Rapid liquid exchange structure of liquid chromatography-tandem mass spectrometry

Abstract

The utility model relates to the technical field of liquid chromatography-mass spectrometry, and discloses a rapid liquid exchange structure of liquid chromatography-tandem mass spectrometry, which comprises a liquid outlet pipe, a solution channel is arranged in the liquid outlet pipe, the inlet of the solution channel is located at the eccentric position of the end face of the liquid outlet pipe, and the liquid outlet pipe is coaxially and rotatably connected with a conversion connecting seat. A plurality of liquid inlet channels are formed in the conversion connecting seat, when the conversion connecting seat rotates, one liquid inlet channel is communicated with the solution channel, a plurality of positioning assemblies are arranged on the side wall of the conversion connecting seat, and the positions of the positioning assemblies are in one-to-one correspondence with the liquid inlet channels; and a positioning groove in which the positioning assembly can be clamped is formed in the outer side wall of the liquid outlet pipe corresponding to the inlet of the solution channel. According to the invention, the plurality of liquid inlet channels are arranged on the conversion connecting seat, the plurality of liquid inlet channels are respectively communicated with one chromatographic column, and different liquid inlet channels are communicated with the solution channel by rotating the conversion connecting seat, so that rapid exchange of liquid is realized.

Description

Technical Field

[0001] This application relates to the field of liquid chromatography-mass spectrometry (LC-MS), and in particular to a rapid liquid exchange structure for LC-MS / MS. Background Technology

[0002] Liquid chromatography-mass spectrometry (LC-MS) is an instrument that combines liquid chromatography and mass spectrometry. It combines the ability of liquid chromatography to effectively separate thermally unstable and high-boiling-point compounds with the strong component identification capabilities of mass spectrometry. It is an effective method for separating and analyzing complex organic mixtures.

[0003] In a liquid chromatograph, the liquid in the chromatographic column is transferred to the mass spectrometer. Some liquid chromatographs are equipped with multiple chromatographic columns. When the mass spectrometer analyzes each column, it needs to be repeatedly changed and connected to different chromatographic columns. This operation is cumbersome, and the repeated changes can easily contaminate the solvent, leading to inaccurate measurements. Utility Model Content

[0004] To address the issues of cumbersome column connection to a mass spectrometer, which can lead to solvent contamination and inaccurate measurements, this application provides a rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry.

[0005] This application provides a rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry, employing the following technical solution:

[0006] A rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry includes an outlet tube with a solution channel inside. The inlet of the solution channel is located at an eccentric position on the end face of the outlet tube. A conversion connector is coaxially rotatably connected to the outlet tube. The conversion connector has multiple inlet channels, wherein one of the inlet channels communicates with the solution channel when the conversion connector rotates. Multiple positioning components are provided on the side wall of the conversion connector, and the positions of the multiple positioning components correspond one-to-one with the inlet channels. A positioning groove is provided on the outer side wall of the outlet tube corresponding to the inlet of the solution channel, into which the positioning components can be engaged.

[0007] By adopting the above technical solution, multiple liquid inlet channels are set on the conversion connector, and each of the multiple liquid inlet channels is connected to a chromatographic column. By rotating the conversion connector, different liquid inlet channels are connected to the solution channels, thereby realizing rapid liquid exchange. By setting a positioning component and cooperating with the positioning groove, the rotation angle of the conversion connector is determined. At the same time, the positioning component can limit the rotation of the conversion connector and ensure the stability of the conversion connector.

[0008] Optionally, the outlet end of the liquid inlet channel is provided with a flow-blocking component, the flow-blocking component including an inner liner tube slidably connected to the liquid inlet channel, one end of the inner liner tube extending outside the liquid inlet channel, the inner liner tube having a flow-blocking channel communicating with the liquid inlet channel, and a valve body for blocking the flow-blocking channel fixed inside the liquid outlet pipe; a first elastic element is provided between the inner liner tube and the inner wall of the liquid inlet channel, one end of the first elastic element being connected to the outer wall of the inner liner tube, the other end of the first elastic element being fixed to the inner wall of the liquid inlet channel, and the end of the inner liner tube extending outside the liquid inlet channel abutting against the end face of the liquid outlet pipe or being inserted into the solution channel.

[0009] By adopting the above technical solution, a flow-blocking element is used to control the opening and closing of the liquid inlet channel. When one of the liquid inlet channels is connected to the solution channel, the inner liner tube in the liquid inlet channel is moved outward by the force of the first elastic element, the valve body separates from the inner liner tube, and the flow-blocking channel inside the inner liner tube is connected to the liquid inlet channel to ensure normal liquid flow. The inner liner tubes in other liquid inlet channels are compressed in the liquid inlet channel by the force of the outlet pipe end face. The flow-blocking channel of the inner liner tube is blocked by the valve body, and the liquid inlet channel is cut off to avoid liquid leakage.

[0010] Optionally, the end of the inner liner tube near the outlet tube has a spherical end face.

[0011] By adopting the above technical solution, when the conversion connector is rotated, the spherical end face of the inner liner tube is squeezed into the liquid inlet by the solution channel inlet, and the inner liner tube will not be stuck in the solution channel, thus ensuring the normal rotation of the conversion connector.

[0012] Optionally, the positioning component includes a positioning block, the conversion connector has a through hole, the positioning block is slidably connected in the through hole, a second elastic element is provided between the positioning block and the inner wall of the through hole, one end of the second elastic element is connected to the positioning block, the other end of the second elastic element is connected to the inner wall of the through hole, one end of the positioning block extends to the inner side of the conversion connector and is engaged in the positioning groove or abuts against the outer wall of the liquid outlet pipe.

[0013] By adopting the above technical solution, the liquid inlet channel and the solution channel are connected by rotating the conversion connector. The positioning block is subjected to the action of the second elastic element, and the positioning block is stuck into the positioning groove, restricting the rotation of the conversion connector.

[0014] Optionally, the outlet pipe is provided with a connecting part at one end near the conversion connector, the conversion connector is provided with a connecting groove, the connecting groove is rotatably sleeved on the connecting part, and a plurality of sealing rings are provided between the outlet pipe and the conversion connector, the surfaces of the sealing rings respectively abutting against the inner wall of the connecting groove and the outer wall of the connecting part.

[0015] By adopting the above technical solution, the stability of the connection between the conversion connector and the liquid outlet pipe is increased by setting the connecting part and the connecting groove. At the same time, by setting multiple sealing rings, the sealing between the conversion connector and the liquid outlet pipe is ensured, and liquid leakage is avoided.

[0016] Optionally, the outlet pipe is provided with an anti-overflow protrusion, and the conversion connector is provided with a slot into which the anti-overflow protrusion can be engaged.

[0017] By adopting the above technical solution, the anti-overflow protrusion is snapped into the slot to ensure a stable connection between the conversion connector and the outlet pipe. By setting the anti-overflow protrusion, a groove for storing liquid is formed at the end of the outlet pipe. When the conversion connector is disassembled, the liquid remaining in the inlet channel falls into the groove, preventing the liquid from spilling.

[0018] Optionally, an end cap is provided at the connection between the conversion connector and the outlet pipe. The end cap is sleeved on the conversion connector, and a convex ring is provided on the conversion connector. A limit ring is provided on the inner side of one end of the end cap, and the limit ring abuts against the convex ring. The other end of the end cap is threaded to the outlet pipe.

[0019] By adopting the above technical solution and setting an end cap, the connection between the conversion connector and the outlet pipe is made tight and stable, avoiding gaps at the connection between the outlet pipe and the conversion connector, which could cause multiple inlet channels to communicate with each other.

[0020] Optionally, the conversion connector is provided with multiple connectors, each corresponding to a liquid inlet channel.

[0021] By adopting the above technical solution and setting a connector, it is easy to connect to the chromatographic column and the disassembly efficiency is improved.

[0022] Optionally, the adapter connector has a rotating part at one end near the connector head, and the surface of the rotating part is provided with anti-slip texture.

[0023] By adopting the above technical solution, the torque is increased by setting a rotating part, the force of the rotation conversion connector is reduced, and the friction is increased by setting anti-slip texture, which facilitates the rotation conversion connector.

[0024] In summary, this application includes at least one of the following beneficial technical effects:

[0025] 1. By setting multiple liquid inlet channels on the conversion connector, each liquid inlet channel is connected to a chromatographic column. By rotating the conversion connector, different liquid inlet channels are connected to the solution channels, thereby achieving rapid liquid exchange.

[0026] 2. By setting a positioning component and cooperating with the positioning groove, the rotation angle of the conversion connector is determined. At the same time, the positioning component can limit the rotation of the conversion connector and ensure the stability of the conversion connector. Attached Figure Description

[0027] Figure 1 This is a schematic diagram of the rapid liquid exchange structure of the liquid chromatography-tandem mass spectrometry of this application.

[0028] Figure 2 This is an exploded diagram of the rapid liquid exchange structure obtained by liquid chromatography-tandem mass spectrometry in this application.

[0029] Figure 3 This is a cross-sectional view of the rapid liquid exchange structure of the liquid chromatography-tandem mass spectrometry of this application.

[0030] Figure 4 yes Figure 3 Enlarged view of section A.

[0031] Figure 5 yes Figure 3 Enlarged view of section B in the middle.

[0032] Figure 6 yes Figure 3 Enlarged view of section C.

[0033] Reference numerals: 1. Outlet pipe; 11. Solution channel; 12. Connecting part; 13. Anti-overflow protrusion; 14. External thread; 15. Positioning groove; 2. Converter connector; 21. Inlet channel; 22. Connecting groove; 23. Slot; 24. Through hole; 25. Positioning block; 26. First elastic element; 27. Rotating part; 28. Protruding ring; 3. End cap; 31. Limiting ring; 32. Internal thread; 4. Connector; 5. Flow-stopping element; 51. Inner liner; 511. Flow-stopping channel; 512. Spherical end face; 52. Second elastic element; 53. Valve body; 6. Sealing ring. Detailed Implementation

[0034] The embodiments of this application are described in detail below, and examples of the embodiments are shown in the accompanying drawings.

[0035] In the description of this specification, the references to "certain embodiments," "one embodiment," "some embodiments," "illustrative embodiment," "example," "specific example," or "some examples" refer to specific features, structures, materials, or characteristics described in connection with the described embodiment or example, which are included in at least one embodiment or example of this application. In this specification, the illustrative expressions of the above terms do not necessarily refer to the same embodiment or example. Furthermore, the specific features, structures, materials, or characteristics described may be combined in any suitable manner in one or more embodiments or examples.

[0036] This application discloses a rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry, referring to... Figure 1 and Figure 2The system includes an outlet pipe 1, which has a solution channel 11. The inlet of the solution channel 11 is located at the eccentric end face of the outlet pipe 1. A conversion connector 2 is rotatably connected to the outlet pipe 1. The conversion connector 2 has multiple inlet channels 21, which are evenly distributed along the circumference of the conversion connector 2. When the conversion connector 2 rotates, one of the inlet channels 21 is connected to the solution channel 11. Multiple positioning components are provided on the side wall of the conversion connector 2, and the positions of the multiple positioning components correspond one-to-one with the inlet channels 21. A positioning groove 15 is provided on the outer side wall of the outlet pipe 1 at the inlet of the solution channel 11, into which the positioning components can be inserted.

[0037] The conversion connector 2 is equipped with multiple connectors 4, each corresponding to a liquid inlet channel 21. The connectors 4 facilitate connection to the chromatographic column and improve disassembly efficiency.

[0038] The adapter connector 2 has a rotating part 27 at one end near the connector 4, and the surface of the rotating part 27 is provided with anti-slip texture. By providing the rotating part 27, the torque is increased and the force required to rotate the adapter connector 2 is reduced; by providing anti-slip texture, the friction is increased, making it easier to rotate the adapter connector 2.

[0039] Reference Figure 3 and Figure 4 A flow-blocking element 5 is installed at the outlet end of the liquid inlet channel 21 to control the opening and closing of the liquid inlet channel 21. The flow-blocking element 5 includes an inner liner tube 51 slidably connected inside the liquid inlet channel 21. One end of the inner liner tube 51 extends outside the liquid inlet channel 21. A flow-blocking channel 511 communicating with the liquid inlet channel 21 is opened inside the inner liner tube 51. A valve body 53 for blocking the flow-blocking channel 511 is fixed inside the liquid outlet pipe 1. A first elastic element 26 is provided between the inner liner tube 51 and the inner wall of the liquid inlet channel 21. The first elastic element 26 is a spring. One end of the first elastic element 26 is connected to the outer wall of the inner liner tube 51, and the other end of the first elastic element 26 is fixed to the inner wall of the liquid inlet channel 21. The end of the inner liner tube 51 extending outside the liquid inlet channel 21 abuts against the end face of the liquid outlet pipe 1 or is inserted into the solution channel 11.

[0040] In use, when one of the liquid inlet channels 21 is connected to the solution channel 11, the inner liner tube 51 in the liquid inlet channel 21 is moved outward by the force of the first elastic element 26, the valve body 53 is separated from the inner liner tube 51, and the internal intercepting channel 511 of the inner liner tube 51 is connected to the liquid inlet channel 21 to ensure normal liquid flow; the inner liner tube 51 in other liquid inlet channels 21 is compressed in the liquid inlet channel 21 by the force of the end face of the liquid outlet pipe 1, the intercepting channel 511 of the inner liner tube 51 is blocked by the valve body 53, the liquid inlet channel 21 is cut off, and the problem of liquid leakage is avoided.

[0041] The end of the inner liner tube 51 near the outlet tube 1 is a spherical end face 512. When the conversion connector 2 is rotated, the spherical end face 512 of the inner liner tube 51 is squeezed by the edge of the inlet of the solution channel 11, which facilitates squeezing the inner liner tube 51 into the inlet channel 21 and ensures the normal rotation of the conversion connector 2.

[0042] Reference Figure 3 and Figure 5 The positioning component includes a positioning block 25. A through hole 24 is provided on the side wall of the conversion connector 2. The positioning block 25 is slidably connected in the through hole 24. A second elastic element 52 is provided between the positioning block 25 and the inner wall of the through hole 24. The second elastic element 52 is a spring. One end of the second elastic element 52 is connected to the positioning block 25, and the other end of the second elastic element 52 is connected to the inner wall of the through hole 24. One end of the positioning block 25 extends to the inner side of the conversion connector 2 and is engaged in the positioning groove 15 or abuts against the outer wall of the liquid outlet pipe 1.

[0043] When the conversion connector 2 is rotated, when the liquid inlet channel 21 is connected to the solution channel 11, the positioning block 25 corresponding to the liquid inlet channel 21 is subjected to the action of the second elastic element 52, so that the positioning block 25 is stuck in the positioning groove 15, restricting the rotation of the conversion connector 2, while the positioning blocks 25 in other positions are compressed in the through hole 24.

[0044] Reference Figure 2 and Figure 3 A connecting part 12 is provided at one end of the outlet pipe 1 near the conversion connector 2. A connecting groove 22 is provided on the conversion connector 2. The connecting groove 22 is rotatably sleeved on the connecting part 12, which increases the connection area between the outlet pipe 1 and the conversion connector 2 and increases the stability of the connection between the conversion connector 2 and the outlet pipe 1. Multiple sealing rings 6 are provided between the outlet pipe 1 and the conversion connector 2. The surfaces of the sealing rings 6 abut against the inner wall of the connecting groove 22 and the outer wall of the connecting part 12, respectively.

[0045] Meanwhile, by setting multiple sealing rings 6, the sealing between the conversion connector 2 and the liquid outlet pipe 1 is ensured, thus preventing liquid leakage.

[0046] An anti-overflow protrusion 13 is provided at the end of the connecting part 12, and a slot 23 is provided in the connecting groove 22 for the anti-overflow protrusion 13 to be engaged. The anti-overflow protrusion 13 is engaged in the slot 23 to ensure a stable connection between the connecting seat and the connecting groove 22. At the same time, by providing the anti-overflow protrusion 13, a groove for storing liquid is formed at the end of the liquid outlet pipe 1. When the connecting seat 2 is disassembled and changed, the liquid remaining in the liquid inlet channel 21 falls into the groove, preventing the liquid from spilling.

[0047] Reference Figure 3 and Figure 6An end cap 3 is provided at the connection between the conversion connector 2 and the outlet pipe 1. The end cap 3 is fitted onto the conversion connector 2, which has a raised ring 28. A limiting ring 31 is provided on the inner side of one end of the end cap 3, and the limiting ring 31 abuts against the raised ring 28. The other end of the end cap 3 has an internal thread 32, and the outer wall of the outlet pipe 1 has an external thread 14. The end cap 3 is threadedly connected to the outlet pipe 1. By providing the end cap 3, the connection between the conversion connector 2 and the outlet pipe 1 is made tight and stable, avoiding gaps at the connection between the outlet pipe 1 and the conversion connector 2, which could cause multiple inlet channels 21 to communicate with each other.

[0048] The implementation principle of the rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry in this application embodiment is as follows: In use, multiple chromatographic columns are connected to the connector 4 respectively. By rotating the conversion connector 2, different liquid inlet channels 21 are connected to the solution channels 11. When the liquid inlet channel 21 is connected to the solution channels 11, the inner liner tube 51 in the liquid inlet channel 21 moves outward under the action of the second elastic element 52, and the inner liner tube 51 separates from the valve body 53. The liquid inlet channel 21 and the solution channels 11 are connected through the intercepting channel 511, thereby realizing rapid liquid exchange. At the same time, by setting the positioning block 25 and cooperating with the positioning groove 15, the rotation angle of the conversion connector 2 is determined. At the same time, the positioning block 25 can restrict the rotation of the conversion connector 2 and ensure the stability of the conversion connector 2.

[0049] Although embodiments of this application have been shown and described above, it is understood that the above embodiments are exemplary and should not be construed as limiting this application. Those skilled in the art can make changes, modifications, substitutions and variations to the above embodiments within the scope of this application.

Claims

1. A rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry, characterized in that, The system includes an outlet pipe (1), which has a solution channel (11) inside. The inlet of the solution channel (11) is located at the eccentric end face of the outlet pipe (1). A conversion connector (2) is coaxially rotatably connected to the outlet pipe (1). The conversion connector (2) has multiple inlet channels (21). When the conversion connector (2) rotates, one of the inlet channels (21) is connected to the solution channel (11). Multiple positioning components are provided on the side wall of the conversion connector (2). The positions of the multiple positioning components correspond one-to-one with the inlet channels (21). A positioning groove (15) is provided on the outer side wall of the outlet pipe (1) corresponding to the inlet of the solution channel (11) for the positioning components to be inserted.

2. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, The outlet end of the liquid inlet channel (21) is provided with a flow-blocking component (5). The flow-blocking component (5) includes an inner liner tube (51) slidably connected to the liquid inlet channel (21). One end of the inner liner tube (51) extends to the outside of the liquid inlet channel (21). A flow-blocking channel (511) communicating with the liquid inlet channel (21) is opened in the inner liner tube (51). A valve body (53) for blocking the flow-blocking channel (511) is fixed in the outlet pipe (1). A first elastic element (26) is provided between the inner liner tube (51) and the inner wall of the liquid inlet channel (21). One end of the first elastic element (26) is connected to the outer wall of the inner liner tube (51). The other end of the first elastic element (26) is fixed to the inner wall of the liquid inlet channel (21). The end of the inner liner tube (51) extending outside the liquid inlet channel (21) abuts against the end face of the outlet pipe (1) or is inserted into the solution channel (11).

3. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 2, characterized in that, The end of the inner liner tube (51) near the liquid outlet tube (1) has a spherical end face (512).

4. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, The positioning component includes a positioning block (25), and the conversion connector (2) has a through hole (24). The positioning block (25) is slidably connected in the through hole (24). A second elastic element (52) is provided between the positioning block (25) and the inner wall of the through hole (24). One end of the second elastic element (52) is connected to the positioning block (25), and the other end of the second elastic element (52) is connected to the inner wall of the through hole (24). One end of the positioning block (25) extends to the inner side of the conversion connector (2) and is engaged in the positioning groove (15) or abuts against the outer wall of the liquid outlet pipe (1).

5. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, The outlet pipe (1) is provided with a connecting part (12) at one end near the conversion connector (2). The conversion connector (2) is provided with a connecting groove (22). The connecting groove (22) is rotatably sleeved on the connecting part (12). A plurality of sealing rings (6) are provided between the outlet pipe (1) and the conversion connector (2). The surfaces of the sealing rings (6) respectively abut against the inner wall of the connecting groove (22) and the outer wall of the connecting part (12).

6. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 5, characterized in that, The connecting part (12) is provided with an anti-overflow protrusion (13), and the connecting groove (22) is provided with a slot (23) into which the anti-overflow protrusion (13) can be inserted.

7. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, An end cap (3) is provided at the connection between the conversion connector (2) and the outlet pipe (1). The end cap (3) is sleeved on the conversion connector (2). A convex ring (28) is provided on the conversion connector (2). A limiting ring (31) is provided on the inner side of one end of the end cap (3). The limiting ring (31) abuts against the convex ring (28). The other end of the end cap (3) is threaded to the outlet pipe (1).

8. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, The conversion connector (2) is provided with a plurality of connectors (4), and each connector (4) corresponds to a liquid inlet channel (21).

9. The rapid liquid exchange structure for liquid chromatography-tandem mass spectrometry according to claim 1, characterized in that, The conversion connector (2) has a rotating part (27) at one end near the connector (4), and the surface of the rotating part (27) is provided with anti-slip texture.

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