Collagen gel patch
By designing a collagen gel patch that includes a drug release layer, a collagen matrix layer, and a semi-permeable layer, the problem of insufficient collagen ratio adjustment in traditional patches is solved, resulting in better wound healing and inhibiting scar formation.
Patent Information
- Application Number
- CN202422764862.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Utility models(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-13
- Publication Date
- 2025-11-14
- Estimated Expiration
- 2034-11-13
AI Technical Summary
Traditional medical collagen patches lack support for type III collagen, making it difficult to dynamically regulate the ratio of type I to type III collagen. This leads to excessive secretion of type I collagen, causing abnormal proliferation and scar formation.
A collagen gel patch was designed, comprising a drug release layer, a collagen matrix layer, a hydrogel layer, and a semi-permeable layer. By dynamically adjusting the collagen ratio, it inhibits excessive secretion of type I collagen, promotes tissue healing, and reduces scar formation.
It effectively increases the level of type III collagen in the wound, inhibits excessive secretion of type I collagen, promotes the recovery of tissue flexibility, reduces scar formation, and improves wound healing.
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Figure CN223542074U_ABST
Abstract
Description
Technical Field
[0001] This utility model relates to the field of medical dressing technology, and in particular to a collagen gel dressing. Background Technology
[0002] Medical dressings are medical products used to cover, protect, and promote wound healing. Their main functions are to maintain a moist wound environment, reduce the risk of infection, absorb exudate, and provide mechanical protection. Collagen dressings, building upon traditional medical dressings, offer unique advantages due to their high content of bioactive collagen. Collagen, an essential component of human skin, can mimic the natural extracellular matrix, supporting cell proliferation and tissue regeneration, and accelerating wound healing. Furthermore, collagen has excellent biocompatibility, promoting angiogenesis and reducing scar formation, making it particularly suitable for the care of chronic wounds, surgical incisions, and burns. Therefore, collagen dressings play a crucial role in wound repair, contributing to faster and better wound healing.
[0003] Traditional medical collagen dressings require thorough wound cleaning and disinfection to remove dirt and exudate, ensuring sterility. Next, select an appropriate size collagen dressing based on the wound size, cutting it as needed. Gently place the dressing over the wound surface, ensuring close contact and direct application of the collagen. Secure the dressing with sterile gauze or medical tape to prevent displacement. During use, regularly check wound healing and adjust dressing replacement frequency based on exudate levels. Aseptic technique should be used during dressing changes to avoid contaminating the wound. This type of dressing helps maintain a moist environment, promotes cell regeneration, and accelerates wound healing.
[0004] Traditional medical collagen dressings typically use type I collagen as the main component, lacking support for type III collagen. This makes it difficult to increase the level of type III collagen in the wound area, thus hindering the dynamic regulation of the ratio of type I to type III collagen. Consequently, it is difficult to effectively inhibit the excessive secretion of type I collagen, leading to abnormal proliferation and scarring. Utility Model Content
[0005] To overcome the above shortcomings, this invention provides a collagen gel patch, which aims to improve upon the lack of support for type III collagen in traditional medical collagen patches, making it difficult to dynamically adjust the ratio of type I and type III collagen, and thus difficult to effectively inhibit the excessive secretion of type I collagen, leading to abnormal proliferation and scarring.
[0006] To achieve the above objectives, the present invention provides the following technical solution: a collagen gel patch, comprising an adhesive edge, an extended adhesive portion fixedly connected to the outer wall of the adhesive edge, a drug release layer disposed on the inner wall of the adhesive edge, an auxiliary component disposed above the drug release layer, the auxiliary component being used to improve the therapeutic effect of the drug release layer, and an adsorption component disposed on the inner wall of the adhesive edge, the adsorption component being used to adsorb exudate;
[0007] The auxiliary component includes a collagen matrix layer disposed above the drug release layer. The outer wall of the collagen matrix layer is fixedly connected to the inner wall of the adhesive edge, and a hydrogel layer is disposed above the collagen matrix layer.
[0008] Furthermore, the adsorption component includes a semi-permeable layer, the outer wall of which is fixedly connected to the inner wall of the adhesive edge, and a sponge outer protective layer is disposed above the semi-permeable layer.
[0009] Furthermore, an external protective film is attached to the lower part of the extended adhesive portion, and an adhesive portion is fixedly connected to the upper surface of the external protective film. A double-sided adhesive portion is fixedly connected to the outer wall of the drug release layer. One side of the double-sided adhesive portion is attached to the outer wall of the adhesive edge, and the other side of the double-sided adhesive portion is attached to the adhesive portion. A replacement component is provided on the lower surface of the external protective film, which facilitates the switching of the drug release layer.
[0010] Furthermore, the replacement component includes an adhesive part two, the upper surface of which is attached to the lower surface of the adhesive part one, a protective bottom is fixedly connected to the outer wall of the adhesive part two, and a disinfection layer is fixedly connected to one side of the outer wall of the protective bottom.
[0011] Furthermore, the outer wall of the hydrogel layer is fixedly connected to the inner wall of the adhesive edge, and the outer wall of the sponge outer protective layer is fixedly connected to the inner wall of the adhesive edge.
[0012] Furthermore, the semi-permeable layer is located between the hydrogel layer and the outer protective layer of the sponge, and the semi-permeable layer is used to allow excess exudate to pass through.
[0013] Furthermore, the outer wall of the protective bottom is fixedly connected with a second lip section, which is used to tear off the protective bottom.
[0014] Furthermore, an easy part is fixedly connected to the outer wall of the outer protective film, and the easy part is used to tear off the outer protective film.
[0015] This utility model has the following beneficial effects:
[0016] 1. In this invention, the outer protective film is first peeled off through the easy part, and then pasted onto the affected area through the adhesive edge and extended adhesive part. At this time, the drug release layer adheres to the affected area, and the properties of the collagen matrix layer itself promote wound healing and repair the damaged skin barrier. Then, the hydrogel layer actively releases water and absorbs exudate, while helping the wound bed to accumulate growth factors, further promoting granulation tissue growth and wound healing. Finally, the semi-permeable layer and the sponge outer protective layer absorb excess exudate, solving the problem of difficulty in dynamically adjusting the ratio of type I and type III collagen during application, and difficulty in inhibiting excessive secretion of type I collagen, which leads to abnormal proliferation and scar formation. This invention achieves the goal of exogenously supplementing recombinant human type III collagen functional gel, which can effectively increase the level of type III collagen in the wound area, inhibit excessive secretion of type I collagen, promote the recovery of tissue flexibility, inhibit scar formation, reduce pigmentation, and improve clinical treatment effect.
[0017] 2. In this utility model, the protective bottom can first be torn off by the second part of the adhesive, so that the second part of the adhesive can be separated from the first part of the adhesive. Then, the corresponding drug release layer is placed according to the needs, and the double-sided adhesive part is pasted on the outer wall of the adhesive edge and offset to achieve the placement of the adhesive edge. This allows the corresponding drug release layer to be replaced or placed according to specific needs, more accurately meeting the specific needs of different patients and wounds, and enhancing the treatment effect. Attached Figure Description
[0018] Figure 1 This is a three-dimensional structural diagram of a collagen gel patch proposed in this utility model;
[0019] Figure 2 This is a schematic diagram of one side of the outer protective layer of the sponge in a collagen gel patch according to the present invention.
[0020] Figure 3 This is a schematic diagram of the protective bottom side structure of a collagen gel patch proposed in this utility model.
[0021] Legend:
[0022] 1. Adhesive edge; 2. Outer protective layer of sponge; 3. Semi-permeable layer; 4. Hydrogel layer; 5. Collagen matrix layer; 6. Drug release layer; 7. External protective film; 8. Adhesive part one; 9. Easy part one; 10. Adhesive part two; 11. Sterilization layer; 12. Protective bottom; 13. Easy part two; 14. Double-sided adhesive part; 15. Extended adhesive part. Detailed Implementation
[0023] The technical solutions of the present utility model will be clearly and completely described below with reference to the accompanying drawings of the embodiments. Obviously, the described embodiments are only some embodiments of the present utility model, and not all embodiments. Based on the embodiments of the present utility model, all other embodiments obtained by those of ordinary skill in the art without creative effort are within the protection scope of the present utility model.
[0024] Reference Figure 1 - Figure 3 The present invention provides an embodiment of a collagen gel patch, comprising an adhesive edge 1, an extended adhesive portion 15 fixedly connected to the outer wall of the adhesive edge 1 to further improve the adhesive effect, a drug release layer 6 provided on the inner wall of the adhesive edge 1 to achieve treatment of different lesions, an auxiliary component provided above the drug release layer 6 to improve the therapeutic effect of the drug release layer 6, and an adsorption component provided on the inner wall of the adhesive edge 1 to adsorb exudate.
[0025] The auxiliary components include a collagen matrix layer 5, which is positioned above the drug release layer 6. The outer wall of the collagen matrix layer 5 is fixedly connected to the inner wall of the adhesive edge 1. The collagen matrix layer 5 provides an ideal environment for promoting tissue regeneration and cell migration, promoting cell proliferation, migration and differentiation, and accelerating healing. A hydrogel layer 4 is positioned above the collagen matrix layer 5. The hydrogel layer 4 prevents the collagen from drying out and helps absorb exudate, maintaining a moist environment and enhancing the stability of the collagen. The adsorption components include a semi-permeable layer 3, whose outer wall is fixedly connected to the inner wall of the adhesive edge 1. A sponge outer protective layer 2 is positioned above the semi-permeable layer 3. For high-exudate wounds or chronic wound care, excess exudate will be absorbed by the sponge outer protective layer 2 through the semi-permeable layer 3, thereby preventing the wound from becoming too wet and causing infection or maceration. At the same time, the additional absorption and buffering effect of the sponge outer protective layer 2 can help improve the wound environment and promote healing.
[0026] Reference Figure 1 - Figure 3An outer protective film 7 is attached to the lower part of the extended adhesive portion 15. An adhesive portion 8 is fixedly connected to the upper surface of the outer protective film 7. The outer protective film 7 effectively protects the adhesive edge 1 and the extended adhesive portion 15. Simultaneously, the outer protective film 7 can be easily removed via the adhesive portion 9, allowing the adhesive edge 1 and the extended adhesive portion 15 to be used. A double-sided adhesive portion 14 is fixedly connected to the outer wall of the drug release layer 6. One side of the double-sided adhesive portion 14 is attached to the outer wall of the adhesive edge 1, and the other side of the double-sided adhesive portion 14 is attached to the adhesive portion 8. The drug release layer 6 can be easily removed from one side of the adhesive edge 1 via the double-sided adhesive portion 14 on the outer wall of the drug release layer 6 without affecting the adhesion effect. A replacement component is provided on the lower surface of the outer protective film 7. The replacement component facilitates the switching of the drug release layer 6. The replacement component includes an adhesive portion 2 10. The upper surface of the adhesive portion 2 10... The surface is attached to the lower surface of the first adhesive part 8. The outer wall of the second adhesive part 10 is fixedly connected to the protective bottom 12. The outer wall of the protective bottom 12 is fixedly connected to one side of the protective bottom 12. The second adhesive part 10 can be separated from the first adhesive part 8 through the second slip part 13, and then the protective bottom 12 can be removed. Then the drug release layer 6 can be replaced or placed. At the same time, the disinfection layer 11 is used for further disinfection. The outer wall of the hydrogel layer 4 is fixedly connected to the inner wall of the adhesive edge 1. The outer wall of the outer protective layer 2 is fixedly connected to the inner wall of the adhesive edge 1. The semi-permeable layer 3 is located between the hydrogel layer 4 and the outer protective layer 2. The semi-permeable layer 3 is used to allow excess exudate to pass through. The outer wall of the protective bottom 12 is fixedly connected to the second slip part 13. The second slip part 13 is used to tear off the protective bottom 12. The outer wall of the outer protective film 7 is fixedly connected to the first slip part 9. The first slip part 9 is used to tear off the outer protective film 7.
[0027] Working principle: When collagen gel dressing is needed, first, lift the easy part 9 to peel off the outer protective film 7, then place the drug release layer 6 above the wound, and adhere it around the wound through the adhesive edge 1 and the extended adhesive part 15. At this time, the collagen matrix layer 5, with its high tensile strength, biodegradability, low antigenic activity, low irritation, low cytotoxicity, and properties that promote cell growth, cell adhesion, and synergistic wound repair with new cells and tissues when used as an artificial organ skeleton or wound dressing, recombines human-derived collagen. At the same time, the hydrogel layer 4 actively releases water and absorbs exudate, while also helping to... The wound bed accumulates growth factors, effectively promoting granulation tissue growth and wound healing. In addition, the exogenous supplementation of recombinant human type III collagen functional gel can effectively increase the local type III collagen level in the wound, thereby inhibiting the excessive secretion of type I collagen, which causes abnormal tissue proliferation and scar formation, and reducing pigmentation. Finally, combined with the drug release layer 6, a good clinical treatment effect is achieved. During this process, some exudate will be absorbed by the hydrogel layer 4. When there is excessive exudate, it will be absorbed by the upper sponge outer protective layer 2 through the semi-permeable layer 3. When the exudate reaches a certain amount, it can be detected by the sponge outer protective layer 2, and the choice can be made whether to change the dressing.
[0028] In addition, before applying the patch, the protective bottom 12 is first peeled off through the second part 13, thereby separating the second part 10 from the first part 8. At this time, the corresponding drug release layer 6 can be placed on one side of the collagen matrix layer 5 as needed, and then the double-sided adhesive part 14 around the drug release layer 6 is pasted to the lower surface of the adhesive edge 1, thereby achieving the effect of replacing the drug release layer 6 as needed.
[0029] Finally, it should be noted that the above are merely preferred embodiments of the present utility model and are not intended to limit the present utility model. Although the present utility model has been described in detail with reference to the foregoing embodiments, those skilled in the art can still modify the technical solutions described in the foregoing embodiments or make equivalent substitutions for some of the technical features. Any modifications, equivalent substitutions, improvements, etc., made within the spirit and principles of the present utility model should be included within the protection scope of the present utility model.
Claims
1. A collagen gel patch, comprising an adhesive edge (1), characterized in that: An extended adhesive portion (15) is fixedly connected to the outer wall of the adhesive edge (1). A drug release layer (6) is provided on the inner wall of the adhesive edge (1). An auxiliary component is provided above the drug release layer (6). The auxiliary component is used to improve the therapeutic effect of the drug release layer (6). An adsorption component is provided on the inner wall of the adhesive edge (1). The adsorption component is used to adsorb exudate. The auxiliary component includes a collagen matrix layer (5) disposed above the drug release layer (6), the outer wall of the collagen matrix layer (5) is fixedly connected to the inner wall of the adhesive edge (1), and a hydrogel layer (4) is disposed above the collagen matrix layer (5).
2. The collagen gel patch according to claim 1, characterized in that: The adsorption assembly includes a semi-permeable layer (3), the outer wall of which is fixedly connected to the inner wall of the adhesive edge (1), and a sponge outer protective layer (2) is provided above the semi-permeable layer (3).
3. The collagen gel patch according to claim 1, characterized in that: An external protective film (7) is attached to the lower part of the extended adhesive portion (15). An adhesive portion (8) is fixedly connected to the upper surface of the external protective film (7). A double-sided adhesive portion (14) is fixedly connected to the outer wall of the drug release layer (6). One side of the double-sided adhesive portion (14) is attached to the outer wall of the adhesive edge (1), and the other side of the double-sided adhesive portion (14) is attached to the adhesive portion (8). A replacement component is provided on the lower surface of the external protective film (7). The replacement component facilitates the switching of the drug release layer (6).
4. The collagen gel patch according to claim 3, characterized in that: The replacement component includes an adhesive part two (10), the upper surface of which is attached to the lower surface of the adhesive part one (8), and a protective bottom (12) is fixedly connected to the outer wall of the adhesive part two (10), and a disinfection layer (11) is fixedly connected to one side of the outer wall of the protective bottom (12).
5. A collagen gel patch according to claim 2, characterized in that: The outer wall of the hydrogel layer (4) is fixedly connected to the inner wall of the adhesive edge (1), and the outer wall of the sponge outer protective layer (2) is fixedly connected to the inner wall of the adhesive edge (1).
6. A collagen gel patch according to claim 2, characterized in that: The semi-permeable layer (3) is located between the hydrogel layer (4) and the outer protective layer (2) of the sponge, and the semi-permeable layer (3) is used to allow excess exudate to pass through.
7. A collagen gel patch according to claim 4, characterized in that: The outer wall of the protective bottom (12) is fixedly connected to a second yoke (13), which is used to tear off the protective bottom (12).
8. A collagen gel patch according to claim 3, characterized in that: The outer wall of the outer protective film (7) is fixedly connected to a Lewis part (9), which is used to tear off the outer protective film (7).