1).

3. The mouse cage for behavioral research according to claim 1, characterized in that: The bottom of the inner cavity of the cage (1) is provided with a partition slide rail (14), and the partition (2) is slidably connected to the partition slide rail (14); the end of the cage (1) opposite to the drinking mechanism (4) is provided with a partition inlet (15) that is connected to the partition slide rail (14).

4. The mouse cage for behavioral research according to claim 3, characterized in that: The partition (2) has a multi-functional partition plate slot (22) with openings at both ends and the bottom, and the bottom of the partition plate slide rail (14) is provided with a multi-functional partition plate slide rail (16); the multi-functional partition plate (3) can be slidably connected to the multi-functional partition plate slot (22) and the multi-functional partition plate slide rail (16).

5. The mouse cage for behavioral research according to claim 2 or 3, characterized in that: The partition (2) includes a partition working part (23) located in the inner cavity of the cage (1) and a partition fixing part (24) passing through the partition inlet (15) and located outside the cage (1); at least one side of the partition fixing part (24) is provided with a fixing block (25), and one end of the partition (2) with the partition inlet (15) is also provided with a clamping member (5) located on the same side of the partition (2) as the fixing block (25); the clamping member (5) includes a clamping slide rail (51) and a clamping slider (52) slidably connected to the clamping slide rail (51), and the clamping slider (52) is detachably connected to the fixing block (25).

6. The mouse cage for behavioral research according to claim 5, characterized in that: The partition fixing part (24) is provided with fixing blocks (25) on both sides. The partition (2) with the partition inlet (15) is provided with two clamping members (5) that match the fixing blocks (25) on different sides of the partition fixing part (24). The clamping sliders (52) in the two clamping members (5) are respectively provided with buckles (53) and slots (54). The buckles (53) and slots (54) are detachably connected.

7. The mouse cage for behavioral research according to claim 1, characterized in that: The drinking mechanism (4) includes a water bottle holder (41) located at one end of the cage (1), a water bottle (42) located in the water bottle holder (41), and a drinking pipe (43); one end of the drinking pipe (43) is connected to the water outlet of the water bottle (42), and the other end passes through the cage (1) and is located in the inner cavity of the cage (1).

8. The mouse cage for behavioral research according to claim 7, characterized in that: The interactive holes (21) are arranged sequentially from one end of the partition (2) to the other end of the partition (2), and the center distance between adjacent interactive holes (21) is 1 to 3 cm; and / or, the interactive holes (21) are rectangular in shape, the length of the interactive holes (21) is 0.5 to 1 cm, and the width of the interactive holes (21) is 0.5 to 1 cm.

9. The mouse cage for behavioral research according to claim 8, characterized in that: The center distance between adjacent interactive holes (21) gradually decreases from one end of the partition (2) to the other end of the partition (2); and / or, the width of the interactive hole (21) gradually decreases from one end of the partition (2) to the other end of the partition (2).

10. The mouse cage for behavioral research according to claim 1, characterized in that: The number of interactive holes (21) is 5 to 10; and / or the shape of the interactive holes (21) is any one of rectangle, circle, ellipse, triangle or trapezoid.